Expression of annexin a1. Medical search. Frequent questions

Annexin A1, also known as lipocortin I, is a protein that is encoded by the ANXA1 gene in humans. (wikipedia.org)
The gene for annexin A1 (ANXA1) is upregulated in hairy cell leukemia. (wikipedia.org)
ANXA1 protein expression is specific to hairy cell leukemia. (wikipedia.org)
Annexin A1 (AnxA1) is a protein secreted by phagocytic cells which plays a pivotal role on the resolution of inflammation by enhancing phagocytosis carried out by phagocytes. (maastrichtuniversity.nl)
Down-modulating AnxA1 in BV2 cells impaired gene and protein expression of PPAR gamma, effects reversed by treatment with recombinant AnxA1 (rAnxA1). (maastrichtuniversity.nl)
Annexin A1 (ANXA1) is a protein related to inflammation , immunity and tumorigenesis . (bvsalud.org)
Here, we analyzed ANXA1 expression and localization by HCC microarray and immunofluorescence experiments. (bvsalud.org)
Moreover, the expression of ANXA1 in mesenchymal cells was positively correlated with programmed death - ligand 1 expression. (bvsalud.org)
Knockdown of ANXA1 expression inhibited HCC cell proliferation and migration by increasing the M1/M2 macrophage ratio and promoting T-cell activation. (bvsalud.org)
The protein annexin A1 (ANXA1) is key to the phagocytosis of apoptotic leukocytes during peripheral inflammatory resolution, but the pathophysiological significance of its expression in the CNS that is restricted almost exclusively to microglia is unclear. (westminster.ac.uk)
IHC staining of FFPE human placenta with Annexin A1 antibody (clone ANXA1/3727). (nsjbio.com)
The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. (nsjbio.com)
The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. (nsjbio.com)
We recently used a proteomic-based screen to identify a novel mitotic complex including the membrane-associated Annexin A1 (ANXA1) protein that interacts with and regulates cortical recruitment of the LGN spindle orientation complex in mitotic mammary epithelial cells. (southampton.ac.uk)
We describe a novel intestinal epithelial FPR signaling pathway that is activated by an endogenous FPR ligand, annexin A1 (ANXA1), and its cleavage product Ac2-26, which mediate activation of ROS by an epithelial NADPH oxidase, NOX1. (phoenixbiotech.net)
Additionally, increased ANXA1 expression was observed in the intestinal epithelium and infiltrating leukocytes in the mucosa of ulcerative colitis patients compared with normal intestinal mucosa. (phoenixbiotech.net)
In this study, epididymal adipose tissue from male annexin 1 (ANXA1)-null and wild-type control mice were used to explore the potential role of ANXA1 in adipocyte biology. (ox.ac.uk)
Qualitatively similar but significantly attenuated responses to the catecholamines were observed in tissue from ANXA1-null mice, an effect that was not associated with changes in beta-adrenoceptor mRNA expression. (ox.ac.uk)
ANXA1 gene deletion did not affect glucocorticoid receptor expression or the ability of dexamethasone to suppress catecholamine-induced lipolysis. (ox.ac.uk)

Annexin A1 belongs to the annexin family of Ca2+-dependent phospholipid-binding proteins that have a molecular weight of approximately 35,000 to 40,000 Dalton and are preferentially located on the cytosolic face of the plasma membrane. (wikipedia.org)

Introduction: The aim of this study was quantify annexin A1 expression in macrophages and cluster of differentiation 4 (CD4)+ and cluster of differentiation 8 (CD8)+ T cells from the skin of patients with cutaneous leishmaniasis (n=55) and correlate with histopathological aspects. (fiocruz.br)
Conclusions: Annexin A1 is differentially expressed in CD163+ macrophages and T cells depending on the histopathological features of Leishmania-infected skin, which might affect cell activation. (fiocruz.br)
In resting conditions, human and mouse immune cells such as neutrophils, monocytes, and macrophages contain high levels of annexin A1 in their cytoplasm. (wikipedia.org)
Annexin A1 promotes neutrophil detachment and apoptosis, and phagocytosis of apoptotic neutrophils by macrophages. (wikipedia.org)
Expression of macrophages (CD68 + cells) iNOS, COX-2 and pro-resolving proteins FPR2/ALX, ChemR23 and Annexin A1 was determined in formalin fixed paraffin embedded samples by immunohistochemistry. (bmj.com)
Targeting of Annexin A1 in Tumor-associated Macrophages as a therapeutic strategy for hepatocellular carcinoma. (bvsalud.org)
Abstract INTRODUCTION This study aimed to determine the number of macrophages and apoptotic cells and perform annexin-A1 detection in patients with leishmaniasis. (scielo.org)
The exudative cellular reaction displayed higher levels of annexin-A1 detection in macrophages and apoptotic cells. (scielo.org)
The correlation between annexin-A1 detection in apoptotic cells and macrophages was observed in exudative necrotic reaction and exudative necrotic-granulomatous reaction. (scielo.org)
The aim was to quantify the macrophages M1 and M2 and the annexin A1 expression in the skin lesions of patients with cutaneous leishmaniasis. (scielo.org)
Using the immunofluorescence technique, macrophages were identified by CD163 marker, differentiated by anti-MHCII and anti-CD206 antibodies, and annexin A1 expression was determined by arbitrary unit (a.u.) densitometry. (scielo.org)
RESULTS: In M1 macrophages, a greater expression of this protein was observed in the exudative cellular reaction type lesions (136.3 ± 2.6 a.u., assuming mean and standard derivation) when compared to the expression in the lesions of exudative granulomatous reaction, exudative necrotic reaction and exudative necrotic-granulomatous reaction patients (108.0 ± 2.3, 121.6 ± 3.2 and 124.7 ± 2.4 a.u., respectively). (scielo.org)
Regarding M2 macrophages, it was observed that patients with exudative cellular reaction lesion also had a higher expression of this protein (128.8 ± 2.6 a.u.), when compared to the expression in the lesions of exudative granulomatous reaction, exudative necrotic reaction and exudative necrotic-granulomatous reaction patients (105.6 ± 2, 113.9 ± 2.8, 114.3 ± 2.1 a.u., respectively). (scielo.org)
CONCLUSIONS: These data suggest that annexin A1 is assisting macrophages in the phagocytosis process of patients with exudative cellular reaction lesion type. (scielo.org)
Finally, expression of the microRNAs in B-lymphocytes was associated with a decrease in phagocytosis by primary bovine macrophages. (biomedcentral.com)
LXA4 decreased obesity-induced adipose inflammation, attenuating TNF-α and CD11c(+) M1-macrophages (MΦs), while restoring CD206(+) M2-MΦs and increasing Annexin-A1. (borgesonlab.org)
Treatment of human alveolar macrophages (AMs) with the synthetic GC dexamethasone (Dex) did not alter the expression of TLRs −1, −4, and −6. (frontiersin.org)

The main mechanism of glucocorticoids' anti-inflammatory effects is to increase the synthesis and function of annexin A1. (wikipedia.org)
Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins, and leukotrienes, annexin A1 may have potential anti-inflammatory activity. (wikipedia.org)
Upon induction by modified NSAIDS and other potent anti-inflammatory drugs, annexin A1 inhibits the NF-κB signal transduction pathway, which is exploited by cancerous cells to proliferate and avoid apoptosis. (wikipedia.org)
Elucidating how annexin A1 and PPAR gamma interact with one another provides basis for further research aimed at understanding molecular pathways and cell signaling events involved with these factors, expanding existing knowledge on the anti-inflammatory effects of such factors. (maastrichtuniversity.nl)
Annexin A1 is a protein involved in anti-inflammatory or pro-resolution actions in different tissues while its presence and biological role on ocular surface has been scarcely examined. (ucm.es)
In addition, considering the significant role of inflammation in dry eye pathology, the potential anti-inflammatory activity of Ac2-26, an annexin A1 peptide mimicking its N-terminus, was assessed. (ucm.es)
12/13041-4 - Evaluation of skin heterologous graft using acellular matrices obtained from porcine skin and annexin A1 action as anti-inflammatory / immunosuppressive agent. (fapesp.br)

Under hyperosmotic conditions increased protein levels of intracellular and secreted annexin A1 as well as higher expression of its receptor Fpr2 (formyl peptide receptor type 2) were found. (ucm.es)
Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. (phoenixbiotech.net)

In vitro and in vivo analyses show that exogenous and endogenous annexin A1 counter-regulate the activities of innate immune cells, particularly extravasation and the generation of proinflammatory mediators, which ensures that a sufficient level of activation is reached but not exceeded. (wikipedia.org)
The expression of genes through miRNA is regulated by endogenous regulatory pathways, resulting in high stability and biocompatibility ( 5 ). (spandidos-publications.com)

gene and protein expression of proliferated-activated receptor gamma (PPAR gamma) and CD36, STAT6 phosphorylation and phagocytosis of apoptotic neurons were investigated. (maastrichtuniversity.nl)

the expression levels of protein associated with apoptosis and endoplasmic reticulum stress (ERS) of SKO-007 cells in various groups were detected by Western blotting method. (researchgate.net)
CONCLUSIONS: Our data demonstrate the relevance of annexin-A1 in the regulation of apoptosis and phagocytosis in leishmaniasis. (scielo.org)

Altered annexin A1 expression levels through modulation of the immune system effects the initiation and spread of breast cancer, but the association is complex and conclusions of published studies often conflict. (wikipedia.org)
Annexin A1 modulation mechanism on the expression of the Translocator Protein (TSPO). (usp.br)
Novel candidate markers of inflammatory modulation included PBMC manifestation of annexin A1 and caspase 8, and the arachidonic acid metabolite 5,6-DHET. (woofahs.com)

In this study, potential changes in annexin A1 protein expression and secretion on the ocular surface after exposure to hyperosmolar conditions were evaluated. (ucm.es)

GILZ protein and gene expression was quantified in blood neutrophils, along with markers of inflammation (CRP, extracellular DNA) or its resolution (Annexin A1). (springeropen.com)
Contrary to some markers of inflammation or its resolution, the levels of gilz gene expression were related to ARDS severity. (springeropen.com)

The aim of this study was to investigate expression of pro-resolving proteins in pathological supraspinatus tendons compared to normal samples. (bmj.com)
We hypothesised that expression of pro-resolving proteins would increase in tendinopathic compared to normal supraspinatus. (bmj.com)
Discussion Tenocytes in tendinopathic supraspinatus are the predominant cell type expressing pro-resolving proteins ChemR23, FPR2/ALX and Annexin A1. (bmj.com)
In addition, numerous important cellular proteins, such as B-cell lymphoma-2 homologous antagonist/killer, Myc proto-oncogene protein, cyclin-dependent kinase inhibitor 1B, DNA replication licensing factor MCM-7, retinoblastoma 1 and Annexin A1, are degenerated through the UBE3A-mediated ubiquitin proteasome pathway ( 7 ). (spandidos-publications.com)
2D-PAGE for proteome studies gives a map of proteins which reflect changes in protein expression levels, as well different isoforms and posttranslational modifications. (hindawi.com)
Network displaying biological cable connections between genes and proteins chosen on highest relationship of expression transformation to CRP transformation (time 9 vs. time 0, n = 18). (woofahs.com)

Following cell activation (for example, by neutrophil adhesion to endothelial-cell monolayers), annexin A1 is promptly mobilized to the cell surface and secreted. (wikipedia.org)
Given the numerous pathophysiologic roles of neutrophils in the acute respiratory distress syndrome (ARDS), we postulated that neutrophil GILZ expression might be induced during ARDS, to modulate the inflammatory process and participate in lung repair. (springeropen.com)
Neutrophil GILZ expression was detected at the transcriptional and/or translational level in 9/17 ARDS patients (in particular 7/10 severe ARDS) and in 2/14 ventilated controls. (springeropen.com)
GILZ was expressed in about ¾ of the corticosteroid-treated patients and its expression could also occur independently of corticosteroids, suggesting that inflammatory signals may also induce neutrophil GILZ expression in vivo. (springeropen.com)

When applied to clinical placenta samples apolipoprotein A1 was found to be accumulated in the preeclamptic placenta, where it may either have a nutritional effect or act as a modifier of signal transduction. (hindawi.com)

Cytosolic and membrane staining was detected for annexin A1 in corneal and conjunctival epithelial cells. (ucm.es)
Annexin A2 and S100A10 as Candidate Prognostic Markers in Epithelial Ovarian Cancer. (cancerindex.org)
The aim of this study was to examine whether Annexin A2 and S100A10 expression can be used as prognostic markers for epithelial ovarian cancer (EOC). (cancerindex.org)

Higher expression of annexin A1 during pathological conditions could increase the strength of TCR signalling through the mitogen-activated protein kinase signalling pathway, thereby causing a state of hyperactivation of T cells. (wikipedia.org)

Exposure of MCF-7 breast cancer cells to high physiological levels (up to 100 nM) of estrogen lead to an up-regulation of annexin A1 expression partially through the activation of CREB, and dependent on activation of the estrogen receptor alpha. (wikipedia.org)
For this reason, mitochondrial carrier gene expression needs tight regulation. (cancerindex.org)
Gene deletion reveals roles for annexin A1 in the regulation of lipolysis and IL-6 release in epididymal adipose tissue. (ox.ac.uk)

Recombinant full-length human Annexin A1 protein was used as the immunogen for the Annexin A1 antibody. (nsjbio.com)

These findings suggest a potential role of annexin A1 and its mimetic peptide modulating key inflammatory events associated to dry eye. (ucm.es)

LXs restored adipose expression of autophagy markers LC3-II and p62. (borgesonlab.org)

The activation of T cells results in the release of annexin A1 and the expression of its receptor. (wikipedia.org)
The overexpression of miRNA‑375 significantly suppressed the levels of protein expression of ubiquitin‑protein ligase E3A (UBE3A) and Insulin‑like growth factor‑1 receptor (IGF‑1R) in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)

Expression of Annexin A2 and S100A10 was evaluated in EOC tissue samples (n=303) by immunohistochemistry. (cancerindex.org)
Univariate Cox regression analysis showed that Annexin A2 and S100A10 in stromal tissue correlated with shorter overall survival (OS). (cancerindex.org)
The gene expression of some trophic factors involved in tissue remodeling was congruent with the cellular events. (fapesp.br)

Annexin A1 has important opposing properties during innate and adaptive immune responses: it inhibits innate immune cells and promotes T-cell activation. (wikipedia.org)

The expression of both markers correlated to histological subtype, histological grading, International Federation of Gynecology and Obstetrics (FIGO) stage, and macro-radical surgery. (cancerindex.org)

MicroRNA (miRNA) molecules, a series of single-stranded non-coding RNA chains measuring 20-25 nucleotides in length, regulate gene expression at the transcriptional level by complementary pairing with target gene mRNA ( 5 ). (spandidos-publications.com)
Silencing of TSN was accompanied by a significant decrease in S100A11 expression at both mRNA and protein level. (oncotarget.com)

Abe T, Marutani Y, Deng L, Matsui C, Fukasawa M, Suzuki R, Wakita T, Matsuura Y, Shoji I. Hepatitis C virus disrupts Annexin 5-mediated occludin integrity through downregulation of PKCα and PKC𝜂 expression, thereby promoting viral propagation. (kobe-u.ac.jp)

It did, however, augment IL-6 expression and modify the inhibitory effects of glucocorticoids on IL-6 release. (ox.ac.uk)

Significance of the study The findings of this work provide evidence that the glucocorticoid-mediated protein annexin A1 modulates PPAR gamma expression and that PPAR gamma is important for annexin A1-mediated efferocytosis. (maastrichtuniversity.nl)
Multivariate Cox regression analysis demonstrated no independent prognostic significance of stromal Annexin A2 expression. (cancerindex.org)

Methods: Infecting species were identifi ed by polymerase chain reaction-restriction fragment length polymorphism, and expression of annexin A1 was analyzed by immunofl uorescence. (fiocruz.br)
One of the most important epigenetic mechanisms investigated in the study was DNA methylation, a chemical reaction that adds methyl groups (made up of hydrogen and carbon atoms) to the DNA base cytosine, potentially preventing the expression of certain genes. (mypharmacynews.com)

The proposal capitalizes on our experience of enteropathogenic studies in the SIV model;immunophenotypic analysis by multi-color flow cytometry;ligated intestinal loop model for in vivo studies of mucosal responses and bacterial translocation;high throughput gene expression profiling of isolated mucosal cells, and imaging technologies to visualize multiple cell types. (grantome.com)

Weighted Gene Co-expression Network Analysis Reveals Different Immunity but Shared Renal Pathology Between IgA Nephropathy and Lupus Nephritis. (cdc.gov)

Reduced expression of the protein ANNEXIN-A1 correlated with higher stemness indices in samples of lung adenocarcinoma. (mypharmacynews.com)

0.01) with predominant expression by tenocytes. (bmj.com)

The overexpression of miRNA‑375 significantly increased caspase‑3 and caspase‑9 activities, induced B‑cell lymphoma 2 (Bcl‑2)/Bcl‑2‑associated X protein, tumor protein 53 and cyclin‑dependent kinase inhibitor 1 protein expression and suppressed cyclin D1 and survivin protein expression in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)
Previous studies have identified that UBE3A exhibits abnormal expression in numerous tumor cells, including prostate, cervical and breast cancer ( 6 , 7 ). (spandidos-publications.com)
Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance. (nsjbio.com)

They processed data relating to genetics, including DNA sequences, and to gene expression, as well as epigenetic features - chemical reactions that influence genome functioning and hence phenotype by activating and deactivating genes. (mypharmacynews.com)
Network showing biological contacts between genes and protein chosen on highest relationship of expression transformation to CRP transformation. (woofahs.com)

Expression in CD8+ T cells followed the same trend. (fiocruz.br)
Protein expression and function of organic anion transporters in short-term and long-term cultures of Huh7 human hepatoma cells. (cancerindex.org)

Scope includes mutations and abnormal protein expression. (cancerindex.org)

A pair of annexin repeats may form one binding site for calcium and a phospholipid. (nsjbio.com)
A native form of annexin A1 together with a truncated form were detected by western blot analysis. (ucm.es)

The altered cytokine milieu correlated with increased GLUT-4 and IRS-1 expression, suggesting improved insulin sensitivity. (borgesonlab.org)

Anatomy5

Diseases1

Chemicals and Drugs21

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes5

Information Science3

ANXA119

Belongs to the annexin family1

Macrophages17

Anti-inflammatory7

Formyl peptide2

Endogenous2

Apoptotic1

Apoptosis2

Modulation3

Secretion1

Inflammation2

Proteins6

Neutrophil4

Placenta1

Epithelial3

Pathological1

Regulation3

Recombinant1

Inflammatory1

Adipose1

Receptor2

Tissue3

Promotes1

Markers1

MRNA2

Downregulation1

Glucocorticoids1

Significance2

Reaction2

Responses1

Immunity1

Lung1

0.011

Tumor3

Genes2

Cells2

Abnormal1

Form2

Insulin1