Expression micro rna that regulates. Medical search. Frequent questions

Recent genome-wide molecular genetic studies have identified several protein-coding genes and microRNAs (miRNAs) significantly associated with BD. (en-journal.org)
These miRNAs are around 22 nucleotides in size that are central and negative regulators of gene expression. (mbpinc.net)
Moreover, the block expression at the post-transcriptional levels and transcriptional levels, on the basis of perfect or imperfect match in sequences among miRNAs and target genes is also there. (mbpinc.net)
These miRNAs are known to be the "epigenetic controllers" since they impact gene expression without brining any changes in the genomic sequence. (mbpinc.net)
Changed and manipulated expression of miRNAs is commonly seen in several pathological conditions like cancer. (mbpinc.net)
Also, miRNAs have the ability to influence the expression of several targets. (mbpinc.net)
As a result, the gene targets can be regulated with the help of a plethora of different miRNAs, simultaneously. (mbpinc.net)
Scientists further worked showed that despite of the differences between cell lines in the gene expression level, the miRNAs-gene network is very slightly influenced or disrupted in these pathways. (mbpinc.net)
This also showed that there is an inverse correlation between methylation statuses of the above mentioned miRNAs along with the expression of their gene targets. (mbpinc.net)
All in all, the data shows a very complex, multi-level interaction of all the epigenetically changed and influenced miRNAs that weren't able to completely regulate the cell cycle. (mbpinc.net)
Our laboratory has reported that microRNAs (miRNAs) are differentially expressed in CD. (elsevierpure.com)
This study was designed to determine whether miRNAs regulate NOD2 expression as well as downstream nuclear factor kappaB activation and inflammatory responses in colonic epithelial HCT116 cells. (elsevierpure.com)
Regulation of NOD2 expression by miRNAs was determined by luciferase reporter construct assays and transfection of specific miRNA mimics. (elsevierpure.com)
Conclusions: To our knowledge, this is the first report demonstrating that miRNAs regulate NOD2 and its signaling pathway. (elsevierpure.com)
Four miRNAs downregulate NOD2 expression, suppress NF-κB activity, and inhibit interleukin-8 and CXCL3 messenger RNA expression. (elsevierpure.com)
miRNAs are a family of small non-coding RNAs that emerged as significant and versatile regulators involved in regulation of immune responses. (frontiersin.org)
MicroRNAs (miRNAs) are highly conserved, single-stranded, small non-coding RNAs that have been shown to act as essential regulators of gene expression at the posttranscriptional level. (frontiersin.org)
This study aimed to identify the role of AA in oxidized low-density lipoprotein (ox-LDL)-induced vascular smooth muscle cell (VSMC) behaviours and to explore the effects of microRNAs (miRNAs). (hindawi.com)
MicroRNAs (miRNAs) are small noncoding sequences involved in the negative regulation of gene expression. (hindawi.com)
Several studies have shown that miRNAs play multiple roles in the phenotypic transformation, migration, and proliferation of VSMCs by inhibiting ERK1/2 activation [ 11 , 12 ], partly by regulating the tissue inhibitor of metalloproteinases (TIMPs)-MMPs and p21-cyclins interactions [ 13 - 18 ]. (hindawi.com)
microRNAs (miRNAs) are important regulators of target messenger RNA translation by binding mainly to complementary sequences of the 3′ untranslated region of target messenger RNA transcripts thereby leading to RNA degradation and/or inhibition of protein synthesis [ 4 ]. (hindawi.com)
MicroRNAs (miRNAs) are short (21-24 nucleotides) sequences of RNA that reduce gene expression by promoting the breakdown of messenger RNAs (mRNAs) and by repressing translation of mRNAs into proteins. (freethoughtblogs.com)
We show that, similar to metazoan steady-state systems, endogenous miRNAs in Chlamydomonas can regulate gene expression both by destabilization of the mRNA and by translational repression. (freethoughtblogs.com)
The miRNAs are small stretches of RNA made by host cells to regulate gene expression. (feedstuffs.com)
To see if RNA viruses other than hepatitis C use host miRNA, the researchers developed a screening method that chemically attaches those miRNAs to their targets. (feedstuffs.com)
Micro RNAs (MiRNAs) are endogenous, small RNA molecules that were identified in a wide range of eukaryotes. (usda.gov)
About 30% of the human protein-coding genes are negatively regulated by miRNAs which suggests that they have a major role in regulating gene expression. (usda.gov)
We now have identified and characterized 54 miRNAs from rainbow trout somatic tissues and profiled their expression patterns. (usda.gov)
The majority of the miRNAs showed characteristic tissue-specific expression patterns suggesting potential roles in maintaining tissue identity. (usda.gov)
MicroRNAs (miRNAs) are short non-coding RNAs, which are shown to post-transcriptionally regulate gene expression. (qiagen.com)
MicroRNAs (miRNAs) are small noncoding RNAs that can post-transcriptionally regulate gene expression. (tufts.edu)
First, with a profiling study, I identified a unique pattern of viral miRNA expression by normal persistently infected primary B cells in vivo and a subset of miRNAs that might be associated with cell growth and are deregulated in tumors. (tufts.edu)
In all, these studies on expression profiles and molecular functions of EBV miRNAs provide significant insights into the role of EBV in persistent infection and oncogenesis. (tufts.edu)
MicroRNAs (miRNAs) são pequenos RNAs não-codantes, conservados ao longo da evolução, capazes de regular a expressão gênica através da degradação ou repressão da tradução de moléculas-alvo de RNA mensageiro. (bvsalud.org)
O presente estudo realiza uma revisão da literatura sobre miRNAs, enfocando aspectos relacionados à biogênese, mecanismos de ação e o papel potencial desses pequenos RNAs na carcinogênese oral. (bvsalud.org)
Thus, is not completely clear whether the altered expression of miRNAs is cause or consequence of malignant transformation. (bvsalud.org)
Como os miRNAs podem regular mais de um RNAm-alvo 33 , estima-se que estes pequenos RNAs controlem a expressão de aproximadamente 30% dos genes que codificam proteínas 23 . (bvsalud.org)
O presente estudo realiza uma revisão da literatura sobre miRNAs, enfocando aspectos relacionados à biogênese, mecanismos de ação e o papel potencial dessas pequenas moléculas de RNA na carcinogênese oral. (bvsalud.org)
This thesis focuses on microRNAs (miRNAs), which modulate gene expression in healthy and tumour cells. (lu.se)
that asthma is intensively regulated by a variety of microRNAs (miRNAs). (cdc.gov)
MiRNAs are approximately 19- to 25-nucleotide estimated about 250,000 and mortality does not appear single-stranded, noncoding RNAs that exist in both to correlate well with prevalence. (cdc.gov)
Th)1 cells.5 Meanwhile, the function and immunity of with genetic predisposition, involving multiple cells, DCs are closely regulated by miRNAs. (cdc.gov)
To understand the functional analyses of miRNAs and their role in neural stem cells by characterizing and identifiying known and novel RNAs bound to the mouse and human RNA induced Silencing Complex in various cell types of the brain. (lu.se)
MicroRNAs (miRNAs) are an integral part of the post-transcriptional machinery of gene expression and have been implicated in the carcinogenic cascade. (cdc.gov)
DEFB1 expression after transfection with two micro RNAs (miRNAs), hsa-miR-186-5p and hsa-miR-340-5p, provided evidence that DEFB1 expression could be modulated by these miRNAs and hsa-miR-186-5p had a higher binding efficiency with DEFB1. (cdc.gov)
Simple Summary: This study identified a set of 73 microRNAs (miRNAs) that can accurately detect lung cancer tumors from normal lung tissues. (cdc.gov)
Based on the consistent expression patterns associated with patient survival outcomes and in tumors vs. normal lung tissues, 10 miRNAs were considered to be putatively tumor suppressive and 4 miRNAs were deemed as oncogenic in lung cancer. (cdc.gov)
This study identified a set of 73 microRNAs (miRNAs) that classified lung cancer tumors from normal lung tissues with an overall accuracy of 96.3% in the training patient cohort (n = 109) and 91.7% in unsupervised classification and 92.3% in supervised classification in the validation set (n = 375). (cdc.gov)
Experimentally confirmed target genes were identified for the 73 diagnostic miRNAs, from which proliferation genes were selected from CRISPR-Cas9/RNA interference (RNAi) screening assays. (cdc.gov)

The mir-10 microRNA precursor is a short non-coding RNA gene involved in gene regulation. (wikipedia.org)
It is part of an RNA gene family which contains mir-10, mir-51, mir-57, mir-99 and mir-100. (wikipedia.org)
Expression of miR-10ba in mouse embryos shows a similar pattern to that of the Hoxb4 gene. (wikipedia.org)
As a result, the functionalities of DNA methylation are highly dependent on context and therefore have a completely opposite impact on gene expression, especially if it happens in the promoter of a coding gene or a miRNA. (mbpinc.net)
This reveals that DNA methylation regulates gene expression on a rich profusion of levels, and regulates cell homeostasis along with cancer progression. (mbpinc.net)
A single-nucleotide polymorphism (rs3135500) located in the NOD2 3'-untranslated region significantly reduced miR-192 effects on NOD2 gene expression. (elsevierpure.com)
Regulatory non-coding RNAs and RNA-binding proteins (RBPs) are important research areas in gene regulation and RNA biology. (rochester.edu)
Our laboratory is interested in the understanding of pathophysiological function and molecular mechanism of new non-coding RNAs (and RBPs) and new modes of gene regulation in c. (rochester.edu)
We also identified a novel mRNA processing mechanism that expands human proteome at the posttranscriptional level and regulates gene expression (Yao, P, et al. (rochester.edu)
The long-term objective of our laboratory is to identify novel RNA-based molecular mechanisms that control gene expression and conduct pathophysiological function in cardiac system, as well as to develop novel therapeutic approaches for the prevention or treatment of human cardiovascular diseases. (rochester.edu)
MicroRNAs, as their name implies, are small RNAs that provide an essential regulation of gene expression by controlling translation of protein expressing messenger RNAs. (rvc.ac.uk)
miR-128-5p directly targeted the 3′UTR-binding sequences of the p21 gene, negatively regulated p21 expression, and supported the proliferation of VSMCs. (hindawi.com)
The immune-related DEOSGs and hub genes were identified by weighted gene co-expression network analysis (WGCNA) and protein-protein interaction (PPI) analysis, respectively. (nature.com)
Oxidative stress is involved in the modulation of gene expression patterns and metabolic activities, characterized by the disruption of redox homeostasis 7 . (nature.com)
To do this, the scientists based their sequence inputs on microRNA, small RNA molecules that regulate cellular gene expression. (udel.edu)
One of the biggest changes in evolutionary theory in the late 20th century was the growing appreciation for the central role of changes in gene expression in macroevolution. (freethoughtblogs.com)
We have only known that microRNAs even existed since the early 1990's, and their importance in gene regulation and development wasn't appreciated until the 2000's. (freethoughtblogs.com)
Although they are structurally similar, plant and animal microRNAs repress gene expression through very different mechanisms. (freethoughtblogs.com)
Weighted gene co‑expression network analysis was performed, and a protein‑protein interaction network was constructed and further analyzed using Cytoscape and STRING. (spandidos-publications.com)
Comparative Toxicogenomics Database and TargetScan were used to identify the hub‑gene‑related diseases and the microRNAs that regulated the central hub genes. (spandidos-publications.com)
MicroRNAs are tiny ribonucleic acid (RNA) molecules (~22 nucleotides long) that recently have been found to play important roles in regulating gene expression in eukaryotic organisms, including plants and animals. (sciencedaily.com)
The complex then cleaves the mRNA into smaller pieces, thereby preventing translation of the protein it encodes, and thus inhibiting or "silencing" gene expression. (sciencedaily.com)
There are many AGO1-like proteins in animals and other eukaryotes as well, indicating that the RNA-induced silencing complex is of ancient evolutionary origin, and that microRNA-mediated regulation of gene expression is shared among many eukaryotes. (sciencedaily.com)
Background: MicroRNAs (miRNA) are small, highly conserved, non-coding RNAs that regulate gene expression of target mRNAs through cleavage or translational inhibition. (usda.gov)
miRNA expression in malignant cells is often related to alterations in miRNA copy numbers and gene locations. (qiagen.com)
Estrogen receptor alpha mutations regulate gene expression and cell growth in breast cancer through microRNAs. (utah.edu)
Total RNA was isolated from whole lung 24 and 48 hours post final exposure and was further processed for gene expression and microRNA array analysis. (cdc.gov)
Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
In the last decade, diagnostic and prognostic evaluation has been facilitated by global gene expression profiling (GEP), provid- ing a new powerful means for the classification, prediction of survival, and response to treatment of lym- phomas. (lu.se)
The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treat- ment. (lu.se)
MicroRNAs (miRNA) are small noncoding RNAs, preserved throughout the evolution, able to regulate gene expression through repression of translation or degradation of target molecules of messenger RNA. (bvsalud.org)
Although more and animals and plants and regulate gene/protein expression more progressions have been made about the through direct complementarity between their 5' region pathogenesis of asthma in recent years, the increasing and the 3' untranslated region of target mRNAs. (cdc.gov)
A gene, the basic unit of heredity, is a segment of DNA containing all the information necessary to synthesize a polypeptide (protein) or a functional RNA molecule. (msdmanuals.com)
A gene is a segment of DNA that provides the code to construct a protein or RNA molecule. (msdmanuals.com)
We are interested in how gene expression is regulated in the brain and how this process influence neurodegenerative diseases, psychiatric disorders and brain tumors. (lu.se)
Significant downregulation of beta-defensin1 gene (DEFB1) expression was observed when human bronchial epithelial cells (HBEpCs) were exposed to IAV. (cdc.gov)
We detail how influenza viruses evade the host changes in host gene expression. (cdc.gov)

Immunohistochemical staining was performed to confirm the expression of related proteins in OA and non‑OA tissue samples. (spandidos-publications.com)
Research reported in The Plant Cell shows that microRNAs control the accumulation of transcription factor proteins that regulate the expression of genes in the auxin response pathway. (sciencedaily.com)
Messenger RNA (mRNA) molecules are encoded by genes and are themselves templates for the proteins that carry the main metabolic functions in a cell. (sciencedaily.com)
Thus, we compared the expression profile of 24 selected miRs in IFN-β-treated Huh-7 cells and in three different clones of Huh-7 cells carrying a self-replicating HCV RNA which express all viral proteins (HCV replicon system). (biomedcentral.com)
Degradation of cellular proteins in the ubiquitin-proteasome system regulates various biological processes. (helsinki.fi)
MicroRNA is a type of RNA, a chemical cousin of DNA, that attaches to a protein's blueprint (a molecule called messenger RNA) and blocks the production of proteins from it. (medlineplus.gov)
In Paper I, we showed that miR-96 can upregulate the mRNA and protein expression of adhesion proteins E-Cadherin and EpCAM through direct interaction with target sites in the mRNA coding sequence. (lu.se)

miRNA binding downregulates the expression of target mRNAs either by decreasing their stability or by inhibiting translation. (en-journal.org)
RNA extraction kits are used to enable the total RNA extraction from tissues and other places.They apply their abilities and functions with the help of base-pairing using 3'UTR if mRNAs. (mbpinc.net)
mRNAs corresponding to several regulatory genes that mediate auxin responses contain short stretches of sequence that are complementary to microRNAs, and therefore have been considered potential targets of microRNA-mediated regulation. (sciencedaily.com)
The plants showed increased accumulation of ARF17 mRNA and altered levels of mRNAs corresponding to several genes that may be regulated by ARF17. (sciencedaily.com)

Circulating extracellular RNAs (ex-RNAs) are an emerging class of biomarkers with target-organ epigenetic effects. (researchgate.net)
Furthermore, altered microRNAs may serve as potential biomarkers to evaluate fungal exposure. (cdc.gov)
Our findings suggest differential expression of microRNAs in the islets during development of type 2 diabetes, and that microRNAs can be utilized as therapeutic targets in the islets or as blood-based biomarkers for disease detection. (lu.se)
To decipher human islet microRNA networks and blood-based microRNA biomarkers to disclose central microRNAs in diabetes development. (lu.se)

Using RNA-Seq, we identified a total of 163 and 568 differentially expressed genes in primary normal human bronchial epithelial (NHBE) cells that were exposed to diacetyl and 2,3-pentanedione, respectively. (nature.com)
We predict several transcription factors to regulate differentially expressed genes between mLT-HSCs and other LT-HSC subsets. (biorxiv.org)
Conclusion and Clinical Relevance: Examination of the pulmonary genetic profiles revealed differentially expressed genes and microRNAs following subchronic inhalation exposure to A. fumigatus. (cdc.gov)

Previously it was known that microRNAs were important for the development of a subset of helper T cells called regulatory T cells, which are required to regulate the immune response and prevent attacks against host tissue that lead to autoimmunity. (rvc.ac.uk)

The group calculated how nucleotides should be arranged to activate the cancer prodrug in the presence of cancer microRNA, but stay inactive and non-toxic in a non-cancerous environment where the microRNA are missing. (udel.edu)

Thus, to maintain a balance between host preservation and inflammatory pathology, the immune response and inflammation need to be tightly regulated. (frontiersin.org)
Extracellular small non-coding RNAs (exRNAs) have been associated with cardiac inflammation and fibrosis and we hypothesized that they are associated with post-MI LVRm phenotypes. (researchgate.net)
INKILN is a Novel Long Noncoding RNA Promoting Vascular Smooth Muscle Inflammation via Scaffolding MKL1 and USP10. (harvard.edu)
Dr. Unwalla's laboratory focuses on the role of small RNA molecules called microRNAs in promoting diseases attributed to inflammation. (fiu.edu)
These factors may regulate myeloid versus lymphoid balance with age, and can potentially mitigate the long-term deleterious effects of inflammation that lead to hematopoietic pathologies. (biorxiv.org)
Klf5 , Ikzf1 and Stat3 regulate age‐ and inflammation-related LT-HSC myeloid-bias. (biorxiv.org)
MicroRNAs not only participate in determining DCs phenotype and then naive T lymphocyte differentiation, but also participate in the regulation of airway inflammation and airway remodeling in asthma. (cdc.gov)

Inhibition of the microRNAs was sufficient to induce EMT in a process requiring upregulation of ZEB1 and/or SIP1. (nih.gov)

miRNA microarray profiling was performed using Lianchuan biological small RNA sequencing analysis. (hindawi.com)
Recently, it has been proposed that also microRNAs (miRs), a class of small non-coding regulatory RNAs, are involved in the antiviral pathway induced by IFN-β treatment. (biomedcentral.com)
This study performs a literature review of miRNA, focusing on aspects related to biogenesis, mechanisms of action and potential role of these small RNAs in oral carcinogenesis. (bvsalud.org)

Here we describe how microRNA-regulated lentiviral vectors can be used to visualize specific cell populations by exploiting endogenous microRNA expression patterns. (lu.se)

Consistent with this, qRT-PCR confirmed that the expression of multiple genes involved in cilia biogenesis was significantly downregulated by diacetyl and 2,3-pentanedione in NHBE cells. (nature.com)
One of these targets is the transcription factor AUXIN RESPONSE FACTOR17 (ARF17), which is thought to repress the expression of a number of other genes involved in auxin responses. (sciencedaily.com)
MicroRNAs regulating genes involved in the pulmonary immune responses were those with the greatest fold change. (cdc.gov)

Auxin influences development by affecting the expression of numerous genes that control the processes of cell division and cell expansion in specific plant tissues at specific stages during the plant life cycle - e.g. for leaves, roots, and floral organs to develop in the correct patterns and correct time sequence. (sciencedaily.com)
Real-time PCR was used to measure miRNA expression patterns in adult somatic tissues and unfertilized eggs. (usda.gov)

MicroRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. (wikipedia.org)
MicroRNAs are ~22 nucleotide long RNA molecules that provide substrate specificity to a protein complex known as the RNA-induced silencing complex. (sciencedaily.com)

Now, the same team - including researchers in the laboratories of Charles M. Rice, the Maurice R. & Corinne P. Greenberg professor and head of the Laboratory of Virology & Infectious Disease, and Robert B. Darnell, the Robert & Harriet Heilbrunn professor and head of the Laboratory of Molecular Neuro-oncology - has found evidence that another RNA virus - bovine viral diarrhea (BVD) virus, which infects cows and other livestock - also depends on miRNA for infection. (feedstuffs.com)

Furthermore, we demonstrated that miR-21 regulates inflammatory responses through NF-κB signaling pathways. (frontiersin.org)
In addition, Ingenuity Pathway Analysis (IPA) integrated with PCR array data showed that the JAK1/STAT3 pathway was significantly altered in cells overexpressing DEFB1, suggesting this to be one of the pathways by which defensin regulates IAV replication in HBEpCs. (cdc.gov)

In this article the researchers describe their identification of important individual microRNAs and relevant genes they regulate to control regulatory T cell development. (rvc.ac.uk)
MicroRNA-15b/16 Enhances the Induction of Regulatory T Cells by Regulating the Expression of Rictor and mTOR. (rvc.ac.uk)

Methods: NOD2 and miRNA expression in stimulated HCT116 cells were assessed by quantitative reverse transcription-polymerase chain reaction. (elsevierpure.com)
Results: Muramyl dipeptide-induced increases in NOD2, interleukin-8, and CXCL3 expression were inversely associated with miRNA expression. (elsevierpure.com)
Deregulation of miRNA expression has been found to contribute significantly to the pathogenesis, progression and prognosis of many types of cancer. (qiagen.com)

The results of the present study indicate that microRNAs play important roles in regulating asthma immune responses. (cdc.gov)

During his post-doctoral training under Dr. Paul Fox at Lerner Research Institute of Cleveland Clinic, he made contributions in understanding the translational control mechanisms regulating VEGFA (vascular endothelial growth factor-A) expression in human monocytes. (rochester.edu)
The mRNA levels in a cell are fine tuned by different mechanisms, one of which is driven by microRNA molecules. (sciencedaily.com)
Our current focus is to study the role of epigenetic mechanisms and microRNAs. (lu.se)

Several studies demonstrate important associations between differential expression of micro-RNAs (miRs) and the prognosis of CRC. (biorxiv.org)

MicroRNAs participate in the regulation of asthma, the goal of this study is to summarize recent researches on the roles of microRNAs in the pathogenesis of asthma. (cdc.gov)

Finally, we constructed the drug, transcription factors (TFs), and microRNA network of the diagnostic genes. (nature.com)
In a PCR array analysis of 84 transcription factors, either overexpressing DEFB1 or siRNA silencing of DEFB1 expression significantly modulated the expression of signal transducer and activator of transcription 3 (STAT3). (cdc.gov)

Consistent with their role in regulating EMT, expression of these microRNAs was found to be lost in invasive breast cancer cell lines with mesenchymal phenotype. (nih.gov)
However, changes in expression of miRNA may be secondary to the tumor phenotype. (bvsalud.org)

Through experiments using RNA interference ( RNAi ) of LanA, we found that its depletion phenocopied the effects in miR-263b-overexpressing flies . (bvsalud.org)

Together, these microRNAs cooperatively regulate expression of the E-cadherin transcriptional repressors ZEB1 (also known as deltaEF1) and SIP1 (also known as ZEB2), factors previously implicated in EMT and tumour metastasis. (nih.gov)
These data suggest that downregulation of the microRNAs may be an important step in tumour progression. (nih.gov)
Single-cell RNA sequencing reveals localized tumour ablation and intratumoural immunostimulant delivery potentiate T cell mediated tumour killing. (utah.edu)

Here, we provide a comprehensive global analysis of the evolutionarily distant unicellular green alga Chlamydomonas reinhardtii to quantify the effects of miRNA on protein synthesis and RNA abundance. (freethoughtblogs.com)

The studies investigated the expression of 102 different miRs associated with prognostic aspects in colorectal cancer patients. (biorxiv.org)
To date, the effect produced by HCV on the expression of microRNAs (miRs) involved in the interferon-β (IFN-β) antiviral pathway has not been explored in details. (biomedcentral.com)
The expression profile of 24 selected miRs in IFN-β-treated Huh-7 cells and in HCV replicon 21-5 clone with respect to Huh-7 parental cells was analysed by real-time PCR. (biomedcentral.com)
The expression profile revealed that 16 out of 24 miRs were modulated in HCV replicon clone 21-5. (biomedcentral.com)
Microarray analysis revealed that 37 out of 1981 genes, predicted targets of the 3 miRs, showed an inverse expression relationship with the corresponding miR in HCV clones, as expected for true targets. (biomedcentral.com)
The present findings reveal that 3 IFN-β-regulated miRs and 37 genes, which are likely their functional targets, were commonly modulated by HCV in three replicon clones. (biomedcentral.com)

While long noncoding RNAs (lncRNAs) are important in cardiac development and disease, their role in physiol. (researchgate.net)
The plant hormone indole-3-acetic acid (IAA), commonly referred to as auxin, plays a major role in regulating plant growth and development. (sciencedaily.com)
Through this role in regulating the activity (expression) of genes, the Dicer protein is involved in many processes, including cell growth and division (proliferation) and the maturation of cells to take on specialized functions (differentiation). (medlineplus.gov)
Overall, our findings suggest a potential role for miR-263b in developmental growth and cell association by suppressing LanA expression in the Drosophila fat body . (bvsalud.org)
Using cell culture, animal and patient studies, we investigated the biological role of microRNA-96 (miR-96) and microRNA-379 (miR-379) in prostate cancer bone metastasis. (lu.se)
We also studied the role of A-to-I RNA editing in regulating miR-379 function. (lu.se)
In conclusion, the reduction in IAV copy number in DEFB1 overexpressing cells suggests that beta-defensin-1 plays a key role in regulating IAV survival through STAT3 and is a potential target for antiviral drug development. (cdc.gov)

The ability to make cells grow if not tightly regulated can lead to diseases especially cancer. (tufts.edu)

Research conducted by three independent groups and reported in The Plant Cell shows that fundamental developmental processes controlled by the plant hormone auxin are regulated by microRNAs in the model plant Arabidopsis thaliana. (sciencedaily.com)

Expression of the miR-200 family was also lost in regions of metaplastic breast cancer specimens lacking E-cadherin. (nih.gov)
Chrysin regulated miR-18a, miR-21, and miR-221 genes in gastric cancer cell line [ 26 ]. (hindawi.com)
MicroRNA in cancer cells contains anomalies that would not be found in healthy cells. (udel.edu)
For example, certain microRNA are present in cancer cells but absent in healthy cells. (udel.edu)
When the cancer microRNAs were present and able to turn the DNA circuit on, cells were unable to grow. (udel.edu)
The expression of miRNA is deregulated in several pathological processes, including cancer. (bvsalud.org)
A recent study of the disparity in breast cancer mortality between AA and EA women concluded that differences in mortality are driven by higher hazard rates of breast cancer death in AA women, irrespective of ER expression [9]. (cdc.gov)
Based on our identified miRNA-regulated network, we discovered three drugsBX-912, daunorubicin, and midostaurinthat can be repositioned to treat lung cancer, which was not known before. (cdc.gov)
Based on our identified miRNA-regulated molecular machinery, an inhibitor of PDK1/Akt BX-912, an anthracycline antibiotic daunorubicin, and a multi-targeted protein kinase inhibitor midostaurin were discovered as potential repositioning drugs for treating lung cancer. (cdc.gov)

AA and the extracellular regulated protein kinase 1/2 (ERK1/2) blocker U0126 markedly inhibited migration, elevated smooth muscle 22 α (SM22 α ) expression, repressed VSMC proliferation, elevated miR-466f-3p and miR-425-3p expression, and suppressed miR-27a-5p and miR-128-5p expression in ox-LDL-induced VSMCs. (hindawi.com)
The migration, phenotypic transformation, and proliferation of VSMCs lead to vascular wall remodeling, which is mediated by activation of extracellular regulated protein kinases 1/2 (ERK1/2) signalling [ 9 ]. (hindawi.com)

While long noncoding RNAs (lncRNAs) are important i. (researchgate.net)

Their study, "Identification of circulating microRNA patterns in patients in psoriasis and psoriatic arthritis," was published online in Rheumatology (Oxford) in February 2023. (medpagetoday.com)

Within the complex, microRNAs are thought to bind to mRNA molecules containing a complementary stretch of RNA sequence. (sciencedaily.com)

Objective: The impact of fungal viability on the pulmonary microRNA and messenger RNA profiles that regulate murine immune responses was evaluated following subchronic inhalation exposure to Aspergillus fumigatus conidia. (cdc.gov)

We found that lipopolysaccharide and Vibrio anguillarum significantly upregulated the expression of fish miR-21. (frontiersin.org)

MicroRNAs regulate the expression of multiple genes and are often dysregulated themselves in response to diseases and environmental stimuli. (fiu.edu)

Pansensitive and panresistant genes to 21 NCCN-recommended drugs with concordant mRNA and protein expression were identified. (cdc.gov)

Overexpression of miR-192, miR-495, miR-512, and miR-671 suppressed NOD2 expression, muramyl dipeptide-mediated NF-κB activation, and messenger RNA expressions of interleukin-8 and CXCL3 in HCT116 cells. (elsevierpure.com)
Hematogenous Routing of Exogenous Messenger RNA Delivered Into the Amniotic Fluid. (harvard.edu)

He received his Ph.D. degree in the laboratory of Dr. En-Duo Wang in Biochemistry and Molecular Biology from Shanghai Institute of Biochemistry and Cell Biology of Chinese Academy of Science in 2008, where he studied the structural and functional interplay of transfer RNA (tRNA) and tRNA synthetase in bacteria, yeast and human. (rochester.edu)

I am molecular and cellular biologist with expertise in virus and microRNAs. (researchgate.net)

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