Expression of connective tissue growth factor. Medical search. Frequent questions

We have previously reported that [ 20 ] exogenous IGF-1 promotes col-I and col-III synthesis in LFCs, which are fibrous connective tissue stem cells. (hindawi.com)
Evaluation of gene expression by in situ and filter hybridization reveals diverse mechanisms, including the influence of metalloproteinases involved in reorganization of fibrous connective tissue. (vumc.org)

Angiotensin II has previously been shown to trigger fibrosis, an effect involving connective tissue growth factor (CTGF). (amrita.edu)
The present study explored whether SGK1 is transcriptionally regulated by angiotensin II and participates in the angiotensin II-dependent regulation of CTGF expression. (amrita.edu)
2015) Increased expression of connective tissue growth factor (CTGF) in multiple organs after exposure of nonhuman primates (NHP) to lethal doses of irradiation. (umaryland.edu)
Quantitative RT-PCR was used to asses mRNA levels of collagenase-1 (MMP-1), stromelysin (MMP-3), vascular endothelial growth factor (VEGF), connective tissue growth factor (CTGF), cyclooxygenase-2 (COX-2), interleukin-1β (IL-1β), type III collagen (COL-III) and fibronectin (FBRN). (cdc.gov)
The effect of CTGF silencing on the TGF-β2-modulated expression of these genes was investigated by transfection of CTGF small interfering (si)RNA before TGF-β2 treatment. (arvojournals.org)
TGF-β2 treatment upregulated the expression of Col1α1, Col4α2, FN, CTGF, TGM2, and TSP-1 mRNA and protein in cultured astrocytes. (arvojournals.org)
Transfection of 10 nM CTGF siRNA inhibited the TGF-β2-induced upregulation of CTGF, Col4α2, Col1α1, TGM2, and FN, whereas TSP-1 expression was not reduced. (arvojournals.org)
TGF-β2 is capable of inducing the expression of ECM and basement membrane components in cultured ONH astrocytes via CTGF and upregulated TSP-1, a protein naturally involved in the activation of latent TGF-β. (arvojournals.org)
Connective tissue growth factor (CTGF), is a secreted matricellular factor that has been linked to increased risk of cardiovascular disease in diabetic subjects. (biomedcentral.com)
Despite the biological role of CTGF in diabetes, it still remains unclear how CTGF expression is regulated. (biomedcentral.com)
Our results using the mTP model identified intensive glucose control treatment and smoking as clinical factors that were associated with decreased and increased odds of observing non-zero CTGF values respectively. (biomedcentral.com)
In addition, hemoglobin A1c, systolic blood pressure, and high density lipoprotein were all shown to be significant risk factors that contribute to increasing CTGF levels. (biomedcentral.com)
One such factor that has been identified as a pathogenic risk determinant for the development of microvascular and cardiovascular complications is connective tissue growth factor (CTGF). (biomedcentral.com)
CTGF is a secreted matricellular potent chemotactic and extracellular matrix-inducing factor that has been implicated in progression of inflammatory and fibroproliferative disorders [ 6 ]. (biomedcentral.com)
Taken together, these studies suggest that CTGF may have substantial value both as a pathogenic risk marker of inflammation-induced tissue injury and as a therapeutic target. (biomedcentral.com)
Despite that the divergent biological effects of CTGF on the vasculature was established, it still remains unclear how CTGF expression is regulated. (biomedcentral.com)
To gain insights into the factors that modulate plasma CTGF levels, circulating levels of CTGF were measured longitudinally in type 1 diabetic patients over a period of 10 years. (biomedcentral.com)
Conclusions CTGF can promote proliferation, growth and metastasis of SKOV3, and that may contribute to the regulation of epithelium-mesenchymal transformation (EMT). (magtechjournal.com)
8] Chu CY, Chang CC, Prakash E, et al .Connective tissue growth factor(CTGF) and cancer progression[J]. J Biomed Sci,2008,15:675-685. (magtechjournal.com)
It has already been shown that the connective tissue growth factor (CTGF), dependent on ERK1/2 phosphorylation, is an important driver of cell invasion. (uni-goettingen.de)
Using immunofluorescence, no correlating increasing influence of ERK1/2 resistance on CTGF expression could be observed. (uni-goettingen.de)

Induced EndoMT in PAECs by inflammatory cytokines IL-1β, tumor necrosis factor α, and transforming growth factor β led to actin cytoskeleton reorganization and the development of a mesenchymal morphology. (surrey.ac.uk)
Cytokines secreted by adipocytes, such as tumor necrosis factor-α, transforming growth factor-β, and interleukin-6, are implicated in NAFLD. (wjgnet.com)
They demonstrated that moderate and high AjA concentrations significantly suppressed tumor necrosis factor (TNF)-alpha secretion, whereas all AjA doses significantly reduced interferon (IFN)-alpha and INF-beta production. (aad.org)
Connective tissue growth factor mediates TGF-β1-induced low-grade serous ovarian tumor cell apoptosis[J]. Oncotarget, 2017,8:85224-85233. (magtechjournal.com)
Connective tissue growth factor in tumor pathogenesis[J]. Fibrogenesis Tissue Repair,2012.doi:10.1186/1755-1536-5-S1-S8. (magtechjournal.com)
Mammary-specific expression of CCN5 in HER2 overexpressing mice delays tumor progression significantly and reduces the tumor burden. (ku.edu)
Initial observations indicate that CCN5 induces expression of P16INK4A and P19ARF, resulting in cell cycle arrest of the tumor cells. (ku.edu)
Using the PubMed database, Cochrane Library and Web of Science, studies published in English evaluating miRs differentially expressed in tumor tissue and significantly associated with the prognostic aspects of CRC were selected. (biorxiv.org)
The T category informs about tumor growth, depth and stage of adjacent tissues invasion. (biorxiv.org)

Genetic and autoimmune factors have been explored, without identification of consistent, reproducible patterns, although autoantibodies to extracellular extracellular matrix (ECM) protein 1 have now been reported by several independent authors. (medscape.com)
Fibrosis is characterized by an excessive accumulation of extracellular matrix components which could result in tissue dysfunction. (springer.com)
Extracellular matrix is a fibrillar network composed of structural (collagens) and adhesion (fibronectin) proteins crucial for tissue architecture and biological pathway Histol Histopathol 27:1515-1528, 2012 . (springer.com)
The extracellular matrix is essential for the architecture of the tissue and a myriad of associated biological functions. (springer.com)
1 2 In tissue culture experiments in trabecular meshwork (TM) cells, TGF-β2 augmented the synthesis of extracellular matrix (ECM) and its cross-linking by transglutaminases. (arvojournals.org)
Genes associated with the extracellular matrix (eg, TIMP-1 , fibulin-1, secreted phosphoprotein-1, matrix Gla protein, and connective tissue growth factor) were upregulated in tissue samples from both the IKs and CNIKs, compared with tissues from the control kidneys. (avma.org)
Microarray analysis also revealed that lipid infusion caused a significant overexpression of extracellular matrix genes and connective tissue growth factor. (elsevierpure.com)
These data suggest that an experimental increase in FFAs decreases the expression of PGC-1 and nuclear encoded mitochondrial genes and also increases the expression of extracellular matrix genes in a manner reminiscent of inflammation. (elsevierpure.com)
Tissue remodeling due to extracellular matrix production and fibroblasts proliferation is directly modulated by growth factors classified according to their biological properties into pro-fibrotic and non-fibrotic growth factors ( 6 ). (atsjournals.org)
A complex extracellular matrix with collagenous and non-collagenous proteins composes mineralized tissue. (bvsalud.org)

Yang D, Yuan J, Liu G, Ling Z, Zeng H, Chen Y, Zhang Y, She Q, Zhou X. Angiotensin Receptor Blockers and Statins Could Alleviate Atrial Fibrosis via Regulating Platelet-Derived Growth Factor/Rac1 /Nuclear Factor-Kappa B Axis. (medsci.org)
To investigate whether the administration of renin-angiotensin system (RAS) inhibitors and statins could alleviate atrial fibrosis via platelet-derived growth factor (PDGF)/Rac1 /nuclear factor-kappa B (NF-κB) axis. (medsci.org)
In addition, other studies demonstrated that AngII activated platelet-derived growth factor-A (PDGF-A), a novel contributor to cardiac remodelling, to result in atrial fibrosis in pressure-overloaded mouse model [ 13 ] . (medsci.org)
superfamily members, platelet derived growth factor and connective tissue growth affect the process and outcome of wound healing. (vumc.org)

In contrast, pathological gene expression in terminal heart failure is accompanied by changes in active histone marks without major alterations in CpG methylation and repressive chromatin marks. (nature.com)
Many of these transitions involve changes of gene expression. (nature.com)
TTF-1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival, and tissue-specific gene expression. (medscape.com)
Evaluation of gene expression through qRT-PCR in cyclically loaded tendons: an in vivo model. (cdc.gov)
We study elastin gene expression in several biological systems. (vumc.org)
In the present study, we established a new collagenase perfusion method through thoracic aorta cannulation to isolate PSCs, and we studied gene expression of TGF-β1, type I collagen, and connective tissue growth factor using primary cultured PSCs. (elsevierpure.com)
We also isolated the PSCs from a WBN/Kob rat, the spontaneous pancreatitis rat, and compared the gene expression with that from a normal rat. (elsevierpure.com)
Regulation of gene expression plays a central role in embryonic development. (biomedcentral.com)
Transcriptomic analyses provide an efficient approach to explore the temporal gene expression profiles in embryos and to search for the developmental regulators. (biomedcentral.com)
The major event of MBT was the activation of a large group of histones and other genes that modify chromatin structure preceding massive gene expression changes. (biomedcentral.com)
Early ontogeny is associated with dramatic gene expression changes that underlie and determine the developmental processes. (biomedcentral.com)
Unilateral ischemic injury differentially altered gene expression in both kidneys, compared with control kidneys. (avma.org)
Using microarrays of complementary DNA, we examined gene-expression profiles of more than 50 normal and neoplastic prostate specimens and three common prostate-cancer cell lines. (nature.com)
Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. (nature.com)
Molecular classification of cutaneous malignant melanoma by gene expression profiling. (nature.com)
Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. (nature.com)

In the first one, local adipose tissue hypoxia could induce fibrosis accumulation which in turn through adipocyte dysfunctions might provoke adipose tissue inflammation. (springer.com)
In the second one, fibrosis could be a result of local adipose tissue inflammation induced by tissue expansion. (springer.com)
Transforming growth factor-β (TGF-β) is an important pro-fibrotic growth factor implicated in airway remodeling and pulmonary fibrosis ( 6-9 ). (atsjournals.org)
Echocardiographic parameters, myocardial fibrosis, NOX2 expression and EndMT were assessed. (dovepress.com)

The incubation of DSS fibroblasts with a synthetic cannabinoid receptor agonist (WIN55, 212- 2) decreased their expression in a dose-dependent manner, together with a parallel reduction in collagen production and pro- fibrotic cytokines, including transforming growth factor-beta (TGF-beta), connective tissue growth factor and interleukin-6 (IL-6). (aad.org)
Another consequence of aging is the accumulation of so-called senescent cells, normal cells that stop dividing, contribute to tissue aging and secrete substances like cytokines that induce inflammation. (qualitycounts.com)
Osteoblasts (cells that make the organic matrix of bone and then mineralize bone) and osteoclasts (cells that resorb bone) are regulated by parathyroid hormone (PTH), calcitonin , estrogen , vitamin D, various cytokines, and other local factors such as prostaglandins. (msdmanuals.com)

Induced EndoMT cells exhibited up-regulation of mesenchymal markers, including collagen type I and α-smooth muscle actin, and a reduction in endothelial cell and junctional proteins, including von Willebrand factor, CD31, occludin, and vascular endothelial-cadherin. (surrey.ac.uk)
In this protocol you will learn about factors both inside your body and from the external environment that can damage skin, hair and nail proteins. (lifeextension.com)
The problem is intrinsic factors, such as the biological aging process, as well as extrinsic factors, such as ultraviolet radiation from sun exposure, compromise the structure and function of these proteins. (lifeextension.com)
The expressions of inflammatory factors and NF‑κB pathway proteins were detected by immunofluorescence, ELISA, western blotting and RT‑qPCR. (spandidos-publications.com)
A hallmark of events observed during segmentation was the induction of multiple transcription factors, including a large group of homeobox proteins in pace with decay of a large fraction of maternal transcripts. (biomedcentral.com)
The oocyte is loaded with maternal mRNAs and proteins that control the cell maintenance and fate and the formation of the body plan prior to the onset of zygotic genome expression [ 3 , 4 ]. (biomedcentral.com)
Expression of hepsin and pim-1 proteins was significantly correlated with measures of clinical outcome. (nature.com)
The migration of SKOV3 was detected by wound healing assay.The expression of EMT-related proteins was detected by Western blot. (magtechjournal.com)
Results After rhCTGF treatment, the proliferation rate of SKOV3 was increased, the colony formation and migzation were enhanced ( P ＜0.05).The expression of E-cadherin was decreased and the expression of vimentin was increased, which were related proteins of EMT( P ＜0.05). (magtechjournal.com)
HUVECs were administrated with TMZ or TMZ and lentivirus, the expression of EndMT and related proteins was observed by wound healing assay, immunoblotting, and immunofluorescence. (dovepress.com)
These markers include a variety of proteins usually including growth factors, and hormones among others. (bvsalud.org)
Three non-collagenous proteins, osteonectin, transforming growth factor β-1 (TGF-β1) and bone morphogenetic proteins (BMPs), have drawn much attention in the literature lately. (bvsalud.org)
Bone morphogenetic proteins (BMPs) form a unique group of proteins within the transforming growth factor beta (TGF-β) superfamily. (bvsalud.org)

Collagens are crucial for the ECM architecture and particularly collagen I, III and VI are key components in animal tissues. (springer.com)
In comparing the expression of these genes with that of hepatic stellate cells (HSCs), we observed a similar pattern, although PSCs expressed type I collagen gene earlier than did HSCs. (elsevierpure.com)
Less commonly, affected individuals have nevi called collagenomas, which are made up of another type of connective tissue called collagen. (medlineplus.gov)

Among the peripheral signals that are generated to regulate the uptake of food, signals from adipose tissue are of major relevance and involve the maintenance of energy homeostasis through processes such as lipogenesis, lipolysis, and oxidation of fatty acids. (wjgnet.com)
Advances in research on adipose tissue suggest an integral role played by adipokines in NAFLD. (wjgnet.com)
Obesity is defined as an excess accumulation of white adipose tissue associated with a low grade inflammation which is one contributor to obesity complications such as diabetes. (springer.com)
Recently, we and others have demonstrated fibrotic depots in white adipose tissue of obese subjects. (springer.com)
Obesity is defined as an expansion of white adipose (WAT) tissue that is associated with low grade inflammation which possibly contributes to the development of health complications such as diabetes, liver pathologies, dyslipidemia, cardiovascular diseases as well as some cancers [ 2 - 4 ]. (springer.com)
However many more pro and anti-inflammatory mediators produced by the adipose tissue have been described since then. (springer.com)
Several anti-diabetic strategies including adiponectin, ezetimibe, liraglutide, taurine, adipose tissue-derived stem cells (ADSCs) and even exercise as well as natural products such GABA tea, geniposide, guava extract, vitamin D have been shown to target autophagy. (frontiersin.org)
The Combination of Resveratrol and Quercetin Attenuates Metabolic Syndrome in Rats by Modifying the Serum Fatty Acid Composition and by Upregulating SIRT 1 and SIRT 2 Expression in White Adipose Tissue - Evid Based Complement Alternat Med. (qualitycounts.com)

Prior to joining Surrey, her research centred around pulmonary hypertension and connective tissue diseases. (surrey.ac.uk)
cDNA and antibody probes are used, respectively, to study regulation of elastin mRNA and protein synthesis, particularly related to modulation of elastin metabolism in diseases of human connective tissues such as blood vessels, lung and skin. (vumc.org)
Transcriptional and post-transcriptional regulation of matrix synthesis is evident in this system The role of mRNA stability, cis-acting mutations, and trans-acting factors are being evaluated in the context of elastic tissue diseases and growth factor responses. (vumc.org)

An in vivo rabbit animal model for the tendinopathy, epicondylitis, was used to examine the effects of repetitive load on the expression of various genes associated with matrix remodeling. (cdc.gov)
Target genes expression after combined YAP/TAZ inhibition was analyzed. (biomedcentral.com)
YAP and TAZ activation is not uncoupled from cell density in CCA cells and both factors cooperatively contribute to proliferation and expression of CIN-associated genes. (biomedcentral.com)
Mechanistically, the complex consisting of YAP and transcription factors promotes the expression of genes involved in DNA replication, cell cycle regulation, chromosomal segregation, but also in the control of cellular stemness. (biomedcentral.com)
Although the cause and effect relationship between FFAs and insulin resistance is complex, plasma FFA is negatively correlated with the expression of peroxisome proliferator activated receptor-γ cofactor-1 (PGC-1) and nuclear encoded mitochondrial genes. (elsevierpure.com)
We assessed two of these genes-hepsin, a transmembrane serine protease, and pim-1, a serine/threonine kinase-at the protein level using tissue microarrays consisting of over 700 clinically stratified prostate-cancer specimens. (nature.com)

The etiology and pathogenesis of lichen sclerosus (LS) is unknown but may include genetic, infectious, environmental, and hormonal factors. (medscape.com)
There are explicit indications, however, that transforming growth factor (TGF)-β2 may be involved in the pathogenesis of POAG. (arvojournals.org)
To evaluate the role of growth factors in the pathogenesis of airway remodeling, a study was undertaken to study the expression of a known fibrogenic growth factor (TGF-β), of a putative fibrogenic growth factor (EGF) and of a hematopoietic growth factor (GM-CSF) in the central airways of asthmatic and chronic bronchitis patients using immunohistochemistry. (atsjournals.org)
In the past several decades, numerous studies have been conducted to understand the pathogenesis of IF/TA and multiple factors and mechanisms have been demonstrated to be involved in the progress of the IF/TA, including immunosuppressive drug toxicity, antibody-mediated injury, and epithelial-mesenchymal transition (EMT) (Figure 1 ). (biomedcentral.com)
These factors have drawn considerable interest to finding optimal therapeutic regimens for this infection, as well as to identifying the pathogenesis, ecology, and the reservoirs of this microorganism. (cdc.gov)

In addition to secreting inflammatory mediators that exacerbate tissue injury, they also encourage fibroblast activation and accumulation of ECM ( 3 ). (spandidos-publications.com)
Granulocyte macrophage-colony stimulating factor (GM-CSF) is a hematopoietic growth factor over-expressed in the bronchial mucosa of asthmatics, which is involved in eosinophil and macrophage accumulation in tissues ( 14 , 15 ). (atsjournals.org)

Immunoblot analysis revealed that lipid infusion also increased the expression of collagens and the connective tissue growth factor protein. (elsevierpure.com)

These signaling pathways regulate various cell functions and are involved in the growth of cells, including new bone cells. (medlineplus.gov)

Regenerative medicine, which regenerates lost or mal-functioning tissues and organs, has been greatly concerned. (go.jp)
Three-dimensional (3D) microfabrication based on 3D measurements of the relevant microstructures has begun to be utilized in engineering various tissue and organs. (go.jp)
Transcriptome profiling of the early stages in Atlantic cod revealed the presence of transcripts involved in patterning and development of tissues and organs long before activation of the zygotic genome. (biomedcentral.com)
During the following segmentation stage major events in the formation of tissues and organs take place. (biomedcentral.com)
Buschke-Ollendorff syndrome is classified as a disorder of connective tissues, which provide support, strength, and flexibility to organs and tissues throughout the body. (medlineplus.gov)

Indeed, MSCs ex vivo pre-conditioning by hypoxia, inflammatory stimulus, or other factors/conditions may stimulate their survival, proliferation, migration, exosome secretion, and pro-angiogenic and anti-inflammatory characteristics in vivo. (biomedcentral.com)
Connective tissue growth factor promotes the proliferation and migration of human ovarian cancer cell line SKOV3[J]. Basic & Clinical Medicine, 2021, 41(2): 193-196. (magtechjournal.com)
However, no influence of ERK1/2 resistance on cell growth could be observed using the proliferation assay with AlamarBlue. (uni-goettingen.de)
TGF-β1 is a multifunctional regulator of cell growth which will either stimulate or inhibit proliferation of mesenchymal cells depending on the presence of other growth factors 7,8,9 . (bvsalud.org)

Next, we have shown that CCN5 protein can induce expression of estrogen receptor-α (ER-α) in mammary epithelial cells. (ku.edu)

Dysregulated autophagy in pancreatic β cells due to hyperglycemia, oxidative stress, and inflammation is associated with diabetes and accompanied by dysregulated autophagy in insulin target tissues and the progression of diabetic complications. (frontiersin.org)

Bedaiwy MA, Burlingame JM, Hussein M, Flyckt R, Assad R, Falcone T. Assessment of vascular endothelial growth factor, basic fibroblast growth factor and transforming growth factor levels in amniotic fluid. (medscape.com)

In the late 1990's, PRP for bone augmentation, Emdogain for periodontal tissue regeneration and rhBMP for bone augmentation were reported. (go.jp)
Currently, clinical trial of FGF2 for periodontal tissue regeneration has been conducted. (go.jp)
As cell-based therapy for regeneration, regeneration of mucous membrane, mandible and maxilla bones and periodontal tissues have been tried. (go.jp)

VEGF receptor expression decreases during lung development in congenital diaphragmatic hernia induced by nitrofen. (medscape.com)
For example proteoglycans sequester biomolecules such as growth factors (TGF-β, VEGF, FGF etc.) and MMPs (Matrix Metalloproteinases). (springer.com)

Specifically, the condition is characterized by skin growths called connective tissue nevi and bone abnormalities, most commonly a pattern of increased bone density called osteopoikilosis. (medlineplus.gov)

Histologic assessment of patients with systemic sclerosis-associated PAH and the hypoxia/SU5416 mouse model identified the presence von Willebrand factor/α-smooth muscle actin-positive endothelial cells in up to 5% of pulmonary vessels. (surrey.ac.uk)

Based on this method 13 , 14 , we used a nuclear staining strategy to isolate CM nuclei from intact prenatal and postnatal human heart tissue and subjected these nuclei to comprehensive analysis of the epigenome during prenatal development, postnatal maturation, and in heart failure. (nature.com)
Leptin and adiponectin can augment the oxidation of fatty acid in liver by activating the nuclear receptor super-family of transcription factors, namely peroxisome proliferator-activated receptor (PPAR)-α. (wjgnet.com)
Compared with the control group, the expression of NOX2, nuclear factor-κB (NF-κB), and Snail was increased in vivo and in vitro but decreased with TMZ treatment. (dovepress.com)
Patients with triple negative breast cancer (TNBC), where the cancer cells do not express nuclear hormone receptors and human epidermal growth factor receptor 2 (HER2), have worse survival rate compared to the patients with luminal subtypes of cancer. (ku.edu)

The present study aimed to identify differentially expressed tissue miRs associated with prognostic factors in CRC patients, through a systematic review of the Literature. (biorxiv.org)

The most common form of these nevi are elastomas, which are made up of a type of stretchy connective tissue called elastic fibers. (medlineplus.gov)

its expression was compared with that of epidermal growth factor (EGF) and granulocyte macrophage colony-stimulating factor (GM-CSF) in bronchial mucosal biopsies from 13 normal subjects, 24 asthmatics, and 19 patients with chronic bronchitis. (atsjournals.org)
Epidermal growth factor (EGF) is another growth factor that participates in repair processes targeted at the resurfacing of a wound with new epithelium ( 12 ). (atsjournals.org)

Mediators of the renoprotection, specifically linked to obesity and body weight control, include a reduced renal inflammation and TGF-beta expression, together with an enhanced level of adiponectin. (hindawi.com)
The mediators of the specific weight effect on the kidney appear to be an obesity-related inflammation, aggravated by a lowered anti-inflammatory adiponectin level, an increased oxidative stress and advanced glycation, and an enhanced TGF-beta expression, all of which might constitute promising therapeutic targets. (hindawi.com)
Identifying the mediators and factors that trigger IF/TA may be useful in early diagnosis and development of novel therapeutic strategies for improving long-term renal allograft survival and patient outcomes. (biomedcentral.com)

Moreover, increased IGF-1 promotes hypertrophy of various tissues [ 14 - 17 ], and mechanical stress plays a vital role in IGF-1 formation [ 18 , 19 ]. (hindawi.com)

During the development process, vimentin is exchanged for new, tissue-specific IFPs. (thermofisher.com)

Following 80 h of cumulative load, tissue from the distal and proximal regions of the flexor digitorum profundus tendon was collected. (cdc.gov)
A correlation between YAP and the CIN marker phospho-H2A histone family member X (pH2AX) was particularly observed in tissues from iCCA and distal CCA (dCCA). (biomedcentral.com)

Friend leukemia virus integration 1 (Fli1) is a member of the Ets family of transcription factors, the deficiency of which is a potential predisposing factor of SSc [ 10 ]. (biomedcentral.com)

In contrast to previous findings in heart tissue, expression of the pathological gene program in heart failure was not accompanied by changes in the CM DNA methylome but by active histone marks. (nature.com)
Different regulatory mechanisms between mRNA and protein expression or localized changes missed due to homogenization of the tissue samples, may explain the discrepancy in findings. (cdc.gov)
Conclusion: The immunohistochemistry findings suggest that BFOL have different processes of osseous tissue production. (bvsalud.org)

Connective tissue growth factor as a novel therapeutic target in high grade serous ovarian cancer[J]. Oncotarget,2015, 6:44551-44562. (magtechjournal.com)

Epigenetic mechanisms and transcription factor networks essential for differentiation of cardiac myocytes have been uncovered. (nature.com)
2014) Changes in Polysialic Acid Expression on Myeloid Cells during Differentiation and Recruitment to Sites of Inflammation: Role in Phagocytosis. (umaryland.edu)

We found that mammary epithelium-specific overexpression of CCN5 in transgenic mice leads to an increase in ER-α expression and that this impact of CCN5 is not restricted to the normal cells. (ku.edu)
Finally, we discuss the effects of CCN5 expression on yet another aggressive breast cancer subtype, characterized by HER2 overexpression. (ku.edu)

Kutasy B, Friemacher F, Duess JW, Puri P. Prenatal administration of retinoic acid increases the trophoblastic insulin-like-growth factor 2 protein expression in the nitrofen model of congenital diaphragmatic hernia. (medscape.com)
Garcia-Gonzalez et al demonstrated, by protein expression experiments, that both CB1 and CB2 receptors were overexpressed in diffuse systemic sclerosis (DSS) skin fibroblasts compared to healthy control fibroblasts. (aad.org)

This technique offers the possibility of manipulating the healing process in a new and precise way, since recombinant expression vectors can be readily modified to understand structure-function relationships in an authentic biological context. (vumc.org)
However, natural MSCs in vivo survival and their biological effects on tissue recovery decrease with long-term cultivation called aging and also injected cells demonstrate poor targeted migration [ 21 ]. (biomedcentral.com)

Fli1 expression is suppressed in dermal fibroblasts, endothelial cells, and perivascular inflammatory cells in involved and noninvolved skin of patients with SSc [ 11 ]. (biomedcentral.com)

Obesity is one of several factors implicated in the genesis of diabetic nephropathy (DN). (hindawi.com)
In several previous studies, we have explored a diabetic rat model, that is, the spontaneously hypertensive/NIH-corpulent rat (SHR/NDmcr-cp), to unravel factors implicated in DN. (hindawi.com)

Cytokine expression was assessed in Tregs by flow cytometry and in skin samples and cultivated cells by immunostaining, immunoblotting, and/or qRT-PCR. (biomedcentral.com)

Signature expression profiles of normal adjacent prostate (NAP), BPH, localized prostate cancer, and metastatic, hormone-refractory prostate cancer were determined. (nature.com)

2015;2015:474032 - 'Resveratrol (RSV) and quercetin (QRC) modify energy metabolism and reduce cardiovascular risk factors included in the metabolic syndrome (MetS). (qualitycounts.com)
These associations should be further explored in longitudinal studies and population-based strategies should be developed to address these cardiovascular risk factors. (cdc.gov)

Thus, the integration of cDNA microarray, high-density tissue microarray, and linked clinical and pathology data is a powerful approach to molecular profiling of human cancer. (nature.com)
Molecular profiling of clinical tissue specimens: feasibility and applications. (nature.com)
Specific tissue miRs are shown to be promising prognostic biomarkers in patients with CRC, given their strong association with the prognostic aspects of these tumors, however, new studies are necessary to establish the sensibility and specificity of the miRs in order to use them in clinical practice. (biorxiv.org)
Since then, many clinicians and researchers from Taiwan have reported risk factors and the clinical spectrum of this disease on the basis of an increasing number of reported cases ( 4 - 12 ). (cdc.gov)

Background: Benign fibro-osseous lesions (BFOL) comprise a diverse group of pathologies characterized by the replacement of normal bone by fibrous tissue and a mineralized product. (bvsalud.org)
We have analyzed the immunohistochemical expression of three molecules involved in bone metabolism, namely osteonectin, TGF-1, and BMP2/4. (bvsalud.org)
For example, a small percentage of affected individuals have melorheostosis , which is characterized by excess bone growth on the surface of existing bones in a pattern resembling dripping candle wax. (medlineplus.gov)
Studies suggest that the enhanced signaling increases the formation of bone tissue, resulting in areas of overly dense bone or excess bone growth. (medlineplus.gov)
Prevention and treatment involve risk factor modification, calcium and vitamin D supplements, exercises to maximize bone and muscle strength, improve balance, and minimize the risk of falls, and drug therapy to preserve bone mass or stimulate new bone formation. (msdmanuals.com)

We herein introduce some applications of existing 3D microfabrication processes in tissue engineering, that is, their applications in using biodegradable polymers or in making organ-structure-mimicking polymer scaffolds. (go.jp)

Commonly affecting those with skin of color, keloids are an aberrant wound response that leads to wound tissue expanding above and beyond the original cutaneous injury. (springer.com)
Keloids are a pathologic response to cutaneous injury in which wound tissue grows beyond the inciting insult. (springer.com)
Connective tissue production and remodeling are also critical to proper wound repair. (vumc.org)

Effect of insulin-like growth factors on lung development in a nitrofen-induced CDH rat model. (medscape.com)
Evidence suggests that obesity and insulin resistance are the major factors that contribute to the development of NAFLD. (wjgnet.com)

Genetic and environmental factors are important for the development of NAFLD. (wjgnet.com)

3 Moreover, perfusion of human anterior eye segments with TGF-β2 in concentrations comparable to those measured in the AH of patients with POAG resulted in an increase of IOP and an increase of ECM in the outflow tissue. (arvojournals.org)
An in vitro model of EndMT was developed using human umbilical vein endothelial cells (HUVECs) via treatment with transforming growth factor-β (TGF-β) at 10 ng/mL for 24 h. (dovepress.com)

Dr. Hankey served as Study Director for a GLP-compliant efficacy study of the growth factor, Neulasta ® , to mitigate the hematopoietic acute radiation syndrome (H-ARS). (umaryland.edu)
Although there is some evidence showing that GM-CSF may have some fibrogenic properties, it is considered as a hematopoietic growth factor rather than a fibrogenic growth factor ( 6 ). (atsjournals.org)

It is unclear how the increased signaling is related to the development of connective tissue nevi in people with Buschke-Ollendorff syndrome. (medlineplus.gov)

However, a recent study has demonstrated that activated fibroblasts regulate tissue-localized transdifferentiation of regulatory T cells (Tregs) into T helper type 2 cell (Th2)-like cells through IL-33 in SSc lesional skin [ 2 ], suggesting that activated dermal fibroblasts amplify an aberrant immune response characteristic of SSc. (biomedcentral.com)

In addition, TMZ effectively inhibited EndMT in ISO-treated rat hearts and TGF-β-treated HUVECs, as manifested by increased CD31 expression, decreased α-SMA expression, and suppressed cell migration. (dovepress.com)

Mechanistically, DIS not only decreased the expressions of inflammatory factors including IL‑1β, NOD‑like receptor thermal protein domain associated protein 3, monocyte chemotactic protein 1, IL‑6, TNF‑α and IL‑18 but also reduced the level of phosphorylation of NF‑κB p65 in vivo and in vitro , which was similar to the impact of Bay11‑7082. (spandidos-publications.com)

The underlying molecular mechanisms and the responsible pathogenic factors leading to these changes in outflow resistance remain unknown. (arvojournals.org)

Anatomy26

Organisms7

Diseases15

Chemicals and Drugs56

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Phenomena and Processes20

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science2

Fibrous connec2

CTGF21

Tumor9

Extracellular10

Platelet-derive4

Gene expression16

Fibrosis4

Cytokines3

Proteins13

Collagen3

Adipose8

Diseases3

Genes6

Pathogenesis5

Accumulation2

Collagens1

Pathways1

Organs5

Proliferation4

Induce1

Complications1

Vascular endoth1

Regeneration3

VEGF2

Abnormalities1

Pulmonary1

Nuclear4

Prognostic factors1

Elastic1

Epidermal2

Mediators3

Promotes1

Vimentin1

Distal2

Transcription factors1

Findings3

Therapeutic target1

Differentiation2

Overexpression2

Protein expression2

Biological2

Perivascular1

Diabetic2

Cytokine1

Prostate cancer1

Cardiovascular risk factors2

Clinical4

Bone5

Processes1

Wound3

Insulin2

Genetic1

Human2

Hematopoietic2

Development1

Regulate1

CD311

Inflammatory1

Mechanisms1