Expression of adhesion. Medical search. Frequent questions

Thus, we conclude that one mechanism by which DHEA may exert its protection in animal models is via the differential regulation of adhesion molecule expression. (biomedcentral.com)
These results as a whole indicated that histamine inhibited the AGE-2- and AGE-3-induced adhesion molecule expression and cytokine production via H2 receptors and the cAMP/PKA pathway. (elsevierpure.com)
Differential regulation of endothelial cell adhesion molecule expression by nitric oxide donors and antioxidants. (uchicago.edu)
Patterns in cell adhesion molecule expression by endothelial cells may play a role in atherogenesis. (duke.edu)

Of the 8 plasma membrane receptors for complement, only deficiencies of CR3 and CR4 due to CD18 deficiency have been described, known as leukocyte adhesion deficiency (LAD) type 1 . (medscape.com)
Leukocyte adhesion deficiency (LAD) is a rare primary immunodeficiency. (medscape.com)
Thus the infections in patients with leukocyte adhesion deficiency act similarly as those observed in patients with neutropenia. (medscape.com)
Labial ulceration from which Escherichia coli was cultured in an 8-month-old girl with leukocyte adhesion deficiency type 1 (LAD I). Note the thin bluish scar at the superior aspect of the labia from an earlier cellulitis. (medscape.com)
This 3-year-old girl had leukocyte adhesion deficiency type I (LAD I) with complete absence of CD18 expression. (medscape.com)
This 10-month-old patient with severe leukocyte adhesion deficiency type I (LAD I) developed a cervical adenitis caused by Klebsiella pneumoniae. (medscape.com)
Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß 2 subunit of LFA1 family (ß2 integrins). (medscape.com)
In milder forms of leukocyte adhesion deficiency I (1-30% expression of CD8), patients may survive to adulthood. (medscape.com)
Patients with leukocyte adhesion deficiency II manifest the Bombay phenotype (ie, negative for O and H blood group antigens with potential production of anti-H antibody). (medscape.com)
However, IgM and IgG serum levels are within the reference range in patients with leukocyte adhesion deficiency II. (medscape.com)
Leukocyte adhesion deficiency II may be classified as one of the congenital disorders of glycosylation (CDG), a rapidly expanding group of metabolic syndromes with a wide symptomatology and severity. (medscape.com)
Currently, 18 subtypes have been reported: 12 are type I (dysfunctional lipid-linked oligosaccharide precursor synthesis), and 6 are type II (dysfunctional trimming/processing of the protein-bound oligosaccharide), including leukocyte adhesion deficiency II (CDG-IIc). (medscape.com)
Variants of leukocyte adhesion deficiency have also been reported, including fully expressed but nonfunctional CD18 and an E selectin that is expressed but rapidly cleaved from the cell surface (only present in soluble form). (medscape.com)
Another reported type of leukocyte adhesion deficiency involves dysfunction in platelet aggregation in addition to a defect in leukocyte adhesion. (medscape.com)
Thus, patients with this type of leukocyte adhesion deficiency manifest both severe bacterial infections and bleeding disorder. (medscape.com)
This leukocyte adhesion deficiency variant is associated with defective expression of the Rap-1 activator CalDAG-GEFI. (medscape.com)
Leukocyte adhesion deficiency results from an adhesion molecule defect that causes granulocyte and lymphocyte dysfunction and recurrent soft-tissue infections. (msdmanuals.com)
Manifestations of leukocyte adhesion deficiency usually begin in infancy. (msdmanuals.com)
Diagnosis of leukocyte adhesion deficiency is by detecting absence or severe deficiency of adhesive glycoproteins on the surface of WBCs using monoclonal antibodies (eg, anti-CD11, anti-CD18) and flow cytometry. (msdmanuals.com)

Tumor necrosis factor-α (TNF-α) and focal adhesion kinase (FAK) are key regulators of inflammatory and integrin-matrix signaling, respectively. (escholarship.org)
Focal adhesion targeting (FAT) domains target the non-receptor tyrosine kinases FAK and Pyk2 to cellular focal adhesion areas, where the signaling molecule paxillin is also located. (rcsb.org)
Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase that regulates cell signaling, proliferation, migration, and development. (rcsb.org)
Upon cell adhesion to the extracellular matrix, FAK is being translocated toward focal adhesion sites and activated. (rcsb.org)
The focal adhesion kinase (FAK) is an intracellular tyrosine kinase associated with the regulation of cell growth, migration, and survival. (elsevierpure.com)
Several molecules are involved in the process of cell adhesion to bone grafts, highlighting the role of integrins, the focal adhesion mechanism, the influence of the collagen matrix, and the activity of alkaline phosphatase in bone matrix formation. (bvsalud.org)

The present study was designed to present evidence to clarify the relationships between learning ability, neuronal cell adhesion molecule L1 expression and hippocampal structural changes in the rat model received X-irradiation at an embryonic stage (E15). (tokushima-u.ac.jp)
tein, and neuronal cell adhesion molecule mRNA were also increased in olfactory bulb. (cdc.gov)

The extracellular region of adhesion GPCRs can be exceptionally long and contain a variety of structural domains that are known for the ability to facilitate cell and matrix interactions. (wikipedia.org)
Autocatalytic processing gives rise to an extracellular (α) and a membrane-spanning (β) subunit, which are associated non-covalently, resulting in expression of a heterodimeric receptor at the cell surface. (wikipedia.org)
Indeed, granule cells from the rostral region of perinatal Gpr56 −/− cerebella show loss of adhesion to extracellular matrix molecules of the pial basement membrane. (jneurosci.org)
Consistent with this hypothesis, developing granule cells from the rostral region of Gpr56 −/− cerebella at birth exhibit a specific defect in cell adhesion to extracellular matrix (ECM) molecules of the pial basement membrane (BM) but no defects in migration, proliferation, or process outgrowth. (jneurosci.org)
These cell adhesion molecules (CAM) will mediate the contact between two cells or between cells and the extracellular matrix, an essential process to the success of the implant. (bvsalud.org)
The main reported mechanisms involve cell adhesion molecules (CAMs) and extracellular matrix components. (bvsalud.org)
Some of these molecules are glycoproteins expressed on the cell surface, socalled cell adhesion molecules (CAM), which mediate either the contact between two cells or the contact among cells and the extracellular matrix, being therefore of fundamental importance for adhesion 3 . (bvsalud.org)
To occur the adhesion of CAMs to the biomaterial, it is necessary their interaction with some components of extracellular matrix, such as proteoglycans, collagen and proteins 23 . (bvsalud.org)

Vascular cell adhesion molecule-1 (VCAM-1), an inducible cell-cell recognition protein on the endothelial cell surface (EC), has been associated with early stages of atherosclerosis. (jci.org)
In view of the accelerated vascular disease observed in patients with diabetes, and the enhanced expression of VCAM-1 in diabetic rabbits, we examined whether irreversible advanced glycation endproducts (AGEs), could mediate VCAM-1 expression by interacting with their endothelial cell receptor (receptor for AGE, RAGE). (jci.org)
The cellular readout was assessed through RT-qPCR, microscopy, and monocyte adhesion for basal expression and upregulation of vascular cell adhesion molecule-1 (VCAM-1) in quiescent and TNF-a stimulated cultured endothelial cell. (temple.edu)

Expression of ICAM-1, VCAM-1, and E-selectin was not altered following incubation with tryptase, but the potent granulocyte chemoattractant IL-8 was released in a dose-dependent fashion in response to physiologically relevant concentrations, with maximal levels in supernatants after 24 h. (eurekamag.com)
Because the engagement of intercellular adhesion molecule (ICAM)-1, B7.1, B7.2, and CD40 on monocytes with their ligands on T cells plays roles in cytokine production, we examined the effects of AGE-2 and AGE-3 on the expression of adhesion molecules and cytokine production in human peripheral blood mononuclear cells (PBMC) and their modulation by histamine in the present study. (elsevierpure.com)
AGE-2 and AGE-3 induced the expressions of ICAM-1, B7.1, B7.2, and CD40 on monocytes and the production of interferon-γ in PBMC. (elsevierpure.com)
To study how iodine and IFN-γ modulate the expression of ICAM-1, we analyzed NOD.H2 h4 thyrocytes in baseline conditions (day 0) and at several time points following supplementation of iodine in the drinking water. (johnshopkins.edu)
To distinguish whether the observed ICAM-1 increase was a direct effect of iodine or a consequence of the immune infiltrate, we treated mouse primary thyrocyte cultures with 0.01 mM sodium iodine and showed a 3-fold increased ICAM-1 expression. (johnshopkins.edu)
To assess interaction between IFN-γ and iodine, we analyzed CD45 and ICAM-1 expression on thyrocytes from NOD.H2 h4 wild-type and NOD.H2 h4 thyr-IFN-γ transgenic littermates. (johnshopkins.edu)
Strikingly, IFN-γ interacted synergistically with iodine to enhance ICAM-1 expression on thyrocytes. (johnshopkins.edu)
These findings suggest that iodine and IFN-γ cooperate to promote thyroidal expression of ICAM-1 in this mouse model of thyroiditis, highlighting the complex interplay present in the pathogenesis of Hashimoto's thyroiditis. (johnshopkins.edu)
Previous studies have shown dependence of intracellular adhesion molecule-1 (ICAM-1) expression in human umbilical vein endothelial cells (HUVEC) on shear stress and have indirectly linked ICAM-1 expression to spatial gradients in shear stress. (duke.edu)
0.01) was evident between ICAM-1 expression and the component of normal stress induced by the expansion. (duke.edu)
Thus, in this in vitro model, normal stress arising from sudden expansion flow modulates the effect of shear stress on ICAM-1 expression. (duke.edu)
In order to determine the effect of ultraviolet radiation (UVR) on the cell adhesion molecules expressed in human dermal microvascular endothelial cells (HDMEC), the cells were exposed to varying UVR doses and the cell surface was examined for expression of intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin. (elsevierpure.com)
UVA irradiation did not affect the surface expression of ICAM-1, VCAM-1, or E-selectin on the HDMEC. (elsevierpure.com)
However, following UVB exposure, ELISA demonstrated a significant increase in the baseline ICAM-1 cell surface expression on the HDMEC. (elsevierpure.com)
This study demonstrated that UVB irradiation can alter ICAM-1 and VCAM-1 expression on the HDMEC surface and that augmentation of ICAM-1 expression and the IL-1 α -dependent induction of VCAM-1 following UVB exposure might be important steps in the pathogenesis of sunburn. (elsevierpure.com)
Intercellular adhesion molecule 1 (ICAM-1), interleukin (IL)-8, and IL-6 levels in the supernatant of VSMCs were measured with enzyme-linked immunosorbent assay 0 and 24 h after grouping. (geneticsmr.com)
TDI asthmatic mice showed increase lung expression of VCAM and ICAM, adhesion molecules important for the recruitment of eosinophils and lymphocytes and disruption of IL-1 signaling prevented this effect. (cdc.gov)

Expression of stress proteins, adhesion molecules, and. (iifiir.org)
Expression of stress proteins, adhesion molecul. (iifiir.org)
Expression of stress proteins, adhesion molecules, and interleukin-8 in endothelial cells after preservation and reoxygenation. (iifiir.org)
Expression of stress proteins can be considered as a new parameter of preservation-associated endothelial activation. (iifiir.org)
Apart from possible protective effects, allograft vasculopathy could be in part a consequence of the antigenic potential of heat shock proteins connected with effects caused by adhesion molecules and inflammatory cytokines. (iifiir.org)
Essential for infectivity is a transmembrane adhesion complex called Nap comprising proteins P110 and P140. (nature.com)
The capability of bacteria to adhere and cause infection is associated with the expression of specific outer membrane proteins [ 14 ]. (biomedcentral.com)
In addition, the effect of the cytokine on components of functional epidermal barrier, tight junctions and adhesion/desmosomal proteins, has not been elucidated. (ox.ac.uk)
The cultures were exposed to cisplatin and cetuximab and the morphological changes of spheroids over time and the expression changes of target proteins were compared. (medsci.org)
These properties will act mediating the action of cell adhesion proteins, regulating cell behavior and causing tissue regeneration. (bvsalud.org)

Junctional adhesion molecule 3 (JAM3) is involved in epithelial cell junction, cell polarity, and motility. (bioone.org)
Pages that link to miR-145-dependent targeting of junctional adhesion molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness. (cu.edu.eg)

Administration of NMDA receptor antagonists upregulates the expression of the polysialylated form of the neural cell adhesion molecule (PSA-NCAM) in the adult hippocampus. (nih.gov)

Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. (jci.org)
Vascular cell adhesion molecule-1 (VCAM-1) plays important roles in development and inflammation. (escholarship.org)
After two, four and 24 hours, fluorescence activated cell sorter (FACS) analysis for vascular cell adhesion molecule-1, intercellular adhesion molecule-1 and E-selectin was performed. (biomedcentral.com)
CD11a/CD18 (LFA-1) expressed on lymphocytes is known to play an important role in lymphocyte trafficking (adhesion to vascular endothelium), as well as interactions to antigen presenting cells (APC). (medscape.com)
Serum levels of interleukin (IL) 1b, IL-6 and soluble vascular cell adhesion molecule-1 (sVCAM-1) were determined by ELISA. (ox.ac.uk)
Confocal image of the same artery showing expression of vascular cellular adhesion molecule-1 (VCAM-1, in red). (lu.se)

Integrin costimulatory signals modulate inflammatory gene expression, but the important control points between these pathways remain unresolved. (escholarship.org)
PAI-1 gene expression has been observed in various cell types, and many regulatory factors have been identified to play a role in PAI-1 gene transcription. (tmu.edu.tw)
The PAI-1 gene expression was induced only in adhered cells but not in non-adhered cells. (tmu.edu.tw)
Our experiment indicates that vitronectin and fibronectin, as components of ECM, may be the factors involved in the regulation of PAI-1 gene expression. (tmu.edu.tw)
This research demonstrates the significant increase of basal VCAM-1 gene expression as well as monocyte adhesion as substrate stiffness increases. (temple.edu)
Diphenylhydantoin plays a role in gene expression related to cytoskeleton and protein adhesion in human normal palate fibroblasts « Dott. (carinci.org)
GXD's primary emphasis is on endogenous gene expression during development. (jax.org)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
If expression of a trait requires only one copy of a gene (one allele). (msdmanuals.com)
The series of experiments revealed the feasibility of targeting platelet adhesion-associated gene therapy . (bvsalud.org)

The CD11/CD18 complex is part of the beta-2 integrin family and is important in adhesion and phagocytosis (see Table 1). (medscape.com)

However, tryptase was a more selective stimulus than TNF-alpha and did not induce increased expression of mRNA for granulocyte-macrophage CSF or stimulate the release of this cytokine. (eurekamag.com)
Expression of processing enzymes was also altered, indicating an indirect effect of the cytokine on filaggrin production/degradation. (ox.ac.uk)

Neutrophils were freshly isolated from blood of 10 male healthy volunteers, stimulated the same way as endothelial cells and analyzed for surface expression of L-selectin, CD11b and CD18. (biomedcentral.com)
We therefore studied the expression of CD54 and its ligands CD18 and CD11b/c in CSS in 10 rats with CSS, 6 rats immunized similarly who did not developed proteinuria (no-CSS group), and 10 normal rats (control group). (unab.edu.co)
We concluded that over-expression of CD54 and its ligands CD18 and CD11b/c in infiltrating leukocytes occur in CSS. (unab.edu.co)
1% expression of CD18). (medscape.com)
With this, we analyzed the phenotypes of CD34 + HSCs and showed that primitive HSCs or CD34 + CD33 - cells expressed adhesion molecules such as CD43, CD44, CD11a, CD11c, CD18, and leukocyte adhesion molecule (LAM-1). (elsevierpure.com)

PAI-1, as an inhibitor of the interaction between vitronectin and integrin αvβ3, may also be a regulator of its own expression. (tmu.edu.tw)

These 2 members mediate leukocyte adhesions to endothelial cells but they also serve as receptors for iC3b (inactivated C3b). (medscape.com)
shown to mediate adhesion of S. pneumoniae to eukaryotic cells ( 9 ). (cdc.gov)

The inhibitory effect of anti-RAGE IgG, a truncated form of the receptor (soluble RAGE) or N-acetylcysteine on VCAM-1 expression indicated that AGE-RAGE-induced oxidant stress was central to VCAM-1 induction. (jci.org)
Formal G protein-coupled signalling has been demonstrated for a number for adhesion GPCRs, however, the orphan receptor status of many of the receptors still hampers full characterisation of potential signal transduction pathways. (wikipedia.org)
Analysis of fungi showed that there were no secretin receptor family GPCRs, which suggests that they evolved from adhesion GPCRs in a later organism. (wikipedia.org)
whereas human epidermal growth factor receptor 2 (HER2)-positive breast cancers can be targeted by specific drugs, the triple-negative breast cancer phenotype is defined by chromosomal instability and low expression levels of estrogen receptor (ER) alpha, progesterone receptor (PR), and HER2, rendering treatment rather difficult. (dovepress.com)
Notwithstanding, to achieve the effectiveness and integration of the grafted tissue to the receptor site, it is necessary a strong cell adhesion, so that it demands many molecules interaction to induce cell differentiation and the bone matrix mineralization formed onto the graft. (bvsalud.org)
In normal breast epithelium, Wnt-5a is important for cell-ECM adhesion and activation of the collagen receptor DDR1. (lu.se)

We report that pharmacological FAK inhibition prevented TNF-α-induced VCAM-1 expression within heart vessel-associated endothelial cells in vivo, and genetic or pharmacological FAK inhibition blocked VCAM-1 expression during development. (escholarship.org)

We found that the colon cancer cell lines HCT-116 and HCT-15 exhibited a confluence-dependent increase in CD26 mRNA and protein, associated with decreased expression of c-Myc, increased USF-1 and Cdx 2 levels, and unchanged HNF-1α expression. (nih.gov)
CD26 mRNA and protein levels increase in a confluence-dependent manner in colon carcinoma cell lines, with c-Myc acting as a repressor and Cdx2 acting as an enhancer of CD26 expression. (nih.gov)
The mRNA expression-based NMF was used to reveal the potential role of platelet adhesion-related genes in COAD . (bvsalud.org)

JAM3 expression in cell-cell junctions decreased with the formation of syncytiotrophoblasts. (bioone.org)
Furthermore, H 2 O 2 -induced oxidative stress reduced JAM3 expression in trophoblasts and cell culture supernatants. (bioone.org)
Activated by cytokines and chemokines, leukocytes and endothelial cells express distinct adhesion molecules on their cell surfaces [ 9 ]. (biomedcentral.com)
Ligand profiles and in vitro studies have indicated a role for adhesion GPCRs in cell adhesion and migration. (wikipedia.org)
Moreover, growing evidence implies a role of adhesion GPCRs in tumour cell metastasis. (wikipedia.org)
Adhesion GPCRs get their name from their N-terminal domains that have adhesion-like domains, such as EGF, and the belief that they interact with cell to cell and cell to extra cellular matrix. (wikipedia.org)
cancer cell growth and spreading, it has also been proposed that GPR56 regulates cell adhesion, but this has remained untested in the nervous system. (jneurosci.org)
FAK expression was 3.0-fold higher in the SCC15 cell line and 5.0-fold higher in the SCC25 cell line compared with normal epithelial cells. (elsevierpure.com)
In the highly invasive SCC25 cell line, FAK expression was 1.5-fold higher compared with the less invasive SCC15 cell line. (elsevierpure.com)
Meanwhile, ectopic expression of c-Myc in both cell lines led to decreased CD26 expression. (nih.gov)
Western blotting was used for protein expression analysis of the collected cell masses (spheroids), and H-E staining was used for structural observation. (medsci.org)
Each cell line formed spheroidal cell aggregates and showed enhancement of cell adhesion molecules over time. (medsci.org)
Cisplatin showed concentration-dependent antitumor effects due to loss of cell adhesion and spheroid disruption in each cell line, while cetuximab exhibited antitumor effects that correlated with EGFR expression in each cell line. (medsci.org)
Cell Adhesion and Growing Assay HeLa cells had been detached from meals in PBS including 5 mm EDTA and gathered by centrifugation. (gasyblog.com)
This study was performed to determine if PGG altered calcium oxalate monohydrate (COM) crystal adhesion to cells, perhaps via a change in cell surface properties. (elsevierpure.com)
PGG also inhibited cell migration after scrape-wounding, decreased subsequent adhesion of crystals to proliferating and migrating cells, and decreased expression of the crystal binding molecule hyaluronan. (elsevierpure.com)
Anti-crystal adhesion effects appear multifaceted involving crystal coating by PGG, as well as decreased cell migration and the associated surface expression of hyaluronan. (elsevierpure.com)
Expression of cadherin/catenin cell--cell adhesion molecules in a onychomatricoma. (medscape.com)
In conclusion, the current study revealed the expression profiles of human TRP channels in 60 different breast cancer tissues and cell lines and furthermore validated the antitumor activity of TRPV1 against SUM149PT breast cancer cells, indicating that activation of TRPV1 could be used as a therapeutic target, even in the most aggressive breast cancer types. (dovepress.com)
In order to be effective and integrated to the receiving area, the bone graft is required to allow a strong cell adhesion, interacting with several molecules to induce migration, differentiation, and thus the mineralization of the new bone on the graft. (bvsalud.org)
This paper is a systematic review of the literature on the mechanisms of cell adhesion to bone grafts associated to nanotechnology, describing the importance and the role of those molecules in the adhesion and thus in tissue regeneration. (bvsalud.org)
After the use of search strategies, 18 articles that describe processes of cell adhesion to bone grafts were selected. (bvsalud.org)
Accurate identification of these mechanisms of cell adhesion is essential for further advancement in tissue engineering, such as the production of biological bone substitutes that achieve a better clinical outcome. (bvsalud.org)

Work utilizing genetic models confined this concept by demonstrating that the primary function of adhesion GPCRs may relate to the proper positioning of cells in a variety of organ systems. (wikipedia.org)

It is a defect in the expression of ligands for selectins due to lack of enzymes required for expression of selectin ligands. (medscape.com)

To clarify the role of adhesion molecules in HSCs, we examined the colony forming capacity after long-term culture with allogeneic irradiated stromal layers. (elsevierpure.com)

Invasion assays after transfections were used to assess the effect of increased FAK expression on invasive potential of oral tumor cells. (elsevierpure.com)
The current results suggest that enhanced expression of FAK in oral carcinoma cells may lead to a selective growth advantage and increased invasive potential of the primary oral tumor. (elsevierpure.com)

Effects of atorvastatin on endothelial function and the expression of proinflammatory cytokines and adhesion molecules in young subjects with successfully repaired coarctation of aorta. (ox.ac.uk)

The capability to adhere to epithelial cells is a key virulence trait, and genes codified in LAA pathogenicity island could be involved in the adhesion during the pathogenesis of LAA-positive STEC strains. (biomedcentral.com)
These genes are encoded in LAA, and are virulence factors that participate in adhesion and autoaggregation. (biomedcentral.com)
Genes encoded in LAA contribute to the adhesion phenotype though the expression of STEC adhesins is a coordinated event that depends not only the strain but also on the environment as well as its genetic background. (biomedcentral.com)
Genes codified in LAA could be involved in the adhesion during the pathogenesis of LAA-positive STEC strains, and little is known about the specific virulence factors that contribute to these pathogeneses. (biomedcentral.com)
IL-17 downregulates filaggrin and affects keratinocyte expression of genes associated with cellular adhesion. (ox.ac.uk)
Moreover, expression of many genes involved in cellular adhesion was also decreased. (ox.ac.uk)
We conclude that IL-17A downregulates the expression of filaggrin and genes important for cellular adhesion which could affect epidermal barrier formation. (ox.ac.uk)
Significance of platelet adhesion-related genes in colon cancer based on non-negative matrix factorization-based clustering algorithm. (bvsalud.org)
Furthermore, platelet adhesion-related genes are gaining attention as potential regulators of tumorigenesis . (bvsalud.org)
The present study aims to investigate the underlying mechanisms of platelet adhesion-related genes in COAD patients . (bvsalud.org)
Then, the differentially expressed platelet adhesion-related genes of COAD were analyzed using the TCGA database, and patients were further classified by employing the non-negative matrix factorization (NMF) analysis method . (bvsalud.org)
High platelet counts are associated with worse survival in real-world patients , and alternations to platelet adhesion-related genes have resulted in poorer prognoses , based on online data. (bvsalud.org)
Based on platelet adhesion-related genes , patients with COAD were classified into two clusters by NMF-based clustering analysis . (bvsalud.org)
Finally, a prognostic nomogram , which included the ALOX12 and ACTG1 genes , was established based on the platelet adhesion-related genes , with a concordance (C) index of 0.879 (0.848-0.910). (bvsalud.org)

Adhesion G protein-coupled receptors (adhesion GPCRs) are a class of 33 human protein receptors with a broad distribution in embryonic and larval cells, cells of the reproductive tract, neurons, leukocytes, and a variety of tumours. (wikipedia.org)
There are 33 human adhesion GPCRs that can be broken down in the 8 groups and 2 independent receptors. (wikipedia.org)
As of today, many of the adhesion GPCRs are still orphan receptors and their signalling pathways have not been identified. (wikipedia.org)

Restitution of Wnt-5a signalling in breast tumour cells confer better adhesion and ability to activate DDR1 as well as a less malignant-looking phenotype. (lu.se)

Colon adenocarcinoma cells were grown to confluence, and expression of CD26 and transcription factors implicated in its regulation was confirmed by immunofluorescence and Western blotting. (nih.gov)
The enhanced expression of CD26 in serum-depleted media and a requirement for HIF-1α suggest a role for nutrients or growth factors in the regulation of CD26 protein expression. (nih.gov)

At the age of defect onset, GPR56 expression is restricted specifically to developing granule cells in the rostral cerebellum, suggesting that GPR56 regulates properties of these cells. (jneurosci.org)
Interference RNA-mediated knockdown of GPR56 recapitulates the loss of adhesion seen in knock-outs, and reexpression of GPR56 rescues the adhesion defect in knock-out granule cells. (jneurosci.org)

Flow cytometric analysis of the HDMEC stimulated with IL-1 α for 24h demonstrated that 12% of the cells expressed VCAM-1 but either IL-1 α or UVB irradiation alone failed to induce VCAM-1 expression. (elsevierpure.com)

These data are consistent with the hypothesis that AGE-RAGE interaction induces expression of VCAM-1 which can prime diabetic vasculature for enhanced interaction with circulating monocytes. (jci.org)

A deep understanding of the Nap structure and adhesion mechanism will facilitate the development of anti-adherence therapies. (nature.com)
Here, we address the structure and mechanism of the Nap adhesion complex and reveal an intricate interplay between P110 and P140. (nature.com)
Our work evaluates the mechanism involved in confluence-dependent CD26 expression in colon cancer. (nih.gov)
Increased expression of adhesion molecules represents a plausible mechanism. (cdc.gov)

It is clear that Th1/Th2 bias influences expression of the protein, but an analysis of the effects of interleukin-17 (IL-17) on the expression of the protein and profilaggrin-processing enzymes has not yet been reported. (ox.ac.uk)

Normal and shear stresses influence the spatial distribution of intracellular adhesion molecule-1 expression in human umbilical vein endothelial cells exposed to sudden expansion flow. (duke.edu)

Sparstolonin B improved inflammatory responses and oxidative stress by inhibiting the NLRP3 inflammasome, inhibiting the expression of FucT-V and downregulating the TLR4/MYD88/NF-𝜅B signaling pathway in order to rescue RA. (hindawi.com)

Exposure of cultured human ECs to AGEs induced expression of VCAM-1, increased adhesivity of the monolayer for Molt-4 cells, and was associated with increased levels of VCAM-1 transcripts. (jci.org)
Therefore, we investigated the in vitro effect of DHEA on the expression pattern of adhesion molecules of human endothelial cells and neutrophils. (biomedcentral.com)
These adhesion molecules enable the deceleration of blood cells on the endothelial layer in order to enable subsequent diapedesis. (biomedcentral.com)
The human pathogen Mycoplasma genitalium , a member of the pneumoniae cluster of mycoplasmas, binds to eukaryotic cells by means of its adhesion complex, the Nap. (nature.com)
Thus, our objectives were to compare hes -negative and hes -positive STEC strains in their adherence capability to epithelial cells (HEp-2) and to evaluate the expression levels of the hes , iha , and tpsA in the bacteria adhered and non-adhered to HEp-2 cells. (biomedcentral.com)
These results support a novel hypothesis that the cerebellar defects in Gpr56 knock-outs, and potentially in human patients with GPR56 mutations, arise from the disrupted adhesion of developing granule cells to the pial BM. (jneurosci.org)
While HIF-1α level also increased when cells were cultured in serum-depleted media, its expression was required but not sufficient for CD26 upregulation. (nih.gov)
PGG exerted anti-adhesion effects whether cells or crystals were pre-coated. (elsevierpure.com)
The administration of Sparstolonin B inhibited the secretion of IL-17 from Th17 cells and triggered the secretion of TGF- β from Treg cells, thus leading to the reduced expression of TLR4, MyD88, and NF- κ B, and the suppression of TNF- α secretion. (hindawi.com)
Higher magnification of the same region, showing very high levels of VCAM-1 and adhesion of immune cells (arrows) at the plaque edges, also areas of turbulent blood flow. (lu.se)

The purpose of the current study was to determine whether elevated FAK expression in oral malignancies was associated with increased invasiveness and oral carcinoma. (elsevierpure.com)
Immunohistochemical analysis was used to assess levels of FAK expression in archived oral carcinoma tissue samples. (elsevierpure.com)
This study focused on the expression and functionality of TRPV1, a nonselective cation channel that was found to be expressed in different carcinoma tissues. (dovepress.com)

We found that Wnt-5a protein expression is reduced in many invasive breast carcinomas and that reduced Wnt-5a expression in the primary tumour strongly correlates with an increased risk of metastatic disease and shorter survival. (lu.se)

Nucleotide-binding oligomerization domain 1 (NOD1) modulates liver ischemia reperfusion through the expression adhesion molecules. (univ-lille.fr)
GSTM1 Modulates Expression of Endothelial Adhesion Molecules in Uremic Milieu. (cdc.gov)

Scope includes mutations and abnormal protein expression. (cancerindex.org)

These studies establish a novel role for GPR56 in the adhesion of developing neurons to basal lamina molecules and suggest that this adhesion is critical for maintenance of the pia and proper cerebellar morphogenesis. (jneurosci.org)

While it is well established that the pathogenesis of these diseases varies, both are characterized by impairment in epidermal barrier function and abnormal IL-17 expression in the skin and peripheral blood. (ox.ac.uk)
NOD.H2 h4 mice spontaneously develop autoimmune lymphocytic thyroiditis that mimics human Hashimoto's thyroiditis, a disease where iodine, IFN-γ, and adhesion molecules have all been implicated in the pathogenesis. (johnshopkins.edu)

however, no study has examined the expression profiles of human TRP channels in breast cancer on a large scale. (dovepress.com)

2 - 4 Expression profiling on a genomic scale led to the classification of the intrinsic subtypes of breast cancer, thus allowing for the prediction of disease progression and patient stratification. (dovepress.com)

The expression of Wnt-5a protein co-variates with that of Syk, a tyrosine kinase that is lost in up to 30% of invasive breast carcinomas and associated with poor prognosis. (lu.se)

Anatomy41

Organisms6

Diseases7

Chemicals and Drugs125

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes50

Disciplines and Occupations2

Technology, Industry, Agriculture6

Information Science4

Molecule expression4

Leukocyte adhesion d19

Focal6

Neuronal cell adh2

Extracellular8

Endothelial cell3

ICAM17

Proteins10

Junctional adhesion molecule2

Neural cell adh1

Vascular6

Gene10

Beta-2 integrin family1

Cytokine2

CD185

Integrin1

Mediate2

Receptor6

Blocked VCAM-1 expression1

MRNA3

Cell23

Function of adhesion1

Ligands1

Role of adhesion1

Tumor2

Cytokines1

Genes14

Receptors3

Phenotype1

Regulation2

Defect2

Induce1

Induces expression1

Mechanism4

Interleukin1

Intracellular1

Oxidative1

Cells10

Carcinoma3

Tumour1

Modulates2

Protein expression1

Neurons1

Pathogenesis2

Human1

Disease Progression1

Tyrosine kinase1