• Hypoxemia in OSA has been proven to have a significant impact on increased expression of proinflammatory cytokines influencing the hyperalgesic priming of nociceptors. (iasp-pain.org)
  • Meanwhile, GTE reduced the expression of pro-inflammatory cytokines including IL-1β, TNF-α and IL-6 in retina and vitreous humor. (nature.com)
  • These findings demonstrate that GTE is an effective agent in suppressing LPS-induced retinal inflammation, probably through its potent anti-oxidative property and a receptor-mediated action on transcription factors that regulate production of pro-inflammatory cytokines. (nature.com)
  • Pharmacological blockade of CD36 in Treg from subjects with prediabetes decreased Teff production of the Th17 cytokines that differentiate overall prediabetes inflammation. (diabetesjournals.org)
  • We show that inflammatory cytokines trigger activation of dermal lymphatic endothelial cells (LECs), leading to expression of the key leukocyte adhesion receptors intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin, as well as a discrete panel of chemokines and other potential regulators of leukocyte transmigration. (birmingham.ac.uk)
  • The aim of the present study was to elucidate the effects of NQ on airway inflammation, the local expression of cytokines such as IL-4 and IL-5 and chemokines such as eotaxin, macrophage chemoattractant protein (MCP)-1, and keratinocyte chemoattractant (KC) and Ig production related to antigen exposure. (ersjournals.com)
  • Following stimulation with IL-1β and TNF-α, the mRNA expression levels of chemokines and their receptors increased, showing different responses to various proinflammatory cytokines. (kyobobook.co.kr)
  • Increased PTGS2 expression induced by cytokines, would clarify the upregulation of PTGS2 in the inflamed membranes of chorioamnionitis. (5htreceptor.com)
  • Neuroinflammation has been linked to the expression of genes that spew, among others, two inflammatory enzymes, iNOS and COX-2, and two cytokines, IL-1β and TNF-α. (usda.gov)
  • Changes in lavage fluid cytokines indicative of inflammation, immune function, and endothelial function after sub-chronic exposure were limited and varied over time. (cdc.gov)
  • CYTOKINES, and expression of cell activation markers and is a critical regulator of SEPTIC SHOCK. (bvsalud.org)
  • Crucially, this increase was correlated with a reduction in the expression of tumour necrosis factor (TNF)-alpha, keratinocyte-derived chemokine (KC) and macrophage inflammatory protein (MIP)-2, suggesting a potential role for miRNAs in the regulation of inflammatory cytokine production. (northumbria.ac.uk)
  • In the oral cavity , high levels of HMGB1 have been detected in the gingival tissue from periodontitis and peri-implantitis patients , and it has been shown that secreted HMGB1 induces pro-inflammatory cytokine expression, such as interleukin (IL)-1ß, IL-6 , and tumor necrosis factor (TNF)-α, which prolong inflammation . (bvsalud.org)
  • The current authors investigated the effects of naphthoquinone (NQ), one of the extractable chemical compounds of DEP, on antigen-related airway inflammation, local expression of cytokine proteins, and antigen-specific immunoglobulin (Ig) production in mice. (ersjournals.com)
  • Through experimentation, it will be determined if Aquamin can restore barrier expression in cytokine/ lipopolysaccharide (LPS) induced inflammation in normal colon tissue derived colonoids. (umich.edu)
  • Results: Cytokine stimulation was seen to cause an upregulation of proinflammatory moieties and a decrease in barrier proteins while Aquamin was seen to upregulate anti-inflammatory and antimicrobial proteins with increased expression of proteins involved in the barrier structure. (umich.edu)
  • Functionally, 'TGF-beta-converted' T(reg) cells generated from TIEG1-deficient mice were unable to suppress airway inflammation in vivo. (nih.gov)
  • The current authors have previously demonstrated that diesel exhaust particles (DEP) enhance antigen-related airway inflammation in mice. (ersjournals.com)
  • Furthermore, a recent study has shown that organic chemicals in DEP, rather than their carbonaceous nuclei, are important contributors to the aggravating effects of airway inflammation. (ersjournals.com)
  • Pulmonary exposure to NQ dose-dependently aggravated antigen-related airway inflammation, as characterised by infiltration of eosinophils and lymphocytes around the airways and an increase in goblet cells in the bronchial epithelium. (ersjournals.com)
  • These results provide the first experimental evidence that naphthoquinone can enhance antigen-related airway inflammation in vivo , and that naphthoquinone can, to some extent, partly play a role in the pathogenesis of diesel exhaust particle toxicity on the condition. (ersjournals.com)
  • DEP enhance the antigen-specific immunoglobulin (Ig)E response 5 , 6 and aggravate airway inflammation induced by repetitive intratracheal instillation of antigen in vivo 7 - 10 . (ersjournals.com)
  • The current authors have recently demonstrated that extracted organic chemicals from DEP, rather than residual carbonaceous nuclei of DEP after extraction, predominantly enhance antigen-related airway inflammation in mice 17 . (ersjournals.com)
  • More recently, it has also been demonstrated that PQ aggravates antigen-related airway inflammation in mice, and that PQ also has adjuvant activity for antigen-specific Igs 25 . (ersjournals.com)
  • 2012). antigens that induce airway inflammation with the release of Although many studies investigated the association between inflammatory mediators. (cdc.gov)
  • Characteristic changes in OSA such as nocturnal hypoxemia, sleep fragmentation, and systemic inflammation are considered to have a curtailing impact on pain perception. (iasp-pain.org)
  • Cd exposure is strongly associated with oxidative stress, inflammation, antioxidant depletion, and liver cells apoptosis. (springer.com)
  • The present study aimed to investigate the effects of S/V on the expression of metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1), inflammation and apoptosis in human umbilical vein endothelial cells (HUVECs) induced by oxidized low‑density lipoprotein (ox‑LDL) and to elucidate its possible mechanism. (spandidos-publications.com)
  • Overall, the findings suggested that S/V could downregulate the expression of MALAT1, inhibit inflammation and apoptosis and improve endothelial function in ox‑LDL‑induced HUVECs via inactivating the TLR4/NF‑κB signaling pathway. (spandidos-publications.com)
  • Quercetin also improve the action of the drug 5-Fluorouracil (5-FU) promoting increased expression of p53 and apoptosis in breast cancer T47D cells [ 6 , 7 ]. (biomedcentral.com)
  • West Nile virus capsid (WNV-cp)-DJY protein expression induces apoptosis. (cdc.gov)
  • These pro- has been implicated as contributing apoptosis, inflammation, and several liferating cel s replace dead cel s to the cancer phenotype, through pleiotropic responses. (who.int)
  • NAC can protect liver tissue against Cd by elevating antioxidants capacity, mitigating oxidative stress and inflammation, as well as down-regulating of apoptotic genes. (springer.com)
  • Therefore, with the aim to summarize the current knowledge on the initiation of the atherosclerotic process, in this paper, we review the early markers of atherosclerosis and we address the main therapeutic targets for preventing atheroma formation at its very initial stages focusing on inflammation, oxidative stress, endothelial dysfunction, and the interaction between platelets and endothelium. (hindawi.com)
  • Agricultural Research Service ( ARS ) scientists have found that blueberry extracts helped quell the inflammation that was produced when the brain's immune cells responded to oxidative stress, based on a cell-culture study. (usda.gov)
  • Here, we evaluated cardiac inflammation, oxidative stress, DNA damage, and coagulation events in mice with adenine (0.2% w/w in feed for 4 weeks)-induced CKD. (uaeu.ac.ae)
  • In conclusion, the administration of adenine in mice induced CKD-associated cardiac inflammation, oxidative stress, Nrf2 expression, and DNA damage. (uaeu.ac.ae)
  • In the placenta only one of the inflammatory control genes was upregulated, and none of the prostaglandin genes was impacted by inflammation, but because the intrauterine inflammation was largely restricted to chorioamnionitis/deciduitis, we can not rule out that placentas impacted by villitis, which show altered leukotriene synthesis [5], would also show prostaglandin pathway expression modifications . (5htreceptor.com)
  • Conclusion The mechanism of inhibiting the expression of MOG gene and protein in the myelin sheath was found in the brain tissue damage induced by intrauterine inflammation in neonatal rats.Early application of rhEPO can promote the expression of MOG gene and protein,to play a protective role in nerve repairment.The best treatment may last for 14 days. (magtech.com.cn)
  • Expression of c-myc and Ask-1 genes was considered using RT-PCR. (springer.com)
  • 687 genes differentiated tumor samples before and after treatment, among which 310 genes did not show the same differential expression in the placebo group or normal samples. (karger.com)
  • This revealed that the expression of inflammation-related genes following intracerebroventricular injection of LPS was significantly higher and more prolonged in apoE4 than in apoE3 transgenic mice. (nih.gov)
  • Figure 2: Aberrant insulin signaling and disrupted expression of Foxo1-regulated genes in DLKO but not 2LKO livers. (nature.com)
  • Figure 6: Insulin-regulated expression of Foxo1 target genes was compromised in the Foxo1 −/− and TLKO primary hepatocytes. (nature.com)
  • B) Bar graph representing the direction and magnitude of change in expression for six representative genes (IL8, TIMP1, MAO, PDGFRβ, CD44, EPHA2), one invariant control (IL8Rβ) and two housekeeping controls (GAPDH, β-actin) relative to the expression in splenic hematomas. (biomedcentral.com)
  • To confirm the histological observations of inflammation, we measured the expression of 3 known inflammatory genes, getting significant upregulation of all 3 in amnion and choriodecidua samples from the INF group. (5htreceptor.com)
  • Among the prostaglandin pathway genes, PTGS2 was upregulated with inflammation in both amnion and choriodecidua, whereas CBR1 and HPGD have been downregulated in choriodecidua. (5htreceptor.com)
  • The exclusive expression patterns of prostaglandin pathway and inflammatory handle genes that we have observed recommend that in β adrenergic receptor Antagonist medchemexpress circumstances of uncomplicated spontaneous preterm labour, there is certainly no underlying inflammatory expression profile. (5htreceptor.com)
  • Lau used a detection method to find and measure the expression of genes that produced iNOS and COX-2 in the stress-induced cell cultures. (usda.gov)
  • The expression levels of LPIN1-target genes [peroxisome proliferator-activated receptors delta and alpha (PPARδ, PPARα), peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), acyl-coenzyme A dehydrogenase, very long (ACADVL), carnitine palmitoyltransferase IB and 2 (CPT1B and CPT2)] were not affected while lipin-2 protein level, a closely related member of the family, was increased. (nih.gov)
  • Furthermore, we link increased expression of inflammasome components NLRP3 and ASC in monocytes with site-specific DNA hypomethylation around the corresponding genes NLRP3 and PYCARD. (liverpool.ac.uk)
  • The genes whose expression influences osteoarthritis risk are typically involved in the formation and maintenance of bone and cartilage. (medlineplus.gov)
  • The expression of mRNA p53 was up regulated in mice received DPE 125 mg/kg BW. (biomedcentral.com)
  • Chronic inflammation in mice model that are initiated by the DSS causes colitis, deoxyribonucleic acid (DNA) damage and encourages the emergence of adenoma [ 11 , 12 ]. (biomedcentral.com)
  • Genome-wide gene expression profiling was employed to study the effects of apoE genotype on hippocampal gene expression in LPS-treated mice, transgenic for either apoE4 or the AD benign allele, apoE3. (nih.gov)
  • These findings suggest that the increased brain inflammation in apoE4 mice is related to disregulation of NF-kappaB signaling pathway. (nih.gov)
  • Figure 1: Liver-specific deletion of Akt1 in Akt2 whole-body knockout mice resulted in severe hyperglycemia and the disruption of Foxo1-regulated gene expression. (nature.com)
  • We conclude that AMPK activation suppresses STAT1 signaling and inhibits vascular inflammation through the upregulation of MKP-1. (diabetesjournals.org)
  • There was also a significant association between expression of IκBα, which inhibits the proinflammatory transcription factor NF-κB, and scores on the positive scale, the negative scale, the general psychopathology scale, as well as the total score on the Positive and Negative Syndrome Scale. (medscape.com)
  • Ongoing studies focus on identifying potential targets to suppress decidual inflammation as a potential means of arresting labour. (bmj.com)
  • Expression profiling in vivo demonstrates rapid changes in lung microRNA levels following lipopolysaccharide-induced inflammation but not in the anti-inflammatory action of glucocorticoids. (northumbria.ac.uk)
  • BACKGROUND At present, nothing is known of the role of miRNAs in the immune response in vivo despite the fact that inflammation is thought to underlie multiple acute and chronic diseases. (northumbria.ac.uk)
  • Dive into the research topics of 'Expression profiling in vivo demonstrates rapid changes in lung microRNA levels following lipopolysaccharide-induced inflammation but not in the anti-inflammatory action of glucocorticoids. (northumbria.ac.uk)
  • The current authors have recently shown that PQ induces recruitment of inflammatory cells, such as eosinophils and neutrophils, into the lung with the lung expression of pro-inflammatory molecules such as interleukin (IL)-5 and eotaxin in vivo 24 . (ersjournals.com)
  • We investigated the effects of a nutrient mixture (NM) including ascorbic acid, quercetin, naringenin, hesperetin, tea catechins, lysine, proline, arginine and N-acetyl cysteine in experimental in-vivo and in-vitro inflammation triggered by bacterial lipopolysaccharide (LPS). (drrathresearch.org)
  • Transforming growth factor-beta (TGF-beta) signaling in naive T cells induces expression of the transcription factor Foxp3, a 'master' regulator of regulatory T cells (T(reg) cells). (nih.gov)
  • The ocular inflammation can be induced by systemic injection of lipopolysaccharide (LPS), an endotoxin isolated from Gram-negative bacteria. (nature.com)
  • RESULTS To address this question, we have examined the differential expression of 104 miRNAs using real-time PCR during the innate immune response in mouse lung following exposure to aerosilised lipopolysaccharide (LPS). (northumbria.ac.uk)
  • In this regard it truly is worth mentioning that oxytocin, a powerful uterotonic agent, stimulates PTGS2 expression in human myometrial cells through previously undescribed pathways for instance NFAT (nuclear issue of activated T cells) [54]. (5htreceptor.com)
  • NF-κB pathways are associated with immunity, inflammation and cell survival. (springer.com)
  • Oral administration of GTE reduces significantly infiltration of inflammatory cells and exudation of proteins in the aqueous humor, which are associated with reduced expression and secretion of proinflammatory factors in the ciliary body and iris 13 . (nature.com)
  • The Role of Inflammation, Hypoxia, and Opioid Receptor Expression in Pain Modulation in Patients Suffering from Obstructive Sleep Apnea. (iasp-pain.org)
  • Apolipoprotein E4 (apoE4), the major genetic risk factor of Alzheimer's disease (AD), is associated with enhanced brain inflammation. (nih.gov)
  • 1] Merelli A,Czornyj L.Erythropoietin as a new therapeutic opportunity in brain inflammation and neurodegenerative diseases[J].Int J Neurosci,2015,125(11):793-797. (magtech.com.cn)
  • However, a new study in Science Translational Medicine indicates that getting a massage doesn't just feel good, it will actually bolster chemical signals to reduce inflammation and promoting the repair of muscle cells. (scitechdaily.com)
  • While massages are one of the most common forms of alternative medicine since they reduce pain, the study actually shows that massages change gene expression and reduce inflammation which in turn makes them clinically beneficial to patients. (scitechdaily.com)
  • Adipose tissue inflammation appears to be a risk factor for the progression of chronic kidney disease (CKD), but the effect of CKD on adipose tissue inflammation is poorly understood. (mdpi.com)
  • The purpose of this study was to clarify the involvement of uremic toxins (indoxyl sulfate (IS), 3-indoleacetic acid, p-cresyl sulfate and kynurenic acid) on CKD-induced adipose tissue inflammation. (mdpi.com)
  • Thus, we tested ivacaftor as therapeutic strategy for MI-associated target tissue inflammation that is characterized by CFTR. (lu.se)
  • In this study, for the first time, the impact of Marham-Mafasel on joint inflammation, histopathological changes and IL-1β gene expression was evaluated in RA animal model. (sanabel.ir)
  • This research aimed to determine the levels of IL-22, myeloperoxide (MPO), proliferation and wild-type p53 expression after the administration of DPE to murine models of CAC. (biomedcentral.com)
  • HMGB1 mediates various mechanisms such as inflammation , cell migration , proliferation, and differentiation. (bvsalud.org)
  • The Xanthogranulomatous Process (XP), is a form of acute and chronic inflammation characterized by an exuberant clustering of foamy macrophages among other inflammatory cells. (wikipedia.org)
  • Itch cooperated with TIEG1 to induce Foxp3 expression, which was reversed by TIEG1 deficiency. (nih.gov)
  • These results suggest TIEG and Itch contribute to a ubiquitin-dependent nonproteolytic pathway that regulates inducible Foxp3 expression and the control of allergic responses. (nih.gov)
  • These data suggest that Treg control of Teff metabolism regulates inflammation differentially in prediabetes compared with type 2 diabetes. (diabetesjournals.org)
  • CONCLUSION We have shown that the LPS-induced innate immune response is associated with widespread, rapid and transient increases in miRNA expression in the mouse lung and we speculate that these changes might be involved in the regulation of the inflammatory response. (northumbria.ac.uk)
  • The goal of the current investigation was to examine lung injury, inflammation, oxidant generation, and effects on the lung global gene expression profile following a whole-body acute or sub-chronic inhalation exposure to COV. (cdc.gov)
  • One and 28 d after acute exposure, and 1, 28, and 90 d following sub-chronic exposure, bronchoalveolar lavage was performed on the left lung to collect cells and fluid for analyses, the apical right lobe was preserved for histopathology, and the right cardiac and diaphragmatic lobes were processed for gene expression analyses. (cdc.gov)
  • Conclusion: Taken together, the results from this exposure paradigm, including concentration, duration, and exposure chamber parameters, did not indicate significant and toxicologically relevant changes in markers of injury, oxidant generation, inflammation, and gene expression profile in the lung. (cdc.gov)
  • Here, CFTR is downregulated in brain, heart, and lung tissue and associates with inflammation and degenerative processes. (lu.se)
  • Repurposing Methotrexate in Dampening SARS-CoV2-S1-Mediated IL6 Expression: Lessons Learnt from Lung Cancer. (cdc.gov)
  • NAC treatments significantly decreased the expression of c-myc , and Ask-1 in rats exposed to single or continuous Cd. (springer.com)
  • Here we investigated the anti-inflammatory effect of GTE on lipopolysaccharides (LPS)-induced retinal inflammation in rats and explored the underlying mechanism. (nature.com)
  • Ocular inflammation was induced in adult rats by injecting 1 mg/kg LPS into the left footpad. (nature.com)
  • Objective To study the neuroprotective effect of rhEPO on brain tissue of newborn rats with intrauterine infection by detecting the changes of MOG expression,in order to provide reference for clinical intervention. (magtech.com.cn)
  • Inflammation and immunity are key factors for the development and complications of atherosclerosis, and therefore, the whole atherosclerotic process is a target for diagnosis and treatment. (hindawi.com)
  • After adipogenesis was induced in primary cultured orbital fibroblasts from patients with GO (n =5) and following stimulation with interleukin (IL)-1β and tumor necrosis factor (TNF)-α, the mRNA expression levels of chemokines and their receptors were analyzed. (kyobobook.co.kr)
  • In contrast, the lack of effect of dexamethasone in either control or challenged animals implies that the actions of glucocorticoids per se are not mediated through changes in miRNAs expression and that LPS-induced increases in miRNA expression are not mediated via classical inflammatory transcription factors. (northumbria.ac.uk)
  • Also, overt mature GO tissues showed reduced mRNA expression of chemokines compared to controls, which might indicate the existence of a shorter window for effective medical inflammatory treatment. (kyobobook.co.kr)
  • Barrier dysfunction could be a result of toxic insult or inflammatory attacks on epithelial cells which line the colon, although now it is being recognized that tissue could be subject to injury or inflammation due to pre-existing weakness. (umich.edu)
  • The discovery of a form of otherwise unrecognized inflammation in the early 1990s (6) and its widespread presence in many chronic diseases (7) led to the suggestion that many, if not all, such diseases may have this type of inflammatory basis (8). (cdc.gov)
  • FLORENCE, Italy - Impaired cognition in first-episode psychosis appears to be associated with expression of inflammatory markers, say Spanish researchers in findings that could point to the eventual targeting of therapies to patient subgroups. (medscape.com)
  • In addition, the team measured the expression of a panel of nine pro- and anti-inflammatory mediators of intracellular inflammation in peripheral blood monon uclear cells, as well as blood plasma. (medscape.com)
  • In addition, patients had increased expression of proinflammatory mediators and reduced expression of anti-inflammatory compounds. (medscape.com)
  • They found that expression of the anti-inflammatory prostaglandin 15d-PGJ2 was significantly inversely associated with sustained attention, at a beta value of -0.312 ( P = .004). (medscape.com)
  • Far better understanding of the roles of PTGS2 inside the distinctive uterine tissues inpreterm and term labour with and without the need of inflammation could clarify when PTGS2 inhibitors are most likely to become helpful. (5htreceptor.com)
  • This process is known as paracellular trans- leakage is peritoneal fluid accumulation asso- port and it is one manner through which perme- ciated with bowel inflammation. (bvsalud.org)
  • Therefore, HMGB1 can prolong inflammation in the periodontal tissue and, conversely, can regenerate or repair damaged tissues in the oral cavity . (bvsalud.org)
  • 6]. The extent of plaque, scales, inflammation and bleeding of gingival, depth of periodontal pockets, and the extent of alveolar bone loss have also been examined in such studies [7]. (bvsalud.org)
  • The response of these colonoids to Aquamin was assessed by measuring differentiation and protein expression, which was determined by different approaches, one of which being proteomic screening of colonoid cultures. (umich.edu)
  • Instead, pericytes and microvascular smooth muscle cells express ACE2 in an organotypic manner.Pericyte deficiency leads toincreased endothelial expression and releaseof Von Willebrand factorand intravascular platelet and fibrin aggregation,suggesting thatpericyteslimit endothelial pro-thromboticresponses. (helsinki.fi)
  • A gene expression analysis revealed that deletion of Akt in liver led to the constitutive activation of Foxo1-dependent gene expression, but again, concomitant ablation of Foxo1 restored postprandial regulation, preventing the inhibition of the metabolic response to nutrient intake caused by deletion of Akt . (nature.com)
  • There have to be an option mechanism for uterine activation in SPL inside the absence of inflammation. (5htreceptor.com)
  • Increased NLRP3 inflammasome activation and IL-1β release in monocytes from CNO patients was suggested to contribute to bone inflammation. (liverpool.ac.uk)
  • Microglial activation as part of the neuroinflammatory response of the brain can occur as an answer to a direct insult to the brain (this includes viral infection), but can also occur following respiratory inflammation and might play an important role in the development of cognitive problems after COVID-19 infection. (medpagetoday.com)
  • In addition, the cartilage damage triggers an immune response, causing inflammation of other joint tissues and leading to further joint damage. (medlineplus.gov)
  • Effect of DPP4/CD26 expression on SARS‑CoV‑2 susceptibility, immune response, adenosine (derivatives mA and CD) regulations on patients with cancer and healthy individuals. (cdc.gov)
  • They have less NFkB, which reduces inflammation, and more PGC-1α, which leads to the creation of more mitochondria that generate energy for cell growth. (scitechdaily.com)
  • Previous studies have shown that the expression of MALAT1 is increased in endothelial cells induced by ox-LDL and its expression level can reflect the damage degree of endothelial cells ( 11 , 12 ). (spandidos-publications.com)
  • Accumulating clinical observations implicatevascular inflammation as an underlyingcause of coagulopathyin severely ill COVID-19 patientsand it was recently suggested that SARS-CoV-2 virus particles infect endothelial cells.Here, we show thatendothelial cells do not expressangiotensin-converting enzyme-2 (ACE2), the SARS-CoV-2 receptor. (helsinki.fi)
  • Although most TSPO in neuropsychiatric disease is typically expressed in microglia, and to a lesser extent in astroglia, the next most common cellular expression is in endothelial cells," they wrote. (medpagetoday.com)
  • Therapeutically increasing CFTR expression attenuates these effects. (lu.se)
  • Inflammation is in a wide spectrum of retinal diseases, causing irreversible blindness and visual impairment. (nature.com)
  • Chronic low-grade inflammation is an important pathogenic factor in the development of type 2 diabetes and cardiovascular diseases ( 1 ). (diabetesjournals.org)
  • Magnetic resonance imaging (MRI) with T2-weighted fat suppression and short tau inversion recovery (STIR) is useful in the diagnostic workup because it reveals edema, a marker of muscle inflammation. (medscape.com)
  • In addition, elevated TSPO expression is not completely specific to glial cells, the researchers acknowledged. (medpagetoday.com)
  • We aimed to determine the significance of detecting expression of some antigens that might be pivotal to the process, namely CD44 and CD117, in patients with active pemphigus vulgaris. (who.int)
  • A disparate array of plasma/serum markers provides evidence for chronic inflammation in human prediabetes, a condition that is most closely replicated by standard mouse models of obesity and metaflammation. (diabetesjournals.org)
  • A disparate array of plasma/serum markers provides evidence for chronic inflammation in prediabetes ( 2 , 3 ) that contrasts with our rich understanding of cellular sources of inflammation in human type 2 diabetes and animal models of insulin resistance (IR) ( 4 ). (diabetesjournals.org)
  • Although these final results help the idea that labour usually happens inside the absence of inflammation, there's evidence that the presence of inflammation is usually a trigger for labour, with [8,12] or without [10,12] signs of infection. (5htreceptor.com)
  • Microglia can become chronically overactivated, for example, in response to accumulation of brain plaques, which in turn is thought to trigger inflammation. (usda.gov)
  • Within the cell, they can trigger changes in gene expression and biochemical reactions, among other things. (sciencedaily.com)
  • This 3-year-old girl had leukocyte adhesion deficiency type I (LAD I) with complete absence of CD18 expression. (medscape.com)
  • In milder forms of leukocyte adhesion deficiency I (1-30% expression of CD8), patients may survive to adulthood. (medscape.com)
  • This leukocyte adhesion deficiency variant is associated with defective expression of the Rap-1 activator CalDAG-GEFI. (medscape.com)
  • STIR findings must be interpreted cautiously, however, because patients with muscle dystrophies may have inflammation as well. (medscape.com)
  • Our observation of various prostaglandin pathway expression profiles in preterm labour and inflammation could have implications for the choice of tocolytics employed in distinctive conditions. (5htreceptor.com)
  • Even though elevation of PTGS2 in placenta and membranes affected by inflammation may very well be countered by selective PTGS2 inhibitors, PTGS2 is not upregulated with preterm labour in these tissues, though it truly is in myometrium [13]. (5htreceptor.com)
  • We observed an increase in PTGS2 expression in the amnion with term versus preterm labour which has also been observed previously [31,32,55]. (5htreceptor.com)
  • 2] Strunk T,Inder T,Wang X,et al.Infection-induced inflammation and cerebral injury in preterm infants[J].Lancet Infect Dis,2014,14(8):751-762. (magtech.com.cn)