Expression in myeloid blasts. Medical search. Frequent questions

Blast-phase chronic myeloid leukemia (BP-CML) is associated with additional chromosomal aberrations, RUNX1 mutations being one of the most common. (nature.com)
The use of BCR-ABL1 tyrosine kinase inhibitors (TKI) has led to excellent clinical responses in patients with chronic phase chronic myeloid leukemia (CML). (oncotarget.com)
Chronic myeloid leukemia (CML) is a malignant hematopoietic stem cell disorder caused by the oncogenic BCR-ABL1 fusion protein. (oncotarget.com)
Immunogen: Blast cells from a chronic myeloid leukemia patient were used as the immunogen for this CD34 antibody. (m-entrepreneurship.com)
To investigate the role of miRNAs in regulating drug resistance and leukemic stem cell (LSCs) fate, we performed global transcriptome profiling in treatment-naïve chronic myeloid leukemia (CML) stem/progenitor cells and identified that miR-185 levels anticipate their response to ABL tyrosine kinase inhibitors (TKIs). (iric.ca)
lt;p>The genes p53, mdm2, p21, c-myc, bcr/abl, bcr, bcl2, bax, and gapdh participate in the regulation of cell proliferation and differentiation, apoptosis and cell distribution for the cell cycle ex vivo in the Ph +cells of chronic myeloid leukemia containing the Ph chromosome and bcr/abl oncogene. (actanaturae.ru)
Expression of these genes correlates with regulation of cell proliferation and differentiation by alternating proliferation and maturation stages for three main Ph +cell types that occur under chronic myeloid leukemia. (actanaturae.ru)
this chromosome leads to the development of chronic myeloid leukemia (CML), as well as acute and chronic lympholeukemias. (actanaturae.ru)
Chronic myeloid leukemia (CML), also known as chronic myelogenous leukemia, is a myeloproliferative disorder characterized by increased proliferation of the granulocytic cell line without the loss of their capacity to differentiate. (askhematologist.com)
In chronic myeloid leukemia (CML) there is a malignant transformation of the multipotential hematopoietic stem cells (pluripotent stem cells). (askhematologist.com)
Chronic myeloid leukemia (CML) initiation and progression is regulated by epigenetic and genetic alterations. (waocp.com)

The molecular mechanisms leading to BP disease progression are complex and involve inhibition of tumor suppressors, genomic instability and block of myeloid differentiation [ 2 ]. (oncotarget.com)
Aberrant expression of lymphocyte antigens on blasts with obvious myeloid differentiation is a well-recognized phenomenon. (medscape.com)
Our approach enables the identification of LSC-specific gene expression programs and the characterization of differentiation blocks induced by leukemic mutations. (nature.com)
We also observed that exposure to HDC altered the expression of genes involved in differentiation and cell cycle progression in AML cells and that these effects required the presence of NOX2. (frontiersin.org)
Additionally, ROS have been implicated in myeloid cell differentiation as high levels of intracellular ROS hinder proper differentiation of myeloid cells into dendritic cells (DC) and macrophages ( 12 ). (frontiersin.org)
Background Acute myeloid leukaemia (AML) is usually characterised by Rabbit Polyclonal to TNFAIP8L2 the proliferation of clonal precursor myeloid cells with arrested differentiation and subsequent accumulation of myeloid blasts in the bone marrow. (scienza-under-18.org)
We demonstrated that PTK7 is expressed in acute myeloid leukemia (AML) and is mostly assigned to granulocytic lineage differentiation. (crcm-marseille.fr)
We further demonstrated that CCAT1 inhibited myeloid cell differentiation and promoted cell proliferation by operating as a competing endogenous RNA (ceRNA) for the miR-155 microRNA (miRNA). (molcells.org)
Ectopic expression of Madm in M1 myeloid cells suppressed cytokine-induced differentiation unlike Mlf1, which promotes maturation. (ustc.edu.cn)
This change in gene activity blocks the maturation (differentiation) of blood cells and leads to the production of abnormal, immature white blood cells called myeloid blasts. (medlineplus.gov)
and (d) most cases of non-T ALL appear to be characterized by the expansion of neoplastic cells "frozen" at different levels along the B cell differentiation pathway, the first detectable marker being heavy chain gene rearrangement, followed by BA-1, B1, and CyIg expression. (jci.org)
in such context, memory NK cells have been initially identified in healthy HCMV-seropositive individuals, mainly on the basis of high expression levels of CD94/NKG2C activating receptor and CD57 terminal differentiation marker [ 17 - 21 ]. (hindawi.com)
Treatment with ATRA should be continued until terminal differentiation of blasts and achievement of complete remission. (medscape.com)
Therapy should not be modified on the basis of incomplete blast maturation (differentiation) detected up to 50 days or more after the start of treatment. (medscape.com)

An extensive review and analysis of previously published data highlighted vague trends, with the greatest likelihood of developing therapy-related myeloid neoplasms (t-MNs) following treatment of hematopoietic malignancies. (medscape.com)
Background Natural killer (NK) cells hold great promise as a source for allogeneic cell therapy against hematological malignancies, including acute myeloid leukemia (AML). (bmj.com)
Table S5: Regions covered by institutional next-generation sequencing (NGS) interrogating the entire exonic or hotspot regions of 81-genes frequently mutated in myeloid malignancies. (ox.ac.uk)
We performed a SNP array on chromosome 6 in CD34 + purified blasts from 19 patients diagnosed with advanced MDS and 8 patients with other myeloid malignancies to evaluate the presence of loss of heterozygosity (LOH) in HLA and its impact on disease progression. (oncotarget.com)
Myelodysplasia syndromes (MDS) are defined by a heterogeneous group of myeloid malignancies characterized by peripheral blood cytopenia and dishematopoiesis and frequently progress to acute myeloid leukemia. (intechopen.com)

4. The short form of RON is expressed in acute myeloid leukemia and sensitizes leukemic cells to cMET inhibitors. (nih.gov)

14. CD34+ cells from acute myeloid leukemia, myelodysplastic syndromes, and normal bone marrow display different apoptosis and drug resistance-associated phenotypes. (nih.gov)
During the period covered by this report, we found that sustained pre-miR-155 expression partially rescued the inhibitory effect of the bone marrow mesenchymal stroma cell (MSC) conditioned medium (CM) on human NK cell cytotoxic activity against CD34+ blast crisis CML (CML-BC) stem and progenitor cells. (dtic.mil)
1, 2] As with other myeloid neoplasms, therapy-related myeloid neoplasms (t-MNs) demonstrate at least 50% erythroid precursors in the bone marrow. (medscape.com)
Acute myeloid leukemia (AML) is characterized by unrestrained growth of myeloid cells in bone marrow (BM) and other organs. (frontiersin.org)
Figure S3: CONSORT diagram of study participants Figure S4: Bone marrow response and recovery following IVO+VEN or IVO+VEN+AZA: (A), Bone marrow blast reduction following one cycle of therapy with IVO+AZA, or IVO+VEN+AZA among all patients with an adequate bone marrow samples (N=28). (ox.ac.uk)
Acute myeloid leukemia originates from leukemia-initiating cells that reside in the protective bone marrow niche. (tum.de)
Here we found that PTK7 is also expressed in normal myeloid progenitors and CD34(+) CD38(-) bone marrow cells in humans. (crcm-marseille.fr)
In the bone marrow, at least 10% of a given myeloid lineage should be affected. (medscape.com)
5% in bone marrow) are not included in this group (see Refractory Anemia with Excess Blasts ). (medscape.com)
15]. The percentage of bone common of which are trisomy 8, mono- marrow blast cells for estimation of the Myelodysplastic syndrome (MDS) is somy 7 and 5q- [11]. (who.int)
Expression levels of ERG , BAALC , and MN1 were determined in bone marrow samples by using oligonucleotide microarrays. (ascopubs.org)
Myelodysplastic syndromes (MDSs) comprises a heterogeneous group of myeloid neoplasms, they are characterized by pancytopenia, bone marrow (BM) hyperplasia, dysplasia, and cytopenias of the peripheral blood. (intechopen.com)
The blast count may be normal or elevated but is less than 20% in the bone marrow and peripheral blood. (intechopen.com)
The bone marrow showed 50% blasts and 30% promyelocytes. (biomedcentral.com)

Therapy-related myeloid neoplasms (t-MNs) are defined by the World Health Organization (WHO) as a distinct heterogeneous group of clonal hematopoietic stem cell disorders that are directly related to previous cytotoxic chemotherapy and/or radiation therapy. (medscape.com)
On the basis of clinical behavior and morphologic features, two predominant and clinically significant types of therapy-related myeloid neoplasms (t-MNs) have been defined, distinguished principally on the basis of the nature of cytotoxic therapy: those arising after treatment with alkylating chemotherapy (eg, cyclophosphamide, chlorambucil, cisplatin) and/or ionizing radiation therapy and those arising after therapy with topoisomerase II inhibitors. (medscape.com)
However, the therapy-related myeloid neoplasms neoplasms (t-MNs) progress quickly regardless of their morphologic appearance at presentation and are considered to be a single diagnostic entity. (medscape.com)
therefore, clinicians should carefully review family histories to identify cancer susceptibility in individuals with therapy-related myeloid neoplasms neoplasms (t-MNs). (medscape.com)
See also Pathology of Acute Myeloid Leukemia With Myelodysplasia-Related Features, Pathology of Other Myeloid Related Precursor Neoplasms, and Pathology of Acute Myeloid Leukemia Not Otherwise Categorized. (medscape.com)
The incidence of therapy-related myeloid neoplasms (t-MNs) is dependent on the type, dose, and intensity of the therapeutic intervention and on the nature of the underlying primary malignancy/disease process. (medscape.com)
however, the risk of developing secondary myeloid neoplasms following alkylating chemotherapy or radiation therapy seems to increase with age. (medscape.com)
The risk of developing therapy-related myeloid neoplasms (t-MNs) dramatically decreases after 10 years. (medscape.com)
6, 7] Significantly, cases of therapy-related myeloid neoplasms (t-MNs) represent approximately 10%-30% of all confirmed cases of (MDSs), acute myeloid leukemia (AML), and myelodysplastic/myeloproliferative neoplasms (MDS/MPN). (medscape.com)
The heritable risk factors predisposing to the development of therapy-related myeloid neoplasms (t-MNs) are the topic of intense study. (medscape.com)
The clinical presentation of therapy-related myeloid neoplasms (t-MNs) is largely dependent on the nature of the antecedent therapeutic regimen. (medscape.com)
Rare germline alterations of myeloperoxidase predispose to myeloid neoplasms. (cdc.gov)

TGIF expression data are presented from multiple tissues, cell lines and primary leukemia cells. (nih.gov)
This was accompanied with the sensitivity of RUNX1 mut blasts to CD19-CAR T cells in ex vivo assays. (nature.com)
The studies showed higher levels of expression in NHL over normal lymphocytes as well as in chronic lymphocytic leukemia over normal B-Cells. (wikipedia.org)
CD133 expression in circulating hematopoietic progenitor cells. (buffalo.edu)
3. Human stem cell factor-antibody [anti-SCF] enhances chemotherapy cytotoxicity in human CD34+ resistant myeloid leukaemia cells. (nih.gov)
8. ERK Activity in Immature Leukemic Cells Drives Clonal Selection during Induction Therapy for Acute Myeloid Leukemia. (nih.gov)
10. Differential antigen expression and aberrant signaling via PI3/AKT, MAP/ERK, JAK/STAT, and Wnt/β catenin pathways in Lin-/CD38-/CD34+ cells in acute myeloid leukemia. (nih.gov)
11. Acquired expression of osteopontin selectively promotes enrichment of leukemia stem cells through AKT/mTOR/PTEN/β-catenin pathways in AML cells. (nih.gov)
12. The effect of the proteasome inhibitor bortezomib on acute myeloid leukemia cells and drug resistance associated with the CD34+ immature phenotype. (nih.gov)
Similar results were obtained using NK cells from wt and miR-155 transgenic (tg) mice and BCR-ABL1-expressing mouse 32Dcl3 myeloid precursors. (dtic.mil)
Leukemia Basophilic A rare acute myeloid leukemia in which the immature cells differentiate towards basophils. (nih.gov)
WHO, 2001) Malignant C7464 Acute Leukemia of Ambiguous Lineage Acute Leukemia of Indeterminate Lineage An acute leukemia in which the blasts lack sufficient evidence to classify as myeloid or lymphoid or they have morphologic and/or immunophenotypic characteristics of both myeloid and lymphoid cells. (nih.gov)
In acute myeloid leukemia (AML), leukemic stem cells (LSCs) underlie mortality but are difficult to isolate due to their low abundance and high similarity to healthy hematopoietic stem cells (HSCs). (nature.com)
While mutational status discriminates between healthy and cancerous cells, gene expression distinguishes stem cells and progenitor cell populations. (nature.com)
Acute myeloid leukemia (AML) serves as a paradigm for the study of cancer stem cells 5 . (nature.com)
The accumulation of these so-called "blast" cells is ultimately fueled by the presence of leukemic stem cells (LSCs). (nature.com)
Classic chemotherapy regimens primarily target actively cycling "blast" cells and initially lead to remission. (nature.com)
Here, we propose that by measuring mutational status and gene expression in single cells simultaneously, cancer stem cells can be uniquely distinguished from both mature cancer cells (based on gene expression) and healthy stem cells (based on mutational status) (Fig. 1a ). (nature.com)
Patterns of membrane CD45 isoform expression by leukaemic blasts and normal mature myeloid cells. (roche.com)
The NAPDH oxidase-2 (NOX2) enzyme is the major source of reactive oxygen species (ROS) that constitute an essential feature of the innate antimicrobial defense mediated by myeloid cells ( 8 , 10 , 11 ). (frontiersin.org)
Extracellular release of ROS from myeloid cells may also trigger dysfunction and apoptosis of adjacent cells, including elements of lymphocyte-mediated immunity ( 14 ). (frontiersin.org)
HDC reduces the NOX2-dependent ROS formation via histamine type 2 receptors (H 2 R) expressed by myeloid cells ( 14 , 15 ). (frontiersin.org)
By this mechanism, HDC safeguards natural killer cells and cytotoxic T cells from apoptosis inflicted by neighboring ROS-producing myeloid cells, thus facilitating immune-mediated elimination of malignant cells ( 14 , 16 - 18 ). (frontiersin.org)
Its expression is a hallmark for identifying pluripotent hematopoietic stem or progenitor cells. (m-entrepreneurship.com)
To investigate the potential effects of pure total flavonoid compounds (PTFCs) from Citrus paradisi Macfadyen separately or combined with arsenic trioxide on the proliferation of human myeloid leukemia cells and the mechanisms underlying the action of PTFCs. (zju.edu.cn)
The results indicated that PTFCs separately or combined with arsenic trioxide inhibited proliferation of leukemia cells in vitro and induced their apoptosis by modulating the expression of apoptosis -related regulator genes. (zju.edu.cn)
Furthermore, this resistance was not correlated with CD33 expression (p-Value: 0.6) in those cells. (scienza-under-18.org)
CD33 is usually a transmembrane cell surface glycoprotein Anguizole receptor that is specific for myeloid cells. (scienza-under-18.org)
The CD33 antigen is usually expressed on approximately 90% of AML myeloblasts, including leukaemic clonogenic precursors as well as normal myeloid precursor cells, but not on CD34+ pluripotent hematopoietic stem cells or in non-haematopoietic tissues [5]. (scienza-under-18.org)
In vitro, expression of PTK7 in cultured leukemia cells promotes cell migration, cell survival, and resistance to anthracycline-induced apoptosis. (crcm-marseille.fr)
We hypothesized that vaccinating against NY-ESO-1 in patients with MDS receiving decitabine would capitalize upon induced NY-ESO-1 expression in malignant myeloid cells to provoke an NY-ESO-1-specific MDS-directed cytotoxic T-cell immune response. (johnshopkins.edu)
Myeloid cells expressing NY-ESO-1, isolated from a patient at different time points during decitabine therapy, were capable of activating a cytotoxic response from autologous NY-ESO-1-specific T lymphocytes. (johnshopkins.edu)
its restored expression impaired survival of drug-resistant cells, sensitized them to TKIs in vitro, and markedly eliminated long-term repopulating LSCs and infiltrating blast cells, conferring a survival advantage in pre-clinical xenotransplantation models. (iric.ca)
Furthermore, HDACi Romidepsin largely reversed gene expression profile of resistant cells and efficiently targeted and removed chemoresistant leukemia blasts in xenograft AML mouse model. (divingintogeneticsandgenomics.com)
The p53, p21, mdm2, and gapdh genes overexpress in active proliferating myeloid cells in the cell cycle S+G2/M phases and when the phases are coincident with the proliferation stage. (actanaturae.ru)
The expression levels of these genes in neutrophils are lower than those in myelocytes and lower by an order of magnitude than that in the cells with a prolonged proliferation stage. (actanaturae.ru)
In the Ph + cells with a high P/D efficiency index (5-20), overexpression of the genes in the range of bcr gapdhbcr/abl, as well as a decreased expression of the p53, bcl2, mdm2, p21 gapdh genes is observed for Ph + cells from the CML blast crisis and CML acceleration phase. (actanaturae.ru)
Apoptosis in the Ph + cells is induced by expression of the bax bcl2, p53, p21, c-myc and gapdh genes. (actanaturae.ru)
Myelodysplastic syndrome (MDS) with single lineage dysplasia (SLD), formerly known as refractory cytopenia with unilineage dysplasia (RCUD), is a category of MDS characterized by morphologic dysplasia in at least 10% of the early cells of a single myeloid lineage (red blood cells, white blodd cells, or megakaryocytes) with associated peripheral blood cytopenia. (medscape.com)
Our results suggest that although trisomy 8 cells are in a pro-apoptotic state, they are checked by the enhanced expression of anti-apoptotic signals which provide them with their proliferative advantage. (who.int)
Enforced expression of HLS7 in J2E cells induced a monoblastoid phenotype, thereby recapitulating the spontaneous erythroid to myeloid lineage switch. (ustc.edu.cn)
In contrast, HLS7 promoted maturation of M1 monoblastoid cells and increased myeloid colony formation in vitro. (ustc.edu.cn)
These data show that HLS7 can influence erythroid/myeloid lineage switching and the development of normal hemopoietic cells. (ustc.edu.cn)
In this study, we demonstrate that ectopic expression of Mlf1 prevented J2E erythroleukemic cells from undergoing biological and morphological maturation in response to erythropoietin (Epo). (ustc.edu.cn)
Cord Blood-Derived Quiescent CD34+ Cells Are More Transcriptionally Matched to AML Blasts Than Cytokine-Induced Normal Human Hematopoietic CD34+ Cells. (ox.ac.uk)
While t(8;21) is important for leukemia development, one or more additional genetic changes are typically needed for the myeloid blasts to develop into cancerous leukemia cells. (medlineplus.gov)
Immunoglobulin heavy chain gene rearrangement was evaluated in 19 cases of acute lymphoblastic leukemia (ALL) and correlated with the immunological phenotypic expression on primary or phorbol diester (12-O-tetradecanoylphorbol-13-acetate [TPA])-induced cells. (jci.org)
Incubation with TPA allowed the detection of one B cell marker in a case in which the primary cells were negative, and increased the expression of B cell markers in all but one of the cALLs tested. (jci.org)
Epigenetic deregulation of expression of various genes act as crucial drivers in promoting Leukemic stem cells (LSC) self-renewal potential leads to advanced phase of CML [9]. (waocp.com)
The leukemic cells in an acute myeloid leukemia (AML) patient with a t(9;11)(p22;p15) were recently shown to have a fusion between the NUP98 gene and the LEDGF gene but it was not demonstrated that this fusion was recurrent in other leukaemia patients with the same translocation. (biomedcentral.com)
AB - A panel of monoclonal antibodies to monomorphic determinants of the MHC class II subregion locus products: DP, DR and DQ, was used to investigate the expression of these antigens on early lymphocytes and macrophages from human fetal liver (13 20 weeks), placenta (16 weeks and term) and cord blood, in relation to the class II phenotype of cells from adult tonsil and peripheral blood. (nih.gov)

WHO, 2001) Malignant C4673 Acute Biphenotypic Leukemia An acute leukemia of ambiguous lineage characterized by blasts which coexpress myeloid and T or B lineage antigens or concurrent B and T lineage antigens. (nih.gov)
PMID- 3894221 TI - Differential expression of HLA class II antigens on human fetal and adult lymphocytes and macrophages. (nih.gov)
Fetal liver sections and cell suspensions showed differential expression of class II antigens. (nih.gov)

Here, we report that human NOX2 + myelomonocytic/monocytic AML cell lines showed increased expression of maturation markers along with reduced leukemic cell proliferation after exposure to HDC in vitro . (frontiersin.org)
Its expression is regulated during maturation of the myeloid lineage, resulting in low level expression on peripheral granulocytes and tissue macrophages [4]. (scienza-under-18.org)
Expression of these genes decreases to a considerable level under alternation of the Ph +cell proliferation and maturation stages and whenever the expression is greatly diminished under significant neutrophil accumulation and especially under repeated alternation of the stages. (actanaturae.ru)
In the course of neutrophil maturation, gene expression levels decrease in the range of gapdh actin c-myc, bcr/abl,p21 p53 bcl2 bax. (actanaturae.ru)
The blocking of Ph + cell apoptosis, neutrophil accumulation, and decrease in the expression of the p53, mdm2 and p21, c-myc, bcr/abl genes occur at the maturation stage. (actanaturae.ru)

Acute myeloid leukemia (AML) is an aggressive and difficult-to-treat hematologic malignancy, characterized by the accumulation of immature myeloid blasts. (haematologica.org)
CML progression towards blast crisis requires accumulation of epigenetic and genetic alterations along with BCR-ABL1 translocation [6]. (waocp.com)

C (Tyr113His) is strongly associated with acute myeloid leukemia and KMT2A rearrangements in early age. (cdc.gov)
One of the genes isolated (HLS7) is homologous to the novel human oncogene myeloid leukemia factor 1 (MLF1) involved in the t(3;5)(q25.1;q34) translocation associated with acute myeloid leukemia. (ustc.edu.cn)
4. Myeloid leukemia factor 1 (MLF1) is a novel oncoprotein involved in translocations associated with acute myeloid leukemia (AML), especially erythroleukemias. (ustc.edu.cn)

The Revised International Prognostic Score and some somatic mutations in myelodysplastic syndrome (MDS) are independently associated with transformation to acute myeloid leukemia (AML). (oncotarget.com)
As with all types of MDS , MDS-SLD carries a risk of progression or transformation to acute myeloid leukemia. (medscape.com)

As expected for homeobox genes, the minimal promoter region for isoform 4 has multiple Sp1 binding sites and a CpG island raising the possibility that the low TGIF expression seen in some AML patients and leukemia cell lines may be secondary to methylation. (nih.gov)
In a study with 48 patients who had non-Hodgkin's lymphoma (NHL) and lymphocytic leukemia, hPim-2 expression was analyzed using in-situ hybridization, quantitative RT-PCR and FACS analysis. (wikipedia.org)
Elevated PIM2 levels have also been found in primary blasts from acute myeloid leukemia patients. (wikipedia.org)
13. Effect of Compound Zhebei Granule () combined with chemotherapy on surface markers of leukemia stem cell in patients with acute myeloid leukemia. (nih.gov)
A total of 260 patients with CML were enrolled in a phase II trial, of whom 229 had a confirmed diagnosis of CML in blast crisis. (nih.gov)
Approximately 30% of therapy-related myeloid neoplasm (t-MN) cases involve patients treated for nonneoplastic disorders, and those treated with high-dose chemotherapy followed by autologous stem cell transplantation. (medscape.com)
In patients with acute myeloid leukemia (AML), treatment with histamine dihydrochloride (HDC) and low-dose IL-2 (HDC/IL-2) in the post-chemotherapy phase has been shown to reduce the incidence of leukemic relapse. (frontiersin.org)
Correlation Analysis and Prognostic Impacts of Biological Characteristics in Elderly Patients with Acute Myeloid Leukemia. (cdc.gov)
New prognostic factors and scoring system for patients with acute myeloid leukemia. (cdc.gov)
Results We identified c-Cbl mutations in 5% and 9% of patients with chronic myelomonocytic leukemia (CMML) and sAML, and also in CML blast crisis and juvenile myelomonocytic leukemia (JMML). (ewha.ac.kr)
For patients whose resistance to conventional anthracycline AML regimens is related to ABC protein expression, a combination with AVE9633 could be beneficial. (scienza-under-18.org)
Flow cytometry revealed that high blast counts in patients with acute myeloid leukemia correlate with high CXCR4 expression. (tum.de)
The wide range of CXCR4 surface expression in patients was reflected in cell lines of acute myeloid leukemia. (tum.de)
We conclude that PTK7 is a planar cell polarity component expressed in the myeloid progenitor compartment that conveys promigratory and antiapoptotic signals into the cell and that represents an independent prognosis factor of survival in patients treated with induction chemotherapy. (crcm-marseille.fr)
We demonstrated that patients with acute myeloid leukemia (AML) receiving decitabine exhibit induction of NY-ESO-1 expression in circulating blasts. (johnshopkins.edu)
Results: Analysis of samples serially obtained from the 7 patients who reached the end of the study demonstrated induction of NY-ESO-1 expression in 7 of 7 patients and NY-ESO-1-specific CD4 þ and CD8 þ T-lymphocyte responses in 6 of 7 and 4 of 7 of the vaccinated patients, respectively. (johnshopkins.edu)
Conclusions: These data indicate that vaccination against induced NY-ESO-1 expression can produce an antigen-specific immune response in a relatively nonimmunogenic myeloid cancer and highlight the potential for induced antigen-directed immunotherapy in a group of patients with limited options. (johnshopkins.edu)
1. The NPM-MLF1 fusion protein is expressed in blasts from patients with myelodysplasia/acute myeloid leukemia (MDS/AML) containing the t(3;5) chromosomal rearrangement. (ustc.edu.cn)
We analyzed ERG , BAALC , and MN1 expression levels in a cohort of 210 patients with CN-AML who received intensive chemotherapy. (ascopubs.org)
ERG expression levels predicted OS in elderly patients (ie, age 60 years or older) with CN-AML ( P = .006) as well as in younger patients ( P = .013). (ascopubs.org)
Some patients progress directly from the chronic to the blast phase. (askhematologist.com)
Enhanced frequency of promoter hypermeythylation of TFAP2A (transcription factor AP2 alpha) and EBF2 (early B cell factor 2) was observed in CML blast crisis phase patients compared to chronic phase [11]. (waocp.com)
A Study to check for safety and Efficacy of Galinpepimut-S (GPS) in comparison to Investigators Choice of Best Available Therapy in patients with Acute Myeloid LeukemiaÃ¢â? (who.int)
Introduction: La mise en place depuis Septembre 2016 au Centre Hospitalier Universitaire (CHUL) d'une consultation d'hématologie dédiée aux adultes drépanocytaires a été l'occasion de mener cette étude dont le but principal était d'établir les profils clinique et paraclinique de l'adulte drépanocytaire régulièrement suivi.Patients et méthodes : Il s'agissait d'une étude rétrospective. (bvsalud.org)

M6 Acute Myeloid Leukemia An acute myeloid leukemia characterized by a predominant immature erythroid population. (nih.gov)

Malignant C6923 Acute Bilineal Leukemia An acute leukemia of ambiguous lineage in which there is a dual population of blasts with each population expressing markers of a distinct lineage (myeloid and lymphoid or B-and T-lymphocyte). (nih.gov)
FAB M7 An acute myeloid leukemia in which at least 50% of the blasts are of megakaryocytic lineage. (nih.gov)
Its expression is gradually lost as lineage committed progenitors differentiate. (m-entrepreneurship.com)
[ 1 , 3 ] The 2016 revised WHO classification of MDS primarily relies on the degree of dysplasia and blast percentages for disease classification, in which specific cytopenias have a small impact on the classification and the manifested lineage(s) of significant morphologic dysplasia did not often correlate with the specific cytopenia(s) in individual MDS cases. (medscape.com)
Myelodysplastic syndrome (MDS) with single lineage dysplasia (SLD) is characterized by morphologic dysplasia of a single myeloid lineage with associated one or two peripheral blood cytopenia(s). (medscape.com)
cDNA representational difference analysis was used to identify myeloid-specific genes that may be associated with an erythroid to myeloid lineage switch involving the murine J2E erythroleukemic cell line. (ustc.edu.cn)

Translocation (8;21)/AML1-ETO is considered a favorable cytogenetic abnormality in acute myeloid leukemia (AML). (medscape.com)
Translocation (8;21)(q22;q22) results in the production of a detectable AML1-ETO fusion transcript by juxtaposition of the 5' portion of the acute myeloid leukemia (AML) gene on chromosome 21 to the 3' portion of the ETO gene on chromosome 8. (medscape.com)
In fact, CD19 expression is highly specific for AML, with t(8;21) occurring in 63% to 80% of adult and pediatric AML cases with t(8;21) and only rarely in the absence of AML1-ETO translocation. (medscape.com)
CML is caused by expression of the chimeric BCR-ABL tyrosine kinase oncogene, the product of the t(9;22) Philadelphia translocation. (nih.gov)
3. A yeast two-hybrid screen was conducted to identify binding partners of Mlf1, an oncoprotein recently identified in a translocation with nucleophosmin that causes acute myeloid leukemia. (ustc.edu.cn)
A genetic rearrangement (translocation) involving chromosome 21 is associated with a type of blood cancer known as core binding factor acute myeloid leukemia (CBF-AML). (medlineplus.gov)

One case of common ALL (cALL), one case of T-ALL, and one undifferentiated acute leukemia that responded to anti-myeloid drugs after unsuccessful anti-lymphoid induction therapy, had germ line heavy chain genes. (jci.org)
20%. These are usually myeloblasts but lymphoid blast crisis occurs in about 20% of cases. (askhematologist.com)

Colon cancer-associated transcript-1 ( CCAT1 ) gene encodes an lncRNA whose over-activation was observed in an expanding list of primary human solid tumors and tumor cell lines, however its biological roles in acute myeloid leukaemia (AML) has not been reported yet at present. (molcells.org)
2423}. Whole-genome sequencing has ing has shown that more than half of all shown that more than half of all cases cases of MDS-MLD carry mutations in of MDS-MLD carry mutations in genes genes that are also mutated in MDS with that are also mutated in MDS with excess excess blasts and acute myeloid leukae- blasts and acute myeloid leukaemia. (who.int)

Pathomorphologic features included monocytosis, monocytoid blasts, aberrant expression of phosphoSTAT5, and c-kit overexpression. (ewha.ac.kr)

Myelodysplastic Syndromes (MDS) are a range of heterogeneous clonal hematologic diseases characterized by ineffective hematopoiesis and a tendency to develop acute myeloid leukemia (AML) [ 1 ]. (oncotarget.com)

5. Expression of Bcl-2-related genes in normal and AML progenitors: changes induced by chemotherapy and retinoic acid. (nih.gov)
Western blots showed changes in the expression of genes for poly ADP-ribose polymerase (PARP), caspase 3/9, and P65. (zju.edu.cn)
Bcr/abl overexpression is observed under low expression of the p53, p21, mdm2 genes. (actanaturae.ru)
There were significant positive correlations between the expression levels of all three genes. (ascopubs.org)

Our study suggests that KIT activating mutations in AML with t(8;21) are associated with diminished CD19 and positive CD56 expression on leukemic blasts and, thus, can be phenotypically distinguished from AML1-ETO leukemias without KIT mutations. (medscape.com)
The aim of this study was to characterize the immunophenotype of AML1-ETO leukemia and concurrent cytogenetics of myeloid blasts with and without KIT activating mutations. (medscape.com)
E), Clonal hierarchy of baseline mutations assessed using bulk myeloid NGS panel on baseline samples. (ox.ac.uk)
It is likely that many different genomic mutations, epi-genetic aberrations, or abnormalities in gene expression could contribute to AML progression. (molcells.org)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
Induction therapy should not be modified based on the presence of leukemia cell characteristics that have variably been considered to predict a poorer prognosis (eg, secondary chromosomal abnormalities, FLT3 mutations, CD56 expression, BCR3 PML-RARA isoform). (medscape.com)

Blast crisis is the most advanced stage of chronic myelogenous leukemia (CML) and is highly refractory to therapy. (nih.gov)
Acute myeloid leukemia from a patient who presented 10 months after therapy with topoisomerase II inhibitor. (medscape.com)
The azanucleosides, azacitidine and decitabine, are first-line therapy for MDS that induce promoter demethylation and gene expression of the highly immunogenic tumor antigen NY-ESO-1. (johnshopkins.edu)
In conclusion, these results revealed new mechanism of lncRNA CCAT1 in AML development, and suggested that the manipulation of CCAT1 expression could serve as a potential strategy in AML therapy. (molcells.org)
After 54 months, the patient relapsed with frank leukemia and a white cell count of 50 x 10 9 /L. Due to the patient's wishes, only supportive therapy was given, and she died of her disease a few days later with a rapidly escalating blast cell burden. (biomedcentral.com)

Genetic variants involved in oxidative stress, base excision repair, DNA methylation, and folate metabolism pathways influence myeloid neoplasias susceptibility and prognosis. (cdc.gov)

Acute Lymphoblastic Leukemia by Gene Expression Signature Gene expression-based patient cluster groups in acute lymphoblastic leukemia. (nih.gov)
Acute Lymphoblastic Leukemia ROSE Cluster Unique gene expression-based patient cluster groups in high-risk B-precursor acute lymphoblastic leukemia determined by Recognition of Outliers by Sampling Ends (ROSE). (nih.gov)
Characterizing gene expression differences between HSCs, pre-LSCs and LSCs would be a valuable step towards that goal. (nature.com)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
Based on principal component analysis and gene expression profiling we demonstrate that CD34+ HSPCs that do not undergo ex vivo expansion are transcriptionally similar to minimally differentiated AML blasts. (ox.ac.uk)
They can identify the heterozygous deletions wich result in haplo-insufficient gene expression (e.g. (intechopen.com)

To evaluate CXCR4 imaging in acute myeloid leukemia, we first tested CXCR4 expression in patient-derived primary blasts. (tum.de)

15. Combining simvastatin with the farnesyltransferase inhibitor tipifarnib results in an enhanced cytotoxic effect in a subset of primary CD34+ acute myeloid leukemia samples. (nih.gov)
Variant CD45R expression with autosomal dominant inheritance affects both helper/inducer (CD4+) and suppressor/cytotoxic (CD8+) T cell populations. (roche.com)

MDS are characterized by elevated risk of progression to secondary acute myeloid leukemia (AML) [ 1 , 2 ]. (intechopen.com)

A global study for acute myeloid leukemia with RARG rearrangement. (cdc.gov)
This rearrangement occurs in approximately 7 percent of acute myeloid leukemia cases in adults. (medlineplus.gov)

Although the introduction of BCR-ABL1 tyrosine kinase inhibitors (TKI) has improved clinical responses and outcomes significantly, blast phase (BP) disease remains a major therapeutic challenge [ 1 ]. (oncotarget.com)
The cell polarity PTK7 receptor acts as a modulator of the chemotherapeutic response in acute myeloid leukemia and impairs clinical outcome. (crcm-marseille.fr)

Extramedullary acute myeloid leukemia (eAML): Retrospective single center cohort study on clinico-pathological, molecular analysis and survival outcomes. (cdc.gov)

Results P-gp activity, but not MRP1 and BCRP, attenuated AVE9633 and DM4 cytotoxicity in myeloid cell lines. (scienza-under-18.org)

1. Potential CD34 signaling through phosphorylated-BAD in chemotherapy-resistant acute myeloid leukemia. (nih.gov)
2. Molecular responses during chemotherapy in acute myeloid leukemias in predicting poor-response to standard chemotherapy. (nih.gov)

Correlation between myeloperoxidase expression and gene alterations and prognosis in acute myeloid leukemia]. (cdc.gov)
Distinct gene alterations with a high percentage of myeloperoxidase-positive leukemic blasts in de novo acute myeloid leukemia. (cdc.gov)

Recently, several novel molecular prognostic markers were identified in cytogenetically normal acute myeloid leukemia (CN-AML). (ascopubs.org)
In this study, high ERG expression levels emerged as a strong negative prognostic factor and provided prognostic information in addition to established molecular markers. (ascopubs.org)

Marrow hypercellular with gross myeloid hyperplasia. (askhematologist.com)

Furthermore, we efficiently sensitized primary AML blasts to anthracycline-mediated cell death using a recombinant soluble PTK7-Fc protein. (crcm-marseille.fr)
Minimal bcr/abl expression is observed under overexpression of p53, mdm2, p21, c-myc, as well as under cell maximum at the S and G2/M phases. (actanaturae.ru)
This was confirmed by comparing the cell cycle status of the AML blasts and the HSPCs. (ox.ac.uk)
However, the unique cALL case with a germ line configuration was also HLA-DR positive, which confirmed that both the cALL antigen and HLA-DR antigen were not per se expression of B cell commitment. (jci.org)

Isoform-specific real-time PCR analysis showed that even though these isoforms were broadly expressed all except isoform 4, had very low level of expression. (nih.gov)
Since TGIF, levels have recently implicated to play a role in acute myelogenous leukemia we proceeded to characterize the minimal promoter region of isoform 4 as a first step in understanding mechanisms of TGIF expression. (nih.gov)
Language": "en", "Country": "XG", "Code": "Intended Use" }, { "Name": "Background Information", "Value": "CD45R, also named MB1, is the isoform of CD45, the protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. (roche.com)

Anatomy1

Organisms1

Diseases10

Chemicals and Drugs6

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes1

Technology, Industry, Agriculture2

Information Science1

Health Care1

Chronic myeloid11

Differentiation14

Malignancies5

Expressed in acute myeloid1

Bone14

Neoplasms12

Cells51

Antigens3

Maturation5

Accumulation2

Associated with acute myeloid3

Transformation to acute myeloid2

Patients24

Immature1

Lineage6

Translocation6

Lymphoid2

Leukaemia2

Aberrant1

Myelodysplastic1

Genes4

Mutations6

Therapy5

Genetic1

Gene expression6

Primary blasts1

Cytotoxic2

Progression1

Rearrangement2

Clinical2

Extramedullary1

Cytotoxicity1

Chemotherapy2

Myeloperoxidase2

Markers2

Hyperplasia1

Cell4

Isoform3