Expression of fatty acid binding protein. Medical search. Frequent questions

The fatty-acid-binding proteins (FABPs) are a family of transport proteins for fatty acids and other lipophilic substances such as eicosanoids and retinoids. (wikipedia.org)
The FABPs are intracellular carriers that "solubilize" the endocannabinoid anandamide (AEA), transporting AEA to the breakdown by FAAH, and compounds that bind to FABPs block AEA breakdown, raising its level. (wikipedia.org)
The cannabinoids (THC and CBD) are also discovered to bind human FABPs (1, 3, 5, and 7) that function as intracellular carriers, as THC and CBD inhibit the cellular uptake and catabolism of AEA by targeting FABPs. (wikipedia.org)
In contrast to numerous studies conducted to investigate the crucial role of fatty acid binding protein 5 (FABP5) in prostate cancer, investigations on the possible involvement of other FABPs are rare. (liverpool.ac.uk)
The chronological changes in the gene expression for three species of cytosolic fatty acid-binding proteins (FABPs) in the rat brain were examined by Northern and in situ hybridization analyses. (elsevierpure.com)
FABPs are a class of cytoplasmic proteins that bind long chain fatty acids. (thermofisher.com)
Fatty acid-binding proteins (FABPs) were originally described as intracellular proteins that can affect lipid fluxes, metabolism and signalling within cells. (nih.gov)

Fatty acid binding proteins (FABP) are small (approximately 13-14 kDa) intracellular proteins with a high degree of tissue specificity. (thermofisher.com)
In general, autophagy degrades long-lived damaged intracellular proteins, in contrast to the ubiquitin-proteasome system, which controls the degradation of short-lived proteins [ 2 ]. (hindawi.com)

Ian Sanderson first became interested in the intestine as a graduate student under Dr Dennis Parsons in Oxford where he examined the exit of absorbed amino acids from the enterocyte. (qmul.ac.uk)
After the degradation of damaged proteins and lipids, amino acids and fatty acids are released into the cytoplasm and recycled for new biosynthesis of cellular components or energy production [ 4 ]. (hindawi.com)
For example, in an environment rich in amino acids, cells do not expend energy for making amino acid biosynthetic enzymes. (go.jp)
However, if the environment becomes depleted of amino acids (nutritional downshift), cells will be exposed to a lack of both the amino acid biosynthetic enzymes and the amino acids required to make these enzymes. (go.jp)
To solve this dilemma, cells must use their own proteins as sources of amino acids in response to the nutritional downshift. (go.jp)
Once amino acid biosynthetic enzymes start to accumulate, the cell is able to produce its own amino acids, and a new growth phase begins. (go.jp)
In Escherichia coli , amino acid starvation leads to the accumulation of an unusual molecule, polyphosphate (polyP), a linear polymer of many hundreds of orthophosphate residues. (go.jp)
Nateglinide is an amino acid derivative that stimulates insulin secretion from the pancreas (within 20 minutes of oral administration), which, in turn, reduces blood glucose levels. (medscape.com)
Thus, citric acid cycle intermedi- ates are not used for adenosine triphosphate (ATP) production and are shuttled out of the mitochondria, providing precursors for nucleotide, amino acid, and lipid synthesis path- ways for the dividing cell [13]. (who.int)

1993), as well uptake and translocation of long-chain fatty acids as NMR solution structures (Hodsdon et al. (lu.se)

The expression for heart(H)-FABP became evident after birth, with a gradual increase and confined to the gray matter, suggesting that the expression of H-FABP mRNA is neuron-specific in postnatal brain. (elsevierpure.com)
B-FABP mRNA was transiently expressed in perinatal gray as well as white matter and the expression in glial cells persists only in the olfactory nerve fiber layer at the adult stage. (elsevierpure.com)
The expression for S-FABP was evident in the prenatal gray matter and S-FABP mRNA was expressed in glial cells at early postnatal stage, whereafter the expression decreased to, but remained at weak levels in the adult brain. (elsevierpure.com)
0·05) mRNA abundance of jejunal fatty acid-binding protein 2, intestinal than those in the CON and DLM groups. (cambridge.org)
By integrating miRNA and mRNA expression profiles, we identified differentially expressed miRNAs and their target genes involved in several hallmarks of cancer. (biomedcentral.com)

Obesity element binding protein 1 and fatty acid synthase. (cdc.gov)
Expression of sterol regulatory element binding protein 1 (SREBP-1), ATP-citrate lyase (ACL), fatty acid synthase (FAS), malic enzyme (ME), acetyl-CoA carboxylase (ACC), and stearoyl-CoA (?9) desaturase 1 (SCD1) genes in ad lib birds declined from their highest levels just prior to photo-stimulation to reduced levels as the birds came into and maintained egg production. (usda.gov)
Transfection of HepG2 cells with sense or antisense miR-370 or miR-122 upregulated and downregulated, respectively, the transcription factor sterol-regulatory element binding protein 1c (SREBP-1c) and the enzymes diacylglycerol acyltransferase-2 (DGAT2), fatty acid synthase (FAS), and acyl-CoA carboxylase 1 (ACC1) that regulate fatty acid and triglyceride biosynthesis. (nih.gov)
Image analysis of the matched maps identified 7 proteins that were either over- or down-expressed: activated protein kinase c receptor (LACK), alpha tubulin (×2), prostaglandin f2-alpha synthase, protein disulfide isomerase, vesicular transport protein and a hypothetical protein. (who.int)

In conclusion, the ad lib and restricted feeding regimes produced significantly different effects on hepatic gene expression related to lipid metabolism in broiler breeders. (usda.gov)
Acyl-CoA binding protein (ACBP) maintains a pool of fatty acyl-CoA molecules in the cell and plays a role in fatty acid metabolism. (rcsb.org)
Adipose tissue plays an important role in metabolism through its storage and release of triglycerides, peptide hormones (adipokines) and other proteins, and in the case of brown fat, for its role in thermogenesis ( 1 ). (diabetesjournals.org)
As the functions of this protein family have been further elucidated, it has become evident that they are critical mediators of metabolism and inflammatory processes, both locally and systemically, and therefore are potential therapeutic targets for immunometabolic diseases. (nih.gov)
RXR is a protein that acts as a nutritional sensor for lipids and vitamin A derivatives, altering gene expression and influencing biological functions as important as immunity, cell differentiation or metabolism. (ub.edu)
Significant amounts of this protein are present in white fat and plasma, and scientists believe that it plays a role in sugar and insulin metabolism. (medicalnewstoday.com)
Liver-type fatty acid binding protein (L-FABP) is involved in the formation and metabolism of fatty acids. (geneticsmr.com)
We previously observed that treatment of mice with a dominant negative form of cJun (dn-cJun) increased the expression of genes involved in lipid metabolism and modulated the expression of nine microRNAs (miR). (nih.gov)
To investigate the potential effect of these miRs on the expression of the genes of lipid metabolism, we performed studies in cultured HepG2 cells. (nih.gov)
Our data suggest that miR-370 acting via miR-122 may have a causative role in the accumulation of hepatic triglycerides by modulating initially the expression of SREBP-1c, DGAT2, and Cpt1alpha and, subsequently, the expression of other genes that affect lipid metabolism. (nih.gov)

By analyzing the expression of specific genes involved in the synthesis, transport, and storage of fat, as well as other metabolic pathways, it may be possible to assess the potential metabolic consequences of feed restriction and other management practices on growth, body composition and performance of broiler breeders. (usda.gov)
Overexpression of SREBP1 (sterol regulatory element binding protein 1) promotes de novo fatty acid synthesis and triacylglycerol accumulation in goat mammary epithelial cells. (oregonstate.edu)
Except for a demonstrated role in controlling the expression of FASN, a regulatory role of SREBP1 on milk fat synthesis is very likely, but has not yet been demonstrated in goat mammary epithelial cells (GMEC). (oregonstate.edu)
To explore the regulatory function of SREBP1 on de novo fatty acids and triacylglycerol synthesis in GMEC, we overexpressed the mature form of SREBP1 (active NH2-terminal fragment) in GMEC using a recombinant adenovirus vector (Ad-nSREBP1), with Ad-GFP (recombinant adenovirus of green fluorescent protein) as control, and infected the GMEC for 48 h. (oregonstate.edu)
In infected cells, we assessed the expression of 20 genes related to milk fat synthesis using real time-quantitative PCR, the protein abundance of SREBP1 and FASN by Western blot, the production of triacylglycerol, and the fatty acid profile. (oregonstate.edu)
The aim of the present study was to determine whether increased consumption of methionine as dl -methionine (DLM) or its hydroxy analogue dl -2-hydroxy-4-methylthiobutanoic acid (HMTBA) could benefit milk synthesis and neonatal growth. (cambridge.org)

Intracellular and extracellular interactions with proteins enables the functional and mechanistic diversity of lipids. (nih.gov)
Once RXR detects maternal GLA, it launches genetic programs that equip the mitochondrion - the energy center of cells - with the proteins needed to start consuming lipids, the main source of energy in the mature heart. (ub.edu)

DIM also enhanced glucose uptake by increasing expression of glucose transporter 4 in adipocytes. (researchgate.net)
The sympathetic nervous system regulates this function through β-adrenergic stimulation of brown mature adipocytes' dissipation of energy in the form of heat mediated by mitochondrial uncoupling protein-1 (UCP-1) activation. (springer.com)

Macrophage inflammatory protein-2: chromosomal regulation in rat intestinal epithelial cells. (qmul.ac.uk)
Expression of the intestinal-specific FABP (I-FABP) is strictly limited to the small intestine mucosa. (biomedcentral.com)

The hepatic adenomas are heterogeneous and slightly hyperintense relative to the fatty liver. (medscape.com)
Reverse transcription polymerase chain reaction in conjunction with capillary electrophoresis and laser-induced fluorescence detection (RT-PCR/CE-LIF) was used to quantify hepatic expression of specific genes relative to that of b-actin in total RNA samples. (usda.gov)
Hepatic expression of fatty acid binding protein (FABP), very low density apolipoprotein II (ApoVLDL-II) and apolipoprotein B (ApoB) genes increased in both ad lib and restricted breeders following photo-stimulation, whereas apolipoprotein A1 (ApoA1) gene expression declined in both groups. (usda.gov)
Abdominal fat pad weights were significantly higher in the ad lib as compared to restricted birds following photo-stimulation and the expression of lipoprotein lipase (LPL) in this tissue showed a similar pattern of expression to that observed for the hepatic lipogenic enzyme genes. (usda.gov)
Hepatic leptin receptor gene expression did not differ significantly for ad lib as compared to restricted birds at any time. (usda.gov)
Non-alcoholic fatty liver disease is associated with obesity, non-insulin dependent diabetes, and hypertriglyceridemia and represents the hepatic manifestation of the metabolic syndrome[ 4 ]. (wjgnet.com)
Berry intake changes hepatic gene expression and DNA methylation patterns associated with high-fat diet. (lu.se)

ABSTRACT In order to define the protein expressional changes related to the process of meglumine antimoniate resistance in anthroponotic cutaneous leishmaniasis (CL), we performed a comparative proteomics analysis on sensitive and resistant strains of Leishmania tropica isolated from Iranian CL patients. (who.int)

The protein that the researchers wanted to target was fatty acid-binding protein 4 (fabp4). (medicalnewstoday.com)

Results DIM, but not I3C, increased adipocyte differentiation through upregulation of peroxisome proliferator‐activated receptor γ and CCAAT/enhancer‐binding protein α. (researchgate.net)
Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities. (harvard.edu)

Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common liver disease worldwide, it causes chronic hepatitis, which leads to cirrhosis and hepatocellular carcinoma. (scirp.org)
Ninty subjects were enrolled in this study who attended the Hepatology, Gastroenterology and Internal medicine clinics in Benha University Hospitals between January 2017 and January 2018 and divided into group I included 70 consecutive patients with non-alcoholic fatty liver disease who were diagnosed by ultrasound with or without elevated liver enzymes and group II included 20 healthy control subjects without NAFLD (by ultrasound) with normal liver enzymes. (scirp.org)
The relationship between NAFLD and retinol-binding protein 4 - an updated systematic review and meta-analysis. (nih.gov)
Nonalcoholic fatty liver disease (NAFLD) is highly prevalent and can result in nonalcoholic steatohepatitis (NASH) and progressive liver disease including cirrhosis and hepatocellular carcinoma. (wjgnet.com)
An estimated 30% of adults and 10% of children and adolescents in the United States have nonalcoholic fatty liver disease (NAFLD), defined as liver fat content exceeding 5% (Figure 1 )[ 1 - 3 ]. (wjgnet.com)
Although the molecular mechanisms that regulate autophagy are not fully understood, recent work indicates that dysfunctional/impaired autophagic functions are associated with the development and progression of nonalcoholic fatty liver disease (NAFLD), alcoholic fatty liver disease (AFLD), and hepatocellular carcinoma (HCC). (hindawi.com)

The mechanisms responsible for the increased adipos- of Patient with ity are changes in gene expression of multiple enzymes and transcription factors by the virus ( 8-15 ). (cdc.gov)
Protein phosphorylation is a signalling mechanism that regulates most aspects of cellular life, and protein kinases, which carry out this post-translational modification, constitute the largest family of enzymes encoded by the human genome. (lu.se)
[ 12 ] The activity of key mitochondrial enzymes of the tricarboxylic acid cycle, β-oxidation, and the electron transport system, conversely, were unchanged, [ 12 ] leaving many unanswered questions regarding the effects of CR on muscle-specific mitochondrial function in humans. (medscape.com)

MicroRNAs (miRNAs) are small non-coding RNA molecules of about 22 nucleotides which function to silence the expression of their target genes. (biomedcentral.com)
In addition to numerous protein-coding genes, many microRNAs (miRNAs) also play important roles in breast cancer. (biomedcentral.com)

Thereafter we assessed the expression status of FABP6 and FABP9 in both prostate cell lines and in human tissues. (liverpool.ac.uk)
FABP6 protein was overexpressed only in 1 of the 5 malignant cell lines and its immunostaining intensities were not significantly different between benign and malignant prostate tissues. (liverpool.ac.uk)
Obesity was defi ned expression chronically in tissues. (cdc.gov)
The expressions of mTOR and Ki-67 in tissues were detected by immunohistochemical staining. (bvsalud.org)
Expression of SREBF1 was modest in mammary compared with the other tissues in dairy goats but its expression increased approximately 30-fold from pregnancy to lactation. (oregonstate.edu)

9-cis-retinoic acid enhances fatty acid-induced expression of the liver fatty acid-binding protein gene. (unil.ch)
Increased OLR1 expression, resulting either from TZD treatment or adenoviral gene delivery, significantly augments adipocyte cholesterol content and enhances fatty acid uptake. (jci.org)

a single fatty acid molecule with high af®nity in Cistola et al. (lu.se)

Cell proteins were analysed with 2-dimensional electrophoresis and differentially expressed proteins were identified by matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry. (who.int)

DIM also improved diabetic nephropathy by inhibiting the expression of PKC-α, the marker of albuminuria, and TGF-β1, an indicator of renal hypertrophy, in diabetic mice. (researchgate.net)
Notably, this was also the only group in which tibial adiponectin expression was lower than in WT mice, suggesting a close association between MAT adiponectin production and circulating adiponectin. (frontiersin.org)
Deficiency of fatty acid-binding proteins in mice confers protection from development of experimental autoimmune encephalomyelitis. (harvard.edu)
In this study, using polyoma middle T antigen (PyMT) mice, a widely used luminal B breast cancer model, we profiled microRNA (miRNA) expression at four time points that represent different key developmental stages of cancer progression. (biomedcentral.com)
In a widely used mouse model of breast cancer, mammary gland-specific expression of the polyoma middle T (PyMT) oncoprotein under the control of the MMTV promoter/enhancer in transgenic mice (MMTV-PyMT) results in widespread transformation of the mammary epithelium and subsequent development of multifocal mammary adenocarcinomas and metastatic lesions in the lymph nodes and in the lungs [ 2 ]. (biomedcentral.com)

They also noted lower blood glucose levels, less inflammation , and improved biomarkers of nonalcoholic fatty liver disease. (medicalnewstoday.com)

Interplay of retinol binding protein 4 with obesity and associated chronic alterations (Review). (nih.gov)

Certain very abundant ribosomal proteins can be the sacrificial substrates targeted for degradation at the onset of the downshift. (go.jp)

In a healthy person, excess fat is stored as triglycerides in the adipose tissue, and fatty acids are released into the bloodstream only in response to an increased energy requirement, for example, during fasting. (jci.org)

Presently, our main project evolves around the AMP-activated protein kinase (AMPK) family, which consists of AMPK and another 12 related kinases, of which we are particularly interested in the salt-inducible kinases (SIK) 1-3. (lu.se)

Among 82 newly discovered breast-cancer-related miRNAs, 35 can potentially regulate 271 protein-coding genes based on their sequence complementarity and expression profiles. (biomedcentral.com)

The antidiabetic thiazolidinediones (TZDs) also promote MAT expansion and hyperadiponectinemia, even without increasing adiponectin expression in white adipose tissue (WAT). (frontiersin.org)
However, rosiglitazone significantly increased adiponectin protein expression in WAT, suggesting that WAT contributes to hyperadiponectinemia in this context. (frontiersin.org)
To directly compare the specificity and efficacy of different Cre lines in mediating adipocyte specific recombination, transgenic Cre lines driven by the adipocyte protein 2 (aP2) and adiponectin (Adipoq) gene promoters, as well as a tamoxifen-inducible Cre driven by the aP2 gene promoter (iaP2), were bred to the Rosa26R (R26R) reporter. (diabetesjournals.org)

A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. (nih.gov)

Finally, rosiglitazone upregulated uncoupling protein 1 in brown adipose tissue (BAT), but this protein was undetectable in tibiae, suggesting that MAT is unlikely to share thermogenic properties of BAT. (frontiersin.org)
OLR1 expression in white adipose tissue is increased in obesity and is further induced by PPARγ ligand treatment in vivo. (jci.org)
Avian species do not have brown adipose tissue (BAT), and lack Uncoupling Protein 1 ( UCP1 ) [ 12 ]. (biomedcentral.com)
An overall aim of our research is to study the regulation and function of protein phosphorylation cascades with relevance to type 2 diabetes, with a particular focus on adipose tissue, since this tissue is involved in the pathogenesis of diabetes. (lu.se)

They are abundantly present in various cell types and seem to play an important role in the intracellular utilization of fatty acids. (thermofisher.com)

Depending on the expression status of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), it can be classified into four molecular subtypes: luminal A, luminal B, HER2-positive, and basal-like (or triple-negative) breast cancer. (biomedcentral.com)

Many existing tissue-engineering approaches focus on delivery of selected proteins (growth factors, transcription factors etc.) or nucleic acids to host or implanted stem cells to achieve lineage specific differentiation. (frontiersin.org)

Fatty acid-binding protein 3 (FABP3) located in renal mesangial and distal tubular cells, and had been shown to be a sensitive marker of renal injury, potentially be a mediator in pathogenesis of chronic kidney disease (CKD). (medsci.org)
MAT content was assessed by osmium tetroxide staining and adipocyte marker expression. (frontiersin.org)

We aimed to assess the value of liver fatty acid binding protein (L-FABP) in the diagnosis of non-alcoholic fatty liver disease in comparison to ultrasonography. (scirp.org)

According to weighted gene co-expression network analysis, pathways positively related to adipogenic differentiation are significantly activated at the differentiation stage, while WNT, FOXO and other pathways that inhibit preadipocyte differentiation are negatively regulated. (biomedcentral.com)

These, together with measured binding-specificity differences, suggest that there is a potential for the design of molecules that might selectively block the acyl-CoA binding site. (rcsb.org)
NOESY, nuclear Overhauser fatty acid, only eight water molecules are effect spectroscopy. (lu.se)
The autophagophore membrane then elongates and encloses the molecules to be degraded forming an autophagosome, which occurs in two separate conjugation reactions catalyzed by autophagy-related proteins (ATGs). (hindawi.com)

The study shows the usefulness of proteomics in identifying proteins that may express differences between sensitive and resistant L. tropica isolates. (who.int)

Autophagy is a cellular catabolic process that eliminates damaged cell organelles, unfolded proteins, and various intracellular pathogens through lysosomal degradation. (hindawi.com)
Protein degradation in this bacterium appears to be triggered by the accumulation of polyP. (go.jp)
Here I propose to call the polyP-Lon complex the "stringent protease," and I discuss new insights of protein degradation control in bacteria. (go.jp)

Age- and sex-adjusted FABP3 levels were positively associated with uric acid, urinary albumin-to-creatinine ratio, FABP1, FABP2, and fatty liver index, but negatively associated with eGFR and hemoglobin. (medsci.org)

Examples of these endeavours include the Human Genome Project, and more recently, the Structural Genomics (SG) initiative.The SG initiative pursues the expansion of structural coverage to include at least one structural representative for each protein family to derive the remaining structures using homology modelling. (uchile.cl)
[ 11 ] In the CALERIE phase 1 study, however, we demonstrated that 6 months of 25% CR in healthy human s increased the expression of genes involved in mitochondrial biogenesis and mitochondrial DNA (mtDNA) copy number. (medscape.com)

This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. (nih.gov)
NGAL is a 25-kD protein of the lipocalin family. (medscape.com)

Anatomy15

Organisms11

Diseases6

Chemicals and Drugs90

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes37

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Health Care2

FABPs7

Intracellular proteins2

Amino9

Long chain1

MRNA5

Synthase4

Metabolism10

Synthesis6

Lipids2

Adipocytes2

Intestinal2

Hepatic7

Abstract1

FABP41

Peroxisome prolifer2

NAFLD6

Enzymes3

MicroRNAs2

Tissues5

Enhances2

Molecule1

Differentially expressed1

Mice5

Nonalcoholic fatty l1

Alterations1

Substrates1

Triglycerides1

Kinase1

Regulate1

Adiponectin3

Deficiency1

Adipose4

Abundantly1

Epidermal1

Transcription1

Marker2

Liver disease1

Pathways1

Molecules3

Proteomics1

Degradation3

FABP31

Human2

Lipocalin family2