Expression increase fetal proteins. Medical search. Frequent questions

Furthermore, SARS-CoV-2 spike (S) protein expression was investigated in cells of the placenta, amnion, and umbilical cord. (news-medical.net)
In a previous report using the resources of the New Hampshire Birth Cohort Study (NHBCS), we found that low-to-moderate i n utero exposure to arsenic, a highly toxic and widespread pollutant, was associated with altered expression of several key developmental genes in the fetal portion of the placenta. (biomedcentral.com)
Using NanoString technology, we further analyzed the fetal placenta samples from the NHBCS for the expression of genes encoding arsenic transporters and metabolic enzymes. (biomedcentral.com)
We found that maternal arsenic exposure was strongly associated with expression of the AQP9 gene, encoding an aquaglyceroporin transporter, in female but not male fetal placenta. (biomedcentral.com)
Our results suggest that AQP9 is upregulated in response to arsenic exposure in female, but not male, fetal placenta. (biomedcentral.com)
Based on these results and prior studies, increased AQP9 expression may lead to increased arsenic transport in the female fetal placenta, which in turn may alter the expression patterns of key developmental genes that we have previously shown to be associated with arsenic exposure. (biomedcentral.com)
SP-C mRNA was detected in mouse uterus, placenta and fetal membranes and in human placenta, amnion and chorion. (bmj.com)
An increase in the expression of SP-C was detected in placenta, uterus and fetal membranes after LPS challenge. (bmj.com)
SP-C mRNA and proSP-C were detected in mouse uterus, placenta and fetal membranes and LPS increased the expression. (bmj.com)
Its outer membrane contains a heat shock protein that induces cell death (apoptosis) in placenta cells that are vital for normal fetal development. (blogspot.com)
Gestational hypoxia is a major contributor to fetal growth restriction (FGR) and perinatal morbidity and mortality and has been closely linked to the activation of the unfolded protein response (UPR) in the placenta. (researchgate.net)
Lead can cross the placenta and enter the developing fetal brain. (cdc.gov)
No other inflammatory changes or viral inclusions were identified in the placenta or fetal organs. (cdc.gov)
PCR for M1 capsid protein confirmed influenza A. Immunohistochemical testing was performed on tissue from the placenta and on a sampling of fetal organs by using influenza A virus (H1N1)-specific antibody. (cdc.gov)

Since obesity is also associated with increased inflammatory immune cell numbers in fat tissue, they tested whether numbers of particular subsets of immune cells called M1 and M2 macrophages are different in the fat tissues of offspring whose mothers were fed a low protein diet. (usda.gov)
To investigate whether immune-mediated mechanisms are involved in the pathogenesis of autism, we used immunocytochemistry, cytokine protein arrays, and enzyme-linked immunosorbent assays to study brain tissues and cerebrospinal fluid (CSF) from autistic patients and determined the magnitude of neuroglial and inflammatory reactions and their cytokine expression profiles. (blogspot.com)
Fresh-frozen tissues available from seven patients and CSF from six living autistic patients were used for cytokine protein profiling. (blogspot.com)
Immunocytochemical studies showed marked activation of microglia and astroglia, and cytokine profiling indicated that macrophage chemoattractant protein (MCP)-1 and tumor growth factor-beta1, derived from neuroglia, were the most prevalent cytokines in brain tissues. (blogspot.com)
Central to the action of GCs in target tissues is the expression and function of two isozymes of 11beta-hydroxysteroid dehydrogenase (11beta-HSD) that serve to interconvert active cortisol (F) and inactive cortisone (E). 11beta-HSD type 1 (11bet. (endocrine-abstracts.org)
In the present study, researchers assessed the effects of coronavirus disease 2019 (COVID-19) on fetal brain tissues. (news-medical.net)
The study was conducted between July 2020 and mid-April 2022 in the United Kingdom (UK), wherein human fetal tissues aged 9.0 to 21.0 pcw (post-conception weeks) were obtained from the HDBR (human development biology resource). (news-medical.net)
Next, the team examined the counts of cleaved caspase-3+ cells to determine whether the older or recent hemorrhages were related to increased cell deaths within cortical tissues. (news-medical.net)
In addition, SARS-CoV-2 was present sparsely in the placental, umbilical cord and amniotic tissues, indicating SARS-CoV-2 presence in maternal and fetal tissues. (news-medical.net)
The ontogeny evaluation of the key nucleases responsible for ASO metabolism and pharmacologic activity revealed a differential nuclease expression and activity, which could affect the metabolic pathway and pharmacologic effect of ASOs in different tissues and age groups. (uantwerpen.be)
The same protein exists in other bacteria but is located within the cytoplasm, where it can less easily affect the host's tissues. (blogspot.com)
This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. (thermofisher.com)
ENU during the final week of gestat the rapidly changing patterns of gene In both the fetus and the pregnant ion is approximately 50 times that of expression in fetal target tissues, female rat, the target organ for single the mother. (who.int)

Homeobox protein Hox-B3 is a protein that in humans is encoded by the HOXB3 gene. (wikipedia.org)
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. (wikipedia.org)
Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML). (wikipedia.org)
Hoxa5 gene may be essential for the expression of SP-A and SP-B in term rabbits. (medsci.org)
Associations of ACE exposures with differential methylated positions, regions, and CpG modules determined using weighted gene co-expression network analysis were evaluated adjusting for covariates. (bvsalud.org)
This identified IOX1, a pan-histone demethylase inhibitor, which selectively downregulates α-globin expression without perturbing erythroid differentiation or general gene expression, more specifically β-like globin expression. (haematologica.org)
Homozygotes for a gene trapped allele die throughout fetal growth and development showing pallor and altered placental labyrinth vasculature. (jax.org)
GXD's primary emphasis is on endogenous gene expression during development. (jax.org)
What does this gene/protein do? (cancerindex.org)
What pathways are this gene/protein implicaed in? (cancerindex.org)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
Beclin l, the mammalian counterpart of the yeast Atg6 gene, is an essential protein in autophagy ( 10 ). (spandidos-publications.com)
Furthermore, gene silencing of GLUT3 eradicated the increase in Δψ m associated with transient glutamate excitation and potently sensitized neurons to excitotoxicity. (jneurosci.org)
Using inferred gene co-expression for three neuronal cell types-excitatory, inhibitory, and neural progenitor-we implicate several hundred genes in risk (FDR \(\le \hspace{0.17em}\) 0.05), ~ 60% novel, with characteristics of genuine ASD genes. (springer.com)
Disrupted protein interactions identify gene sets involved in risk for ASD. (springer.com)
Their gene expression during brain development and within cell types highlights how they relate to ASD. (springer.com)
The pathology is caused by a mutation in the huntingtin gene which results in the production of an abnormal protein, mutant huntingtin (mHtt). (bmj.com)
Absence of ILC2s leads to utero-placental abnormalities, including poor vascular remodelling, increased Il1b and decreased Il4, Il5 , and Il13 gene expression, and reduced alternative activation of dendritic cells (DCs) and macrophages. (elifesciences.org)
Myocardial gene expression of glucose transporter 1 and glucose transporter 4 in response to uteroplacental insufficiency in the rat. (childrensmercy.org)
Recently, it was demonstrated that mTOR may produce a gene shift leading to altered protein expression. (oncotarget.com)
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. (thermofisher.com)
While multiple systems potentially take into account the increased loss of TRIII manifestation in these human being malignancies, including lack of heterozygocity from the gene and epigenetic rules (11C13), we'd also determined TGF-1-mediated repression of TRIII message amounts inside a breasts cancers model (11). (accessibletech4all.org)
11), altered liver structure and function (12), altered naire data from 8,765 children aged 5 to 7 years, smoking gene expression (13), and possibly type 2 diabetes mel- after pregnancy was not associated with childhood obesity litus (10). (cdc.gov)
Additional mechanisms include generating reactive oxygen species and altering gene expression (ATSDR, 2007). (cdc.gov)
The increased cases of neurodevelopmental disorders in children, together with their increased susceptibility to OP neurotoxicity cannot be explained by genetic factors alone but could be related to gene-environment interactions. (cdc.gov)
Maternal PON1 status (PON1 activity levels, the most important measurement, and functional Q192R phenotype) modulates the detrimental effects of exposure to the OP chlorpyrifos oxon on fetal brain gene expression and biomarkers of exposure. (cdc.gov)
The normal RUNX1 protein, produced from the RUNX1 gene, is part of a protein complex called core binding factor (CBF) that attaches (binds) to DNA and turns on genes involved in blood cell development. (medlineplus.gov)
The normal ETO protein, produced from the RUNX1T1 gene, turns off gene activity. (medlineplus.gov)
Increasing evidence emphasize that a substantial variance of protein expression is conveyed at the levels of protein synthesis and degradation, and that post-transcriptional control of gene expression plays a critical role in multiple aspects of cell biology, including coordination of cellular processes and rapid alteration of cellular phenotype. (lu.se)
First, we looked at LIN28B, a gene recognized as the master regulator of fetal blood cell formation. (lu.se)

Rapamycin suppressed cell migration when exposed to fetal bovine serum (FBS) while increasing the cell adhesion protein phospho-FAK (pFAK). (oncotarget.com)
Adult bovine serum contains a variety of nutrients including inorganic minerals, vitamins, salts, proteins and lipids as well as growth factors that promote animal cell growth. (sagepub.com)
Proteins present in MS, FS and CMS but absent in fetal bovine serum (FBS) were selected by two-dimensional gel electrophoresis and identified by peptide mass fingerprinting. (sagepub.com)
Human being ovarian tumor Ovca420 cells had been taken care of in RPMI moderate supplemented with 10% fetal bovine serum. (accessibletech4all.org)
Human being breasts cancers MDA-MB-231 cells had been cultured in Improved Eagle's Moderate, supplemented with nonessential proteins, sodium pyruvate and 10% fetal bovine serum. (accessibletech4all.org)

Previous studies have reported that maternal SARS-CoV-2 infections and immunological responses elevate the risk of altered fetal brain development, fetal death, growth restrictions and severe pathologies such as intraventricular hemorrhages and pneumonia. (news-medical.net)

Homeobox (HOX) genes encode proteins that are important in normal foetal development. (endocrine-abstracts.org)
By regulating the expression of several genes in host liver cells, NS5A also induces cellular proliferation, and influences the curative effect of interferon ( 7 ). (spandidos-publications.com)
The ~1.5 Mb candidate region was shown to contain five protein-coding genes. (biomedcentral.com)
We also identified several genes that do not appear to be protein coding, and generated 17 kb of novel transcript sequence data from re-sequencing 97 EST clones. (biomedcentral.com)
The candidate interval was shown to exhibit an extraordinary level of alternate splicing - 19 transcripts were identified for the 5 protein coding genes, but it appears that a significant portion (14/19) of these alternate transcripts did not have an open reading frame, hence their functional role is questionable. (biomedcentral.com)
We investigate the functional relevance of de novo missense variants, specifically whether they are likely to disrupt protein interactions, and nominate novel genes in risk for ASD through integrated genomic, transcriptomic, and proteomic analyses. (springer.com)
For genes encoding the disrupted interactions, we evaluate their expression patterns across developing brains and within specific cell types, using both bulk and inferred cell-type-specific brain transcriptomes. (springer.com)
Finally, we integrate protein interactions and cell-type-specific co-expression networks together with published association data to implicate novel genes in ASD risk in a cell-type-specific manner. (springer.com)
Genes encoding disrupted complementary interactors tend to be risk genes, and an interaction network built from these proteins is enriched for ASD proteins. (springer.com)
Consistent with other studies, genes identified by disrupted protein interactions are expressed early in development and in excitatory and inhibitory neuronal lineages. (springer.com)
Using the newly released and larger ASC dataset, we confirm these observations and take them in several new directions: (1) By defining a set of genes encoding these disrupted protein interactors in ASD subjects and another for their siblings, we evaluate their expression patterns in developing brain from fetal to early postnatal development and within general cell types of brain tissue. (springer.com)
Multivariable linear regression analysis was used to examine their relationship with arsenic exposure and with key developmental genes, after stratification by fetal sex. (biomedcentral.com)
Moreover, AQP9 expression associated with that of a subset of female-specific arsenic-responsive genes. (biomedcentral.com)
Placentas exhibit signs of adaptation to stress, including larger maternal blood spaces and increased expression of nutrient transporter genes. (elifesciences.org)
GO-AgNPs induced significant cytotoxicity by the loss of cell viability, production of reactive oxygen species (ROS), cell cycle arrest, increasing leakage of lactate dehydrogenase (LDH) and level of Malondialdehyde (MDA), increasing expression of pro-apoptotic genes and decreasing expression of anti-apoptotic genes. (researchsquare.com)
The ABC superfamily of genes encodes proteins that transport a number of substrates across cell membranes. (medscape.com)
Chromosome 21 likely contains 200 to 300 genes that provide instructions for making proteins. (medlineplus.gov)
The RUNX1-ETO fusion protein forms CBF and attaches to DNA, but instead of turning on genes that stimulate the development of blood cells, it turns those genes off. (medlineplus.gov)
Researchers believe that having extra copies of genes on chromosome 21 disrupts the course of normal development, causing the characteristic features of Down syndrome and the increased risk of health problems associated with this condition. (medlineplus.gov)
However, prior to lineage commitment, genes are primed at low expression levels. (lu.se)

Localization and quantification of glucose transporters in liver of growth-retarded fetal and neonatal rats. (childrensmercy.org)
Improved survival has been achieved with intense supportive care and systemic retinoid therapy in the neonatal period. (medscape.com)

Factors that cause a low incidence of tumours in offspring after birth, compared contribute to fetal susceptibility to near the end of gestation, in offspring with the incidence and multiplicity of these agents include maternal, pla that were exposed trans placental y. the same types of tumours in their cental, and fetal metabolism, the im This pattern can be seen in the directly exposed mothers. (who.int)

Studies in humans have shown that men and women whose birth weights were at the lower end of the normal range, who were thin or short at birth, or who were small in relation to placental size have increased rates of coronary heart disease. (bmj.com)
Differences in fetal placental macrophages, or Hofbauer cells (HBCs), have been observed in maternal obesity, and lipid metabolism is a key function of resident macrophages that may be deranged in inflammation/immune activation. (bvsalud.org)
Placental expression of glucose transporter proteins 1 and 3 in growth-restricted fetal rats. (childrensmercy.org)
Demographic and that this particular family of angiogenic clinical data were collected during routine proteins plays an important role in placental obstetric visits. (who.int)

Despite an increase in knowledge with regard to identification of critical signaling pathways in bone sarcomas, they are characterized by a relatively high morbidity and mortality [ 4 ]. (oncotarget.com)
Intrahepatic cholestasis of pregnancy (ICP) is a condition specific to pregnancy, leading to increased fetal morbidity and mortality. (medscimonit.com)

Our data show that selective silencing of α-globin expression in erythroid cells is pharmacologically feasible, and IOX1 is a lead compound to developing new therapy to treat β-thalassemia through the novel pathway of downregulating α-globin expression. (haematologica.org)
D) Representative flow cytometry plots of cells stained with fluorescein isothiocyanate (FITC)-conjugated anti-CD71 and phycoerythrin (PE)-conjugated anti-CD235a antibodies, demonstrating sequential expression of CD71 followed by CD235a and subsequent loss of CD71. (haematologica.org)
SARS-CoV-2 spike (S) expression was sparse in cortical microtubule-associated protein 2 (MAP2)-positive and HuC/D-positive neurons and the nestin-positive and Hopx (homeodomain-only protein)-positive radial glial, and Sox2 (sex-determining region Y-box 2)-positive ventricular zone and subventricular zone progenitor cells. (news-medical.net)
In addition, NS5A significantly increases the expression of inducible nitric oxide synthase, cyclin D1 and nuclear factor-κB, but decreases p53 protein expression in HepG2 cells ( 6 ). (spandidos-publications.com)
Increasing amounts of evidence indicate that autophagy is induced by a number of stressors in tumor cells, such as starvation, growth factor deprivation, hypoxia, damage stimulation and therapeutic drugs, and is an important survival mechanism in response to cellular stress ( 9 ). (spandidos-publications.com)
ZEB1 protein was also present in human fetal periventricular stem and progenitor cells and ZEB1 inhibition impaired migration of in vitro propagated human neural stem cells. (cardiff.ac.uk)
Increases in the amount of PAPP-A mRNA in granulosa cells during follicular development occurs in some but not all species, indicating that other proteases or protease inhibitors may be involved in IGFBP degradation. (bioone.org)
In the developing liver, the complete or partial persistence of the primitive double-layered cylinder of biliary-type cells that surrounds the branches of portal vein and its mesenchyme gives origin to portal tracts with an increased number of bile duct structures. (nih.gov)
Both heterogeneity and tissue specialization of immune cells may hold the key to understanding the pathophysiology of some important pregnancy complications, such as miscarriage and fetal growth restriction (FGR), which is defined as the failure of the fetus to achieve its genetically determined growth potential. (elifesciences.org)
Replace the medium on the cells expressing an ACP-tag fusion protein with the labeling medium and incubate at 37°C, 5% CO2 for 60 minutes. (neb.com)
Where protein turnover is rapid, we recommend analyzing the cells under the microscope immediately after the labeling reaction or, if possible, fixing the cells directly after labeling. (neb.com)
After labeling the ACP-tag fusion proteins, the cells can be fixed with standard fixation methods such as para-formaldehyde, ethanol, methanol, methanol/acetone, etc., without loss of signal. (neb.com)
The severity of the phenotypes correlates with the expression levels of the hEGFR KI allele, which is not efficiently expressed in epithelial and bone cells, but is expressed at similar and even higher levels as the endogenous Egfr in brain and heart. (silverchair.com)
Despite the significant progresses made in the past decade, the precise mechanisms on what and how chlamydia-secreted proteins interact with host cells remain largely unknown, and will therefore still represent major research directions of the chlamydial field in the foreseeable future. (blogspot.com)
The present study improves our awareness of basic mechanisms which relate mTOR activity to the biology of glioblastoma cells. (oncotarget.com)
Cells had been infected using the ALK5QD-expressing adenovirus 100.A Stream of human being ESTs using the 1st coding exon of TRIII revealed the current presence of 80 ESTs, 75 which contained sequences homologous towards the proximal 5 UTR (A). message and proteins amounts in ovarian (Ovca420) and breasts cancers (MDA-MB-231) cell lines in both a dosage- and time-dependent way. (accessibletech4all.org)
A) Intervillous (maternal) spaces with clusters/sheets of histiocytes (chronic intervillositis) and fibrotic fetal chorionic villi with Hofbauer cells-histiocytic inflammation (hematoxylin. (cdc.gov)
which may render the genetic mate doses of NDMA is the kidney, but a Transplacental carcinogenesis rial of fetal cells highly accessible to much lower incidence of tumours is stu dies with ENU in nonhuman pri carcinogens. (who.int)
Less commonly, Down syndrome occurs when part of chromosome 21 becomes attached (translocated) to another chromosome during the formation of reproductive cells (eggs and sperm) or very early in fetal development. (medlineplus.gov)
Proteins are the machinery of the cell, responsible for executing the functions essential for cells to operate, survive, differentiate and divide. (lu.se)

An ultrasound at 18 weeks demonstrated early growth restriction and oligohydramnios with normal appearing fetal kidneys and head. (cdc.gov)

Environmental injury has been associated with endoplasmic reticulum (ER) stress, a response characterized by activation of the unfolded protein response, proteasomal degradation of proteins, and induction of HSPA5, also known as GRP78 or BiP. (bioone.org)

It is currently unknown whether maternal LP diet-induced offspring obesity is associated with changes in M1, M1b, or M2 cell numbers and expression of inflammatory factors in fat tissue. (usda.gov)
Using rat offspring whose mothers were fed a low protein diet during pregnancy and who were fed a high-fat diet post-weaning, the investigators tested whether increased fat tissue was correlated with changes in numbers of adipose tissue M1, M1b and M2 macrophages. (usda.gov)
Fat tissue growth rate was highest in maternal low protein and post-weaning high fat diet group. (usda.gov)
In summary, these results indicate that a maternal low-protein diet combined with a post-weaning high fat diet contributes to changes in M1, M1b and M2 cell numbers to increase fat tissue inflammation. (usda.gov)
Fetal lung tissue histology was observed by hematoxylin and eosin (H&E) staining. (medsci.org)
Electron transport chain (ETC), oxidative phosphorylation, and UCP1 proteins were measured in the interscapular BAT (iBAT) and thoracic perivascular adipose tissue (tPVAT) as well as inflammatory and oxidative parameters. (met-vasc.com)
Influenza A virus (H1N1) was identified in maternal and fetal tissue, confirming transplacental passage. (cdc.gov)
Use of human fetal tissue raises several ethical issues, but are there alternative cell sources that can substitute effectively? (lu.se)
Through understanding functional recovery in terms of neuronal subtype and connectivity, the work presented in this thesis aims to bring the prospect of CRT closer to the clinic, I also describe the generation of a very promising alternative cell source that could rival fetal tissue. (lu.se)
Transplantations of fetal tissue in the 1980s and 1990s provided proof-of-concept for the potential of cell replacement therapy for PD and some patients benefitted greatly from their transplants. (lu.se)

However, substitution of serum in cell culture blood from slaughter-houses is used currently for the media has not been successful due to the presence of production of plasma proteins (Belhocine et al. (sagepub.com)
Serum adiponectin levels in pre-eclamptic women were significantly higher than in normal pregnant women and the increase was more marked in cases of severe pre-eclampsia. (who.int)

Important cytoprotective mechanisms activated by oxidative inflammatory conditions are mediated by nitrated fatty acids that covalently modify proteins to limit inflammation and oxidant stress. (aspetjournals.org)
Taken together, our study demonstrated that GO-AgNPs potentially induce oxidative damage to DNA, which result in toxicity and cell apoptosis in caprine fetal fibroblast cell due to an increased generation of ROS. (researchsquare.com)
Hemodynamic overload activates Gαq-mediated signaling responsible for transcriptional reactivation of fetal growth programs, activation of the mitogen-activated protein kinase (MAPK) cascade, and oxidative stress. (dissertation.com)
In turn, chronic fetal hypoxaemia promotes oxidative stress, and maternal antioxidant therapy in animal models of hypoxic pregnancy has proven to be protective with regards to fetal growth and cardiovascula. (researchgate.net)

They also demonstrated that obesity in such offspring is associated with an increased risk for type 2 diabetes. (usda.gov)
Maternal low protein models result in fetal programming of obesity. (usda.gov)
INTRODUCTION: Maternal obesity is associated with increased risk of offspring obesity and cardiometabolic disease. (bvsalud.org)
Tosh DN, Fu Q, Callaway CW, McKnight RA, McMillen IC, Ross MG, Lane RH, Desai M. Epigenetics of programmed obesity: alteration in IUGR rat hepatic IGF1 mRNA expression and histone structure in rapid vs. delayed postnatal catch-up growth. (childrensmercy.org)
Our hypothesis is that AT2R activation could increase BAT mass and activity in obesity. (met-vasc.com)
glucocorticoids, protein restrictions, and maternal diet and obesity. (cdc.gov)

also known as ASH1), neurogenic differentiation factor 1 (NeuroD1), yes-associated protein 1 (YAP1) and POU class 2 homeobox 3 (POU2F3). (cancerindex.org)

This protein serves as a transcriptional activator of cell growth. (spandidos-publications.com)

Hoxb5 mRNA and protein levels decreased in the term group, with a relative expression ratio of 0.48:1 and 0.50:1, however, Hoxa5 mRNA and protein levels increased in the term group with a relative expression ration of 2.99:1 and 2.33:1, respectively, for the term to preterm groups. (medsci.org)
Challenge of rGMCs with 1 or 10 μM HgCl 2 or Pb 2 acetate increased HSPA5 mRNA and protein levels. (bioone.org)

The fetal origins hypothesis states that fetal undernutrition in middle to late gestation, which leads to disproportionate fetal growth, programmes later coronary heart disease. (bmj.com)
The hypothesis states that coronary heart disease is associated with specific patterns of disproportionate fetal growth that result from fetal undernutrition in middle to late gestation. (bmj.com)
The expression of two apoptosis-related proteins, Fas (a transmembrane cell surface protein involved in the apoptosis) and Bcl-2 (an anti-apoptotic protein), was studied by immunohistochemistry in the liver of 11 normal fetuses of different gestational ages (14-40 weeks of gestation) and in 40 fetuses with Meckel syndrome (16-38 weeks of gestation). (nih.gov)
During gestation, expression of Fas and Bcl-2 decreased and increased, respectively. (nih.gov)
In 2008, a 30-year-old primigravida physician experienced intrauterine fetal demise (IUFD) at 20 weeks' gestation, as established by last menstrual period and confirmed by ultrasound at 8 weeks. (cdc.gov)

Cortical hemorrhage was observed among 26 specimens out of 661 fetal brain specimens. (news-medical.net)
Therefore, the number of fetal specimens with cortical hemorrhages observed in the present study was unusual. (news-medical.net)
In the cortical regions of the hemorrhagic specimens, blood vessels situated proximal to erythrocyte clusters showed significantly lower claudin-5 expression compared to away from vessels located far from the erythrocyte clusters. (news-medical.net)
Immunohistochemical assessment of 295 surgical specimens consisting of various types of pediatric and adult brain cancers showed that ZEB1 expression was significantly higher in infiltrative lesions than less invasive tumors such as pilocytic astrocytoma and ependymoma. (cardiff.ac.uk)
Figure 1 , panel A). Histologic analysis of fetal autopsy specimens showed scattered luminal histiocytes of the lung and gut. (cdc.gov)

Primiparous ewes ( n =32) were assigned to dietary treatments in a 2×2 factorial arrangement to determine effects of nutrient restriction and melatonin supplementation on maternal and fetal pancreatic weight, digestive enzyme activity, concentration of insulin-containing clusters and plasma insulin concentrations. (cambridge.org)
In summary, the maternal pancreas responded to nutrient restriction by decreasing pancreatic weight and activity of digestive enzymes while melatonin supplementation increased α -amylase content. (cambridge.org)

survivors show male infertility, impaired spermatogenesis, increased testis apoptosis and azoospermia. (jax.org)
Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) modulates cellular apoptosis, which is involved in the occurrence and development of liver cancer. (spandidos-publications.com)
Furthermore, it was confirmed that Beclin 1 expression by NS5A was involved in the negative regulation of starvation‑induced liver cancer apoptosis, which was accompanied by reduced p53 and apoptosis regulator Bax expression, as well as decreased caspase‑3/-7 activation. (spandidos-publications.com)

Thus, there is a crucial need for an improved understanding of the molecular mechanisms underlying sexually dimorphic responses in utero, in order to effectively prevent, diagnose and treat the effects of prenatal toxicant exposure. (biomedcentral.com)

In humans, low protein intake by women in late but intrauterine exposure was (20). (cdc.gov)
These findings suggested a causal relationship between early exposure and fetal demise. (cdc.gov)
We report a second trimester fetal demise that occurred after exposure to seasonal influenza A virus (H1N1) early in pregnancy. (cdc.gov)
Studies in experimental incidence and multiplicity of tumours to Wilms tumour in humans - in the animals increase and the latency period de adult rat after perinatal exposure to a creases with increasing dose. (who.int)
As these kinds of health effects data become available and methods to assess levels of significant human exposure improve, these MRLs will be revised. (cdc.gov)

In the canonical Wnt/β-catenin signaling, a Wnt ligand binds to a cell surface receptor complex consisting of the members of Frizzled family and the transmembrane protein LRP 5 and 6 to prevent phosphorylation and degradation of β-catenin by the GSK3β/APC/Axin destruction complex. (oncotarget.com)

Antenatal glucocorticoids accelerate fetal lung maturation and reduce mortality in preterm babies but can trigger adverse effects on the cardiovascular system. (researchgate.net)

The relative expression ratios of SP-A and SP-B mRNA in the term to preterm groups were 2.45:1 and 2.94:1, respectively. (medsci.org)

We have recently reported that HD brains are also characterised by vascular abnormalities, which include changes in blood vessel density/diameter as well as increased blood-brain barrier (BBB) leakage. (bmj.com)
Our data show that treatment with FIN improves kidney and vascular damage in a new rat model of DKD with T1D associated with a reduction in inflammation, fibrosis and osteogenic factors independently from changes in glucose homeostasis. (met-vasc.com)
This was the first study to suggest that smoking tension and vascular defects (8,9), altered fetal pancreatic during pregnancy is linked to adverse changes in the lipo- development and structure (10), altered glucose tolerance protein levels of children (19). (cdc.gov)

Using a rat model of prenatal low protein (LP, 8% protein) diet followed by a postnatal high fat energy diet (HE, 45% fat) or low fat normal energy diet (NE, 10% fat) for 12 weeks, we investigated the effect of these diets on adiposity, programming of the offspring ATM phenotype, and the associated inflammatory response. (usda.gov)

In the maternal low protein diet group, M1 cell numbers did not change while M2 cell numbers increased when the offspring were fed a high-fat diet. (usda.gov)
In the maternal normal protein group, both M1 and M2 cell numbers increased when fed a post-weaning high-fat diet. (usda.gov)
The ratio of M1 and M2 did not change with maternal and post weaning diets while M1b cell numbers increased in maternal normal protein and post-weaning high-fat diet group. (usda.gov)
The main feature of fetal growth is cell division. (bmj.com)
Cortical hemorrhages were associated with reduced integrity of blood vasculature and increased immunological cell infiltration in the fetal brain. (news-medical.net)
Notably, inhibition of the CaMKK (calmodulin-dependent protein kinase kinase) had little affect on GLUT translocation, whereas the inhibition or knockdown of AMPK (compound C, siRNA) activity prevented GLUT3 translocation to the cell surface after glutamate excitation. (jneurosci.org)
In summary, our data suggest that the activation of AMPK and its regulation of cell surface GLUT3 expression is critical in mediating neuronal tolerance to excitotoxicity. (jneurosci.org)
This protein is ubiquitously expressed and known to confer toxicity to multiple cell types. (bmj.com)
From forced expression studies in both cell lines and primary turned ON/OFF. (lu.se)

The mice had significantly increased blood testosterone concentrations, cyclic guanosine monophosphate (cGMP) levels and total nitric oxide synthase (T-NOS) activity in the corpus cavernosum and an increase in the number of mouse matings within 30 min (all p = 0.000). (bvsalud.org)
After 4 weeks of treatment, CXA-10 [2.5 millligrams per kilogram (mpk), p.o.] significantly attenuated increases in plasma cholesterol, heart weight, and kidney weight observed in the model without impacting systemic arterial blood pressure. (aspetjournals.org)
However, a significant increase only in GLUT3 surface expression was identified 30 min after excitation, with this high surface expression remaining significantly above control levels in many neurons for up to 4 h. (jneurosci.org)
HBD3 secretion level increased significantly (7.8 +/- 1.9 pg/micrograms) in the CHD but only if the stimulus was applied on the AMN side. (biomedcentral.com)
D showed a 10-fold increase of kidney damage markers Kim-1 and Ngal which was significantly suppressed in D-FIN. (met-vasc.com)
Relaxant responses to acetylcholine and the AMPK activator (AICAR) were significantly impaired in HF mice but improved in HF-Chow mice. (met-vasc.com)
The protein levels of AMPKα, p-CREB and antioxidant systems (heme oxygenase-1 (HO-1) and catalase) were significantly reduced in HF but normalized in HF-Chow mice. (met-vasc.com)
Elevated levels significantly increased risk more than severity of pre-eclampsia. (who.int)

The broad interest of our group lies in understanding the molecular differences between fetal and adult hematopoiesis . (lu.se)
By using in-depth mass spectrometry-based quantitative proteomics to monitor protein levels in a comprehensive and quantitative manner, our ongoing research aims at defining the fetal- and adult-specific proteomic programs that regulate normal and malignant hematopoiesis. (lu.se)

Molecular chaperones are known to play a role in stabilizing protein structure and function during events of cellular stress. (bioone.org)

A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates. (childrensmercy.org)

Investigators at the Grand Forks Human Nutrition Research Center had shown in a previous study that maternal undernutrition such as a low protein diet causes the offspring to become obese. (usda.gov)
However, it is not known whether maternal undernutrition increases ATM phenotypic expression in F1 offspring. (usda.gov)
The programming of blood pressure, insulin responses to glucose, cholesterol metabolism, blood coagulation, and hormonal settings are all areas of active research.The BMJ's recent editorial on the fetal origins hypothesis stated that it rests only on the "very general" proposition that fetal undernutrition causes coronary heart disease. (bmj.com)

Expression levels of the primary neuronal glucose transporters (GLUTs) isoforms 1, 3, 4, and 8 were found to be unaltered within a 24 h period after excitation. (jneurosci.org)

The non-steroidal mineralocorticoid receptor antagonist (MRA) finerenone (FIN) improves kidney and cardiovascular outcomes in patients with chronic kidney disease (CKD) in type 2 diabetes (T2D). (met-vasc.com)
However, glucocorticoid treatment in the infant can increase the risk of long-term cardiovascular complications including. (researchgate.net)
Our understanding of fetal cardiovascular physiology has markedly increased in the last 50 years, with the introduction of suitable animal models. (researchgate.net)
The results support the theory that adiponectin might be part of a feedback mechanism improving insulin sensitivity and cardiovascular health in pre-eclamptic patients. (who.int)

Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome. (childrensmercy.org)

Diabetic patients with and without chronic lung disease are at increased risk of respiratory infection. (ersjournals.com)
Surfactant protein-C (SP-C) increases the surface adsorption and lowers surface tension of lung surfactant. (bmj.com)
1 However, SP-C expression may not be restricted to lung. (bmj.com)
Lately, we have proven that TRIII manifestation is considerably downregulated at both message and proteins levels in a wide spectrum of human being malignancies, including malignancies of the breasts, lung, ovary, pancreas and prostate (11C15). (accessibletech4all.org)

Increasing evidence suggests that such sex differences also exist during fetal development. (biomedcentral.com)

Ewes supplemented with melatonin had increased pancreatic mass ( P =0.03) and α -amylase content (kU/pancreas and U/kg BW). (cambridge.org)

During embryonic life-that is, during the first eight weeks after conception-the body does not increase greatly in size, but the basic human form is laid down in miniature. (bmj.com)
Human infections with H7N9 viruses occurred each year and the viruses gained virulence markers that potentially enhance the risk for humans and may have increased their spread into the human population, making this virus a notable pandemic threat 3 , 4 . (nature.com)
This protease activity has recently been ascribed to serine metalloprotease(s), including pregnancy-associated plasma protein-A (PAPP-A), which was first detected in human follicular fluid nearly 20 yr ago. (bioone.org)
have found that it synthesizes proteins that manipulate the signalling pathways of its human host. (blogspot.com)

Improved methods using mass spectrometry to monitor OP-adducted biomarker proteins are needed and will be extremely helpful in early life biomonitoring, while measurement of PON1 status as a biomarker of susceptibility will help identify mothers and children highly sensitive to OPs. (cdc.gov)

P-glycoprotein expression in mouse brain increases with maturation. (childrensmercy.org)

The largest family of membrane receptors, known as G protein-coupled receptors (GPCRs), are essential to cellular signaling and regulate physiological processes. (uantwerpen.be)

Glutamate excitation induced a rapid alteration in the AMP:ATP ratio that was associated with the activation of the AMP-activated protein kinase (AMPK). (jneurosci.org)

Maternal WSD reduced insulin-stimulated glucose uptake and impaired insulin signaling at the level of Akt phosphorylation in fetal muscle. (diabetesjournals.org)

Transcription factors associated with epithelial‐to‐mesenchymal transition (EMT) have been linked to this invasion, and we found that hypoxia increased in vitro invasion up to fourfold in glioblastoma neurosphere lines and induced the expression of ZEB1. (cardiff.ac.uk)

During normal pregnancy, the fetus grows and develops in an immunologically privileged environment, part of this privilege is associated with the intrinsic capacity of the maternal-fetal interface to respond promptly and efficiently to any immunological challenge [ 1 ]. (biomedcentral.com)

[ 6 ] ABCA12 encodes a transmembrane protein that mediates lipid transport. (medscape.com)

Chronic fetal hypoxaemia is a common pregnancy complication that increases the risk of infants experiencing respiratory complications at birth. (researchgate.net)
A second trimester fetal demise followed influenza-like illness in early pregnancy. (cdc.gov)

Indeed, maternal ILC2s promote fetal growth and protect against fetal mortality upon systemic endotoxin challenge. (elifesciences.org)

mRNA levels of Hoxa5 , Hoxb5 , SP-A , and SP-B were compared by quantitative reverse transcriptase polymerase chain reaction, and protein expression of Hoxa5 and Hoxb5 was compared by western blot analysis. (medsci.org)
Relative levels of heat shock protein (Hsp)70 were measured in developing and diapausing embryos of A. limnaeus using quantitative Western blots. (bioone.org)

ASL glucose concentrations are increased in respiratory disease and by hyperglycaemia. (ersjournals.com)
FS showed elevated total protein and sodium concentrations compared to MS and CMS. (sagepub.com)

The encoded protein functions as a sequence-specific transcription factor that is involved in development. (wikipedia.org)
This review summarizes evidence for the role of proteolytic enzymes that degrade and inactivate insulin-like growth factor binding proteins (IGFBP) during follicular development in mammals. (bioone.org)
Constitutive expression of Hsp70 during development may afford these embryos protection from environmental stresses during development more quickly than relying on the induction of a classic heat shock response. (bioone.org)
Therefore, we hypothesized that there may be a protein that acts as a tumor inhibitor during these early stages of life, preventing the development of leukemia. (lu.se)
In paper I, we used a mouse model that generates leukemia, and we tested the effect of LIN28B expression on leukemia development. (lu.se)

Elevated ASL glucose in intensive care patients was associated with increased Staphylococcus aureus infection. (ersjournals.com)
The skin barrier is severely compromised, leading to excessive water loss, electrolyte abnormalities, temperature dysregulation, and an increased risk of life-threatening infection. (medscape.com)
Epidemics of influenza B, and to a lesser extent of influenza A, infection have been associated with an increased incidence of Reye syndrome among children and adolescents in the United States. (cdc.gov)

Anatomy10

Organisms4

Diseases4

Chemicals and Drugs21

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Phenomena and Processes30

Disciplines and Occupations1

Information Science3

Placenta14

Tissues13

Gene30

Bovine serum5

Altered fetal brain1

Genes20

Neonatal2

Contribute to fetal1

Placental4

Morbidity and morta2

Cells20

Growth restriction1

Activation of the unfolded protein1

Tissue10

Serum2

Oxidative4

Obesity6

Homeobox1

Transcriptional1

MRNA and protein levels2

Gestation5

Specimens5

Restriction2

Apoptosis3

Mechanisms1

Exposure5

Degradation1

Glucocorticoids1

Preterm1

Vascular3

Postnatal1

Cell9

Significantly8

Adult2

Molecular1

Modulates1

Undernutrition3

Transporters1

Cardiovascular4

Maternal diet1

Lung4

Differences1

Pancreatic1

Human4

Susceptibility1

Maturation1

Regulate1

Kinase1

Phosphorylation1

Hypoxia1

Immunological1

Transmembrane protein1

Pregnancy2

Mortality1

Quantitative2

Concentrations2

Development5

Infection3