Expression of lineage specific transcription factors cell lineage. Medical search. Frequent questions

AB - Lineage-selective expression of developmental genes is dependent on the interplay between activating and repressive mechanisms. (imperial.ac.uk)
Second, altering the MSC state by inducing differentiation into multiple lineages did not affect the exosomal properties or endocytosis but triggered the expression of lineage-specific genes and proteins in vitro and in vivo respectively. (frontiersin.org)
c-maf targets are IL-4 in Th2 cells, the crystalline genes in lens fiber cells, insulin gene in islet, p53 and L7 where it exerts its transcriptional role through binding to a Maf recognition element (MARE). (thermofisher.com)
Significantly differentially expressed (SDE) immunological genes and transcription factor (TF) were selected for functional pathways and transcriptional signaling identification. (frontiersin.org)
Background: Bivalent chromatin domains consisting of the activating histone 3 lysine 4 trimethylation (H3K4me3) and repressive histone 3 lysine 27 trimethylation (H3K27me3) histone modifications are enriched at developmental genes that are repressed in embryonic stem cells but active during differentiation. (researchgate.net)
Here we show that bivalent domains and chromosome architecture for bivalent genes are dynamically regulated during the cell cycle in human pluripotent cells. (researchgate.net)
Central to this is the transient increase in H3K4-trimethylation at developmental genes during G1, thereby creating a 'window of opportunity' for cell-fate specification. (researchgate.net)
While the observation that NHR-67 forms punctae associated with transcriptional repressors in non-invasive cells is intriguing, the work does not yet established a clear link between the formation and dissolution of NHR-67 condensates with the activation of downstream genes that NHR-67 is actively repressing. (elifesciences.org)
In adult mice, IL-7/IL-7R signaling up regulates expression of early B cell factor (EBF), and EBF in turn regulates expression of B cell-specific genes required for the transition from lymphoid progenitor to pro-B cells. (biolegend.com)
Transcriptional activity is regulated by DNA binding transcription factors, but these typically act in more than one cell lineage activating different subsets of target genes in each. (edu.au)
The activities of transcription factors and other genes involved in cell fate decisions can be measured by a number of different gene expression quantification experiments. (lu.se)
Thus RUNX1/ETO contributes to increased expression of miR451 target genes and interferes with normal gene expression during differentiation. (uni-frankfurt.de)
Gene expression data from 24 experiments for 8 different cell types of the human myelopoietic lineage were used to generate an integrated myelopoiesis dataset of 9,425 genes, each reliably associated to a unique genomic position and chromosomal coordinate. (biomedcentral.com)
This approach allowed identifying specific chromosomal regions significantly highly or weakly expressed, and clusters of differentially expressed genes and of transcripts related to specific functional modules. (biomedcentral.com)
The analysis of genomic expression during human myelopoiesis using an integrative computational approach allowed discovering important relationships between genomic position, biological function and expression patterns and highlighting chromatin domains, including genes with coordinated expression and lineage-specific functions. (biomedcentral.com)
The correlation among co-expression and co-localization of genes was also investigated and confirmed in different organisms [ 12 ]. (biomedcentral.com)
For instance, the existence of tissue-specific gene clusters may be related to the efficient activation of gene expression in a particular cell lineage, by genetic and epigenetic mechanisms, or related to the repression of entire chromosomal regions containing genes expressed in a specific cell type, e.g. during the developmental switches leading to different cell lineages [ 25 ]. (biomedcentral.com)
While PU.1-dependent induction of myeloid-specific target genes has been intensively studied, negative regulation of stem cell or alternate lineage programs remains incompletely characterized. (zfin.org)
Induction of anemia resulted in mobilization of the quiescent to the active cluster and of the early to later stage of cell cycle, with marked increase in expression of certain transcription factors (TFs) while maintaining expression of interferon response genes. (nih.gov)
Lineage-specific genes were differently expressed between cells, and correlated with the cell cycle stages with a specific augmentation of erythroid related genes in the G2/M phase. (nih.gov)
This study reveals effects of cell cycle progression on the expression of lineage specific genes in precursor cells, and suggests that hematopoietic stress changes the balance of renewal and differentiation in these homeostatic cells. (nih.gov)
Furthermore, the information generated will allow future investigations of specific genes involved in particular stages of duck adipogenesis. (biomedcentral.com)
However, the existence of specific transcriptional repressors responsible for the silencing of lineage inappropriate genes remains elusive. (eur.nl)
Here we addressed the molecular mechanism behind repression of non-lymphoid genes in B cells. (eur.nl)
We found that HDAC7 specifically interacted with the transcription factor MEF2C in pre-B cells and was recruited to MEF2 binding sites located at the promoters of genes critical for macrophage function. (eur.nl)
Thus, in B cells HDAC7 is a transcriptional repressor of undesirable genes. (eur.nl)
Our findings uncover a novel role for HDAC7 in maintaining the identity of a particular cell type by silencing lineage-inappropriate genes. (eur.nl)
Activation of selected lineage-specific genes and repression of alternative lineage-affiliated genes result in tightly regulated cell differentiation transcriptional programmes. (ox.ac.uk)
First identified in embryonic stem cells, SEs mediate pluripotent state maintenance by promoting the expression of pluripotent identity genes, including Oct4 , Sox2 , Nanog and Klf4 . (nature.com)
By using these indicator and fate-mapping mice, we will study the development of various lymphocyte subsets at steady state and in autoimmune and infectious settings, and compare the gene expression patterns through RNA-seq in "pure" Th and ILC subsets generated both in vitro and in vivo to identify lineage-specific genes. (nih.gov)
Lineage-specific genes found in mice studies may serve as new biomarkers for identifying human T-cell subsets and/or targets for treating specific human diseases. (nih.gov)
Supervised analysis of kinase genes revealed a high-level FLT3 expression in a subset of cases without molecular rearrangements. (aacrjournals.org)
Genomic profiling also identifies genes associated with poor outcome in cases without molecular aberrations and specific genes that may be new therapeutic targets in adult ALL. (aacrjournals.org)
A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. (origene.com)
In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. (origene.com)
This lineage has spread in countries where adamantane is not widely used because of linkage to advantageous mutations in genes other than M2. (cdc.gov)
Inactivation of tumor suppressor genes, whose products normally provide negative control of cell proliferation, contributes to malignant transformation in various cell types. (medscape.com)
Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
TP53 activates the expression of genes involved in apoptosis, cell cycle regulation (p21), and MDM2. (medscape.com)
Another important class of tumor suppressor genes involved in cell cycle control and in the generation of human cancers is the cyclin-dependent kinase (CDK) inhibitors. (medscape.com)
1 In particular, morpholino oligonucleotides (MOs) have been used to block the expression of targeted genes in several invertebrate and vertebrate models. (cdc.gov)

Gene activation is dependent on cell-specific transcription factors that recognize transcriptional enhancer sequences. (imperial.ac.uk)
By screening for proteins that colocalize with NHR-67 punctae, we identified new regulators of uterine cell fate maintenance: homologs of the transcriptional co-repressor Groucho (UNC-37 and LSY-22), as well as the TCF/LEF homolog POP-1. (elifesciences.org)
We propose a model in which association of NHR-67 with the Groucho/TCF complex suppresses the default invasive state in non-invasive cells, which complements transcriptional regulation to add robustness to the proliferative-invasive cellular switch in vivo . (elifesciences.org)
This valuable data study presents convincing data that expression of the C. elegans transcription factor NHR-67 is sufficient to drive an invasive fate, and that the alternative proliferative fate is associated with NHR-67 transcriptional down-regulation. (elifesciences.org)
The work will be of interest to developmental biologists studying transcriptional control of cell fate specification in animals, especially once issues around the functional significance of the NHR-67 contiaining punctae are resolved. (elifesciences.org)
The purpose of this study was to investigate whether an aberrant DNA methylation of transcriptional and inflammatory factors, including TBX21, GATA3, RORγt, FOXP3, IFN-γ, IL-4, IL-17A and TGF-β , in CD4 + T confers risk to BD. (oncotarget.com)
HCK expression is up-regulated at the transcriptional level during myeloid differentiation of hematopoietic cells. (uni-frankfurt.de)
Site-directed mutagenesis of the proximal promoter region showed that two GC-rich sequence elements are essential for transcriptional activity in myeloid cells. (uni-frankfurt.de)
Differentiation of multipotent stem cells into mature cells is fundamental for development and homeostasis of mammalian tissues, and requires the coordinated induction of lineage-specific transcriptional programs and cell cycle withdrawal. (regionh.dk)
In their recently published review in Stem Cell Research & Therapy , Bertie G öttgen's group from the University of Cambridge discuss the transcriptional regulation of haematopoetic transcription factors. (biomedcentral.com)
The subsequent synergistic regulation of POL II carboxyterminal domain (CTD) phosphorylation by BRD4 and RPAP2 initiated ZBTB16 transcriptional elongation, which facilitated MSC osteogenesis via the key osteogenic transcription factor SP7. (nature.com)
After the binding of the RPAP2-Pol II complex to BRD4 on SEs, RPAP2 dephosphorylates Ser5 at the Pol II CTD to terminate the transcriptional pause, and BRD4 phosphorylates Ser2 at the Pol II CTD to initiate transcriptional elongation, which synergistically drives efficient transcription of ZBTB16, ensuring proper osteogenesis. (nature.com)
These data suggest that transcriptional changes after transformation in ovarian cancer are closely related to epigenetic remodeling in lineage-specific transcription factors. (nih.gov)

Distinct types of cell death and the implication in diabetic cardiomyopathy. (koreamed.org)
Here, we investigated this dichotomy in vivo by examining two cell types in the developing Caenorhabditis elegans somatic gonad that derive from equipotent progenitors, but exhibit distinct cell behaviors: the post-mitotic, invasive anchor cell and the neighboring proliferative, non-invasive ventral uterine (VU) cells. (elifesciences.org)
Naive T helper cells differentiate into two subsets, Th1 and Th2, each with distinct functions and cytokine profiles. (nih.gov)
Electrophoretic mobility shift analysis using nuclear extracts obtained from RAW264 cells and from the promonocytic cell line U-937 revealed the formation of at least three distinct protein-DNA complexes at each of these sites, one of which was found to contain the transcription factor Sp1. (uni-frankfurt.de)
Abstract: A network of lineage-specific transcription factors and microRNAs tightly regulates differentiation of hematopoietic stem cells along the distinct lineages. (uni-frankfurt.de)
Human myelopoiesis is an exciting biological model for cellular differentiation since it represents a plastic process where multipotent stem cells gradually limit their differentiation potential, generating different precursor cells which finally evolve into distinct terminally differentiated cells. (biomedcentral.com)
scRNA-seq on murine hematopoietic stem cells (HSC) and their progeny MPP1 separated the cells into 3 main clusters with distinct features: active, quiescent, and an un-characterized cluster. (nih.gov)
To date, the central role of specific transcription factors in positively regulating these distinct differentiation processes to acquire a B cell-specific genetic program is well established. (eur.nl)
These findings highlight how tissue-specific transcription factors coordinate cell cycle exit with differentiation through the use of distinct gene regulatory elements. (regionh.dk)
Together, our findings suggest a role for Notch in the induction of a Clara cell-specific program of gene expression, and reveals that the NEB microenvironment in the developing airways is a niche for a distinct subset of Clara-like precursors. (harvard.edu)
Stem cells of all organs - including the lung, which harbors distinct stem cells for each separate tissue that makes up the lung as a whole - reside in niches described as a microenvironment that supports and maintains the 'stemness' of cells as a critical reservoir for maintaining tissue homeostasis and responding to injury [ 3 ]. (karger.com)
Haematopoiesis, the process by which phenotypically distinct mature cells are generated from multipotent blood stem cells, is one of the best understood models of adult stem cell development and differentiation. (biomedcentral.com)
After being activated through their T-cell receptor (TCR) in a particular cytokine milieu, naive CD4 T cells differentiate into distinct Th lineages, including Th1, Th2, and Th17 cells, which are indispensable for different types of immunity to various microorganisms. (nih.gov)
Distinct subsets of ILCs are capable of producing similar sets of characteristic effector cytokines as produced by Th cells. (nih.gov)
Within B-lineage ALL, distinct signatures were associated with ALL1/AF4 and E2A/PBX1 gene rearrangements. (aacrjournals.org)
After more than four decades of intensive research, the cellular origins of acute lymphocytic leukemia (ALL) have been well defined, and several distinct genetic mechanisms that lead to malignant transformation of these cells have been identified ( 1 - 4 ). (aacrjournals.org)
However, as development proceeds, they underwent two sequential lineage segregation events to finally generate two regionally distinct adult stem cell pools. (columbia.edu)
Follicular dendritic cells are a distinct lineage (a different cell type than conventional dendritic cells), do not express class II MHC molecules, and therefore do not present antigen to Th cells. (msdmanuals.com)

Here we have used a highly efficient procedure based on lentiviral-mediated transgenesis to carry out in vivo fine-mapping of, cis-regulatory sequences that control lineage-specific activation of Neurog3, a master regulator of pancreatic endocrine differentiation. (imperial.ac.uk)
Although MSC EVs show great promise for regenerative medicine applications, insights into their uptake mechanisms by different target cells and the ability to control MSC EV properties for defined function in vivo have remained elusive knowledge gaps. (frontiersin.org)
Most clinical trials which utilize ADSCs for OA treatment have been based on the autologous cells from the stromal vascular fraction, as have most of the in vivo studies ( 6 , 7 ). (spandidos-publications.com)
IL-7 also controls T cell-dendritic cell interactions that are essential for both T-cell homeostasis and activation in vivo . (biolegend.com)
To understand the underlying regulatory mechanisms of this fundamental process, we investigated how the tissue-specific transcription factors, CEBPA and CEBPE, coordinate cell cycle exit and lineage-specification in vivo during granulocytic differentiation. (regionh.dk)
We show that Scgb3a2 expression in vivo is Notch-dependent at early stages and ectopically induced by constitutive Notch1 activation, and also that in vitro Notch signaling together with the pan-airway transcription factor Ttf1 (Nkx2.1) synergistically regulate secretoglobin gene transcription. (harvard.edu)
The goal of this thesis is to address these gaps of knowledge using a variety of technologies, including functional and lineage tracing analysis in vivo in mouse genetic models, injury modeling, high-throughput profiling and gene regulation approaches. (columbia.edu)

Mesenchymal stem cells (MSCs) are multipotent cells with regenerative and immunomodulatory properties. (frontiersin.org)
Human mesenchymal stem cells (HMSCs) are multipotent somatic stem cells that can be isolated from a variety of tissues such as the bone marrow, adipose tissue, and dental pulp. (frontiersin.org)
Many existing tissue-engineering approaches focus on delivery of selected proteins (growth factors, transcription factors etc.) or nucleic acids to host or implanted stem cells to achieve lineage specific differentiation. (frontiersin.org)
Mouse naive embryonic stem cells have recently been shown to give rise to embryonic and extra-embryonic stem cells capable of self-assembling into post-gastrulation structured stem-cell-based embryo models with spatially organized morphogenesis (called SEMs) 3 . (nature.com)
Here we extend those findings to humans using only genetically unmodified human naive embryonic stem cells (cultured in human enhanced naive stem cell medium conditions) 4 . (nature.com)
Student projects in my lab will revolve around cell-fate decisions in Spermatogonial Stem Cells (SSC). (utsa.edu)
SSCs are adult-tissue stem cells in the mammalian testis that balance self renewing and differentiating fate decisions to give rise to and sustain the entire spermatogenic lineage. (utsa.edu)
In the present study, the potential of using exosomes isolated from adipose‑derived stem cells (ADSCs) as a therapeutic tool for reducing chronic inflammation and promoting chondrogenesis was investigated using patient‑derived primary cells. (spandidos-publications.com)
Adipose tissue-derived stem cells (ADSCs) have been characterized as having the ability to self-renew and differentiate into different connective tissue cells, including osteoblasts, adipocytes, chondrocytes and myocytes, under specific inductive stimuli ( 4 ). (spandidos-publications.com)
In total, 1-10% of nucleated cells in adipose tissue are ADSCs, whereas only 0.0001-0.01% of nucleated cells in bone marrow are stem cells ( 5 ). (spandidos-publications.com)
We have shown that MOZ/MYST3 is essential for the development of haematopoietic stem cells and that QKF/MYST4 has a critical role in neural stem cells and in brain development. (edu.au)
He, then, has translated some of this knowledge in the stem cell research field contributing to develop protocols and methods for generating sub-type specific telencephalic neurons through in vitro differentiation of embryonic and neural stem cells. (michaeljfox.org)
The differentiation of hematopoietic stem cells (HSC) into myeloid lineages requires the transcription factor PU.1. (zfin.org)
In multiple organs, including the lungs, age-related tissue and organ dysfunction interferes with tissue regeneration, which requires functional stem cells. (karger.com)
Stem cells are characterized by their ability to undergo self-renewal to maintain stem cell reserves, and, when required, to produce new, terminally differentiated cells. (karger.com)
During aging, a decline in organ function can be traced to a loss of stem cell function due to increased cell turnover, depletion of stem cells, and alterations to the stem cell niche. (karger.com)
In this study, we present integrated quantitative proteome, transcriptome, and methylome analyses of hematopoietic stem cells (HSCs) and four multipotent progenitor (MPP) populations. (lu.se)
As the major cell precursors in osteogenesis, mesenchymal stem cells (MSCs) are indispensable for bone homeostasis and development. (nature.com)
Mesenchymal stem cells (MSCs) show trilineage differentiation because these cells differentiate into osteocytes, chondrocytes and adipocytes. (nature.com)
Basal cells (BCs) are multipotent tissue-specific stem cells of a variety of organs including the skin, digestive and respiratory tract. (columbia.edu)
However, the embryonic origin of these adult stem cells remains elusive. (columbia.edu)
[ 17 , 18 ] TCF7L2 protein is increased during adipogenesis in 3T3-L1 cells and in primary adipocyte stem cells. (medscape.com)
A potentially pre-clinical aspect of this thesis is detailed in paper №4 where I describe a robust protocol for the generation of functional mesDA neurons from human embryonic stem cells that are functional in a rat model of PD. (lu.se)
Sozzi E, Nilsson F, Kajtez J, Parmar M, Fiorenzano A. Generation of Human Ventral Midbrain Organoids Derived from Pluripotent Stem Cells . (lu.se)

The epigenetic regulation of spatiotemporal gene expression is crucial for human development. (researchgate.net)
Dr. Carless' research focuses on identifying genetic and epigenetic factors associated with complex diseases, and in understanding how these might contribute to disease risk, and be leveraged as potential novel therapies. (utsa.edu)
The review is the first in a series on epigenetics and regulation , the next article looks at the epigenetic regulation of satellite cell activation during muscle regeneration and will be published soon. (biomedcentral.com)
ChIPseq will be applied to assess genome-wide epigenetic modifications and DNA binding sites for key transcription factors in different cell types. (nih.gov)
e.g. inflammation, genotoxicity, and This chapter focuses on issues as- ellers, growth factors, growth factor epigenetic alterations) and can have sociated with the understanding and receptors, signal transducers, and both genetic and epigenetic origins. (who.int)
Activating mutations upstream may also underlie some epigenetic or within the ERK1/2 cascade are events that change cell signalling. (who.int)

First, it was tested whether patient‑derived ADSCs could differentiate into chondrogenic and osteogenic lineages. (spandidos-publications.com)
In response to morphogens, the hONPs differentiate along several neural lineages. (scirp.org)

The activated JAK proteins in turn phosphorylate specific residues on the IL-7R creating docking sites for signaling molecules such as STAT5 and to a lesser extent STAT1 and STAT3. (biolegend.com)
This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. (novusbio.com)
Here, we report an interaction between H3K4 demethylase JARID1A and the haematopoietic-specific master transcription proteins SCL and GATA1 in red blood cells. (ox.ac.uk)
Binding of viral proteins to their ligands activates signaling pathways-focal adhesion kinase for human herpesvirus 8, JAK1, tyk2 and STAT1/2 for West Nile virus (WNV), I κ B-kinase, and nuclear transcription factor κ B (NF-κB) for influenza virus-resulting in virus entry, DNA delivery to nucleus, and modulation of protein expression that stimulate or inhibit virus replication. (cdc.gov)

These receptors trigger inflammation through the NFkB-dependent and interferon regulatory factor-dependent signaling pathway. (medscape.com)
We are testing the hypothesis that specific transcription factors form regulatory networks to execute gene expression programs important for SSC fate decisions (self-renewal and differentiation), and ultimately, spermatogenesis. (utsa.edu)
Rapid MYC-driven progressors exhibited a high number of activated/exhausted CD8(+) T cells with reduced immunosuppressive regulatory T (T-reg) cells, while late MYC acquisition in slow progressors was associated with lower CD8(+) T cell infiltration and more abundant T-reg cells. (unav.edu)
The programmes governing the function and fate of cells are to a large extent driven by the coordinated activity of transcription factors forming complex and dynamic gene regulatory networks (GRNs). (lu.se)
This averaging effect hampered the analysis of finer regulatory mechanisms at the single-cell level, the fundamental unit for any fate decision process. (lu.se)
T helper (Th) type 1, Th2, Th17 and regulatory T cell (Treg) are the major subpopulations of CD4 + T cells. (oncotarget.com)
Deregulation of this regulatory network contributes to impaired lineage fidelity and leukemogenesis. (uni-frankfurt.de)
To test for such negative regulatory events, we searched for PU.1-controlled microRNAs (miRs) by expression profiling using a PU.1-inducible myeloid progenitor cell line model. (zfin.org)
We provide evidence that PU.1 directly controls expression of at least four of these miRs (miR-146a, miR-342, miR-338 and miR-155) through temporally dynamic occupation of binding sites within regulatory chromatin regions adjacent to their genomic coding loci. (zfin.org)
At the proliferation stage, proliferation related pathways and basic cellular and metabolic processes were inhibited, while regulatory factors that initiate differentiation enter the ready-to-activate state, which provides a precondition for initiating adipose differentiation. (biomedcentral.com)
The authors review recent studies that have identified specific regulatory codes within multiple modular regulatory regions in the genome, and how tissue-specific expression is mediated by cooperation between different modular elements. (biomedcentral.com)
We also found an unexpectedly dynamic pattern of transcript isoform regulation, suggesting a critical regulatory role during HSC differentiation, and a cell cycle/DNA repair signature associated with multipotency in MPP2 cells. (lu.se)
Other CD4 T cells include follicular T cells (Tfh) and regulatory T cells (Treg). (nih.gov)
Tfh cells are critical for promoting antibody responses, whereas Treg cells, which consist of naturally occurring regulatory T cells (nTregs) and inducible regulatory T cells (iTregs), are involved in maintaining immune tolerance and lymphocyte homeostasis. (nih.gov)
However, emerging data suggest that there are many more critical transcription factors in the regulatory network that are critical for T-cell fate determination and function. (nih.gov)
We envisioned that enzyme-activatable cMOs could overcome these limitations, as the triggering enzymes could be expressed in individual cell populations using cis regulatory elements. (cdc.gov)

Autophagy is a remarkable patho (physiological) process in the cell homeostasis regulation including EC. (koreamed.org)
Up-regulation of autophagy induces endothelial cell regeneration/differentiation and improves the function of impaired ones. (koreamed.org)
In addition, IL-7 controls T-cell size and metabolism through the activation of PI3 kinase-dependent pathways and regulation of glucose metabolism. (biolegend.com)
Although the pathogenesis of BD is still not clear, numerous studies have suggested that environmental factors, infection triggers, abnormal autoimmune regulation and genetic susceptibility are closely associated with BD [ 3 ]. (oncotarget.com)
Our results show that Sp1 plays an essential role in the regulation of the differential gene expression of the HCKgene. (uni-frankfurt.de)
Furthermore, we observed that inhibition of RUNX1/ETO in Kasumi1 cells and in RUNX1/ETO positive primary acute myeloid leukemia patient samples leads to up-regulation of miR144/451. (uni-frankfurt.de)
Finally, we manually assembled a proposed regulation network model of subcutaneous preadipocyte differentiation base on the expression data, and suggested that E2F1 may serve as an important link between the processes of duck subcutaneous preadipocyte proliferation and differentiation. (biomedcentral.com)
Subsequently, CEBPE confers promoter-driven cell cycle exit by sequential repression of MYC target gene expression at the G1/S transition and E2F-meditated G2/M gene expression, as well as by the up-regulation of Cdk1/2/4 inhibitors. (regionh.dk)
Moreover, the molecular signatures of tracheal embryonic E18.5 preBCs and adult TrBCs were generated through high-throughput profiling, which provided hints about the genetic regulation of airway BC maturation process and generated potential molecular landmarks for the in vitro ES/iPS cell differentiation towards airway BCs. (columbia.edu)
Regulation of lineage-restricted transcription factors has been shown to influence malignant transformation in several types of cancer. (nih.gov)
The reason for its use is the higher number of platelets, which is an important source of growth factors, such TGF- β1, that hypothetically possess a stimulating effect on regulation and differentiation in mesenchymal tissue repair 10 . (bvsalud.org)

Histone modifications and chromatin-associated protein complexes are crucially involved in the control of gene expression, supervising cell fate decisions and differentiation. (researchgate.net)
Their cell lineage-specific effects are governed by chromatin structure. (edu.au)
We are currently investigating the function of chromatin modifiers during embryonic development, in adult stem cell populations and in cancer, and modelling chromatin-based intellectual disability to discover ameliorating treatments. (edu.au)
To gain insight into the molecular mechanisms mediating HDAC7 repression in pre-B cells, we undertook co-immunoprecipitation and chromatin immunoprecipitation experimental approaches. (eur.nl)
Chromatin remodelling and transcription factors play important roles in lineage commitment and development through control of gene expression. (ox.ac.uk)
However, the complex functional and physical interplay between transcription factors and chromatin-modifying enzymes remains elusive. (ox.ac.uk)
We designed the present study in order to understand whether changes in gene expression between FTSECs and HGSOCs relate to alterations in PAX8 binding to chromatin. (nih.gov)

Human MC were initially divided into three subsets based on the cell surface expression of CD14 and CD16, and recently classified based on CD40 expression ( 2 - 5 ). (frontiersin.org)
Murine MC are divided into three subsets based on surface expression of lymphocyte antigen 6 complex, locus C (Ly6C) ( 3 , 4 ). (frontiersin.org)
TBX21 (Th1) , GATA3 (Th2) , RORγt (Th17) and FOXP3 (Treg) are the primary subset-specific transcription factors of these CD4 + T cell subsets and can regulate T cell differentiation. (oncotarget.com)
To identify and study Th and ILC subsets at a finer level, multi-color "reporter" mice reflecting the expression of key transcription factors, such as T-bet, GATA3, RORγ t and Foxp3, are being prepared through cross-breeding after generation of single reporter mouse strains using BAC transgenic or knock-in strategies. (nih.gov)

This thesis work showed the newly identified p63+ airway progenitors before E10.5 are multipotent for all lung epithelial lineages and this multipotency gets restricted to proximal fate at E10.5. (columbia.edu)

Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma. (cancerindex.org)
This study suggests that specific transcription factors and treatment with morphogens can restrict human adult olfactory-derived progenitors to a dopaminergic neuronal lineage. (scirp.org)
Lately, his group employed lineage-specific transcription factors for reprogramming cellular identity and generating therapeutic relevant neuronal subtypes from conversion of skin fibroblasts. (michaeljfox.org)
The effect of microglial cells with differential SPI1 expression on other brain cell types will be assessed in vitro by analyzing reactivity of astrocytes and viability of neuronal cells. (brightfocus.org)
Shane Grealish: Cell Replacement Therapy for Parkinson's Disease: The Importance of Neuronal Subtype, Cell Source and Connectivity for Functional Recovery. (lu.se)
The aim of this thesis was to understand how particular factors such as neuronal content, placement and cell source, affect functional outcome after transplantation into the rodent brain. (lu.se)
Through understanding functional recovery in terms of neuronal subtype and connectivity, the work presented in this thesis aims to bring the prospect of CRT closer to the clinic, I also describe the generation of a very promising alternative cell source that could rival fetal tissue. (lu.se)

Cell-to-cell interactions set off a cascade of events that may result in T- or B-cell activation and, ultimately, host defense. (medscape.com)
Ly6C high MC exhibited activated neutrophil degranulation, lysosome, cytokine production/receptor interaction and myeloid cell activation pathways, and Ly6C low MC presented features of lymphocyte immunity pathways in both mice. (frontiersin.org)
In this fashion, IL-7 induces cell activation, survival, and proliferation of T lymphocytes. (biolegend.com)
Mechanistically, ISWI is required for lineage determining transcription factors (LDTFs) binding on enhancers and LDTF-induced activation of enhancers. (nih.gov)
The activation of these factors may correlate with stages of differentiation. (nih.gov)
Every differentiation step is characterized by the activation of a new, lineage-specific, genetic program and the extinction of the previous one. (eur.nl)
We demonstrate that CEBPA promotes lineage-specification by launching an enhancer-primed differentiation program and direct activation of CEBPE expression. (regionh.dk)
Here we identify expression of the secretoglobin Scgb3a2 and Notch activation as early events in a program of secretory cell fate determination in developing murine airways. (harvard.edu)
Similarly, unnecessary activation of Th1, Th17 or Th2 cells by harmless environmental- or self-antigens can cause organ-specific autoimmune diseases or allergic inflammatory diseases. (nih.gov)
Activation of p21 or p16 therefore causes cell cycle arrest. (medscape.com)
We characterize the activation kinetics of these reagents in vitro and demonstrate their efficacy in zebrafish embryos that express NfsB either ubiquitously or in defined cell populations. (cdc.gov)

It regulates Th2 differentiation and lineage-specific hematopoiesis. (thermofisher.com)

The Hsieh laboratory is a neural stem cell biology laboratory that focuses on 4 major areas: (1) epilepsy-in-a-dish, (2) 3D cerebral organoids, (3) patient recruitment, and (4) mechanisms of adult neurogenesis. (utsa.edu)
To enhance vaccine potency and improve thus responses to ICI, we analyzed the gene expression profile of an immunosuppressive dendritic cell (DC) population induced during vaccination, with the goal of identifying druggable inhibitory mechanisms. (unav.edu)
Although many related studies have been performed, differences in cell lines, experimental conditions and downstream mechanisms have generally resulted in contradictory findings. (nature.com)
[ 16 ] Potential mechanisms through which TCF7L2 variants influence T2DM include its role in adipogenesis, myogenesis, and pancreatic islet development, as well as in beta-cell survival and insulin secretory granule function. (medscape.com)

This project will elucidate the protective features of immune cell types in the brain and define molecules that regulate brain response to disease. (brightfocus.org)
Interestingly, the ILCs also express many key transcription factors that are found in Th cells, suggesting that a given transcription factor may regulate one particular type of immune response in different immune cells. (nih.gov)
Although more and animals and plants and regulate gene/protein expression more progressions have been made about the through direct complementarity between their 5' region pathogenesis of asthma in recent years, the increasing and the 3' untranslated region of target mRNAs. (cdc.gov)

Ly6C high MC presented downregulated co-stimulatory receptors (CD2, GITR, and TIM1) which direct immune cell proliferation, and upregulated co-stimulatory ligands (LIGHT and SEMA4A) which trigger antigen priming and differentiation. (frontiersin.org)
A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. (cancerindex.org)
The upregulation of miR‑145 and miR‑221 was associated with the enhanced proliferation of periosteal cells and chondrogenic potential, respectively. (spandidos-publications.com)
ED 50 =1.0 - 5 ng/ml, corresponding to a specific activity of 0.2 - 1 x 10 6 units/mg, as determined by PHA activated PBL proliferation induced by IL-7 in a dose dependent manner. (biolegend.com)
Several neurotrophic factors were detected in the pre-transfected hONPs which have potential roles in the maintenance, survival and proliferation of dopaminergic neurons. (scirp.org)
In this proposal we will use downregulation and overexpression of SPI1 in microglial cells, mimicking the human genetics findings, and analyze diverse cellular functions - phagocytosis (uptake, degradation), cell viability, proliferation, migration, apoptosis, oxidative stress and inflammatory response, to define SPI1 role in microglia at the cellular level. (brightfocus.org)
In response to mito- pendence between the key mecha- gens, cell proliferation is triggered by nistic characteristics. (who.int)
H - Ras cell proliferation are also linked with haematopoietic cel s. (who.int)

Much of this process relies on the morphogenesis of the extra-embryonic tissues and the effect this has on the organization of embryonic cells. (nature.com)

HHcy in Cbs -/- mice reinforced inflammatory features in Ly6C high MC by upregulating inflammatory TFs ( Ets1 and Tbx21 ) and strengthened lymphocytes functional adaptation in Ly6C low MC by increased expression of CD3, DR3, ICOS, and Fos . (frontiersin.org)
Such analyses can reveal detailed expression dynamics and functional relationships for differentiation. (keio.ac.jp)
Single-cell transcriptomics and functional assays defined a high ratio of CD8(+) T cells versus T-reg cells as a predictor of response to immune checkpoint blockade (ICB). (unav.edu)
Anderson, L. and Caldwell, M.A. (2007) Human neural progenitor cell transplants into the subthalamic nucleus lead to functional recovery in a rat model of Parkinson's disease. (scirp.org)
This study aimed at investigating the genomic expression during myeloid differentiation through a computational approach that integrates gene expression profiles with functional information and genome organization. (biomedcentral.com)
Then, his group identified a minimal combination of three transcription factors (Mash1, Nurr1 and Lmx1a) able to directly convert model and human fibroblasts into functional dopaminergic neurons. (michaeljfox.org)
Ectopic expression of the most robustly induced PU.1 target miR, miR-146a, directed the selective differentiation of HSC into functional peritoneal macrophages in mouse transplantation assays. (zfin.org)
METHODS: In patients (N = 1,581) concurrently randomly assigned 1:1 to nivolumab plus chemotherapy or chemotherapy and in those with tumor PD-L1 expression at a combined positive score (CPS) of ≥5, health-related quality of life (HRQoL) was assessed using the EQ-5D and Functional Assessment of Cancer Therapy-Gastric (FACT-Ga), which included the FACT-General (FACT-G) and Gastric Cancer subscale (GaCS). (bvsalud.org)
In paper №3, I also identify the specific mesDA population (A9) that is critical for functional recovery, with transplants that lack A9 neurons failing to improve motor recovery. (lu.se)

Ly6C low MC manifested activated T-cell signaling pathways and potentially can adapt the function of lymphocytes. (frontiersin.org)
The pathogenesis is multifactorial and involves dysregulation in the signaling pathways, membrane lipids ratio disturbance, cell-cell adhesion disturbance, unfolded protein response, lysosomal and mitochondrial stress, autophagy dysregulation, and oxidative stress. (koreamed.org)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
According to weighted gene co-expression network analysis, pathways positively related to adipogenic differentiation are significantly activated at the differentiation stage, while WNT, FOXO and other pathways that inhibit preadipocyte differentiation are negatively regulated. (biomedcentral.com)
Our current hypothesis is that SPI1 influences transition of microglia from the homeostatic to the damage-associated phenotype that may be protective in neurodegeneration due to upregulation of specific pathways essential for combating brain tissue damage. (brightfocus.org)
In this review, we examine aging as a process dependent on specific changes in molecular pathways within multiple lung cell populations. (karger.com)

IL-7 is necessary to specify CD8 lineage differentiation during CD4/CD8 cell fate choice in the thymus by inducing expression of the transcription factor Runx3. (biolegend.com)
Here, we performed genetic fate mapping, showing that VGLUT3 lineage sensory neurons are divided into two groups, based on transient or persistent VGLUT3 expression. (jneurosci.org)
Fate-mapping experiments to address T-cell plasticity and stability are being performed using reporter mice in which inducible-Cre expression is under the control of cytokine or transcription factor locus. (nih.gov)

T-cell acute lymphocytic leukemia protein 1 (i.e. (wikipedia.org)
The protein encoded by TAL1 is a basic helix-loop-helix transcription factor. (wikipedia.org)
This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. (cancerindex.org)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
In the nuclei of VU cells, residual NHR-67 protein is compartmentalized into discrete punctae that are dynamic over the cell cycle and exhibit liquid-like properties. (elifesciences.org)
Furthermore, we show that Snf2h co-localized with CTCF and the genomic binding of CTCF is globally decreased without change of the protein levels in ISWI KO cells. (nih.gov)
Aberrant DNA methylation of GATA binding protein 3 (GATA3), interleukin-4 (IL-4), and transforming growth factor-β (TGF-β) promoters in. (oncotarget.com)
The human hemopoietic cell kinase (HCK) is a member of the src family of protein tyrosine kinases specifically expressed in myeloid cells and to a minor extent in B-lymphoid cells. (uni-frankfurt.de)
Antibody reactivity against recominant protein and cell lysate for WB. (novusbio.com)
For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)
The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)
The p19ARF protein, which is encoded by the same locus as p16, also leads to cell cycle arrest by inhibiting the ability of MDM2 to inactivate TP53. (medscape.com)
The p16INK4A protein is a cell-cycle inhibitor that acts by inhibiting activated cyclin D:CDK4/6 complexes, which play a crucial role in the control of the cell cycle by phosphorylating Rb protein. (medscape.com)
DeMarini, and Chapter 20, by Rice and cell death determine the size protein in several signal ing path- and Herceg). (who.int)

Other cellular components of the innate immune system include mononuclear phagocytes, dendritic cells, and NK cells. (medscape.com)
c-maf is the cellular counterpart of oncogenic v-maf that belongs to the family of basic region leucine zipper domain transcription factors. (thermofisher.com)
Thus, it has been argued that the observed bivalency simply reflects cellular heterogeneity arising from the averaging of cells that carry either, but not both, marks at a given locus (Fig. 2). (researchgate.net)
A growing body of evidence suggests that cell division and basement membrane invasion are mutually exclusive cellular behaviors. (elifesciences.org)
A growing body of evidence suggests that cell cycle progression and invasion through a basement membrane are mutually exclusive cellular behaviors in both development and disease states (reviewed in Kohrman and Matus, 2017 ). (elifesciences.org)
During development of the hermaphroditic reproductive system, the proximal granddaughters of the Z1 and Z4 somatic gonad progenitors, Z1.pp and Z4.aa, give rise to four cells that will adopt one of two cellular fates: a proliferative ventral uterine (VU) cell or the terminally differentiated, invasive anchor cell (AC) ( Figure 1A ) ( Kimble and Hirsh, 1979 ). (elifesciences.org)
Cellular immunology, T cell immunity, autoimmune diseases: The immune system plays a fundamental role in the defense against microbial pathogens. (utsa.edu)
We report that the histone deacetylase HDAC7 was highly expressed in pre-B cells but dramatically down-regulated during cellular lineage conversion to macrophages. (eur.nl)
The goal of this project is to elucidate the role of microglial cells, brain-resident immune cells, in Alzheimer's disease and their protective features in disease at the cellular and molecular level. (brightfocus.org)
At the cellular and whole organ level, degenerative changes that are a hallmark of natural aging (shorter telomeres, increased expression of cellular senescence markers, increased DNA damage, oxidative stress, and apoptosis, accompanied by diminished elasticity) reach pathological levels in aging humans in the form of chronic respiratory disease. (karger.com)
At the cellular level, aging is marked by depletion of adult stem cell reservoirs, the inability to maintain baseline homeostasis, a reduced response to stress, an increased accumulation of damaged DNA leading to telomere shortening, and mitochondrial dysfunction [ 1,2 ]. (karger.com)
At the Molecular and Cellular Immunoregulation Section (MCIS), the functions of known key transcription factors, including GATA3 and T-bet, and novel, potentially critical transcription factors during Th and ILC differentiation/development are being investigated with various genetically modified mice including conditional knockout strains. (nih.gov)

Dendritic cells are present in the skin (as Langerhans cells), lymph nodes, and tissues throughout the body. (msdmanuals.com)
Dendritic cells in the skin act as sentinel APCs, taking up antigen, then traveling to local lymph nodes where they can activate T cells. (msdmanuals.com)

Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. (lu.se)

We and others have synthesized light-activatable cMOs that allow spatiotemporal control of RNA splicing or translation, complementing the use of conditional knockouts to study stage- and tissue-specific differences in gene function. (cdc.gov)
18 , 19 We surmised that cyclic cMOs containing an NfsB-cleavable linker could be used with analogous lines to knock down gene function in a tissue-specific manner (Figure 1 a). (cdc.gov)

B lymphopoiesis is the result of several cell-commitment, lineage-choice, and differentiation processes. (eur.nl)

To elucidate the molecular basis of the differential HCK gene expression, the genomic region containing the HCK promoter was isolated and functionally characterized. (uni-frankfurt.de)
Molecular changes underlying stem cell differentiation are of fundamental interest. (nih.gov)
We will use transcriptomic analysis of these cells under baseline and stimulated conditions to elucidate the protective microglial features at the molecular level. (brightfocus.org)
Our data will elucidate the molecular and phenotypic changes in microglia associated with the protective phenotype in AD due to reduced SPI1 expression and concomitant changes in other genetic risk factors of AD regulated by SPI1 such as TYROBP, CD33, MS4A4A, MS4A6A, APOE, and CLU. (brightfocus.org)
Dr. Zhu received his bachelor's degree summa cum laude from the department of biology, NanKai University, Tianjin, China, and his Ph.D. in biochemistry and molecular biology from the Shanghai Institute of Biochemistry (now known as Shanghai Institute of Biochemistry and Cell Biology), Chinese Academy of Sciences. (nih.gov)
BCR/ABL + gene expression pattern was more heterogeneous and was most similar to ALL without known molecular rearrangements. (aacrjournals.org)

Pathway analysis implicates immune response in the etiology of AD, and given that genetic risk alleles are enriched in myeloid cell types, it has been proposed that impaired microglial function is a major contributing factor to AD risk. (brightfocus.org)
The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. (origene.com)

IL-7 is essential for normal murine B cell development, and plays a key role in regulating the homeostasis and function of the T-cells. (biolegend.com)

By crossing Snf2l-/-;Snf2hf/f mice with Myf5-Cre, which is selectively expressed in precursor cells giving rise to brown adipose tissue (BAT) and skeletal muscle, we demonstrate that Snf2h, but not Snf2l, is essential for adipose tissue and muscle development in mice. (nih.gov)
Most lineage specific TFs were stochastically expressed in the early precursor cells, but a few, such as Klf1, were detected only at very low levels in few precursor cells. (nih.gov)

Therefore, gene activity is an important mechanism in embryonic development and adult stem cell differentiation. (edu.au)
Transcription factors (nurr1, pitx3 and lmx1a) that promote embryonic mouse or chicken dopaminergic development were employed to determine if they would modulate lineage restriction of these adult human progenitors. (scirp.org)
Lineage labeling of Upk3a-expressing cells during development showed that these cells remain largely uncommitted during embryonic development and contribute to Clara and ciliated cells in the adult lung. (harvard.edu)
To characterize gene expression signatures in acute lymphocytic leukemia (ALL) cells associated with known genotypic abnormalities in adult patients. (aacrjournals.org)
Gene expression profiles from 128 adult patients with newly diagnosed ALL were characterized using high-density oligonucleotide microarrays. (aacrjournals.org)
Previous reports showed that p63+ cells appear early during airway development, but these do not express markers of adult BCs, raising the question whether these cells represent BC precursors. (columbia.edu)
In addition, single cell RNA-sequencing analyses revealed heterogeneity of adult BCs in the tracheal and esophageal epithelia. (columbia.edu)

By utilizing multiple lineage-tracing lines, an underappreciated diversity of this pool was revealed by showing a novel subpopulation carrying secretory lineage marker spatially restricted to intrapulmonary airways. (columbia.edu)
Recent studies have shown that fallopian tube secretory epithelial cells (FTSECs) give rise to the most common form of ovarian cancer, high-grade serous ovarian carcinomas (HGSOCs). (nih.gov)

The use of olfactory progenitors as a cell-based therapy for Parkinson's disease (PD) would allow harvest without invasive surgery, provide an autologous cell population, eliminate need for immunosuppression and avoid the ethical concerns associated with embryonic tissues. (scirp.org)
Cell Replacement Therapy for Parkinson's Disease - Evaluating the potential of autologous grafting. (lu.se)

Collectively, this study shows that ISWI is critical for cell differentiation through correct genomic binding of LDFTs. (nih.gov)
In particular, several genomic studies suggested the existence of relationships between gene expression and genomic position. (biomedcentral.com)

Macrophages are phagocytic cells present in tissues throughout the body. (msdmanuals.com)
In combination with transgenic organisms, such enzyme-actuated antisense tools will enable gene silencing in specific cell types, including tissues that are not amenable to optical targeting. (cdc.gov)

Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
The concurrent advance in bioinformatic methods, as well as in high throughput technologies for the analysis of gene expression profiles, allowed deepening the knowledge of genome structure and function. (biomedcentral.com)

However, given that bivalent domains can still be observed-albeit in lower proportion-in unipotent cells such as T cells and MEFs, an admixture of cell populations appears to be an unlikely explanation for the observed coexistence of these marks. (researchgate.net)
Single cells in these populations exhibit different com- stem cell differentiation, Shannon information binations of regulator activity that suggest the presence of multiple theory, entropy configurations of a potential differentiation network as a result of multiple entry points into the committed state. (lu.se)
These factors are very common in human populations and together with rare familial cases of Alzheimer's disease suggest that brain inflammation contributes to disease progression. (brightfocus.org)
While much work has focused on the failure of epithelial cell populations as a key component of the aging process, additional studies have shown that aging, as a global phenomenon in the lung, also impacts resident endothelial, mesenchymal, and immune cell populations. (karger.com)
Transcriptomic profiling of T-cell populations in non-muscle invasive and muscle invasive bladder cancer. (lu.se)
11 , 12 Light-dependent gene silencing can be achieved through whole-organism irradiation or the targeted illumination of specific cell populations. (cdc.gov)

This improved efficacy was associated with higher tumor T-cell infiltration and overexpression of PD-1/PD-L1. (unav.edu)
B16-OVA tumors benefited from a synergistic effect, reaching 75% of tumor rejection, but higher levels of exhausted T-cells in LLC-OVA tumors co-expressing PD-1, LAG3 and TIM3 precluded similar levels of efficacy. (unav.edu)
TAp63a, a homolog of the p53 tumor suppressor, is a quality control factor in the female germline. (uni-frankfurt.de)
Medulloblastoma is defined by the World Health Organization (WHO) as "an embryonal neuroepithelial tumor arising in the cerebellum or dorsal brainstem, presenting mainly in childhood and consisting of densely packed small round undifferentiated cells with mild to moderate nuclear pleomorphism and high mitotic count. (medscape.com)
These changes can be inherited and are, therefore, found in every cell, but more often, they are somatically acquired and restricted to tumor cells. (medscape.com)

We found that the hematopoietic master regulator RUNX1 controls the expression of certain microRNAs, of importance during erythroid/megakaryocytic differentiation. (uni-frankfurt.de)
The histone H3K4 demethylase JARID1A directly interacts with haematopoietic transcription factor GATA1 in erythroid cells through its second PHD domain. (ox.ac.uk)

Kim and Park, 2017 ) and make HMSCs attractive cells for regenerative therapies. (frontiersin.org)
We have recently reported the identification of SPI1 as a genetic risk factor for AD in the previously described CELF1 locus in the biggest AD GWAS dataset to date (Huang, Marcora et al, 2017). (brightfocus.org)

This laboratory pursues several lines of investigation to understand how T cells contribute to autoimmune diseases and protection from infection, and how to modulate T cell immunity for therapeutic purposes in humans. (utsa.edu)
Analyses of genetic information in patients with Alzheimer's disease have identified a multitude of intrinsic factors that modulate our predisposition to develop dementia. (brightfocus.org)

Natural-killer (NK) cells are specialized lymphocytes that have cytotoxic properties in addition to their ability to produce cytokines that assist in the orchestration of adaptive immunity. (medscape.com)
The adaptive immune system consists of 2 types of lymphocytes: T cells (70-75% of the adaptive immune force) and B cells (10-20% of the adaptive immune force). (medscape.com)
To circumvent this limitation, we screened mice engineered to carry eight MM lesions (NF-kappa B, KRAS, MYC, TP53, BCL2, cyclin D1, MMSET/NSD2 and c-MAF) combinatorially activated in B lymphocytes following T cell-driven immunization. (unav.edu)
Lymphocytes, CD4 T cells in particular, play a central role in orchestrating adaptive immune responses. (nih.gov)

Binding of complement to a foreign substance, or antigen, amplifies and augments the body's innate immune system by means of its role as an opsonin (a factor that enhances phagocytosis of unwanted particles) and as a chemoattractant (a factor that recruits cells to areas of inflammation). (medscape.com)
This aggressive variant of prostate cancer is characterized by hormone refractoriness, low or absent androgen receptors and is associated with low serum levels of prostate specific antigen (PSA). (auanews.net)
Although some antigens (Ags) can stimulate the immune response directly, T cell-dependent acquired immune responses typically require antigen-presenting cells (APCs) to present antigen-derived peptides within major histocompatibility complex (MHC) molecules. (msdmanuals.com)

We will use microglial-specific ablation of SPI1 in mice to confirm and expand our findings in cells by analyzing the transcriptome and different biomarkers with immunohistochemistry. (brightfocus.org)
Genetic ablation of Ascl1 prevented NEB formation and selectively interfered with the formation of this subpopulation of cells. (harvard.edu)

However, at least Id1 and Hes1 were significantly activated in both HSC and MPP1 cells in anemic mice. (nih.gov)
Analyses of mice with a conditional knock-out of Runx1 in VGLUT3 lineage neurons demonstrate that Runx1 is pivotal to the development of VGLUT3-persistent neurons, such as the expression of VGLUT3 and TH and the formation of the longitudinal lanceolate endings. (jneurosci.org)
I also describe the development of a novel behavioural task that is predictive of mesDA neuron cell loss in mice. (lu.se)

Specific manipulation of the immune system for therapeutic purposes is now possible. (medscape.com)
The generation of receptors specific for antigens is a unique and complex process that generates 10 12 specific receptors for each cell type of the adaptive immune system, including T and B cells. (medscape.com)
NK cells are specialized effectors of the innate immune system that destroy their targets by antibody-dependent cell-mediated cytotoxicity, have prominent antitumor effects, and are potent killers of virally infected cells. (medscape.com)
Monocytes (MC) are bone marrow (BM) derived mononuclear phagocytes that play an important role in innate immune response and are the major immune cell population in chronic tissue inflammatory ( 1 , 2 ). (frontiersin.org)
We subsequently show how eQTLs have dynamic allelic effects in B cells transitioning from naïve to memory states, and demonstrate how commonly segregating alleles lead to inter-individual variation in immune function. (iscb.org)
A complete understanding of how transcription factor complexes are regulated and how they precisely control heterogeneity, plasticity, and stability of Th cells and ILCs has great implication in designing strategies to treat a broad range of immune-related diseases, including chronic bacterial and viral infections such as HIV, autoimmune diseases, allergic diseases, and cancers. (nih.gov)
Overview of the Immune System The immune system distinguishes self from nonself and eliminates potentially harmful nonself molecules and cells from the body. (msdmanuals.com)
they have receptors for the crystallizable fragment (Fc) region of immunoglobulin (Ig) G and for complement, which enable them to bind with immune complexes and present the complex to B cells in germinal centers of secondary lymphoid organs. (msdmanuals.com)

EndoDB: a database of endothelial cell transcriptomics data. (koreamed.org)

Surprisingly, lineage analysis showed that early in development these cells were able to generate all epithelial cell types of the airways and alveolar compartment. (columbia.edu)

A DNA fragment containing 101 base pairs of the 5′-flanking sequence showed strong promoter activity in the macrophage cell line RAW264 but was inactive in the non-monocytic cell lines HUT-78 and NIH-3T3. (uni-frankfurt.de)
This development occurs under the influence of macrophage colony-stimulating factor (M-CSF), which is secreted by various cell types (eg, endothelial cells, fibroblasts). (msdmanuals.com)
At infection sites, activated T cells secrete cytokines (eg, interferon-gamma [IFN-gamma]) that induce production of macrophage migration inhibitory factor, preventing macrophages from leaving. (msdmanuals.com)

At present, the master regulators of Th lineages that have been identified include T-bet/Stat4 (Th1), GATA-3/Stat5 (Th2), RORγt/Stat3 (Th17), Foxp3/Stat5 (Treg) and Bcl-6/Stat3 (Tfh), respectively. (nih.gov)

M, Peterson C. 2018 Haematopoietic stem suggests that during differentiation a stem cell approaches a stable equili- cells: entropic landscapes of differentiation. (lu.se)

Endothelial cells (EC) are the anatomical boundaries between the intravascular and extravascular space. (koreamed.org)
Fig. 2 Schematic presentation of the role of autophagy in endothelial cells. (koreamed.org)

Many promoters in embryonic stem (ES) cells harbor a distinctive histone modification signature that combines the activating histone H3 Lys 4 trimethylation (H3K4me3) mark an. (researchgate.net)
TETs' role in the crosstalk with specific histone modifications, however, is largely elusive. (researchgate.net)

Remarkably, retroviral gene transduction of T-bet into polarized Th2 and Tc2 primary T cells redirects them into Th1 and Tc1 cells, respectively, as evidenced by the simultaneous induction of IFNgamma and repression of IL-4 and IL-5. (nih.gov)

but how these cell states are regulated in the context of development is not well understood. (elifesciences.org)
Thus, T-bet initiates Th1 lineage development from naive Thp cells both by activating Th1 genetic programs and by repressing the opposing Th2 programs. (nih.gov)
In line with this observation, disruption of Dicer expression or specific antagonization of miR-146a function inhibited the formation of macrophages during early zebrafish development. (zfin.org)
Although Notch signaling is essential for the development of these cells, it is unclear how Notch influences Clara cell specification and if diversity is established among Clara cell precursors. (harvard.edu)
Recently, a class of innate lymphoid cells (ILCs), whose development requires signaling through the IL-2 receptor (IL-2R) common γ chain and IL-7Rα , has been discovered. (nih.gov)
PAX8 is a nuclear transcription factor that controls the embryologic development of the Müllerian system, including the fallopian tubes. (nih.gov)
it is involved in the development of a wide variety of cell lineages and organs. (medscape.com)

Therefore, our study shows that SEs orchestrate the osteogenesis of MSCs by targeting ZBTB16 expression, which provides an attractive focus and therapeutic target for osteoporosis. (nature.com)

In clinical series, high CD8(+) T/T-reg cell ratios underlie early progression in untreated smoldering MM, and correlated with early relapse in newly diagnosed patients with MM under Len/Dex therapy. (unav.edu)

Anatomy25

Organisms14

Chemicals and Drugs119

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes73

Disciplines and Occupations1

Information Science4

Genes41

Transcriptional13

Distinct18

Vivo7

Stem cells24

Epigenetic6

Differentiate2

Proteins4

Regulatory16

Regulation11

Chromatin7

Subsets4

Multipotent1

Neuronal7

Activation11

Regulates1

Mechanisms4

Regulate3

Proliferation8

Embryonic cells1

Functional9

Pathways6

Fate3

Protein14

Cellular12

Dendritic2

Hematopoiesis1

Tissue-specific2

Commitment1

Molecular6

Myeloid cell2

Murine1

Precursor cells2

Adult7

Secretory2

Therapy for Parkinson's disease2

Genomic2

Tissues2

Gene expression profiles2

Populations6

Tumor5

Erythroid2

20172

Modulate2

Lymphocytes4

Antigen3

Ablation2

Mice3

Immune8

Transcriptomics1

Epithelial cell1

Macrophage3

Regulators1

Haematopoietic1

Endothelial cells2

Histone2

Repression1

Development7

Therapeutic1

Progression1