• However, only aquaporin-3 (AQP3), a member of the aquaporin family, showed significantly higher levels in the CBD-treated group than in the control group at both the mRNA and protein levels. (layv.co)
  • This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. (antibodies-online.com)
  • Aquaporin-3 (AQP3) is a membrane protein that contributes to the water homeostasis of the epidermis, and decreased AQP3 expression following ultraviolet (UV)-irradiation of the skin is associated with reduced skin moisture. (kyobobook.co.kr)
  • It has been shown that astaxanthin treatment inhibits the inflammatory effects of UV radiation by decreasing UV-induced reactive nitrogen species production, inflammatory cytokine expression, and apoptosis (cell death) in the epidermis ( Yoshihisa et al. (loaskin.com)
  • Aquaporin-3 in the epidermis: more than skin deep. (kiev.ua)
  • The aquaglyceroporin AQP3 is abundantly expressed in keratinocytes of mammalian skin epidermis. (edu.sa)
  • In the present work, we examined the overall expression of AQPs in cells from human skin and we reviewed data on the functional role of AQPs in skin, particularly in the epidermis. (edu.sa)
  • But in keratinocytes, the major cell type of the epidermis, only the aquaglyceroporins AQP3, 10 were found. (edu.sa)
  • In particular, we find a correlation between the absence of AQP3 and intercellular edema in the epidermis in two different experimental models: eczema and hyperplastic epidermis. (edu.sa)
  • In conclusion, we suggest that in addition to glycerol, AQP3 may be important for water transport and hydration in human skin epidermis. (edu.sa)
  • This review focuses on emerging topics encompassing the functional involvement of aquaporin channel proteins (AQPs) and membrane transport systems, also allowing permeation of NO and hydrogen peroxide, a major ROS, in oxidative stress physiology and pathophysiology. (hindawi.com)
  • This notion has been challenged by the discovery of new membrane transport functions, especially those exerted by aquaporins (AQPs), a family of membrane channel proteins widespread in nature [ 10 , 11 ]. (hindawi.com)
  • Background/Aim: Recent studies have revealed aquaporins (AQPs) as targets for novel anti-tumor therapy since they are likely to play a role in carcinogenesis, tumor progression and invasion. (dsmc.or.kr)
  • The aquaporins (AQPs) are a family of transmembrane proteins forming water channels. (edu.sa)
  • By RT-PCR on primary cell cultures, we found that up to 6 different AQPs (AQP1, 3, 5, 7, 9 and 10) may be selectively expressed in various cells from human skin. (edu.sa)
  • Juan Fuentes ABSTRACT Aquaporins (AQPs) are specific transmembrane water channels with an important function in water homeostasis. (silverchair.com)
  • Our results revealed that UVA irradiation decreases AQP3 expression at the protein and messenger RNA (mRNA) levels, but that MEL treatment significantly ameliorated these effects. (kyobobook.co.kr)
  • With advancing age, the amount of Hyaluronic Acid in the skin progressively decreases, causing imperfections such as wrinkles, expression and aging lines and loss of volume (emptying, skin depressions, etc.) in particular on the cheekbones, cheeks and lips. (pharmaflorence.com)
  • Here, we show that signal transduction by H2O2 depends on entry into the cell by transit through aquaporin-3 (AQP3), a plasma membrane H2O2-conducting channel. (bvsalud.org)
  • To ensure that a quantity of water flows into the skin tissues useful to form the natural filler substance with hyaluronic acids, the AQP3 complex is inserted, formed by three molecules (Acetyl Hexapeptide-37, Glyceryl Glucoside, Galactoarabinan) which favor the formation of "Aquaporins" or "channel" proteins on the cell membrane of the keratinocytes and fibroblasts of the skin allowing the very fast flow of water molecules inside and outside the cells. (pharmaflorence.com)
  • It works synergistically with glycerin as it up-regulates Aquaporin 3 (AQP3), an important transmembrane protein that transports our beloved friend glycerin, along with its' hydrating groupie water molecules that surround it, into the cell. (incidecoder.com)
  • Suberoylanilide hydroxamic acid (SAHA) (a HDAC inhibitor) increases expression of aquaporin-3 in normal skin cells (keratinocytes). (wikipedia.org)
  • Here, we report for the first time that MELs ameliorate the UVA-induced downregulation of AQP3 in cultured human epidermal keratinocytes (HaCaT keratinocytes). (kyobobook.co.kr)
  • 114(3): 568-573, 2017 01 17. (bvsalud.org)
  • 2017). By activating the antioxidant defense system, Astaxanthin r egulates anti-inflammatory gene expression and inhibits the progression of inflammation (Ahmed et al. (loaskin.com)
  • 2017;312(3):302-13. (kiev.ua)
  • Steve F. Perry ABSTRACT The present study tested the hypothesis that zebrafish ( Danio rerio ) aquaporin -1a1 (AQP1a1) serves as a multi-functional channel for the transfer of the small gaseous molecules, CO 2 and ammonia, as well as water. (silverchair.com)
  • The incubation and fledging durations 23±3 days 43±6 days (Medway 1957;Langham 1980;Lim 2002) Swiftlets engage in yearround breeding activities between the months of October and February (Langham 1980) Construction of a single nest by swiftlets typically requires around 30-45 days during the breeding season, but in the nonbreeding season, this process takes approximately 60-80 days (Aowphol et al. (researchgate.net)
  • Collectively, our findings suggest that MELs can be used as a potential ingredient that modulates AQP3 expression to improve skin moisturization following UVA irradiation-induced damage. (kyobobook.co.kr)
  • Here, we report that AQP3 deletion in mice affects renal function and modulates renal injury. (bvsalud.org)
  • More precisely, recent data support the hypothesis that, in vivo external calcium, through activation of calcium-sensing receptors, modulates the expression/trafficking of AQP2. (uniba.it)
  • Aquaporin 3 (AQP-3) is the protein product of the human AQP3 gene. (wikipedia.org)
  • Our mitogenactivated protein kinase inhibitor analysis revealed that phosphorylation of c-Jun N-terminal kinase (JNK), but not extracellular signal-regulated kinase or p38, mediates UVA-induced AQP3 downregulation, and that MEL treatment significantly suppressed the UVA-induced phosphorylation of JNK. (kyobobook.co.kr)
  • Following IR, AQP3 deletion inhibited activation of mitogen-activated protein kinase (MAPK) signaling and produced an increase in the ratios of Bax/Bcl-2, cleaved caspase-3/caspase-3 and p-p53/p53. (bvsalud.org)
  • Caspase 3, CD44, Akt/ mTOR, and p38/STAT3 protein expression levels were measured by Western blotting. (fabad.org.tr)
  • Compared to control-treated cells, CD44 (3.2- fold) and p-STAT3 (2.44-fold) protein expressions were upregulated in PEITC-treated cells. (fabad.org.tr)
  • Of high expression in the skin tissue, aryl hydrocarbon receptor (AhR) is a cytoplasmic protein responsible for maintaining skin homeostasis through proliferation, differentiation, cell arrest and apoptosis signals. (uaslp.mx)
  • The encoded protein is the predominant aquaporin found in brain. (antibodies-online.com)
  • Furthermore, it could induce expression of the Nrf2 as well as its downstream markers at the protein level in cells. (inrae.fr)
  • Additionally, 4c(2) as an Nrf2 activator could promote the nuclear translocation of Nrf2 protein and induce the expressions of Nrf2-dependent enzymes HO-1, NQO1, and GPX4. (inrae.fr)
  • PURPOSE: We investigated the expression of the N-myc and STAT interactor (NMI) protein in invasive ductal carcinoma tissue and estimated its clinicopathologic significance as a prognostic factor. (koreamed.org)
  • Although NOD-like receptor protein 3 (NLRP3) inflammasome activation is known to. (koreamed.org)
  • REG4, S100P, SERPINB5 and REG1A protein expression was confirmed by immunohistochemistry (n=23). (bmj.com)
  • Aquaporin-3 (AQP3), a transporter of water, glycerol and H2O2, is expressed in basolateral membranes of principal cells in kidney collecting duct. (bvsalud.org)
  • Expression and function of aquaporins in human skin: Is aquaporin-3 just a glycerol transporter? (edu.sa)
  • To understand the role of aquaglyceroporins in skin, we examined the relevance to human skin of the conclusion, from studies on mice, that skin AQP3 is only important for glycerol transport. (edu.sa)
  • Dive into the research topics of 'Expression and function of aquaporins in human skin: Is aquaporin-3 just a glycerol transporter? (edu.sa)
  • In response to injury, AQP3-depleted colonic epithelial cells showed defective lamellipodia, focal adhesions, and repair after wounding, along with impaired H2O2 responses after exposure to the intestinal pathogen Citrobacter rodentium Correspondingly, AQP3-/- mice showed impaired healing of superficial wounds in the colon and impaired mucosal innate immune responses against C. rodentium infection, manifested by reduced crypt hyperplasia, reduced epithelial expression of IL-6 and TNF-α, and impaired bacterial clearance. (bvsalud.org)
  • Background Aquaporin 3 (AQP3) and Cellular-mesenchymal to epithelial transition factor (c-Met) are both overexpressed in human breast cancer and highly related to proliferation and migration. (scite.ai)
  • Twenty-nine of these genes were significantly regulated in UC-in-remission subjects compared with non-IBD controls, including a large number of epithelial cell-expressed genes such as REG4, S100P, SERPINB5, SLC16A1, DEFB1, AQP3 and AQP8, which modulate epithelial cell growth, sensitivity to apoptosis and immune function. (bmj.com)
  • Given the strong link between the regulation of some of these genes and the growth and dissemination of gastrointestinal cancers, we believe their aberrant expression in UC may provide a mechanism for epithelial hyper-proliferation and, in the context of malignant transformation, for tumour growth. (bmj.com)
  • AQP3 expression showed significant correlation to type III GIM. (oncotarget.com)
  • Results Based on the immunohistochemical results combined with the clinicopathological data of 59 breast cancer patients, c-Met exhibited a significant correlation with AQP3 in breast cancer tissue. (scite.ai)
  • GIM classification was determined via HID-AB staining, and AQP3, CD24, LGR5 and Ki67 expression were determined by immunohistochemistry. (oncotarget.com)
  • Methods We used immunohistochemistry to determine the expression of AQP3 and c-Met in breast cancer tissue specimens and analysed whether there was any correlation between the two molecules. (scite.ai)
  • Materials and Methods: AQP3 expression was investigated on the basis of the immunohistochemistry of tissue microarray specimens from 447 EBC patients who underwent surgery between 2003 and 2008. (dsmc.or.kr)
  • AQP3-deficient kidneys showed significantly reduced ATP content, increased phosphorylated (p)-AMPK, and decreased p-ERK and p-mammalian target of rapamycin (mTOR). (bvsalud.org)
  • Beyond water homeostasis: Diverse functional roles of mammalian aquaporins. (kiev.ua)
  • Additionally, the wound scratch assay showed that AQP3-specific siRNA or c-Met-specific siRNA significantly inhibited breast cancer cell migration, which was promoted by hHGF. (scite.ai)
  • Impaired stratum corneum hydration in mice lacking epidermal water channel aquaporin-3. (kiev.ua)
  • To study the role of AQP3 in cyst development, we generated 2 polycystic kidney disease (PKD) mouse models: kidney-specific Pkd1 knockout mice and inducible Pkd1 knockout mice, each without and with AQP3 deletion. (bvsalud.org)
  • In both models, kidney sizes and cyst indexes were significantly reduced in AQP3-null PKD mice compared with AQP3-expressing PKD mice, with the difference seen mainly in collecting duct cysts. (bvsalud.org)
  • We found collecting duct hyperplasia and cell swelling in kidneys of adult AQP3 null mice. (bvsalud.org)
  • After mild renal ischemia-reperfusion (IR), AQP3 null mice had significantly greater blood urea nitrogen (57mg/dl) and creatinine (136µM) than wild-type mice (35mg/dl and 48µM, respectively), and showed renal morphological changes, including tubular dilatation, erythrocyte diapedesis and collecting duct incompletion. (bvsalud.org)
  • MPO, MDA and SOD following IR in AQP3 null mice were significantly different from that in wild-type mice (1.7U/g vs 0.8U/g, 3.9µM/g vs 2.4µM/g, 6.4U/mg vs 11U/mg, respectively). (bvsalud.org)
  • Bone marrow of 3 mice per group was isolated and differentiated to macrophages with M-CSF (20 ng/ml). 20 ng/ml IL-4 was used to induce alternative macrophage activation and 1 uM Rosiglitazone (RSG) was used to activate PPARg. (gsea-msigdb.org)
  • Mice lacking AQP3 have dry skin and reduced SC hydration. (edu.sa)
  • Aquaporin 3 Expression Loss in Urothelial Carcinoma: Association with Tumor Invasion Depth, but not with Grading? (sagepub.com)
  • Meanwhile, none of selected AQP3 polymorphisms were related to AQP3 expression in tumor tissue or survival in the current study. (dsmc.or.kr)
  • Conclusion: AQP3 expression in tumor tissue may be considered as a potential prognostic marker in patients with HER2-over-expressing EBC after curative surgery. (dsmc.or.kr)
  • Expression of inflammation-related genes such as REG1A and IL8 returned to control levels during remission. (bmj.com)
  • In a matrix-grown Madin-Darby canine kidney cyst model, AQP3 expression promoted cyst enlargement and was associated with increased expression of hypoxia-inducible factor 1-α and glucose transporter 1 and increased glucose uptake. (bvsalud.org)
  • Our data suggest that the slowed renal cyst enlargement in AQP3 deficiency involves impaired energy metabolism in the kidney through AMPK and mTOR signaling and impaired cellular glucose uptake. (bvsalud.org)
  • However, the relationships of AQP3 with GIM classification and with other proteins, and their roles in the transition from GIM to gastric carcinoma (GC) remain unknown. (oncotarget.com)
  • Panneerselvam L, Raghunath A, Perumal E. Differential expression of myocardial heat shock proteins in rats acutely exposed to fluoride. (kiev.ua)
  • In addition, decreased expression of inflammatory cytokines and fibrosis markers and increased expression of AQP5 were observed in both the DFO and FER groups. (impactaging.com)
  • IDC is also claimed to upregulate the expression of CD44 (a hyaluronic acid binding receptor), ceramide synthase (an enzyme required for ceramide synthesis), and decrease transepidermal water loss (TEWL). (incidecoder.com)
  • In the formula of Fillerina 12 Double Filler there are 3 molecules of Collagen with different molecular weights (2,000, 12,000 and 300,000 Dalton) able to favor the density of the extracellular matrix, and improve the filling in synergy with Hyaluronic Acids. (pharmaflorence.com)
  • In the kidney, aquaproin-3 is unresponsive to the antidiuretic hormone vasopressin, unlike aquaporin-2. (wikipedia.org)
  • In the kidney aquaporin-2 (AQP2) provides a target for hormonal regulation of water transport by vasopressin. (uniba.it)
  • We have previously provided molecular evidence of expression of aquaporin 3 (AQP3) in normal human urothelium and in UBC of various stages. (sagepub.com)
  • A. S. Verkman SUMMARY There is considerable potential for translating knowledge of aquaporin structure, function and physiology to the clinic. (silverchair.com)
  • These findings implicate AQP3 as a novel determinant of renal cyst enlargement and hence a potential drug target in ADPKD. (bvsalud.org)
  • Aquaporins: important but elusive drug targets. (kiev.ua)
  • Accordingly, we analyzed the prognostic impact of AQP3 expression and polymorphisms in a number of patients with early breast cancer (EBC). (dsmc.or.kr)
  • Aquaporin 3 levels are often lower in psoriasis than in healthy skin. (wikipedia.org)
  • 3 ] found that 74% of T2DM patients had one or more skin problems, with the highest amount being dry skin (47%), followed by infection (10%), diabetic foot (5%), hair loss, and diabetic dermopathy (4%), respectively. (hindawi.com)
  • No previous study has examined whether the skin-moisturizing effect of MELs might act through the modulation of AQP3 expression. (kyobobook.co.kr)
  • In addition, it is possible that increased expression of AQP3, which plays an important role in skin water retention, is a contributor to the mechanism. (layv.co)
  • To put it more simply - AQP3 makes sure that glycerin and water are well distributed in the outer layer of the skin and thus the skin is well-hydrated. (incidecoder.com)
  • Aquaporin 3 (AQP3) plays an important role in the expression of various skin-related diseases such as vitiligo and psoriasis. (e-ajbc.org)
  • We aim to explore the regulatory mechanism of AQP3 and the function of AQP3 on the skin. (e-ajbc.org)
  • We summarize the distribution of AQP3 in skin and the regulatory mechanism of AQP3, then point out the function of AQP3 on the skin and the development trend of AQP3 as a new target in the field of cosmetic research. (e-ajbc.org)
  • S. Tanaka SUMMARY The ventral pelvic skin of the tree frog Hyla japonica expresses two kinds of arginine vasotocin (AVT)-stimulated aquaporins (AQP-h2 and AQP-h3), which affect the capacity of the frog's skin to absorb water. (silverchair.com)
  • Our results support a novel role for AQP3 in modulating renal injury and suggest the mechanisms involved in protection against hypoxic injury. (bvsalud.org)
  • The study objective was to explore the relationship between c-Met and AQP3 in human breast cancer. (scite.ai)
  • Real-time quantitative polymerase chain reaction and Western blotting were used to detect AQP3 expression in MCF-7 and MDA-MB-231 cells after human hepatocyte growth factor (hHGF) treatment and/or transfection with c-Met silencing small interfering (si)RNA. (scite.ai)
  • Conclusions Our study indicated that AQP3 expression was regulated by c-Met in human breast cancer. (scite.ai)
  • Find Aquaporin 4 ELISA Kits for a variety of species such as anti-Cow Aquaporin 4, anti-Human Aquaporin 4, anti-Mouse Aquaporin 4. (antibodies-online.com)
  • This moisturizer uses a high-concentration of ceramides to better replenish your skin's natural barrier and aquaporins to help generate and lock in moisture. (incidecoder.com)
  • Ceramide-3 replenishes the skin's natural moisture barrier to prevent moisture loss due to evaporation. (eucerin.ca)
  • Recent studies indicate that aquaporin 3 is overexpressed in many types of malignancies such as melanoma and primary effusion lymphomas as well as cancers of the lung, colon, stomach, esophagus, mouth, liver, and pancreatic duct. (wikipedia.org)
  • CrossRef Ikarashi N, Aburada T, Kon R, Sugiyama K. Water control mechanism of byakkokaninjinto and its active components via aquaporins. (kiev.ua)
  • Whereas former studies demonstrated that loss of AQP3 was associated with invasive and high-grade disease and worse progression-free and cancer-specific. (sagepub.com)
  • Here, our study demonstrated that AQP3 and c-Met were overexpressed in 52.5% and 83.1% of breast cancer tissue specimens, respectively. (scite.ai)
  • After 10 days, RNA was isolated and gene expression profiles were analyzed using Mouse Genome 430 2.0 microarrays from Affymetrix. (gsea-msigdb.org)
  • Bovine sperm separation by Swim-up and density gradients (Percoll and BoviPure): Effect on sperm quality, function and gene expression. (proiser.com)
  • Studies in transfected MDCK cells showed that AQP3 expression attenuated reduced cell viability following hypoxia-reoxygenation, with reduced apoptosis and increased MAPK signaling. (bvsalud.org)
  • So far, it is well recognized that a multistep process is involved in the progression from normal gastric mucosa to intestinal-type GC, including chronic gastritis, chronic atrophic gastritis, intestinal metaplasia, dysplasia and invasive carcinoma, which was originally proposed by Correa [ 2 , 3 ]. (oncotarget.com)
  • CD44 is one of the well-known surface markers for hepatocellular carcinoma, and its expression level is related to poor survival and a high recurrence rate. (fabad.org.tr)
  • Previous studies reported aquaporin (AQP)-3 expression in cysts derived from collecting ducts in ADPKD. (bvsalud.org)
  • Studies have shown that hHGF can increase c-Met phosphorylation, and we discovered that the hHGF-induced increase in AQP3 expression was dose dependent. (scite.ai)
  • Studies have shown that astaxanthin can decrease the damage incurred from photogaging by suppressing cell damage caused by free radicals and inhibiting the expression of MMPs in different cells (Kishimoto et al. (loaskin.com)
  • we previously demonstrated that aquaporin 3 (AQP3) is expressed in goblet cells and is positively correlated with GIM severity. (oncotarget.com)
  • Water is also be transported from the luminal side of cells into the vasculature by aquaporin 3. (drugbank.com)
  • We investigated the metabolism of mouse isolated heart under the influence of tricarbonyldichlorothenium (II)- dimer (CORM-2 and 2,3-4,5-bis-O-isopropylidene-βD-fructopyranose sulfamate (topiramate) as potential blockers of aquaporine channel (AQP3) of cardiac myocytes. (kiev.ua)
  • The TSEN placement Typically triggers 5' and 3' to the home', proliferating a downstream' vascular maturation on the 5' T and a 5' receptor nucleus on the 3' mitosis. (evakoch.com)
  • The expression levels. (koreamed.org)
  • These two levels serve degraded by a phosphorylation including at least 6 membranes in a such tail that both leaves the 2' disorder ubiquitination and adducts the 3' heart to the 5' cell. (evakoch.com)