Loading...
  • squamous cell carcinomas
  • Amplification of the CCND1 gene is present in: non-small cell lung cancers (30-46%) head and neck squamous cell carcinomas (30-50%) pancreatic carcinomas (25%) bladder cancer (15%) pituitary adenomas (49-54%) breast carcinoma (13%) Cyclin D1 overexpression is strongly correlated to ER+ breast cancer and deregulation of cyclin D1 is associated with hormone therapy resistance in breast cancer. (wikipedia.org)
  • tissue
  • Patients surgically treated for colorectal carcinoma with up-regulated and down-regulated per2 expression in cancer versus adjacent tissue were studied. (springer.com)
  • Expression of cdc20 and birc5 was increasing in the proximal tissue and decreasing in the cancer tissue. (springer.com)
  • Those cells that migrate to the anterior lateral plate mesoderm are destined to form heart tissue. (ahajournals.org)
  • In normal liver, there is strong cytoplasmic and nuclear ELF expression ( a , arrow), whereas there is a significant decrease in nuclear expression of ELF in HCC tissue ( b , HCC Sample 2, arrows). (nih.gov)
  • Increased cyclin D1 expression in human HCC tissue and cell lines and the effect of ectopic ELF expression. (nih.gov)
  • Constructs intended for bone tissue engineering (TE) are influenced by the initial cell seeding density. (uib.no)
  • EGFL7 is known to be involved in cell migration and blood vessel formation, making EGFL7 and mir-126 opportune targets for disease, such as cancers, which require the continual formation of blood vessels to supply the tumour with nutrients and cell migration pathways to mediate tissue invasion. (wikipedia.org)
  • Tissue repair and maintenance are important parts of the life cycle of an organism, cells and tissues must remain in homeostasis to ensure survival. (wikipedia.org)
  • Rac1 has ubiquitous tissue expression, and drives cell motility by formation of lamellipodia. (wikipedia.org)
  • bone
  • The representation of cyclins and cyclin-dependent kinases (cdks) was analyzed during progressive development of the bone cell phenotype in cultures of normal diploid rat calvarial osteoblasts. (umassmed.edu)
  • In this case-control study, quantitative Real-time PCR was used to rate P14, P27 and P21 expression levels in bone marrow and peripheral blood samples of 93 newly diagnosed AML patients (39 male and 54 female) and 13 healthy people (8 male and 5 female) as the control group. (wcrj.net)
  • Cyclin D1 is expressed in all adult human tissues with the exception of cells derived from bone marrow stem cell lines (both lymphoid and myeloid). (wikipedia.org)
  • Biology
  • It is hoped that this compilation will serve to stimulate thought and experimentation in this intriguing area of cardiomyocyte cell biology. (ahajournals.org)
  • The International Journal of Biochemistry & Cell Biology. (wikipedia.org)
  • Modulation
  • This is due to the modulation of a complex network of gene functions and pathways including drug metabolism, cell cycle , and DNA synthesis and repair. (nih.gov)
  • mammalian
  • Here we test the hypothesis that mature mammalian cardiomyocytes retain substantial cellular plasticity, including the ability to dedifferentiate, proliferate, and acquire progenitor cell phenotypes. (pubmedcentralcanada.ca)
  • That dogma has been undermined by the recognition that the adult mammalian heart contains its own reservoir of progenitor (or stem) cells - . (pubmedcentralcanada.ca)
  • Cytoplasm
  • TBRII is localized in cell membrane in normal liver ( c , arrows), but ectopically accumulated in cytoplasm in HCC ( d , HCC Sample 6, arrow), Smad4 expression is decreased in HCC ( f , HCC Sample 2, arrows) compared with normal liver ( e , arrows). (nih.gov)
  • Once inside the host cell cytoplasm, the virus uses its own reverse transcriptase enzyme to produce DNA from its RNA genome, the reverse of the usual pattern, thus retro (backwards). (wikipedia.org)
  • regulator
  • The Drosophila sim gene encodes a transcription factor that is a master regulator of neurogenesis of midline cells in the central nervous system. (wikipedia.org)
  • mitosis
  • When the diploid cells are duplicated and condensed during mitosis, the result is about 120 micrometers of chromosomes. (wikipedia.org)
  • replication
  • Comparative transcriptomics by RNA-seq revealed Musashi1 's association with gut stem cell signature, cell cycle , DNA replication, and drug metabolism. (nih.gov)
  • Histones are subdivided into canonical replication-dependent histones that are expressed during the S-phase of cell cycle and replication-independent histone variants, expressed during the whole cell cycle. (wikipedia.org)
  • patterns
  • Analysis of TMEM63A expression in the mouse using BioGPS revealed more variable expression patterns, with the highest expression being seen in the stomach and large intestine. (wikipedia.org)
  • In addition to their different localizations, the two DUT isoforms display different expression patterns: while DUT-M is constitutively expressed, DUT-N is under cell cycle control and notably upregulated during S phase. (wikipedia.org)
  • cdk4
  • Here, we show that 40% of elf(+/-) mice spontaneously develop hepatocellular cancer (HCC) with markedly increased cyclin D1, cyclin-dependent kinase 4 (Cdk4), c-Myc and MDM2 expression. (nih.gov)
  • Increase in Cdk4 expression is seen in HCC sample from elf +/− mouse ( d ) as compared with normal liver ( c ). (nih.gov)
  • Stem Cells
  • Stem Cells. (nih.gov)
  • The intestinal epithelium is very peculiar for its continuous cell renewal, fuelled by multipotent stem cells localized within the crypts of Lieberkühn. (nih.gov)