Expression of integrin. Medical search. Frequent questions

Rescue of the β3-integrin subunit resulted in enhanced WNV yields of up to 90 %, regardless of the virus strain used. (nih.gov)
Integrins are cell adhesion molecules that reside on the surface of cells as transmembrane proteins made of an alpha and beta subunit. (harvard.edu)
Upon knockdown of β3 or β5 expression using small interfering RNA (si-RNA) treatment, a marked decrease in the cell surface expression of the αv subunit was observed without a change in the mRNA levels of the αv subunit. (harvard.edu)
Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß 2 subunit of LFA1 family (ß2 integrins). (medscape.com)

an enzyme involved in the production of various eicosanoids) expression, by activating integrin collagen receptors. (lu.se)

The leukocyte integrin p150,95 (CD11c/CD18) as a receptor for iC3b. (wikipedia.org)
This 3-year-old girl had leukocyte adhesion deficiency type I (LAD I) with complete absence of CD18 expression. (medscape.com)
1% expression of CD18). (medscape.com)
Type 1 results from mutations in the integrin beta-2 gene ( ITGB2 ), encoding CD18 beta-2 integrins. (msdmanuals.com)
In the severe form, no expression of CD18 is detected on neutrophils and early death occurs without BMT. (lu.se)
Some patients may have normal CD18 expression with a defective CD18 (β 2 integrin) activity. (lu.se)

Studies in marmosets and humans indicate that thalidomide, and a teratogenic analogue, decrease the expression of beta integrin subunits, most notably beta 3 and the beta 2 produced by leukocytes. (nih.gov)
A cell culture model, based on wild-type and specific integrin knockout cell lines lacking the integrin subunits αv, β1 or β3, was used to investigate the susceptibility to WNV, and to evaluate binding and replication efficiencies of four distinct strains (New York 1999, Uganda 1937, Sarafend and Dakar). (nih.gov)
There are 24 known integrin molecules classified into different families depending on the subunits (i.e. αv family of integrins) or by the ligands they bind to (i.e. (harvard.edu)

lntegrin-Linked Kinase (ILK) is a ubiquitous protein able to regulate outside-inside signaling by binding to integrins. (mun.ca)
Exposure of HTR8-SVneo cells to a low oxygen environment produced a transient increase in the expression of ILK mRNA, but did not affect the level of protein expression nor its kinase activity. (mun.ca)
Interestingly, Egr-1 induction depends on integrin-dependent PI3K/Akt activation, as indicated by the decrease in Egr-1 levels in presence of the pharmacological inhibitor LY294002, the kinase-defective Akt mutant and Akt1/2 shRNAs. (unito.it)
DENV-induced PDI surface expression was mediated through the Lys-Asp-Glu-Leu (KDEL) receptor-Src family kinase signal pathway. (tmu.edu.tw)
Supervised analysis of kinase genes revealed a high-level FLT3 expression in a subset of cases without molecular rearrangements. (aacrjournals.org)
The integrin dependent COX-2 expression was shown to be mediated through the activation of CD47 and its associated G?i3 protein, which in turn lead to protein kinase C? (lu.se)

Our research studied the lncRNA and mRNA expression profiles of monocyte-derived DCs and demonstrated the functional networks that are involved in monocyte-derived DCs-mediated regulation in AR. (frontiersin.org)

Aims: The purpose of this study was to determine the feasibility of a new positron emission tomography (PET) imaging approach using an 18 F-labelled α v β 3 integrin antagonist ( 18 F-Galacto-RGD) to monitor the integrin expression after myocardial infarction. (elsevierpure.com)
Conclusion: Regional 18 F-Galacto-RGD accumulation suggests up-regulation of α v β 3 integrin expression after myocardial infarction, which peaks between 1 and 3 weeks and remains detectable until 6 months after reperfusion. (elsevierpure.com)
abstract = "Aims: The purpose of this study was to determine the feasibility of a new positron emission tomography (PET) imaging approach using an 18F-labelled αvβ3 integrin antagonist (18F-Galacto-RGD) to monitor the integrin expression after myocardial infarction. (elsevierpure.com)

Integrins regulate membrane targeting of Rac and Cdc42, also involved in oncogenesis. (europa.eu)
The objectives of this study were to characterize how the αv integrins regulate each other in both a normal and pro-fibrotic environment in order or decipher any mutual regulation between the αv integrins and to assess if there is a good in vitro model to look at potential compensation mechanisms specifically in an inflammatory environment. (harvard.edu)
OPN through interaction with CD44 or several integrins is known to regulate multiple macrophage functions. (cdc.gov)

Myelination and its effects on integrin receptor expression, localisation and transport within the CNS. (southampton.ac.uk)

Integrin-mediated retention of phosphorylated caveolin in focal adhesions inhibits raft internalisation, which occurs upon its recruitment to caveolae after cell detachment. (europa.eu)

Integrin α v expression increases in various tumors suggest its importance in differentiation, proliferation, and migration. (elsevierpure.com)
CAR is structurally a member of the Ig-type superfamily of cell-cell adhesion molecules, suggesting that its expression may also be related to the state of tumor differentiation. (elsevierpure.com)
CCN1 also induced Jag1 expression in hepatic stellate cells, whereupon they interacted with hepatic progenitor cells to promote their differentiation into cholangiocytes. (jci.org)
DNA methylation and histone modifications play a central role in the epigenetic regulation of gene expression and cell differentiation. (cipsm.de)
Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)

This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). (wikipedia.org)
In milder forms of leukocyte adhesion deficiency I (1-30% expression of CD8), patients may survive to adulthood. (medscape.com)
This leukocyte adhesion deficiency variant is associated with defective expression of the Rap-1 activator CalDAG-GEFI. (medscape.com)

In addition, we propose that loss of CAR expression decreases rigid cell adhesion, possibly increasing the migratory potential. (elsevierpure.com)
Simultaneously, the finding of increased α v expression in invasive cancer suggests a pathogenesis that involves heterophilic adhesion and migration of these cells on various extracellular ligands. (elsevierpure.com)
Since integrins are crucial for cell-matrix interactions, and the beta 2 integrins of leukocytes mediate adhesion to endothelium, it is reasonable to postulate that thalidomide inhibits cell migration in susceptible species, and that this accounts for its anti-inflammatory, anti-angiogenic, and teratogenic activity. (nih.gov)
The α4β1 integrin is a main adhesion receptor mediating MM cell-stroma interactions and MM cell survival, and its expression and function are downregulated by BTZ, leading to inhibition of cell adhesion-mediated drug resistance (CAM-DR) and MM cell apoptosis. (cun.es)
BTZ-resistant MM cells displayed enhanced NF-κB pathway activation relative to parental counterparts, which contributed to upregulated α4 expression and to α4β1-dependent MM cell adhesion. (cun.es)
Here we demonstrate that Egr-1 expression is mainly regulated by integrin-mediated adhesion. (unito.it)
Integrin-dependent adhesion plays a dual role in Egr-1 regulation, either being sufficient 'per se' to induce Egr-1, or required for EGF-dependent expression of Egr-1, which occurs only in adherent cells and not in cells in suspension. (unito.it)
Inhibition of COX-2 expression or specifically inhibiting COX-2 activity, resulted in cell adhesion being favoured over cell migration in a CD47 dependent manner. (lu.se)

Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. (wikipedia.org)
The structural basis for the divalent cation-dependent binding of heterodimeric alphabeta integrins to their ligands, which contain the prototypical Arg-Gly-Asp sequence, is unknown. (rcsb.org)

This research often requires the tissue-specific expression of transgenes to better mirror human diseases, to visualize pathways being studied or to modulate the expression of a disease-related gene. (nature.com)
It was suggested that Tgfβ1 could possibly act as a signaling molecule in controlling collagen gene expression and modulate ECM during ocular growth. (molvis.org)

Antibody inhibitors and siRNA were used to manipulate the expression profiles of LX-2 cells that were incubated under normal culture conditions or after treatment with TGF-Β, a known ligand for the αv integrins and a pro-fibrotic cytokine, to mimic a pro-fibrotic environment in vitro. (harvard.edu)

The integrins' involvement in all of these processes can facilitate the communication between extracellular matrix, inflammatory cells, fibroblasts, and parenchymal cells through their ability to bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands. (harvard.edu)
It is a defect in the expression of ligands for selectins due to lack of enzymes required for expression of selectin ligands. (medscape.com)

Expression of the Escherichia coli tryptophanase operon depends on ribosome stalling during translation of the upstream TnaC leader peptide, a process for which interactions between the TnaC nascent chain and the ribosomal exit tunnel are critical. (cipsm.de)

Integrin signals mediate anchorage-dependence of cell growth, while growth of cancer cells is anchorage-independent. (europa.eu)

Here we report the crystal structure of the extracellular segment of integrin alphaVbeta3 in complex with a cyclic peptide presenting the Arg-Gly-Asp sequence. (rcsb.org)
In conclusion, exposure to MWCNT or asbestos induced gene expression of CD44 and OPN, protein release of OPN, and modifications of the interaction between CD44 and OPN at cellular and extracellular levels. (cdc.gov)
This work uses a purified extracellular domain of integrin ß3 and integrin ß3-positive cells to screen aptamers, specifically targeting integrin ß3 in the native conformation on live cells through the SELEX approach. (bvsalud.org)
Filamin A binds to proteins called integrins, which span the cell membrane and anchor cells to the extracellular matrix. (medlineplus.gov)

Blockade of integrin α v β 5 /α v β 3 , NF-κB, or NOTCH signaling in WT mice also resulted in defective ductular reaction after BDL. (jci.org)

Taken together, our results offer preclinical proof of concept for a method to enhance delivery of chemother-apeutics to breast cancer cells within the bone by exploiting their selective expression of integrin avb3 at that metastatic site. (illinois.edu)
Here we describe a model system, SELective Expression and Controlled Transduction In Vivo (SELECTIV), that enables efficient and specific expression of transgenes by coupling adeno-associated virus (AAV) vectors with Cre-inducible overexpression of the multi-serotype AAV receptor, AAVR. (nature.com)

Autocrine transforming growth factor-{beta}1 activation mediated by integrin {alpha}V{beta}3 regulates transcriptional expression of laminin-332 in Madin-Darby canine kidney epithelial cells. (uchicago.edu)
At the age of defect onset, GPR56 expression is restricted specifically to developing granule cells in the rostral cerebellum, suggesting that GPR56 regulates properties of these cells. (jneurosci.org)

Studies on bladder cancer cell lines have shown that low adenoviral transduction rates were associated with low-level expression of CAR. (elsevierpure.com)
Immunochemistry demonstrated a stage and grade-dependent decrease in CAR expression (90.0%, 83.3%, and 31.3% of normal urothelium and superficial and invasive transitional cell carcinoma [TCC] and 83.3% and 39.5% of low and high-grade TCC, respectively). (elsevierpure.com)
Whether decreased α4β1 expression and activity are maintained or recovered upon development of resistance to BTZ represents an important question, as a potential rescue of α4β1 function could boost MM cell survival and disease progression. (cun.es)
Increased α4β1 expression in resistant cells correlated with enhanced α4β1-mediated cell lodging in the BM, and with disease progression. (cun.es)
These data emphasize the upregulation of α4β1 expression and function as a key event during resistance to BTZ in MM, which might indirectly contribute to stabilize this resistance, as stronger MM cell attachment to BM stroma will regain CAM-DR and MM cell growth and survival. (cun.es)
Loss of integrin alpha3 expression associated with acquisition of invasive potential by ovarian clear cell adenocarcinoma cells. (elsevierpure.com)
Primers were established using these base sequences and the level of expression in each cancer cell line was determined by real-time PCR. (elsevierpure.com)
It was also detected by a microarray analysis as one of the molecules showing a different level of expression between the two cell lines. (elsevierpure.com)
Then the pattern of integrin a3 expression was investigated using immunocytochemical staining, and was found to differ between the two cell lines. (elsevierpure.com)
The findings obtained using these cell lines derived from ovarian clear cell adenocarcinoma indicate that integrin alpha3 may associated with the acquisition of malignant potential by clear cell adenocarcinoma. (elsevierpure.com)
Dive into the research topics of 'Loss of integrin alpha3 expression associated with acquisition of invasive potential by ovarian clear cell adenocarcinoma cells. (elsevierpure.com)
We hypothesized that AAV transgene expression could be targeted to specific tissues or cell types by selectively overexpressing AAVR. (nature.com)
Whereas α2 laminins promoted islet cell clustering, they did not affect gene expression. (nature.com)
In contrast, culturing on Laminin-421 induced the expression of β-cell genes, including Ins1 , MafA , and Glut2 , and significantly improved glucose-stimulated insulin secretion. (nature.com)
Furthermore, cell surface PDI colocalized with β1 and β3 integrins after DENV infection, and the activation of integrins was blocked by PDI inhibition. (tmu.edu.tw)
Integrins are highly conserved among diverse taxa and are expressed by almost every cell type at high numbers. (nih.gov)
Integrins are key regulators of gene expression, cell proliferation and migration. (europa.eu)
We examined the expression level of lncRNA CASP5 in GBM tissues as well as GBM cell lines. (cancerindex.org)
Knockdown of β3 expression using si-RNA treatment did not affect the cell surface expression of αvβ5 and knockdown of β5 expression using si-RNA treatment did not affect the cell surface expression of αvβ3. (harvard.edu)
α2β1γ1) stimulates oligodendrocytes to extend elaborate membrane sheets in vitro (cell spreading), mediated by integrin α6β1. (rupress.org)
Screening a DNA Aptamer Specifically Targeting Integrin ß3 and Partially Inhibiting Tumor Cell Migration. (bvsalud.org)
The S10yh2 aptamer can downregulate the level of integrin heterodimer αvß3 on integrin ß3 overexpressed cancer cells and partially inhibit cell migration behavior . (bvsalud.org)

The present study demonstrated that increased c‑SRC expression was partially associated with HCC resistance to lenvatinib, suggesting that c‑SRC inhibition could reduce the resistance of HCC to lenvatinib. (spandidos-publications.com)

Quantitative RT-PCR analysis confirmed a downregulation at the CAR gene expression level. (elsevierpure.com)

Indirect stimulation, by activating COX-2 expression in a ?2?1 integrin dependent manner was able to elicit a migratory response. (lu.se)

Despite their critical role in fibrosis, integrin compensatory regulation is not fully understood. (harvard.edu)

Vedolizumab (Entyvio, Takeda Pharmaceuticals, Japan) is a monoclonal antibody (mAb) against α4β7, an integrin facilitating leucocyte migration to the gut via binding of MADCAM1 on intestinal endothelium, shown to be efficacious for (IBD) patients with moderate to severe Crohn's disease (CD) and ulcerative colitis (UC). (medscape.com)

The changes in protein expression associated with the development of resistance were analyzed using a proteomic approach, detecting 1,321 proteins and significant changes in the expression of 267 proteins. (spandidos-publications.com)
Using Ingenuity Pathway Analysis bioinformatics software, it was revealed that the activity of multiple signaling pathways varied alongside the changes in expression of these proteins, and c‑SRC was identified as a protein involved in a number of these signaling pathways, with its activity varying markedly upon the acquisition of resistance. (spandidos-publications.com)

Scope includes mutations and abnormal protein expression. (cancerindex.org)

Gene expression profiles from 128 adult patients with newly diagnosed ALL were characterized using high-density oligonucleotide microarrays. (aacrjournals.org)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)

PBMCs are divided into various functional subtypes with respect to the specific cytokine expression profiles, surface markers, and the transcription factors. (frontiersin.org)

The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. (wikipedia.org)

To characterize gene expression signatures in acute lymphocytic leukemia (ALL) cells associated with known genotypic abnormalities in adult patients. (aacrjournals.org)

These data demonstrate that integrin/EGFR cross-talk is required for expression of Egr-1 through a novel regulatory cascade involving the activation of the PI3K/Akt/Forkhead pathway. (unito.it)
Our findings suggest a novel mechanism whereby surface PDI which causes integrin activation is involved in DENV entry, and DENV infection further increases PDI surface expression at later time points. (tmu.edu.tw)
COX-2 expression is synonymous with activation of the protein. (lu.se)

Results of molecular part in the amount of αv, β3, β1 and α4 gene expressions showed a great difference in β3 and αv genes expressions between experimental groups. (civilica.com)
Transgene expression using viral vectors provides an alternative, which allows for temporal expression of genes in mice with reduced cost and effort. (nature.com)
The gene expression of Ppargc1a varied during scleral growth from week 1 to 2, week 2 to 3, week 3 to 6, and week 6 to 8 and was found to interact with a different set of genes at different scleral growth stages. (molvis.org)
DAVID was used to perform the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis for the different expression genes (DEGs). (medscimonit.com)

Mutation in the β 2 integrin gene. (lu.se)

The objective of this study is to explore the long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) expression profiles of monocyte-derived dendritic cells (DCs) obtained from peripheral blood mononuclear cells (PBMCs). (frontiersin.org)

CD11c is an integrin alpha X chain protein. (wikipedia.org)

We performed immunohistochemistry for CAR and integrin α v expression in bladder cancer specimens in 50 paraffin-embedded tumor-normal pairs and confirmed the results by quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of 11 separate bladder tumors and 4 separate normal bladder controls. (elsevierpure.com)

Our study was designed to clarify the involvement of integrins in WNV infection of cells. (nih.gov)

To dissect the molecular basis of integrin-dependent Egr-1 regulation, we show by FLIM-based FRET that in living cells beta1-integrin associates with the EGF receptor (EGFR) and that EGF further increases the extent complex formation. (unito.it)

Using a micelle-based nanoparticle therapy that recognizes integrin avb3 (avb3-MPs of 12.5 nm), we demonstrated specific localization to breast cancer bone metastases in mice. (illinois.edu)

Furthermore, we found a stage and grade-dependent increase in α v integrin expression (13.3%, 46.0%, and 56.3% of normal urothelium, superficial TCC, and invasive TCC and 25% and 52.6% of low and high-grade TCC, respectively). (elsevierpure.com)
Loss of CAR expression correlates with the invasive phenotype in our analysis of bladder cancer. (elsevierpure.com)

Using BTZ-resistant MM cells, we found that they not only rescue their α4β1 expression, but its levels were higher than in parental cells. (cun.es)
In this study, we provide preclinical evidence for an antimetastatic therapy based on targeting integrin b3 (b3), which is selectively induced on breast cancer cells in bone by the local bone microenvironment. (illinois.edu)
By directing AAV transduction through the regulated expression of its receptor, the approach provides precise control over which cells express the AAV-vectored transgene. (nature.com)
We conclude that integrins are involved in WNV infection but not at the level of binding to target cells. (nih.gov)
Cells were analyzed by qPCR and flow cytometry to assess the changes in the integrin expression profile. (harvard.edu)
The integrin profile of LX-2 cells was not changed by antibody treatment targeting αvβ3 or αvβ5. (harvard.edu)
S10yh2 displays specific recognition of cancer cells with varying levels of integrin ß3 expression and demonstrates favorable stability in serum . (bvsalud.org)
In addition to safety, other knowledge gaps relate to possible alterations in drug pharmacokinetics when these two biologics are co-administered, or the possibility that anti-TNFs may increase the number and/or expression level of α4β7+ cells, thereby rendering patients more resistant to subsequent vedolizumab or in need of higher drug dosing. (medscape.com)

2005). Finally, negative revealed that SSEA4 is detectable in the early neuroepi- selection strategies have been also developed as an alter- thelium, and its expression decreases as development native method to enrich for NSCs from both adult proceeds. (lu.se)

Integrin-regulated Rac binding sites are in lipid rafts (membrane domains enriched in cholesterol and glycosphingolipids). (europa.eu)

Due to its key roles in malignant tumor progression and reprograming of the tumor microenvironment , integrin ß3 has attracted great attention as a new target for tumor therapy . (bvsalud.org)

However, the structure-function relationship of integrins ß3 remains incompletely understood, leading to the shortage of specific and effective targeting probes. (bvsalud.org)

MWCNT as well as asbestos induced dose dependent OPN gene expression and protein release by 24 hrs. (cdc.gov)

The specific expression and distribution of the different BM components in the islets were yet to be fully characterized. (nature.com)
The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treat- ment. (lu.se)

Among the known carbapenemases are Klebsiella pneumoniae carbapenemase, or KPC, and Verona integrin-encoded metallo-Beta-lactamase, or VIM. (cdc.gov)

DNA fragments were extracted from the band showing differences in the level of expression by RT-PCR with fluorescent differential display. (elsevierpure.com)

Anatomy36

Organisms7

Diseases7

Chemicals and Drugs127

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Phenomena and Processes56

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science4

Subunit4

Receptors1

CD186

Subunits3

Kinase6

MRNA1

Myocardial Infarction3

Regulate3

Receptor expression1

Focal Adhesions1

Differentiation5

Leukocyte3

Adhesion8

Heterodimeric2

Modulate2

Inhibitors1

Ligands2

Interactions1

Mediate1

Extracellular4

Defective1

Selective expression2

Regulates2

Cell22

Inhibition1

Downregulation1

Migratory1

Fibrosis1

Migration1

Proteins2

Mutations1

Gene Expression Profiles2

Cytokine1

Neutrophils1

Characterize1

Activation3

Genes4

Mutation1

Objective1

Alpha1

Tumors1

Involvement1

Regulation1

Mice1

Invasive2

Cells8

Decreases1

Membrane1

Malignant1

Understood1

Dependent1

Specific2

Beta1

Differences1