• The present study evaluated the prognostic value of the epidermal growth factor receptor (EGFR) mutation status, and excision repair cross-complementation group 1 (ERCC1) and thymidylate synthase (TS) expression following intercalated tyrosine kinase inhibitor (TKI) therapy and platinum- and pemetrexed-based chemotherapies (subsequent second-line treatment) for patients with adenocarcinoma non-small-cell lung cancer (AC-NSCLC). (medsci.org)
  • The EGFR mutation status and ERCC1 and TS expression were evaluated through direct DNA sequencing and immunohistochemical analyses, respectively. (medsci.org)
  • The EGFR mutation status and ERCC1 and TS expression were the significant predictors of clinical outcomes. (medsci.org)
  • Low TS expression was predictive of improved OS of patients with negative EGFR-mutated advanced AC-NSCLC, whereas high ERCC1 expression resulted in poor OS in patients with positive EGFR-mutated advanced AC-NSCLC. (medsci.org)
  • TS and ERCC1 expression levels were effective prognostic factors for negative and positive EGFR-mutated AC-NSCLC, respectively. (medsci.org)
  • In conclusion, the present results indicate that the EGFR mutation status and TS and ERCC1 expression can be used as the predictors of OS after subsequent second-line treatments for AC-NSCLC. (medsci.org)
  • The standard therapies for lung adenocarcinoma include epidermal growth factor receptor (EGFR) mutation targeted therapy and conventional chemotherapy, such as platinum- and pemetrexed-based chemotherapies. (medsci.org)
  • Several biomarkers have been used to predict treatment responses, such as the EGFR mutation status for targeted therapy or the excision repair cross-complementation group 1 (ERCC1) and thymidylate synthase (TS) expression for conventional chemotherapy [ 3 - 8 ]. (medsci.org)
  • The aim of this study was to examine the expression and prognostic impact of human epidermal growth factor receptor 1 (HER1/EGFR) and 3 (HER3), as well as the occurrence of EGFR and KRAS mutations in gastric and esophageal adenocarcinoma. (lu.se)
  • The epidermal growth factor receptor (EGFR) is frequently overexpressed in non-small-cell lung carcinoma (NSCLC), and EGFR inhibitors are promising new therapeutic agents. (nih.gov)
  • It will be important to evaluate EGFR gene and EGFR protein status and signal protein expression to properly interpret future clinical trials using EGFR inhibitors. (nih.gov)
  • Here, we show higher levels of epidermal growth factor receptor (EGFR), but lower levels of miR-370 expression in most human lung cancer cells and non-tumor cells. (oncotarget.com)
  • Induction of miR-370 over-expression significantly reduced the levels of EGFR expression and the EGFR 3'untranslated region (UTR)-regulated luciferase activity in XWLC-05 and H157 cells, suggesting that miR-370 may bind to the 3'UTR of EGFR mRNA. (oncotarget.com)
  • Furthermore, miR-370 over-expression down-regulated the EGFR and hypoxia-inducible factor (HIF)-1α expression, and attenuated the extracellular single-regulated kinase (ERK)1/2 and AKT phosphorylation in XWLC-05 and H157 cells. (oncotarget.com)
  • In contrast, miR370 inhibitor over-expression increased the EGFR and HIF-1α expression as well as the ERK1/2 and AKT phosphorylation in XWLC-05 and H157 cells. (oncotarget.com)
  • Moreover, miR-370 over-expression significantly reduced the levels of EGFR and CD31 expression and inhibited the growth and lung metastasis of xenograft NSCLC tumors in mice. (oncotarget.com)
  • Our study indicates that miR-370 may bind to the 3'UTR of EGFR to inhibit EGFR expression and the growth, angiogenesis and metastasis of non-small cell lung cancer by down-regulating the ERK1/2 and AKT signaling. (oncotarget.com)
  • The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). (wikipedia.org)
  • In many cancer types, mutations affecting EGFR expression or activity could result in cancer. (wikipedia.org)
  • Deficient signaling of the EGFR and other receptor tyrosine kinases in humans is associated with diseases such as Alzheimer's, while over-expression is associated with the development of a wide variety of tumors. (wikipedia.org)
  • Interruption of EGFR signalling, either by blocking EGFR binding sites on the extracellular domain of the receptor or by inhibiting intracellular tyrosine kinase activity, can prevent the growth of EGFR-expressing tumours and improve the patient's condition[citation needed]. (wikipedia.org)
  • Epidermal growth factor receptor (EGFR) is a transmembrane protein that is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor alpha (TGF-α). (wikipedia.org)
  • Upon activation by its growth factor ligands, EGFR undergoes a transition from an inactive monomeric form to an active homodimer. (wikipedia.org)
  • MSI2 control of EGFR expression and activity in an NSCLC cell line panel was studied using RT-PCR, Western blots, and RNA immunoprecipitation. (northwestern.edu)
  • Functional consequences of MSI2 depletion were explored for cell growth and response to EGFR-targeting drugs, in vitro and in vivo. (northwestern.edu)
  • MSI2 depletion significantly reduced EGFR protein expression, phosphorylation, or both. (northwestern.edu)
  • Comparison of protein and mRNA expression indicated a post-transcriptional activity of MSI2 in control of steady state levels of EGFR. (northwestern.edu)
  • Further, depletion of MSI2 in combination with EGFR inhibitors such as erlotinib, afatinib, and osimertinib selectively reduced the growth of EGFR mut NSCLC cells and xenografts. (northwestern.edu)
  • These results define MSI2 as a direct regulator of EGFR protein expression, and suggest inhibition of MSI2 could be of clinical value in EGFR mut NSCLC. (northwestern.edu)
  • Mutations in the kinase domain of the epidermal growth factor receptor (EGFR) are found in a subset of patients with lung cancer and correlate with response to EGFR tyrosine kinase inhibitors (TKI). (elsevierpure.com)
  • Although the expression of wild-type EGFR was also down-regulated by 17-AAG, its degradation required higher concentrations of drug and a longer duration of drug exposure. (elsevierpure.com)
  • 17-AAG treatment, at its maximal tolerated dose, caused a significant delay in H3255 (L858R EGFR) xenograft growth but was less effective than the EGFR TKI gefitinib. (elsevierpure.com)
  • 17-AAG alone delayed, but did not completely inhibit, the growth of H1650 and H1975 xenografts, two EGFR mutant models which show intermediate and high levels of gefitinib resistance. (elsevierpure.com)
  • The present study was performed aiming to evaluate P53 and epidermal growth factor receptor (EGFR) expression in the gingival tissue of opium-dependent patients.Methods: 102 individuals (70 men and 32 women) were entered in the study. (iocv.ir)
  • EGFR expression was significantly higher among the opium-dependent group compared to the control group (P = 0.006).Conclusion: Opium dependency significantly affects EGFR expression in gingival tissue, however it seems to have no significant effect on P53 expression. (iocv.ir)
  • Background: In this study, we intend to determine the immunohistochemical expression of EGFR in cases of head and neck squamous cell carcinoma and its association with prognostic clinico-pathologic features. (aku.edu)
  • Clinico-pathologic features, risk factors, and recurrence status of cases were evaluated, and EGFR immunohistochemistry was performed. (aku.edu)
  • Results: In our study, 52 cases (45.2%) of head and neck SCC were positive and 10 cases (8.7%) were focal positive for EGFR expression, while 53 cases (46.1%) were negative for EGFR expression. (aku.edu)
  • 70%) was noted in 6.1% (7 cases), while 12.2% (14 cases) and 26.1% (30 cases) revealed 51-70% and 11-50% EGFR expression respectively. (aku.edu)
  • On the basis of intensity, strong EGFR expression was noted in 13.9% (16 cases) while 16.5% (19 cases) and 23.5% (27 cases) revealed intermediate and weak EGFR expression respectively. (aku.edu)
  • Significant association of EGFR expression was noted with tumor stage and disease-free survival. (aku.edu)
  • therefore, EGFR expression can help as a prognostic biomarker in head and neck squamous cell carcinoma. (aku.edu)
  • Lung cancer with epidermal growth factor receptor (EGFR)-activating mutations responds favorably to the EGFR tyrosine kinase inhibitors gefitinib and erlotinib. (aacrjournals.org)
  • Here, we showed that hepatocyte growth factor (HGF), a ligand of MET oncoprotein, induces gefitinib resistance of lung adenocarcinoma cells with EGFR -activating mutations by restoring the phosphatidylinositol 3-kinase/Akt signaling pathway via phosphorylation of MET, but not EGFR or ErbB3. (aacrjournals.org)
  • Although a number of studies have shown that patients with activating mutations in exons 18-21 of the epidermal growth factor receptor (EGFR) gene respond particularly well to gefitinib and erlotinib, a prospective, randomised study was needed to differentiate between the prognostic and predictive value of EGFR mutations. (ersjournals.com)
  • This review considers the current evidence linking biomarker profile to efficacy of epidermal growth factor receptor (EGFR)-targeted therapy in advanced nonsmall cell lung cancer (NSCLC) and the clinical implications of recent findings. (ersjournals.com)
  • In NSCLC, activation of the EGFR/HER1 pathway results in a signalling cascade that promotes tumour growth and progression 6 . (ersjournals.com)
  • The ErbB/HER family of receptor tyrosine kinases (RTKs) consists of four family members: the epidermal growth factor receptor (EGFR/ErbB1), HER2 (ErbB2/Neu), HER3 (ErbB3), and HER4 (ErbB4). (plos.org)
  • RT-PCR and immunoblotting assays were used to detect the levels of miR-218-5p and EGFR expression. (jefferson.edu)
  • Cell proliferation, colony formation, wound healing, migration assays, tube formation assays, and tumor growth assays were used to study the function of miR-218-5p/EGFR signaling. (jefferson.edu)
  • The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) is proved to be effective for patients with EGFR sensitive mutations in NSCLC in recent years. (dovepress.com)
  • BACKGROUND: Lung cancer patients with sensitizing epidermal growth factor receptor (EGFR) mutations treated with osimertinib will eventually develop progressive disease (PD). (au.dk)
  • Epidermal growth factor receptor (EGFR)-mutant non-small- cell lung cancer (NSCLC) is clinically and genetically heterogeneous, with concurrent RB1/TP53 mutations , indicating an increased risk of transformation into small cell lung cancer (SCLC). (bvsalud.org)
  • Gene expression analysis of these EGFR knockout tumors revealed altered expression of neuroendocrine synapse -associated lineage genes . (bvsalud.org)
  • There is an increased expression of epigenetic reprogramming factors like Sox2 and gene associated with neural development like NTRK in these EGFR knockout tumors . (bvsalud.org)
  • Tumours from 557 incident cases of CRC, assembled in tissue microarrays, were evaluated for expression of cyclin D1, mismatch repair proteins, beta-catenin and epidermal growth factor receptor (EGFR) by immunohistochemistry, and further, EGFR gene copy number (GCN) alterations by brightfield double-in situ hybridization. (lu.se)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Here, we delineated the possible oncogenic interactions between genes containing germline and somatic mutations in TNBC and non-TNBC and investigated whether there are differences in gene expression and mutation burden between the two types of breast cancer. (hindawi.com)
  • Expression and Prognostic Significance of Human Epidermal Growth Factor Receptors 1 and 3 in Gastric and Esophageal Adenocarcinoma. (lu.se)
  • Dive into the research topics of 'Expression and Prognostic Significance of Human Epidermal Growth Factor Receptors 1 and 3 in Gastric and Esophageal Adenocarcinoma. (lu.se)
  • This indicates that glucocorticoids also affect the cellular growth by mechanisms which do not involve EGF receptors. (medicaljournals.se)
  • Topical retinoids also demonstrate inhibition of various immune factors, including the activity of leukocytes, the release of pro-inflammatory cytokines and other mediators, and the expression of transcription factors and toll receptors involved in immunomodulation (Wolf, 2002). (medscape.com)
  • 08/14/23 gen, progesterone hormone receptors, and human epidermal growth factor receptor 2 (HER2). (bvsalud.org)
  • Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis. (nih.gov)
  • Protein expression was assessed by immunohistochemistry on a scale from 0 to 400 (percentage of positive cells x staining intensity). (nih.gov)
  • The protein expression level was later assessed and data were analyzed statistically.Findings: P53 expression was higher among the opium-dependent group, however the difference was not statistically significant (P = 0.052). (iocv.ir)
  • Interestingly, such lesions appear to show normal nuclear mismatch repair protein expression, thus suggesting a different neoplastic pathway. (medscape.com)
  • Combining these new datasets with existing published gene expression and protein expression data have identified selected panels of novel biomarkers which have been evaluated on over 100 cervical cancer and pre-cancer cases using standard immunohistochemistry approaches. (europa.eu)
  • The results were evaluated with Gene Ontology (GO) enrichment analysis to reveal patterns of protein expression at progression while on osimertinib treatment. (au.dk)
  • Purpose: The present study aimed to examine the clinical implications of CD4, CD8, and FOXP3 expression on the prognosis of human epidermal growth factor receptor 2 (HER2)-positive breast cancer using a web-based database, and to compare the immunohistochemical expression of T-lymphocyte markers using primary and metastatic HER2-positive tumor tissues before and after HER2-targeted therapy. (elsevierpure.com)
  • Methods: Using the cBioPortal for Cancer Genomics and Kaplan-Meier plotter, the mRNA expression, association between T-lymphocyte markers, and survival in HER2-positive cancers were investigated according to various cutoff levels. (elsevierpure.com)
  • According to analysis of the Kaplan-Meier plotter, the impact of T-lymphocyte marker expression on survival was statistically insignificant in clinical HER2-positive tumors, irrespective of the cutoff levels. (elsevierpure.com)
  • The resistance to HER2-directed therapy might involve different and personalized mechanisms, and further research is required to understand the association between immune function and HER2 expression and to overcome the resistance mechanisms to HER2-targeted therapies. (elsevierpure.com)
  • With the addition of trastuzumab, a monoclonal antibody targeting the human epidermal growth factor receptor-2 (HER2), improvements in overall survival have been observed among patients with advanced HER2-positive disease. (carcinogenesis.com)
  • One type of breast cancer is identified by the human epidermal growth factor receptor 2 (HER2) gene amplification. (carcinogenesis.com)
  • Triple negative breast cancer (TNBC) is defined by the absence of expression for oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER2) which has limited targeted therapeutic options. (ecancer.org)
  • Few studies have addressed whether risk reduction pertains to specific breast cancer subtypes defined jointly by hormone receptor (estrogen and progesterone receptor) and human epidermal growth factor receptor 2 (HER2) expression. (medscape.com)
  • Analysis of the WNK1-dependent transcriptome by RNA-Seq demonstrated that WNK1 regulates the expression of 1858 genes during decidualization. (bioone.org)
  • Epidermal growth factor receptor regulates lineage plasticity driving transformation to small cell lung cancer. (bvsalud.org)
  • Clinically relevant improvements in survival have been attained by administering targeted therapy to the appropriate patient population: for example, the addition of trastuzumab to standard first-line chemotherapy in patients with human epidermal growth factor receptor-positive (HER2+) metastatic breast cancer 3 . (ersjournals.com)
  • Ulceration induced the very rapid expression of first rSP and then rITF mRNA, whereas the mRNAs encoding EGF and TGF alpha increased at later times, with maxima recorded at 3 and 6 days, respectively. (nih.gov)
  • Hybridization in situ detected extensive rSP mRNA expression in the regenerative epithelia. (nih.gov)
  • DNA microarrays make it possible to analyze the mRNA expression of thousands of genes simultaneously. (karger.com)
  • Further, the overexpression of HER3 enhanced cyclin D1 mRNA expression, while HER3 deleted of its identified TADs was hindered at doing so. (plos.org)
  • mRNA expression of genes and proteins related to disease pathology were. (lu.se)
  • Expression of the oestrogen regulated pNR-2 mRNA in human breast cancer: relation to oestrogen receptor mRNA levels and response to tamoxifen therapy. (xenbase.org)
  • Phosphorylated tyrosine residues recruit various intracellular adaptor and effector molecules that result in the propagation of growth promoting signal transduction cascades [1] , [2] . (plos.org)
  • Vascular endothelial growth factor receptor-2 (VEGFR2) is a member of the VEGF family of receptor tyrosine kinase proteins, which are expressed on both endothelial and tumor cells, are one of the key proteins contributing to cancer development, and are involved in drug resistance. (researchgate.net)
  • Although the small clinical sample size made it difficult to show the statistical relevance of immunohistochemistry findings, good responses to neoadjuvant treatments might be associated with positive expression of combined T-lymphocyte markers, and approximately half of the samples showed discordance of combined markers between baseline and resistant tumors. (elsevierpure.com)
  • Expression of the RNA-binding protein (RBP) Musashi-2 (MSI2) is elevated in a subset of non-small cell lung cancer (NSCLC) tumors upon progression, and drives NSCLC metastasis. (northwestern.edu)
  • Retinoids are potent agents that can normalize abnormal growth and differentiation in keratinocytes (American Academy of Dermatology [AAD], 2003). (medscape.com)
  • The modulation of epidermal differentiation by retinoids led to its use in premalignant lesions, such as actinic keratoses (Verschoore et al. (medscape.com)
  • this finding indicates that the gene for NFJ syndrome is not located in the epidermal differentiation complex, the type II keratin cluster, or the desmosomal cadherin cluster, respectively. (medscape.com)
  • Abnormal microRNA-370 (miR-370) expression has been frequently reported in several types of cancers, including lung cancer. (oncotarget.com)
  • Out of 99 reviewed cases, 78 formalin fixed, paraffin embedded TNBC cases were assembled into a tissue microarray, stained and analysed for AR expression using immunohistochemistry. (ecancer.org)
  • The TAM receptor and ligand expression was evaluated in LMS cell lines and 358 sarcoma samples by either gene expression or immunohistochemistry. (nature.com)
  • Immunohistochemistry performed in 107 sarcomas showed higher expression of TYRO3 and GAS6 in LMS vs other sarcomas and nuclear TYRO3 only in LMS. (nature.com)
  • p53 Codon 72 Gene Polymorphism Studies and p53 Expression by Immunohistochemistry in Oral Lesions as Risk Factor for Malignancy. (cdc.gov)
  • The effects of 13-cis retinoic acid (RA) and dexamethasone on the levels of epidermal growth factor (EGF) receptor and fibroblast derived proteoglycan core protein (PG40) mRNAs were studied in human skin fibroblasts. (medicaljournals.se)
  • Expression relationships were validated using human tissue microarrays. (northwestern.edu)
  • Besides estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2, novel biomarkers have shown their prognostic and predictive values, complicating our understanding towards to the heterogeneity of such cancers. (jcancer.org)
  • and epidermal growth factor stimulated cyclooxygenase 2 expression in human myometrial cells. (rndsystems.com)
  • Isolation of Salivary Epithelial Cells from Human Salivary Glands for In Vitro Growth as Salispheres or Monolayers. (uc.edu)
  • The TNBC types are defined as breast cancers that lack expression of the oestrogen receptor (ER) and progesterone receptor (PR) and lack amplification of the human epidermal growth factor receptor 2 (HER-2) [ 4 - 6 ]. (hindawi.com)
  • Strong association between c-myb and oestrogen-receptor expression in human breast cancer. (xenbase.org)
  • Expression of the pNR-2/pS2 protein in diverse human epithelial tumours. (xenbase.org)
  • The status of the erbB-2 (human epidermal growth factor receptor 2/neu) proto-oncogene in canine osteosarcoma (OSA) has not been reported previously. (cdc.gov)
  • Human Papillomavirus as a Potential Risk Factor for Oral Premalignant Lesions. (cdc.gov)
  • However, the role and molecular mechanisms of miR-370 in regulating the growth and metastasis of lung cancer have not been clarified. (oncotarget.com)
  • RESULTS: We found that the expression of 7 proteins were significantly altered at PD, compared to a sample taken at osimertinib response. (au.dk)
  • Hypoxia-inducible factor (HIF)-1 is a master regulator whereby cells adapt to changes in oxygen concentrations. (korea.ac.kr)
  • Hypoxia increased the expression of Tenascin-C, whereas both hypoxia and TGF-β1 stimuli increased the release of VEGF, IL-6, IL-8 and MCP-1 in BEAS-2B. (lu.se)
  • HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands. (wikipedia.org)
  • The AP-1 transcription complex controls the expression of a subset of genes that are expressed early in response to extracellular mitogenic stimuli or to stress. (medscape.com)
  • Peripheral lung inflammation may cause a "spill-over" of cytokines, such as interlukin (IL)-6, IL-1β and tumour necrosis factor (TNF)-α, into the systemic circulation, which may increase acute-phase proteins such as C-reactive protein (CRP). (ersjournals.com)
  • Compared with the control cells, induction of miR370 overexpression significantly inhibited the proliferation, clone formation capacity, migration and invasion of XWLC-05 and H157 cells while miR-370 inhibitor over-expression enhanced their tumor behaviors in vitro . (oncotarget.com)
  • It was verified that co-expression of CD80 disrupted the binding of sEV PD-L1 to its receptor PD-1 on T cells and attenuated the immunosuppression mediated by sEV PD-L1 both in vitro and in vivo. (nature.com)
  • Keratinocyte growth factor modulates alveolar epithelial cell phenotype in vitro: expression of aquaporin-5 (AQP5). (hopkinsmedicine.org)
  • Evading growth suppressors', 'enabling replicative immortality', 'inducing angiogenesis' and 'tumor-promoting inflammation' have not been involved in breast cancer classification which need more focus in the future biomarker-related research. (jcancer.org)
  • Different breast tumor subtypes have different risk factors, clinical presentation, histopathological features, outcome, and response to systemic therapies [ 3 - 8 ]. (jcancer.org)
  • Co-expression of CD80 on PD-L1-positive sEVs was examined to evaluate the immunosuppressive and tumor-promotive effects. (nature.com)
  • Fig. 6: Co-expression of CD80 suppressed PD-L1-positive sEV-induced immunosuppression and tumor progression in melanoma model. (nature.com)
  • This warrants further exploration of the predictive and prognostic significance of its expression amongst TNBC and the potential for targeted therapy, specifically androgen antagonists to improve the outcome of this disease with limited therapeutic options. (ecancer.org)
  • pNR-2/pS2 immunohistochemical staining in breast cancer: correlation with prognostic factors and endocrine response. (xenbase.org)
  • The resulting comprehensive gene expression surveys lead to the identification of new genes and pathways with importance in cancer development and progression, or as targets for new therapies. (karger.com)
  • Differentially expressed genes (DEGs) were seared by combing the TCGA database and the Gene Expression Omnibus (GEO) database, and the key molecule AKR1B10 was identified by weighted gene coexpression network analysis (WGCNA). (portlandpress.com)
  • This abrogated expression of the decidual marker genes, insulin like growth factor binding protein 1 ( IGFBP1 ) and prolactin ( PRL ), and prevented adoption of decidual cell morphology. (bioone.org)
  • The mouse one P-domain ( pS2 ) and two P-domain ( mSP ) genes exhibit distinct patterns of expression. (xenbase.org)
  • Using in situ hybridization, we show that although coexpressed in the fundus , the antrum and the antrum -pyloric regions of the stomach , the mouse pS2 and mSP genes exhibit distinct and complementary cellular patterns of expression. (xenbase.org)
  • evaluation of the effectiveness of screening campaigns, Implementation of screening programmes in high- particularly as the stage of cancer at presentation is one income countries was followed by a decrease in advanced of the most important prognostic factors of survival (10) . (who.int)
  • We addressed this problem by integrating germline mutation information from genome-wide association studies with somatic mutation information from next-generation sequencing using gene expression data as the intermediated phenotype. (hindawi.com)
  • Suppresses FGF-mediated angiogenesis in vivo and decreases VEGF expression. (rndsystems.com)
  • To accomplish this goal, various intracellular regions of HER3 were fused to the DNA binding domain of the yeast transcription factor Gal4 (Gal4DBD) and tested for their ability to transactivate Gal4 UAS-luciferase. (plos.org)
  • In this study, the mechanisms underlying low oxygen-dependent and epidermal growth factor (EGF)-dependent expression of HIF-1α were explored using porcine trophectoderm (pTr) cells. (korea.ac.kr)
  • 2000. Hypertonic induction of AQP5 expression through an ERK dependent pathway. (hopkinsmedicine.org)
  • The mouse pS2 gene is highly expressed in the stomach mucosa cells, whereas no pS2 gene expression could be detected in the mouse mammary gland, even during postnatal development processes dependent on growth factors or hormones. (xenbase.org)
  • A model of gastric ulceration in the rat has been used to determine the expression of four messenger RNAs (mRNAs) encoding peptides considered to play active parts in the healing response. (nih.gov)
  • Ulceration was caused under anaesthesia by brief application of a liquid nitrogen-filled cryoprobe to the gastric serosal surface and RNA expression was monitored over the next 10 days. (nih.gov)
  • Strong pS2 gene expression was also observed in the normal gastric mucosa and in the regenerative tissues surrounding ulcerous lesions of the gastrointestinal tract . (xenbase.org)
  • Since neurotrophic factors are the primary architects of neurogenesis, synaptic plasticity, learning, and memory, the findings from preclinical and clinical studies that assess changes in neurogenesis and neurotrophic factors and their relationship to cognitive performance in schizophrenia, and how these mechanisms might be impacted by APD treatment, may provide valuable clues in developing therapies to combat cognitive deficit in schizophrenia. (benthamscience.com)
  • His clinical features included a papulopustular rash, dry skin, chronic diarrhoea, abnormalities of hair growth, breathing difficulties and electrolyte imbalances. (wikipedia.org)
  • In this context, results from initial clinical trials with neurotrophic factors and their future potential to improve cognition and psychosocial functioning in schizophrenia are discussed. (benthamscience.com)
  • Factors affecting Clinical Outcomes after Treatment of Oral Leukoplakia with CO and Diode Laser. (cdc.gov)
  • There was no significant association between AR expression and histologic type or tumour grade. (ecancer.org)
  • Low AKR1B10 expression induced M2 macrophage polarization and promoted the malignant phenotype of GC. (portlandpress.com)
  • The mitogen-activated protein kinase homolog, WNK lysine deficient protein kinase 1 (WNK1), is activated downstream of epidermal growth factor receptor during decidualization. (bioone.org)
  • Carcinomas tend to show strong expression of p53. (medscape.com)
  • Levels of expression of breast epithelial mucin detected by monoclonal antibody BrE-3 in breast-cancer prognosis. (xenbase.org)
  • Cancer is characterized by uncontrolled growth and division of a cell, with extension beyond the normally limiting basement membrane and through the boundaries of normal cells. (medscape.com)
  • Because of its mutated aggressive genetics, this cell has a selective growth advantage over its neighbors. (medscape.com)
  • [ 6 ] These events lead the cancer cell to escape normal cell growth and control mechanisms, to avoid system control mechanisms (ie, immunologic surveillance), and to establish a nutrient supply. (medscape.com)
  • High expression of TYRO3 and AXL was detected in LMS cell lines. (nature.com)
  • Fig. 5: Co-expression of CD80 on sEVs disrupted PD-L1-positive sEV-mediated PD-1 binding and T cell inhibition. (nature.com)
  • motif containing cell growth factors. (xenbase.org)
  • Ovarian cancer cell heparan sulfate 6-O-sulfotransferases regulate an angiogenic program induced by heparin-binding epidermal growth factor (EGF)-like growth factor/EGF receptor signaling. (nih.gov)
  • Despite methodological differences, findings evidence that although IBC presents particular features (lower survival rate and worse prognostics than most types of breast cancer), very few studies examine its epidemiology and specific risk factors in depth and use any other therapeutic approaches than those commonly used for other breast cancer subtypes. (bvsalud.org)
  • Microarray gene expression performed in 251 sarcomas revealed significantly higher expression of TYRO3 and GAS6 in LMS than other sarcomas. (nature.com)
  • Leiomyosarcoma patients with high expression of GAS6 or PROS1 present a significantly worse PFS. (nature.com)
  • Further analysis of the expression of these circulating miRNAs and their association with prognosis in patients with TNBC treated with immunotherapy should be assessed to evaluate their possible use as non‑invasive predictive biomarkers. (spandidos-publications.com)
  • It is very clear that the next decade will witness an explosion of information attempting to elucidate the associations between COPD and its systemic expressions, provide objective evidence of the mechanisms and, in the end, improve the management of patients with COPD. (ersjournals.com)
  • For many, they are the result of a systemic "spill-over" of the inflammatory and reparatory events occurring in the lungs of patients with COPD, with the disease remaining at the centre of the process (fig. 1 ⇓ ), whereas for others the pulmonary manifestations of COPD are one more form of expression of a "systemic" inflammatory state with multiple organ compromise 3 , 4 . (ersjournals.com)
  • چکیده انگلیسی: Background: Although evidence indicates that tobacco use is one of the risk factors for oral cancer, the relationship between opium addiction and oral cancer has not yet been evaluated. (iocv.ir)
  • MicroRNAs (miRNAs) serve a role in gene expression, primarily by interacting with messenger RNAs, and may be potential biomarkers for detecting cancer. (spandidos-publications.com)
  • Breast cancer is the most frequent cancer among wom- but not in limited-resource settings with weak health en worldwide, affecting 2.1 million women annually and systems (4) . (who.int)