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  • vitro
  • In vitro, usual inducers of matrix metalloproteinases such as interleukin-1, interferon-γ, or tumor necrosis factor α did not augment stromelysin-3 in vascular wall cells. (rupress.org)
  • In accordance with the in situ and in vitro data obtained with human material, interruption of the CD40-CD40L signaling pathway in low density lipoprotein receptor-deficient hyperlipidemic mice substantially decreased expression of the enzyme within atherosclerotic plaques. (rupress.org)
  • The expression and activity of the integrins in adult RGCs were preserved in vitro independently of the substrate in which they grew. (arvojournals.org)
  • In summary, our results show that the media formulation, supplement profile, and extracellular matrix composition are important for maximal expression of androgen-induced effects by lacrimal gland acinar cells in vitro. (arvojournals.org)
  • deposition
  • Under in vivo conditions of increased ECM turn-over and deposition, as in the mdx dystrophic muscle and during skeletal muscle regeneration, an induction and relocalization of ALP is observed in a subpopulation of skeletal muscle fibers, whereas in normal skeletal muscle, ALP expression is restricted to blood vessels and some endomysial mononuclear cells. (biomedcentral.com)
  • MMP-3 genotype may be an important determinant of vascular remodeling and age-related arterial stiffening, with the heterozygote having the optimal balance between matrix accumulation and deposition. (genwaybio.com)
  • Hepatic fibrosis is defined pathologically as excessive deposition of extracellular matrix (ECM) as a result of wound-healing responses to various kinds of chronic liver injury. (bmj.com)
  • implicate
  • These observations establish the expression of the unusual matrix metalloproteinase stromelysin-3 in human atherosclerotic lesions and implicate CD40-CD40L signaling in its regulation, thus providing a possible new pathway that triggers complications within atherosclerotic lesions. (rupress.org)
  • stromal
  • However stromal cells are mesenchymal in origin and committed to a non-hematopoietic lineage, and so can be distinguished from 'classical' immune cells by a lack of CD45 expression. (biolegend.com)
  • Many stromal cells associated with cancer express Podoplanin and the expression of this marker has been linked to higher rates of metastases and poor prognosis. (biolegend.com)
  • vivo
  • β-gal-positive cells expressing mesenchymal markers accumulated within 3 weeks of in vivo TGF-β1 expression. (pnas.org)
  • human
  • However, their chronological change of expression (or localization) in the human heart remains elusive. (semanticscholar.org)
  • miR-708 expression was attenuated widely in human RCC specimens. (aacrjournals.org)
  • Owing to their tissue- and disease-specific expression patterns and tremendous regulatory potential, miRNAs are being assessed as potential biomarkers for diagnosis and prognosis of human malignancies ( 11 ). (aacrjournals.org)