• Cranial to the primitive node of the embryonic primitive streak, ectodermal tissue thickens and flattens to become the neural plate. (wikipedia.org)
  • However, it is essential that neural crest and placodes associate together throughout embryonic development to coordinate the emergence of several features in the head, including almost all of the cranial peripheral sensory nervous system and organs of special sense. (frontiersin.org)
  • Here, we model early human neural tube development using human embryonic stem cells cultured in a microfluidic device. (nature.com)
  • 3D reconstitution of the patterned neural tube from embryonic stem cells. (nature.com)
  • Neuronal production in the midbrain-hindbrain domain (MH) of the vertebrate embryonic neural tube depends on a progenitor pool called the `intervening zone' (IZ), located at the midbrain-hindbrain boundary. (biologists.com)
  • False discovery rate-corrected p -values for the top 25 embryonic structure gene sets from the weighted global test on triazole gene expression data from the embryonic stem cell test, together with the effect seen in rat postimplantation Whole Embryo Culture (WEC). (biomedcentral.com)
  • Calcium fluxes have been implicated in the specification of the vertebrate embryonic nervous system for some time, but how these fluxes are regulated and how they relate to the rest of the neural induction cascade is unknown. (ucl.ac.uk)
  • F-J ) Cross sections through different stages of embryonic development corresponding to the embryos shown in A-D. The mouse Isl1- en (green, GFP) and control pCAAG-RFP (red). (elifesciences.org)
  • Also, the expression of neural progenitor markers Pax6, Emx2, Otx2, and Pou3f2 was significantly reduced suggesting that gentamicin may adversely affect early embryonic neurogenesis whereas no Nonivamide effect was seen around the HOXA2 expression of endoderm or hepatic markers during differentiation. (tecnoetica.org)
  • I describe the temporal and spatial expression patterns of these genes through embryonic development. (rice.edu)
  • We provide detailed protocols for lentiviral transduction, neural differentiation, and subsequent analysis of human embryonic stem cells. (lu.se)
  • We then discuss recent studies on the role of neural crest and placodes-and their developmental association-in the head of lamprey embryos, and how comparisons with jawed vertebrates can provide insights into the causes and consequences of this event in early vertebrate evolution. (frontiersin.org)
  • The transcriptomic hallmarks of rostro-caudal organization recapitulated gene expression patterns of the early rostro-caudal neural plate in mouse embryos. (nature.com)
  • A) Injection of XProfilin2 RNA dorsally but not ventrally inhibits gastrulation with the resulting embryos having open neural folds and reduced anterior structures (Severe) or delayed blastopore closure and a curved/bent axis (Mild). (xenbase.org)
  • Expression analysis of several Hox genes in human embryos. (cnr.it)
  • Isolation and expression analysis both in invertebrate and vertebrate embryos of a new homeobox containing gene named Orthopedia (Otp). (cnr.it)
  • Isolation and expression analysis in murine embryos of Dlx5 and Dlx6, two murine homologues of the Drosophila Distal-less gene. (cnr.it)
  • The prechordal plate of pwg mutant embryos deflect laterally or plunge into the yolk, and the overall animalward extension of the prechordal plate is diminished. (rice.edu)
  • I also show that the anterior neural plate of pwg mutant embryos fail to converge dorsally to the same extent as in wild embryos. (rice.edu)
  • Early on, Six3 expression is restricted to the anterior neural plate including areas that later will give rise to ectodermal and neural derivatives. (nih.gov)
  • Based on this expression pattern, we conclude that Six3 is one of the most anterior homeobox gene reported to date. (nih.gov)
  • The region anterior to the primitive node can be generally referred to as the neural plate. (wikipedia.org)
  • They are derived from the area of the neural plate anterior to primitive knot. (wikipedia.org)
  • prc1 (protein regulator of cytokinesis 1) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 14/15, dorsal view, anterior up. (xenbase.org)
  • Inhibition of Xfoxi1a activities by injection of antisense oligonucleotides leads to suppression of non-CNS ectodermal markers (e.g. keratin ) and expansion of the anterior expression domain of the CNS marker Sox2 . (biologists.com)
  • Conversely, misexpression of Xfoxi1a suppresses Sox2 and induces keratin in the anterior neural plate. (biologists.com)
  • The migratory neural crest cell population makes a significant contribution to the anterior segment structures of the eye. (molvis.org)
  • Consequently, several anterior segment dysgenesis phenotypes are associated with mutations in genes expressed during neural crest development. (molvis.org)
  • Ras-dva expression is inhibited in the anterior neural plate by factor Xanf1. (umbc.edu)
  • Downregulation of Ras-dva results in head development abnormalities through the inhibition of several regulators of the anterior neural plate and folds patterning, including Otx2, BF-1, Xag2, Pax6, Slug, and Sox9. (umbc.edu)
  • Finally, based on the chromosomal localization and the expression pattern of the mouse Six3 gene, the human Six3 cognate could be a good candidate to be at least one of the genes affected in patients with holoprosencephaly type 2 due to an interstitial deletion of 2p21-p22. (nih.gov)
  • Treatment with VPA and LiCl resulted in the differential expression of 331 and 164 genes respectively. (plos.org)
  • In addition, their osteogenic differentiation potential was increased, and genes involved in cell adhesion, FGF-2 signalling, cell cycle, stemness, cell differentiation, and cell proliferation were upregulated, compared to that of the MSCs cultured on uncoated plates. (hindawi.com)
  • Mammalian neural tube defects (NTDs) stem from a failure of one or more of these morphogenetic processes ( Harris and Juriloff, 1999 ), and recent genetic experiments in mice have identified individual genes that control specifically the many individual behaviors that comprise neurulation. (silverchair.com)
  • Isolation of the murine homologs of the otd and ems homeobox containing genes and analysis of their expression during brain development. (cnr.it)
  • All zebrafish actinin genes have unique expression profiles, indicating specialization of each gene. (rice.edu)
  • Using a WNT-activating gradient, we generated a neural tissue exhibiting progressive caudalization from forebrain to midbrain to hindbrain, including formation of isthmic organizer characteristics. (nature.com)
  • Along the anteroposterior (AP) axis, the neural plate is finely regionalized into the forebrain, midbrain, hindbrain and spinal cord. (biologists.com)
  • We report here that the bHLH factor Her5 acts as a prepattern gene to prevent neurogenesis in the anlage of the midbrain/hindbrain boundary in the zebrafish neural plate. (silverchair.com)
  • This involves selective suppression of both neurogenin1 ( ngn1 ) and coe2 mRNA expression in a process that is independent of Notch signalling, and where inhibition of either ngn1 or coe2 expression is sufficient to prevent neuronal differentiation across the midbrain-hindbrain boundary. (silverchair.com)
  • Cell culture medium kit for robust generation of midbrain neural organoids from human pluripotent stem cells. (stemcell.com)
  • Expression complexity of the Otx2 locus: transcriptional, post-transcriptional and translational regulation of Otx2 mRNA isoforms control specification and maintenance of forebrain and midbrain regional identities. (cnr.it)
  • Ribes, V. & Briscoe, J. Establishing and interpreting graded Sonic Hedgehog signaling during vertebrate neural tube patterning: the role of negative feedback. (nature.com)
  • Placzek M & Briscoe J (2018) Sonic hedgehog in vertebrate neural tube development . (sheffield.ac.uk)
  • This is followed by the refinement and growth of neural plate cells. (wikipedia.org)
  • The figure demonstrates the development of the neural plate into the neural tube, which is where the neural crest cells are derived from as well. (wikipedia.org)
  • The progenitor cells that make up the precursors to neural tissues in the neural plate are called neuroepithelial cells. (wikipedia.org)
  • Stretched over the notochord, the ectodermal cells on the dorsal portion of the embryo are ultimately the ones that form the neural plate. (wikipedia.org)
  • The formation of the neural plate starts when dorsal mesoderm signals ectodermal cells above it to lengthen into columnar neural plate cells. (wikipedia.org)
  • This different shape distinguishes the cells of the presumptive neural plate from other pre-epidermal cells. (wikipedia.org)
  • These regions furrow and change shape in the same way as MHP cells do before connecting together to form the neural tube. (wikipedia.org)
  • Single-cell transcriptomics revealed that rostro-caudal organization was already established at 24 h of differentiation, and that the first markers of a neural-specific transcription program emerged in the rostral cells at 48 h. (nature.com)
  • E) Graph of line scans for PRC1 signal intensity in representative tailbud epidermal cells (pink) and neural-plate cells (blue). (xenbase.org)
  • This study explores the use of a simple human neurosphere-based in vitro model to characterise the pharmacological and toxicological effects of LiCl and VPA using gene expression changes linked to phenotypic alterations in cells. (plos.org)
  • The activation of exogenous AhR in N2a-Rα cells was confirmed using RNAi, with si-AhR suppressing the expression of exogenous AhR. (biomedcentral.com)
  • Morphologically, N2a-Rα cells bore spontaneous neurites exhibiting axon-like properties with the localization of NF-H. In addition, cdc42 expression was increased in comparison to the control cell line. (biomedcentral.com)
  • The excessive activation of AhR resulted in neural differentiation of Neuro2a cells. (biomedcentral.com)
  • Of course, one of the most important vertebrate features is a population of cells called the Neural Crest Cells (NCCs). (biologists.com)
  • In cephalochordates, the other major chordate subphylum, cells along the lateral borders of the neural plate give rise to melanocytes associated with a series of light-sensing organs in the neural tube, known as Dorsal Ocelli 2 . (biologists.com)
  • Although the peripheral nervous systems of tunicate larvae have several sensory neuron subtypes 9 , none of them have been decisively linked to NCCs, either because they do not arise from the neural plate borders or because they more closely resemble non-NCC-derived sensory cells in vertebrates. (biologists.com)
  • With this new insight, researchers hope to be able to produce different types of neural cells for the treatment of neurological diseases more efficiently. (neurosciencenews.com)
  • With knowledge of how neural cells are formed at different developmental stages, researchers have the opportunity to develop new stem cell therapies more quickly in the laboratory. (neurosciencenews.com)
  • The challenge is that there are thousands of different sub-types of neural cells in the human brain, and for each disease we need to be able to produce exactly the right type of neural cell", says Agnete Kirkeby, researcher at the Wallenberg Centre for Molecular Medicine and the Department of Experimental Medical Science at Lund University. (neurosciencenews.com)
  • Studies on how each individual neural cell forms in the embryo during brain development are essential for the researchers to be able to understand how to produce these specific cells in the laboratory. (neurosciencenews.com)
  • Once we have the map we will also become better at producing human neural cells in the laboratory that could be used for transplantations, regenerative therapy and to study the brain's function as well as different disease states. (neurosciencenews.com)
  • Recently, we showed that Wnt8a is transported on short, actin-based filopodia known as cytonemes to contact responding cells and activate signalling during neural plate formation in zebrafish (1).Wnt/ Ror2 signalling regulates the formation of these Wnt cytonemes (5). (exeter.ac.uk)
  • Migration of Nkx2-5 -en + cells from outside the cardiac crescent towards the heart tube. (elifesciences.org)
  • Briefly, 50,000 cells/cm2 were plated on a 24 well plate coated with Matrigel and maintained in mTeSR1 medium until fully confluent. (tecnoetica.org)
  • Expression analysis of the human Hox Complex in teratocarcinoma cells (N-tera2/D1) upon treatment with retinoic acid and the definition of temporal colinearity concept. (cnr.it)
  • Molecular mechanism controlling the expression of the HOX Complex gene family in human teratocarcinoma cells (N-tera2/D1). (cnr.it)
  • Role of Otx2 in Epiblast Stem Cells (EpiSCs): Otx2 stabilizes the primed EpiSC state by suppressing mesendoderm into neural fate switch in cooperation with BMP4 and Fgf2. (cnr.it)
  • This early process includes occurrence of neural precursor cells, pattern formation of the nervous system, and proliferation and differentiation of neural precursor cells. (justia.com)
  • We will further characterize molecular changes during directed cell differentiation and identify the cells that exhibit a pattern of DNA modification, namely DNA methylation, similar to primary neural cells in human brain. (ca.gov)
  • Finally, cell transplantation in a mouse stroke model will be used to study the mechanisms and efficacy of different types of hESC-derived neural cells in neural repair. (ca.gov)
  • We contrast Foxi3 with another neural plate border transcription factor , Zic5, the progenitors of which initially contribute broadly to all germ layers until gastrulation and gradually become restricted to the neural crest lineage and dorsal neural tube cells . (bvsalud.org)
  • [ 4 , 5 ] The paraxial mesoderm in the trunk is transiently organized into approximately 40 segmental tissue blocks alongside the neural tube, known as somites, the cells of which segregate into 2 subpopulations. (medscape.com)
  • Neural Progenitor Cells Derived from XCL-1 DCXp-GFP are a neuronal lineage reporter cell line that can be used in neuronal differentiation and drug screening. (atcc.org)
  • To download a certificate of analysis for Neural Progenitor Cells Derived from XCL-1 DCXp-GFP ( ACS-5005 ), enter the lot number exactly as it appears on your product label or packing slip. (atcc.org)
  • The certificate of analysis for that lot of Neural Progenitor Cells Derived from XCL-1 DCXp-GFP ( ACS-5005 ) is not currently available online. (atcc.org)
  • This strategy provides a useful tool for visualization and identification of neural progeny derived from human pluripotent stem cells. (lu.se)
  • When a microRNA is present in the cell, it binds to the target sites and downregulates GFP expression, while in cells that do not express the microRNA GFP, it is expressed. (lu.se)
  • The high sequence similarity of Six3 with the Drosophila sine oculis, and its expression during eye development, suggests that this gene is the likely murine homologue. (nih.gov)
  • Munsterberg, A & Lassar, A 1995, ' Combinational signals from the neural tube, floor plate and notochord induce myogenic bHLH gene expression in the developing somite ', Development , vol. 121, pp. 651-660. (uea.ac.uk)
  • scRNAseq data is deposited in the Gene Expression Omnibus with accession number GSE135399 . (nature.com)
  • In addition, in order to phenotypically anchor the gene expression data, changes in the heterogeneity of cell subtype populations and cell cycle phase were monitored using flow cytometry. (plos.org)
  • The forkhead box D3 ( FOXD3 ) gene encodes a forkhead transcription factor that plays an important role in neural crest specification in vertebrates and therefore may be involved in human eye disease. (molvis.org)
  • In addition, using invitro methylation assay we identified 4 new substrates for PRMT6, extending the involvement of this enzyme to other cellular processes beyond its well-established role in gene expression regulation. (embl.de)
  • Furthermore, we assessed the global gene expression profile of MSCs on uncoated and PLL-coated plates. (hindawi.com)
  • [ 2 ] The development of musculoskeletal structures associated with the trunk of the human body is a multistep process involving differential gene expression as well as cell interactions and cell signaling between precursor tissues. (medscape.com)
  • Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. (riken.jp)
  • Finally, we show that LIF increases the expression of the core transcription factors: Klf4, Fbx15, Nanog, Sox2 and c-Myc. (karger.com)
  • Regulation of intracellular calcium by Calfacilitin is required for expression of the neural plate specifiers Geminin and Sox2 and for neural plate formation. (ucl.ac.uk)
  • the closing areas of the neural tube are seen to have very increased elongation activity in the midline compared to already closed areas when the plate was beginning to shape itself into a tube. (wikipedia.org)
  • The midline of the neural plate is referred to the median hinge point (MHP). (wikipedia.org)
  • Targeted injection revealed that Xdsh function was required specifically in the midline for normal neural tube closure. (silverchair.com)
  • We suggest that the inherent movement of the neural folds can accomplish only a finite amount of medial progress and that convergent extension of the midline is necessary to reduce the distance between the nascent neural folds, allowing them to meet and fuse. (silverchair.com)
  • The paired sternal bars fuse in the midline to form a cartilaginous sternal plate at around the 10th week. (medscape.com)
  • The communication between the neural plate and the notochord is important for the future induction and formation of the neural tube. (wikipedia.org)
  • To reduce this heterogeneity, we generated engineered cerebral organoids (enCORs), which use a floating scaffold to increase the efficiency of neural induction and reduce heterogeneity. (researchsquare.com)
  • Neural induction protocol was replicated as published previously [11, 12]. (tecnoetica.org)
  • The medium was then replaced with neural induction medium containing KSR media (15% Knockout Serum Replacement (KO-SR Gibco, cat. (tecnoetica.org)
  • Neurogenin, NeuroD, XASH-3, XATH-3) which are involved in the control of neural induction (i.e., neurogenesis, neural differentiation) and in the coding for basic helix-loop-helix (bHLH) transcription factors are also known. (justia.com)
  • The Foxi3 transcription factor , expressed in the neural plate border at the end of gastrulation , is necessary for the formation of posterior placodes and is thus important for ectodermal patterning. (bvsalud.org)
  • The Foxi3 transcription factor is necessary for the fate restriction of placodal lineages at the neural plate border. (bvsalud.org)
  • MEF2C is another transcription factor essential for normal neural development and spatial distribution in the neocortex. (atlasantibodies.com)
  • Neural crest and placodes are key innovations of the vertebrate clade. (frontiersin.org)
  • Most contemporary researchers in the fields of neural crest and placode "evo-devo" have directed their efforts and expertise toward the study of either neural crest or placodes in isolation, the inevitable result of specialization that characterizes modern scientific research. (frontiersin.org)
  • Here, we review the evolution of the developmental association of neural crest and placodes from the perspective of the jawless (cyclostome or "agnathan") vertebrate lineage. (frontiersin.org)
  • The progressive recruitment of IZ progenitors along the mediolateral (future dorsoventral)axis prefigures the earlier maturation of the MH basal plate. (biologists.com)
  • Her research program encompasses the early neural stem cell niche, neural tube closure, cerebrospinal fluid (CSF), metabolism, and cortical neuronal development. (stanford.edu)
  • As a stem cell and developmental molecular biologist, Dr. Fame is dedicated to broad collaboration focused on translating an understanding of neural development and CSF biology into regenerative strategies for the treatment of neurodevelopmental disease. (stanford.edu)
  • Our research program encompasses the early neural stem cell niche, neural tube closure, CSF, metabolism, and cortical neuronal development. (stanford.edu)
  • Here we define a 4-color flow cytometry panel using CD133, LeX, CD140a, NG2 to define a neural stem cell (NSC) as well as 4 classes of multipotential progenitors and 3 classes of bipotential progenitors, several of which have not been described previously. (karger.com)
  • We used a previously characterized in vitro differentiating neural stem cell (NSC) system to investigate the interplay between Mecp2 isoform-specific expression and DNA methylation at the Mecp2 REs. (biomedcentral.com)
  • number 354227) coated plates in mTeSR1 medium (Stem Cell Technologies, cat. (tecnoetica.org)
  • In Small eye (Pax6) mouse mutants Six3 expression is not affected. (nih.gov)
  • PAX6 expression is detected in both developing brain and sensory organs including eye ( C ) (AMAb91372). (atlasantibodies.com)
  • Figure 1 shows expression profiles of LHX2, PAX6 and MEF2C in the developing mouse brain. (atlasantibodies.com)
  • We describe shared and derived patterns of neural crest and placode development in these animals and compare them to well-studied examples from traditional jawed vertebrate model systems. (frontiersin.org)
  • At different stages of NSC differentiation, Mecp2 isoforms showed reciprocal expression patterns associated with minor, but significant changes in DNA methylation at the Mecp2 REs. (biomedcentral.com)
  • B-C ) Expression patterns of the enhancer-driven GFP/RFP formed in the cardiac crescent at St. 8, compared to corresponding control vectors. (elifesciences.org)
  • G-H ) Expression patterns of the enhancer-driven GFP formed in the cardiac crescent at St. eight for both chick and mouse elements. (elifesciences.org)
  • Here we describe how microRNA-regulated lentiviral vectors can be used to visualize specific cell populations by exploiting endogenous microRNA expression patterns. (lu.se)
  • The musculoskeletal system associated with the trunk develops from paraxial and lateral plate (somatic layer) mesoderm. (medscape.com)
  • The bending of the neural plate involves the formation of hinges, where the neural plate is connected to surrounding tissues. (wikipedia.org)
  • They are expressed in distinct, but often interconnected, areas of the developing nervous system and in some non-neural tissues. (wikipedia.org)
  • Vertebrate neurulation ( Fig. 1 ) involves a precisely orchestrated set of morphogenetic movements within the neural plate itself (intrinsic processes) and also within neighboring tissues (extrinsic processes)( Smith and Schoenwolf, 1997 ). (silverchair.com)
  • We have previously utilised an NT2.D1 neurosphere based model of neuronal differentiation to study the effects of a variety of compounds on neural development [7] . (plos.org)
  • Calfacilitin is a calcium channel modulator essential for initiation of neural plate development. (ucl.ac.uk)
  • Our results elucidate the role of calcium fluxes in early neural development and uncover a new factor in the modulation of calcium signalling. (ucl.ac.uk)
  • Combined expression analysis of Otx, Emx, Dlx and Otp during development and definition of brain segmentary identities. (cnr.it)
  • 2005). Finally, negative revealed that SSEA4 is detectable in the early neuroepi- selection strategies have been also developed as an alter- thelium, and its expression decreases as development native method to enrich for NSCs from both adult proceeds. (lu.se)
  • Cerebral organoids showed high variability in neuronal content and tau expression. (researchsquare.com)
  • We performed gain and loss of function studies for leukemia inhibitory factor (LIF) and showed a depletion of NSCs, a subset of multipotential neural precursors and immature oligodendrocytes in LIF null mice. (karger.com)
  • Virtually all of the neurons and glia that populate the mature brain arise from neural precursors (NPs) that reside immediately adjacent to the lateral ventricles. (karger.com)
  • MSCs on PLL-coated plates exhibited a faster growth rate with increased S-phase and upregulated expression of the stemness markers. (hindawi.com)
  • In this study, we found that antibiotics, pen-strep, and gentamicin did not affect hESC cell viability or expression of pluripotency markers. (tecnoetica.org)
  • CD133+), but are rarely codetected with the neural stem dents, very few human-specific NSC markers have been cell (NSC) marker CD15. (lu.se)
  • However, during directed differentiation towards neural and hepatic fate, significant cell death was noted through the activation of caspase cascade. (tecnoetica.org)
  • This study was therefore designed to understand the effect of routinely used antibiotics such as pen-strep and gentamicin on hESC proliferation and their differentiation towards neural and hepatic fate keeping in mind that, this might also help to understand the side effects of these aminoglycosides in early human embryogenesis in vivo. (tecnoetica.org)
  • Our study demonstrates that Foxi3 uniquely acts early at the neural plate border to restrict progenitors to a placodal and epidermal fate. (bvsalud.org)
  • in 1999 from the original name, Ten-a, and the major site of the protein expression being in the nervous system. (wikipedia.org)
  • Separated channels for the Nkx2-5 -en ( E" ) and Nkx2.5 protein ( E''' ). ( F ). Location of the Isl1 enhancer in chick and mouse genomes. (elifesciences.org)
  • E ) The GFP pattern formed in the cardiac crescent at St. eight overlapped with the Isl1 mRNA expression pattern and its protein expression by staining for Isl1 (red) GFP (green) and Dapi (blue). (elifesciences.org)
  • Furthermore, expression analysis of Sox17, Foxa2, and HNF4at protein level by Western blotting from samples at day 5 and day 9 of differentiation showed similar results as observed by qRT-PCR (Physique 5(b)). of hESCs towards specific cell types often require long-term cell cultures. (tecnoetica.org)
  • Figure 2: Laminar distribution of protein expression profiles in the cerebral cortex of rat. (atlasantibodies.com)
  • Protein expression profiles differ in neurons of various layers. (atlasantibodies.com)
  • Osteonectin expression was evaluated using immunohistochemistry with anti-secreted protein acidic and rich in cystein (anti-SPARC) antibody. (bvsalud.org)
  • Arrowheads show areas of high expression of PRC1 mRNA, including the brain, kidney, and tailbud. (xenbase.org)
  • The neurological properties of N2a-Rα based on AhR activation were evaluated by immunohistochemical analysis of cytoskeletal molecules and by RT-PCR analysis of mRNA expression of neurotransmitter-production related molecules, such as tyrosine hydroxylase (TH). (biomedcentral.com)
  • In tunicates, similar dorsal melanocytes arise from the lateral borders of the neural plate and become associated with a light-sensing ocellus and a gravity-sensing otolith 4 . (biologists.com)
  • Temporal and spatial expression pattern of XProfilin2 . (xenbase.org)
  • Higher magnification panels ( B'''-E''' ) of the dotted square boxes highlight the differential Nkx2-5/Isl1 enhancers expression. (elifesciences.org)
  • In the brain of stressed mouse and autistic human patients, reduced MeCP2 expression is correlated with Mecp2 / MECP2 promoter hypermethylation. (biomedcentral.com)
  • The expression of transposons in the human brain is a rising research field. (lu.se)