Expression in epithelial cells. Medical search. Frequent questions

The Menkes protein is also in retinal pigment epithelial cells and the neurosensory retina. (medscape.com)

The intestinal epithelial cells play an important critical role in the immune response within the intestinal tissue and they are involved in the responses to hypoxic situation [ 27 ]. (hindawi.com)
LTD4 has been shown to induce cell proliferation, survival and migration in intestinal epithelial cells (Int407) via the CysLT1R. (lu.se)

and (d) down-regulation of non-epithelial genes. (rupress.org)
The effects of corticosteroids are predominantly mediated by the inhibition of NF-κB deoxyribonucleic acid (DNA)-binding activity, which controls genes encoding inflammatory cytokines, chemokines and adhesion molecules in respiratory epithelial cells 10 - 13 . (ersjournals.com)
Although no apparent morphologic changes were observed, the B[a]P-exposed A549 cells exhibited enhanced proliferative activity in 1% bovine serum that contained medium, and dramatic changes in expression levels were observed in a large number of genes. (nih.gov)
Amniotic epithelial cells have not been known to produce cancerous tumors in the host despite the fact that these cells do express genes found in embryonic stem cells that are known to promote tumor formation. (wikipedia.org)
Our results determined that 290 genes were consistently up-regulated in P. gingivalis infected epithelial cells . (bvsalud.org)
Kim YD, Cho JS, Kim HS, Song SH: Effect of macrolide on the interleukin-1 β-mediated MUC2/5AC genes expression and mucin secretion in human airway epithelial cells. (karger.com)
Twenty-nine of these genes were significantly regulated in UC-in-remission subjects compared with non-IBD controls, including a large number of epithelial cell-expressed genes such as REG4, S100P, SERPINB5, SLC16A1, DEFB1, AQP3 and AQP8, which modulate epithelial cell growth, sensitivity to apoptosis and immune function. (bmj.com)
Expression of inflammation-related genes such as REG1A and IL8 returned to control levels during remission. (bmj.com)
Given the strong link between the regulation of some of these genes and the growth and dissemination of gastrointestinal cancers, we believe their aberrant expression in UC may provide a mechanism for epithelial hyper-proliferation and, in the context of malignant transformation, for tumour growth. (bmj.com)
Among the genes that remain deregulated during remission, we identify several that are expressed by epithelial cells and are involved in epithelial cell proliferation, resistance to apoptosis and response to stress. (bmj.com)
Using the real-time polymerase chain reaction (qPCR), the expression CCDC80, HSF1, HSPA1A, PGR, SPP1, STAT1, and TAP genes in endometrial samples collected via uterine swabs was compared in SL and WT cows and heifers. (uprm.edu)
In addition, a higher expression of HSPA1A and HSF1 genes was observed in the sampling carried out in March 2021 where the temperature and humidity index (THI) was lower (THI = 73) than in the sampling carried out in November 2020 (THI=75). (uprm.edu)
El primer objetivo del estudio fue investigar la aparente ventaja reproductiva en SL Holstein analizando si los genes candidatos se expresan de manera diferencial entre Holstein SL y WT en el tejido endometrial. (uprm.edu)
Utilizando la reacción en cadena de la polimerasa en tiempo real (qPCR), se comparó la expresión de genes candidatos CCDC80, HSF1, HSPA1A, PGR, SPP1, STAT1 y TAP en muestras de endometrio recolectadas a través de isopos uterinos en vacas y novillas SL y WT. (uprm.edu)
The objective of this study was to identify such differentially expressed genes.MethodsThe interaction between the cell types was simulated in vitro by growing primary cell cultures of human endometrial epithelial cells and trophoblast cells together (co-culture) and separately (control cultures). (regionh.dk)
mRNA expression of genes and proteins related to disease pathology were. (lu.se)
The number of upregulated genes was larger than the numbers of downregulated genes in both groups of virus-infected NHBE cells at both time points. (aacc.org)
Diet-induced obesity led to altered acetylation of lysine 27 on histone H3 (H3K27ac) and to altered monomethylation of lysine 4 on histone H3 (H3K4me1) at numerous loci, with concomitant changes in the expression of genes that were functionally relevant to intestinal cancers. (biomedcentral.com)
Epsin Family Member 3 and Ribosome-Related Genes Are Associated with Late Metastasis in Estrogen Receptor-Positive Breast Cancer and Long-Term Survival in Non-Small Cell Lung Cancer Using a Genome-Wide Identification and Validation Strategy. (nih.gov)
Total RNA from tumors the expression of thousands of genes (3) to address complex questions was isolated using two successive rounds of Trizol. (lu.se)
Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)

Ectopic expression of AUF1 also promoted stemness in mammary epithelial cells, and thereby increased the proportion of cancer stem cells. (nature.com)
These data prompted us to ask whether AUF1 upregulation could promote EMT as well as stemness in mammary epithelial cells. (nature.com)
Here, we have investigated the role of ChoK in the development of breast cancer and found that ChoK is both necessary and sufficient for growth factor-induced proliferation in primary human mammary epithelial cells and an absolute requirement for the specific mitogenic response to heregulin in breast tumor-derived cells. (aacrjournals.org)
Up-regulation of SEPT9_v1 stabilizes c-Jun-N-terminal kinase and contributes to its pro-proliferative activity in mammary epithelial cells. (medlineplus.gov)

Methods Pathways governing airway mucus cell differentiation include SRY (sex determining region Y)-box 2 (SOX2), Notch, forkhead box A3(FOXA3)/SAM pointed domain containing ETS transcription factor (SPDEF), epidermal growth factor (EGF) and the EGF-related neuregulins NRG1α and NRG1β. (bmj.com)
Results In IPF, the bronchiolised and enlarged distal airspaces stained for SOX2 are consistent with epithelial differentiation characteristic of conducting airway epithelium. (bmj.com)
Conclusion Expression of SOX2 and MUC5B and lack of SPDEF in atypically differentiated cells of bronchiolised distal airspaces are consistent with abnormal programming of airway epithelial cells in IPF. (bmj.com)
Neuregulin1α, which drives mucus cell differentiation in vitro, was expressed in normal airway submucosal glands and in lungs from patients with IPF. (bmj.com)
Inhaled fluticasone propionate (FP) is widely used to reduce pulmonary inflammation in chronic obstructive pulmonary disease, but the potential effects of FP on airway epithelial cells from patients with cystic fibrosis (CF) are unknown. (ersjournals.com)
In CF disease, a nonregulated inflammatory lung response occurs through exaggerated nuclear factor (NF)-κB activation and elevated pro-inflammatory cytokines production by airway epithelial cells. (ersjournals.com)
Cystic fibrosis (CF) is a lethal inherited disorder caused by mutations in the gene encoding the CF transmembrane conductance regulator (CFTR) in airway epithelial cells 1 . (ersjournals.com)
One of the major clinical manifestations of CFTR mutations is neutrophil dominated inflammation 2 , 3 , implying that defective CFTR affects the immune function of airway epithelial cells, in particular the production of nuclear factor (NF)-κB-dependent chemokines. (ersjournals.com)
How CFTR dysfunction in CF airway cells contributes to the activation and nuclear localisation of NF-κB is still unclear. (ersjournals.com)
The functional expression of the epithelial sodium channel (ENaC) appears elevated in cystic fibrosis (CF) airway epithelia, but the mechanism by which this occurs is not clear. (wustl.edu)
These data support the hypothesis that wt CFTR can regulate the whole cell, functional, and surface expression of endogenous ENaC in airway epithelial cells and that absence of this regulation may foster ENaC hyperactivity in CF airway epithelia. (wustl.edu)
16-membered) on MUC5AC and MUC2 gene expression and secretion from human airway epithelial cells. (karger.com)
The present study demonstrates that AZM and MDM suppress the synthesis of mucin and TNF-α from human airway epithelial cells. (karger.com)
Shimizu T, Shimizu S: Azithromycin inhibits mucus hypersecretion from airway epithelial cells. (karger.com)
Cigana C, Assael BM, Melotti P: Azithromycin selectively reduces tumor necrosis factor alpha levels in cystic fibrosis airway epithelial cells. (karger.com)
We previously reported that importin 13 (IPO13), a member of the importin-β family of nuclear import proteins, regulates nuclear import of the glucocorticoid receptor in airway epithelial cells, IPO13 serves as a potential marker for corneal epithelial progenitor cells, and IPO13 is associated with corneal cell proliferation. (molvis.org)
Tracheal aspirate IL-8 concentration and airway epithelial cell IL-8 expression are each increased in premature infants undergoing mechanical ventilation. (utmb.edu)
We conclude that airway fluid from mechanically ventilated premature infants contains soluble factors capable of inducing airway epithelial cell IL-8 expression via a NF-κB-dependent pathway, and that IL-1β plays a specific role in this process. (utmb.edu)

The present study investigated the effects of GSK2606414 on proliferation, apoptosis, and the expression of activating transcription factor 4 (ATF4), CCAAT/enhancer‑binding protein homologous protein (CHOP) and vascular endothelial growth factor (VEGF) in human retinal pigment epithelial (RPE) cells under endoplasmic reticulum (ER) stress. (spandidos-publications.com)
Cell proliferation was assessed using the Cell Counting kit‑8 cell viability assay. (spandidos-publications.com)
GSK2606414 treatment inhibited RPE cell proliferation in a dose‑dependent manner, however it did not induce apoptosis. (spandidos-publications.com)
These results demonstrate that ChoK plays an essential role in both normal human mammary epithelial cell proliferation and breast tumor progression. (aacrjournals.org)
Here we investigated the role of IPO13 in the pathogenesis of pterygium and the underlying mechanism including interaction with other cell proliferation-related factors: keratin 17 (K17), a lesional protein and a member of the type I keratins, and c-Jun, a protein of the activator protein-1 complex. (molvis.org)
Caov-3 cell proliferation was assessed using 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-diphenytetrazoliumromide (MTT) assay. (ajol.info)
The results demonstrate that zerumbone inhibits cell proliferation, migration and invasion, but represses the EMT process via inactivation of Wnt/β-catenin signaling pathway. (ajol.info)
Immunohistochemistry (IHC) staining was conducted by using the avidin-biotin complex technique for detecting the antibodies to hypoxia inducible factor-1 (HIF-1) alpha, cytokeratin 20 (CK20), and cell proliferation factor Ki67. (hindawi.com)
The altered gene expression may enhance several cancer-related events such as cell division (proliferation), cell movement, and the development of new blood vessels (angiogenesis) that nourish a growing tumor. (medlineplus.gov)
DESIGN: Proliferation, mitosis and the expression of progenitor lineage markers were assessed in normal squamous oesophagus from 10 patients by immunofluorescence on 3D epithelial whole mounts. (who.int)

ATF4 induces expression of the proapoptotic transcription factor CCAAT/enhancer-binding protein homologous protein (CHOP), which mediates PERK-induced apoptosis ( 16 ). (spandidos-publications.com)
Furthermore, E1A DNA and protein persisted in epithelial cells in the lungs of these animals 9 . (ersjournals.com)
Our recent study reported that C3 opsonisation markedly increases the ability of E. coli strain J96 to internalise into human proximal tubular epithelial cells via CD46, a complement regulatory protein expressed on host cell membrane. (biomedcentral.com)
Moreover, C3 opsonisation promotes E. coli invasion of human uro-epithelial cells via CD46, a complement regulatory protein expressed on host cell membranes [ 13 ]. (biomedcentral.com)
AZM and MDM attenuated PMA-induced MUC5AC and MUC2 gene and protein expression in NCI-H292 cells. (karger.com)
Immunohistochemical and in situ hybridization analyses revealed expression of SLURP-1 protein and mRNA, respectively, exclusively in ciliated bronchial epithelial cells. (elsevierpure.com)
REG4, S100P, SERPINB5 and REG1A protein expression was confirmed by immunohistochemistry (n=23). (bmj.com)
Incubation of tracheal aspirates with 16HBE14o- human bronchial epithelial cells increased IL-8 protein in both cell lysates and supernatants, as well as transcription from the IL-8 promoter. (utmb.edu)
CXCR4 protein could be detected on the surface of 16% of the RPE cells using flow cytometry, Calcium mobilization in response to the CXCR4 ligand stromal cell-derived factor 1 alpha (SDF-1 alpha) indicated that the CXCR4 receptors were functional, Incubation with SDF-1 alpha resulted in secretion of monocyte chemoattractant protein-1, IL-8, and growth-related oncogene iv, RPE cells also migrated in response to SDF-1 alpha. (elsevierpure.com)
together with protein concentration) and lens epithelial cells plus capsule (LECs/capsule) in patients with cataract (CAT), and also suffering from pseudoexfoliation syndrome (PEX), primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (PXG). (molvis.org)
Protein expression was determined by western blot. (ajol.info)
Protease inhibitors and antioxidants suppressed protein kinase C and NF-kappaB activation and induction of IL-8 promoter activity in cells exposed to dust extract. (cdc.gov)
Specifically, the WNT5A gene was hypermethylated at the promotor region in the diabetic cells and its protein was markedly repressed. (medscape.com)
The septin-9 protein also seems to act as a tumor suppressor, which means that it regulates cell growth and keeps cells from dividing too fast or in an uncontrolled way. (medlineplus.gov)
The Menkes protein is synthesized as a single-chain polypeptide localized to the trans-Golgi network in cells. (medscape.com)
Polymorphisms in Natural Killer Cell Receptor Protein 2D (NKG2D) as a Risk Factor for Cholangiocarcinoma. (cdc.gov)

Many other cell types emerge via epithelial-mesenchymal differentiation. (rupress.org)
This provides a new system for molecular analysis of epithelial-mesenchymal interconversions. (rupress.org)
Since epithelial-to-mesenchymal transition (EMT) and the acquisition of cancer stem cell traits are important for cancer onset and progression, we sought to determine the role of AUF1 in these two important processes. (nature.com)
Epithelial-mesenchymal transformation is now recognised as an important feature of tissue remodelling. (ersjournals.com)
Reports from several laboratories suggest that a phenomenon termed epithelial-mesenchymal transformation, in which epithelial cells transform into fibroblasts capable of producing connective tissue matrix, is an important feature of tissue remodelling 10 , 11 . (ersjournals.com)
In the present study, the hypothesis that adenoviral infection followed by persistent expression of its E1A gene is capable of producing epithelial-mesenchymal transformation was examined by investigating guinea pig PLECs that express adenoviral E1A. (ersjournals.com)
Recent studies have shown that cancer-associated fibroblasts (CAFs) and the epithelial-mesenchymal transition (EMT) contribute to invasive and metastatic abilities of ovarian cancer (OC) cells. (oncotarget.com)
Importin 13 (IPO13), a member of the importin-β superfamily, was originally identified in the fetal rat lung and differentially expressed in cells of epithelial and mesenchymal origin. (molvis.org)
To investigate the effects of zerumbone on cell invasion, epithelial-mesenchymal transition (EMT) and the potential signaling pathway involved in ovarian cancer cells. (ajol.info)
Significantly, there are additional non-epithelial stromal cells (NES) that exist alongside TEC within thymic microenvironments, including multiple subsets of mesenchymal and endothelial cells. (frontiersin.org)
Broadly separated into mesenchymal and endothelial cells, NES have been implicated in thymus organogenesis, thymocyte development, tolerance induction and development/maintenance of epithelial stroma. (frontiersin.org)
In early experiments, physical separation of mesenchymal and epithelial stroma from embryonic murine thymus resulted in defective thymus development when epithelium was cultured in vitro in the absence of mesenchyme ( 7 ). (frontiersin.org)
Overexpression of Epsin 3 enhances migration and invasion of glioma cells by inducing epithelial‑mesenchymal transition. (nih.gov)
Sarcomatoid conversion of clear cell renal cell carcinoma in relation to epithelial-to-mesenchymal transition. (lu.se)
Approximately 8% of clear cell renal cell carcinoma cases contain regions of radically different morphology, demonstrating a mesenchymal appearance histologically resembling sarcomas. (lu.se)
In the present study we investigate whether the sarcomatoid conversion of clear cell renal cell carcinoma could be interpreted as linked to the process of epithelial-mesenchymal transition. (lu.se)
Furthermore the sarcomatoid elements demonstrate an enhanced expression of epithelial-mesenchymal transition related mesenchymal markers as compared with the clear cell renal cell carcinoma counterparts. (lu.se)
We further selected a representative case, clinically demonstrating direct overgrowth of the sarcomatoid component into the liver and colon, for extended immunohistochemical characterization, resulting in a further set of positive and negative epithelial-mesenchymal transition markers as well as pronounced transforming growth factor β positivity, indicating that sarcomatoid clear cell renal cell carcinoma may be associated to epithelial-mesenchymal transition. (lu.se)
Transforming growth factor β1 exposure of in vitro cultured primary clear cell renal cell carcinoma cells resulted in cells adopting a mesenchymal morphology similar to sarcomatoid clear cell renal cell carcinoma. (lu.se)
Corresponding changes in RNA levels for key epithelial-mesenchymal transition markers were also seen. (lu.se)
We therefore suggest that sarcomatoid clear cell renal cell carcinoma morphologically and immunohistochemically may represent a completed epithelial-mesenchymal transition and that transforming growth factor β1 could be an important driving force during the sarcomatoid transdifferentiation of clear cell renal cell carcinoma. (lu.se)

E1a induces the expression of epithelial characteristics. (rupress.org)
We have shown that AUF1 induces EMT and stemness in breast epithelial cells via stabilization of the SNAIL1 and TWIST1 mRNAs, and their consequent upregulation. (nature.com)
FP induces apoptosis of eosinophils 18 and also reduces the production of several cytokines such as IL-1β, IL-6, IL-8 and RANTES (regulated on activation, T-cell expressed and secreted) by alveolar macrophages 19 and lymphocytes 20 , 21 . (ersjournals.com)
SGK1 inhibition induces fetal hemoglobin expression and delays polymerization in sickle erythroid cells. (nih.gov)

Thymic epithelial cells (TEC) effect crucial roles in thymopoiesis including the control of negative thymocyte selection. (ox.ac.uk)
Extensive research on thymic epithelial cells (TEC) within the cortex and medulla has defined their essential roles during T-cell development. (frontiersin.org)
Arguably, the most recognized and well-studied stromal populations in thymus biology are thymic epithelial cells (TEC) within the cortical and medullary areas, which are defined by their anatomical separation and function. (frontiersin.org)
Thymoma is a neoplasm of thymic epithelial cells. (medscape.com)
The lymphocytes' selection process and developmental progression are influenced by direct contact between the TCR-CD3 complex on the thymocyte and the major histocompatibility complex (MHC)-antigen complex on thymic epithelial cells, dendritic cells, and B lymphocytes. (medscape.com)

Collectively, these results suggest that SLURP-1 contributes to the maintenance of bronchial epithelial cell homeostasis and to the regulation of TNF-α release from macrophages in bronchial tissue. (elsevierpure.com)
Evaluation of differentiated human bronchial epithelial cell culture systems for asthma research Journal of Allergy. (nottingham.ac.uk)

Case-control studies have shown that the E1A DNA from group C adenoviruses is present in greater amounts in the lungs of patients with COPD than in controls with normal lung function matched for age, sex and smoking history 5 , and that the excess inflammation in the lungs of smokers with severe emphysema is associated with increased numbers of alveolar epithelial cells expressing E1A 6 . (ersjournals.com)
Discussion: In conclusion, our data indicate that bronchial and alveolar epithelial cells respond differently to hypoxia and profibrotic stimuli. (lu.se)
some is secondarily produced by alveolar macrophages and epithelial cells. (msdmanuals.com)

E1a thus appeared to partially convert diverse human tumor cells into an epithelial phenotype. (rupress.org)
Cytokeratin 20 (CK20) is a well-known biomarker for detecting circulating tumor cells (CTCs) in the patients with metastatic CRC [ 19 ]. (hindawi.com)

In particular the strong effect on the IκB-β kinase, which is known to be elevated in bronchial epithelial cells in cystic fibrosis patients, was observed. (ersjournals.com)

Given the importance of Ii in the biology of class II MHC, we sought to examine the expression of II by gastric epithelial cells (GEC) to determine whether class II MHC molecules in these nonconventional APC cells were under the control of II and to further support the role that these cells may play in local immune and inflammatory responses during Helicobacter pylori infection. (utmb.edu)
We used human stomach fetal epithelium (HSFE) and SV40-immortalized human normal gastric epithelial (GES-1) cell lines to mimic primary gastric epithelium of children and adults, respectively. (ncku.edu.tw)

The interaction between the cell types was simulated in vitro by growing primary cell cultures of human endometrial epithelial cells and trophoblast cells together (co-culture) and separately (control cultures). (regionh.dk)
These sequences may be important to the course of events following the interaction between endometrial epithelial and trophoblast cells and responsible for implantation. (regionh.dk)

This study was designed to determine whether miRNAs regulate NOD2 expression as well as downstream nuclear factor kappaB activation and inflammatory responses in colonic epithelial HCT116 cells. (elsevierpure.com)
The SCFAs are rapidly adsorbed from the colonic lumen and constitute a preferred energy source for colonic epithelial cells. (biomedcentral.com)

However, treatment with various approaches, including exogenous WNT5A methylation inhibitors and a nanoconjugate that inhibits WNT5A suppression, improved corneal epithelial wound healing as well as expression of the limbic epithelial stem cells. (medscape.com)
Overall, Wnt-5a is a new corneal epithelial wound healing stimulator that can be targeted to improve wound healing and stem cells in the diabetic cornea," write Ruchi Shah, PhD, of the Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, and colleagues. (medscape.com)

Thus we examined the expression of II on GEC from human biopsy samples and then confirmed this observation using independent methods on several GEC lines. (utmb.edu)
Methods: NOD2 and miRNA expression in stimulated HCT116 cells were assessed by quantitative reverse transcription-polymerase chain reaction. (elsevierpure.com)
Methods: The effects of dust extracts on inflammatory gene expression were analyzed by quantitative polymerase chain reaction (qPCR), enzyme linked immunosorbent (ELISA) and western blot assays. (cdc.gov)

Medullary epithelial cells (mTEC), in conjunction with dendritic cells, then take over control of developing thymocytes. (frontiersin.org)
Dendritic cells and macrophages found in large quantities at the corticomedullary junction arise from mesodermal tissues (bone marrow). (medscape.com)
that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)

The authors sought to identify mechanisms driving the differentiation of mucus cells during the bronchiolisation process. (bmj.com)
In this work, pathways governing mucus cell differentiation were investigated in lung tissues from patients with IPF and other chronic pulmonary disorders. (bmj.com)
Activation of abnormal respiratory epithelial differentiation programs may contribute to the expression of MUC5B and bronchiolisation of the distal lung, a salient feature of IPF. (bmj.com)
The adult alae are commonly used as an indicator of hypodermal seam cell terminal differentiation. (wormatlas.org)

ARPE‑19 human RPE cells were treated with 0.01‑50 µM GSK2606414, and ER stress was induced by thapsigargin (TG) treatment. (spandidos-publications.com)
Disruption of PERK activity has been demonstrated to reduce hydroquinone-induced apoptosis and hypoxia-induced VEGF expression in human RPE cells in vitro ( 5 , 21 ). (spandidos-publications.com)
I have previously reported (Frisch, 1991) that adenovirus E1a is a tumor suppressor gene in certain human cell lines. (rupress.org)
In this study, we further assessed whether C3-dependent internalisation by human tubular epithelial cells is a general feature of uropathogenic E. coli and investigated features of the bacterial phenotype that may account for any heterogeneity. (biomedcentral.com)
To determine whether FP reduces cytokine production in bronchial epithelial cells via NF-κB, the authors investigated the nonstimulated and the Pseudomonas aeruginosa lipopolysaccharide (LPS) stimulated production of NF-κB-dependent interleukin (IL)-6, IL-8 and RANTES (regulated on activation, T-cell expressed and secreted) along with the activation of NF-κB in non-CF and CF human bronchial gland epithelial cells. (ersjournals.com)
The present authors and previous studies, have previously demonstrated that epithelial expression of interleukin (IL)-8 is excessively elevated in the bronchial epithelial cells of human CF adults 6 . (ersjournals.com)
The pluripotency of the human amniotic epithelial cells makes them useful in treating and fighting diseases and disorders of the nervous system as well as other tissues of the human body. (wikipedia.org)
In harvesting embryonic stem cells, a human embryo is destroyed. (wikipedia.org)
These studies are the first to demonstrate the constitutive expression of II by human GEC. (utmb.edu)
Confluent NCI-H292 human mucoepidermoid airways epithelial cells were pretreated with AZM or MDM for 2 h and then stimulated with 200 nmol/l phorbol 12-myristate 13-acetate (PMA) for 8 h. (karger.com)
2. The aim of this work was to investigate how hypoxia affects human lung epithelial cells in combination with profibrotic stimuli and its correlation to pathogenesis. (lu.se)
Normal human bronchial epithelial (NHBE) cell cultures have been an effective model to assess the viral-host interaction. (aacc.org)
Given the important roles of the gut microbiome in regulating host physiology and gene expression, a better understanding of the relationship between the host and the symbiont microbiota should provide new insights into human health and disease risk. (biomedcentral.com)
Crohn's Disease IRGM Risk Alleles are Associated with Altered Gene Expression in Human Tissues. (nih.gov)
High SEPT9_v1 expression in human breast cancer cells is associated with oncogenic phenotypes. (medlineplus.gov)
Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)
These in vitro, and their expression in these human tumour virus. (who.int)

Within this host- bacteria interaction, P. gingivalis can modify the host immune reaction and adjust the gene expression , which is associated with periodontitis pathogenesis and developing strategies . (bvsalud.org)
The production of a diverse αβ-T-cell pool is vital to establishing and maintaining a functional adaptive immune system. (frontiersin.org)

Guinea pig primary peripheral lung epithelial cells (PLECs) transfected with adenovirus E1A (E1A-PLECs) were compared to guinea pig normal lung fibroblasts (NLFs) transfected with E1A (E1A-NLFs). (ersjournals.com)
E1A transfection results in the transformation of peripheral lung epithelial cells and normal lung fibroblasts to a phenotype intermediate between that of the two primary cells. (ersjournals.com)
Adenoviral DNA is retained by peripheral epithelial cells of the lung (PLECs) in humans in whom the viral E1A gene is expressed 4 without replication of a complete virus 5 . (ersjournals.com)
The current results indicated that B[a]P seems to induce EMT in lung cancer cells, and it also may drive disease progression in patients with lung cancer. (nih.gov)
In the present study, we assessed SLURP-1 expression in lung tissue from C57BL/6J mice to investigate the functions of SLURP-1 in pulmonary physiology and pathology. (elsevierpure.com)
Proteases and oxidant stress control organic dust induction of inflammatory gene expression in lung epithelial cells. (cdc.gov)
We studied the mechanisms by which protease activities in poultry dust extracts and intracellular oxidant stress induce inflammatory gene expression in A549 and Beas2B lung epithelial cells. (cdc.gov)
Conclusions: Our studies demonstrate that proteases and intracellular oxidants control organic dust induction of inflammatory gene expression in lung epithelial cells. (cdc.gov)
To prioritise pathways we will undertake high-throughput functional genomic screens using CRISPR, perform lung digital spatial transcriptomic profiling and utilise informative cell and tissue models. (nottingham.ac.uk)
This will inform in-depth mechanistic assays at the cell, tissue and organ scales to identify the key mechanisms underpinning regulation of lung function in health and disease. (nottingham.ac.uk)
EPN3 plays oncogenic role in non-small cell lung cancer by activating the JAK1/2-STAT3 pathway. (nih.gov)

In the present study, we attempted to identify the role of CAF- and EMT-related proteins in OCs, including serous carcinoma, mucinous carcinoma, endometrioid carcinoma and clear cell carcinoma using an immunohistochemical approach. (oncotarget.com)
Nucleocytoplasmic transport is an essential phenomenon in eukaryotic cells controlled by the family of proteins called importins and exportins. (molvis.org)
CheKine™ microquantitative test kits and recombinant proteins help you explore cells with ease! (abbkine.com)
In eukaryotic cells, chromatin comprises a complex consisting of DNA, RNA, and proteins where covalent modifications correlate with regulation of gene expression [ 1 ]. (biomedcentral.com)

abstract = "BackgroundThe interaction between epithelial cells of endometrium and trophoblast cells during implantation is presumed to be accompanied by a change in gene expression in the cell types involved. (regionh.dk)

The changes that occur during adenoviral E1A transformation of primary guinea pig PLECs were also compared with those occurring during the transformation of the fibroblasts that frequently contaminate primary epithelial cultures, and evidence is presented that both cell types are transformed to an intermediate phenotype. (ersjournals.com)

We also observed direct contact between F4/80-positive macrophages and bronchial epithelial cells and the presence of invading macrophages in close proximity to CHT1-positive nerve elements. (elsevierpure.com)

CD74 is known as the major histocompatibility complex (MHC) class II-associated invariant chain (II) that regulates the cell biology and functions of MHC class II molecules. (utmb.edu)

This effect appeared to be achieved via inhibition of the PERK/ATF4/CHOP signaling pathway and suppression of VEGF expression levels. (spandidos-publications.com)

While adult lymphoid progenitor cells are produced by the bone marrow, their lineage commitment and development into mature T-cells is dependent on their migration into the thymus, where essential interactions with heterogeneous thymic stromal cells take place ( 1 ). (frontiersin.org)

Lewis antigen expressions on the gastric epithelium serves as receptors targeted by H. pylori. (ncku.edu.tw)
Retinal pigment epithelial (RPE) cells form part of the blood-retina barrier and have recently been shown to produce various chemokines in response to proinflammatory cytokines, As the scope of chemokine action has been shown to extend beyond the regulation of leukocyte migration, we have investigated the expression of chemokine receptors on RPE cells to determine whether they could be a target for chemokine signaling. (elsevierpure.com)

Increasing evidence suggests that respiratory epithelial cells with dysfunctional CFTR have exaggerated activation of NF-κB/inhibitor of NF-κB complex associated with upregulated expression of chemokines 4 , 5 . (ersjournals.com)
In this study, we aimed to assess host differentially expressed gene signatures in respiratory tract epithelial cells after influenza A virus pdmH1N1 or H7N9 infection. (aacc.org)

Studies have been conducted to evaluate androgen receptor expression in cancer cells and most of the studies have concentrated on cancer epithelial cells and not cancer stromal cells. (journalcra.com)
Development of the prostate gland as well as development of prostatic cancer is closely associated with stromal-epithelial interactions and in the centre of these interactions stands the Androgen Receptor in both stromal and epithelial cells. (journalcra.com)
Results: In the epithelial cells Androgen Receptor expression declined as Gleason grade increased but this correlation was statistically not significant. (journalcra.com)
In the stromal cells a decline in Androgen Receptor expression was also noted but this decline was more pronounced and statistically significant correlation of Androgen Receptor expression was noted between well differentiated carcinomas and moderately and poorly differentiated prostatic carcinomas. (journalcra.com)
Conclusion: Androgen Receptor expression in stromal cells of prostatic carcinoma shows more pronounced decrease as the tumor dedifferentiates compared to Androgen Receptor expression in epithelial cells of prostatic carcinoma. (journalcra.com)
The results presented herein for PGR expression could indicate that the differences in reproductive efficiency of SL and WT cattle could be potentially explained by differences in the concentrations of that hormone and receptor during the reproductive cycle. (uprm.edu)
RT-PCR analysis indicated that the predominant receptor expressed on RPE cells was CXCR4. (elsevierpure.com)
These cells can be characterized in their developmental progression by changes in expression of 3 cell surface markers: CD4, CD8, and the T-cell receptor (TCR)-CD3 complex. (medscape.com)
BT-474 cells, obtained expression of the receptor has important implications for their biology from American Type Culture Collection, were maintained in RPMI 1640 and therapy (1). (lu.se)
High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. (bvsalud.org)
Low IgG2 and polysaccharide response in a T cell receptor expression defect. (lu.se)

Cells from the bronchioloalveolar carcinoma cell line A549 were exposed to benzo(a)pyrene (B[a]P) for 24 weeks, and morphology, proliferative activity, and gene expression profiles were analyzed. (nih.gov)
Herein, a meta-analysis was made to get the differential gene expression profiles in epithelial cells with or without P. gingivalis infection . (bvsalud.org)
To gain global and dynamic gene expression profiles, the NHBE cells cultured from a 24 year old donor were challenged by 3.0 m.o.i. avian H7N9 virus (A/Taiwan/4-CGMH/2014), H1N1pdm virus (A/California/07/2009), or mock control. (aacc.org)

In addition to pathogen virulence factors, complement C3 secreted by host cells also influences the ability of E. coli to invade cells and tissues within the urinary tract. (biomedcentral.com)
Tissues obtained from amniotic cell lines show promise for patients with congenital diseases or malformations of the heart, liver, lungs, kidneys, and cerebral tissue. (wikipedia.org)
Graft-versus-host disease is a potentially serious complication in a recipient of an allograft (usually a haematopoietic stem cell transplant) that arises from the attack of recipient tissues (such as the skin, liver or gut) by donor-derived T cells. (nature.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
The correlation between pO 2 levels and expression levels of prognostic biomarkers was measured in CRC tissues. (hindawi.com)
Thus, the levels of microenvironmental pO 2 affect the expression of predictive biomarkers HIF-1 alpha, CK20, and Ki67 in the development of CRC tissues. (hindawi.com)
While many studies have demonstrated the importance of cTEC and mTEC during T-cell development, thymic stromal microenvironments also contain heterogenous non-epithelial stromal (NES) populations in a similar manner to that seen in peripheral lymphoid tissues. (frontiersin.org)
The epithelial cells and these other stromal tissues of the thymus influence the selection and maturation of the T lymphocytes. (medscape.com)
Tissues and Cells. (lu.se)
genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)

Premalignant squamous lesions of the oral cavity are areas of altered epithelium that are at an increased risk for progression to squamous cell carcinoma (SCC). (medscape.com)
The tissue diagnosis was squamous cell carcinoma in situ. (medscape.com)
The tissue diagnosis was squamous cell carcinoma, minimally invasive. (medscape.com)
The major risk factors for oral squamous dysplasia-and for squamous cell carcinoma (SCC)-are tobacco smoking and alcohol consumption in Western societies, with other important factors, including the use of areca nut/betel quid in other societies, particularly within India and Southeast Asia, associated with an extremely high oral cancer incidence in these countries (see below). (medscape.com)

c-Jun N-terminal kinase (JNK) siRNA and inhibitor (SP600125) experiments showed that Lewis antigen expression and H. pylori colonization were reduced in GES-1 cells but increased in HSFE cells. (ncku.edu.tw)
In conclusion, a higher p38 expression in gastric epithelium counteracting JNK activity in children may contribute to lower Lewis antigen expression and colonization density than in adults after H. pylori infection. (ncku.edu.tw)

MicroRNAs (miRNAs) are an integral part of the post-transcriptional machinery of gene expression and have been implicated in the carcinogenic cascade. (cdc.gov)

Twelve transcripts were identified as being differentially expressed following the interaction between trophoblast and endometrial cells. (regionh.dk)

The progression of AMD may be prevented through anti-inflammation and antioxidation in retinal pigment epithelium (RPE) cells. (nih.gov)
Our findings indicated that P. gingivalis benefited from the survival of epithelial cells , and got its success as a colonizer in oral epithelium . (bvsalud.org)
IPO13 was colocalized with K17 in the epithelium of the pterygium, and overexpression or knockdown of the IPO13 gene induced upregulation or downregulation of K17 expression in PECs, respectively. (molvis.org)
Here, we profile the gut microbiome and chromatin characteristics in colon epithelium from mice fed either an obesogenic or control diet, followed by an analysis of the resultant changes in gene expression. (biomedcentral.com)
Cells which lack ER expression at diagnosis arise from an ER compart- were harvested at 60 - 80% confluency and used as a reference in all hybrid- ment within the mammary epithelium or represent evolution from an izations. (lu.se)

Gene expression in the cell cultures was compared using the Differential Display method and confirmed using a modified Northern Blot method. (regionh.dk)
Differential expression of specific factors observed between avian H7N9 and pdmH1N1 influenza virus strains could explain the variation in disease pathogenicity. (aacc.org)
Cells expressing differential levels of epithelial and progenitor markers were isolated using flow cytometry sorting and characterised by qPCR and IF. (who.int)

Also, these lab grown cells have shown altered gene expression causing a differing phenotype as well as differing antigen levels. (wikipedia.org)

It was demonstrated that a relevant concentration of FP (10 −8 M) inhibited constitutive and P. aeruginosa LPS-induced IL-6 and IL-8 production of non-CF and CF bronchial epithelial cells. (ersjournals.com)
Reducing the mucosal Cl - concentration increased the response to UTP of both cell lines, with a significantly greater increase in MTE 18-(-/-) cells. (brighton.ac.uk)
Graph of the correlation between serum 17-HPG concentration and percentage of cornified preputial epithelial cells in 21 castrated ferrets. (avma.org)
As the copper is concentrated into vesicles for excretion from the cell, the cytosolic copper concentration decreases and ATP7A returns to the trans-Golgi network. (medscape.com)

As SDF-1 alpha expression by RPE cells was detected constitutively, we postulate that SDP-1-CXCR4 interactions may modulate the affects of chronic inflammation and subretinal neovascularization at the RPE site of the blood-retina barrier. (elsevierpure.com)

Alterations in cell viability and metabolic activity were determined. (lu.se)
The eukaryotic epigenome is postulated to respond to environmental stimuli through alterations in chromatin features and, ultimately, gene expression. (biomedcentral.com)
The discovery does not affect gene sequence but entails specific DNA modifications altering gene expression - what are known as epigenetic alterations," he said. (medscape.com)
Alterations in the activity (expression) of the SEPTIN9 gene are associated with certain cancers. (medlineplus.gov)

In the normal thymus, bone marrow-derived precursor cells destined to become thymocytes (or T lymphocytes) enter the thymus at the corticomedullary junction and differentiate as they pass through the thymus. (medscape.com)

Hypothesizing that the differences in expression would allow us to explain the molecular basis of the reproductive advantage of SL cattle. (uprm.edu)
Hipotetizando que las diferencias en la expresión nos permitirían explicar la base molecular de la ventaja reproductiva del ganado SL. (uprm.edu)

Dust extract induction of IL-8 gene expression was associated with increased DHE-fluorescence and 4-HNE staining, and antioxidants suppressed inflammatory gene induction. (cdc.gov)
This is the first report on the involvement of oxidant stress in the induction of inflammatory gene expression by organic dust. (cdc.gov)

Bacterial uptake into epithelial cells is increasingly recognised as an important feature of infection. (biomedcentral.com)
Studies from our group have shown that mice deficient in C3 are resistant to ascending infection and complement can alter bacterial uptake by mouse proximal tubular epithelial cells (PTECs), a primary target of E. coli during the acute phase of pyelonephritis [ 12 ]. (biomedcentral.com)
H. pylori colonization intensity and Lewis antigens were significantly higher in GES-1 than in HSFE cells, whereas IL-8 and IL-6 levels were significantly higher in HSFE than in GES-1 cells after infection. (ncku.edu.tw)
The overexpression of p38 in GES-1 cells downregulated H. pylori-induced JNK activity mimicking H. pylori infection in children. (ncku.edu.tw)
After 12 hours infection, 2313(5.40%) transcripts in pdmH1N1 infected NHBE cells, and 7125(15.94%) transcripts in H7N9 infected cells showed significant differences. (aacc.org)
ATP12A, KRT4, and CEACAM5 gene expression decreased 1273-540 fold 36 hours after H7N9 infection. (aacc.org)

Is the Subject Area "Cell migration" applicable to this article? (plos.org)
Wound healing assay was used to determine Caov-3 cell migration while cell invasion was evaluated using Transwell assay. (ajol.info)

The thymus supports T-cell development via specialized microenvironments that ensure a diverse, functional and self-tolerant T-cell population. (frontiersin.org)
However, experimental evidence suggests these cells are important for thymus function by either directly influencing T-cell development, or by indirectly regulating TEC development and/or function. (frontiersin.org)
In addition to intrathymic selection, and during this medullary residency period, CD4 + and CD8 + single positive (CD4SP, CD8SP) thymocytes acquire the ability to proliferate in response to TCR stimulation, and undergo licensing for cytokine production, prior to exiting the thymus to join the peripheral T-cell pool as Recent Thymus Emigrants (RTE) ( 5 , 6 ). (frontiersin.org)
In this review, we cover how the non-epithelial compartment of thymic stroma represent essential cell populations in regulating thymus function. (frontiersin.org)
This definition excludes other tumors that may affect the thymus, such as lymphoma and germ cell tumors. (medscape.com)

Finally, incubation of tracheal aspirates with a neutralizing antibody against IL-1β reduced epithelial cell IL-8 production, whereas neutralizing antibodies against IL-1α and TNF-α had no effect. (utmb.edu)

Interestingly, the expression of two IκB kinases (IKK)-α/β, the degradation of cytosolic IκB-β inhibitor and the NF-κB deoxyribonucleic acid binding activity were markedly reduced after FP treatment in both CF and non-CF bronchial epithelial cells. (ersjournals.com)
Interestingly, these cells have a high level expression of surface II, which is polarized to the apical surface. (utmb.edu)

To the best of our knowledge, the present study is the first to demonstrate that GSK2606414 has a potential antiproliferative effect in RPE cells in vitro. (spandidos-publications.com)
Recently, an in vitro study on the expression of ΔF508 CFTR (CFTR which contains a deletion of phenylalanine at position 508) in the ovary cells of Chinese hamsters, which do not express CFTR, revealed a seven-fold increase in the activation of NF-κB compared to the wild-type CFTR or the G551D mutant. (ersjournals.com)
Their self-renewing potential was investigated by colony forming cells assays and in vitro organotypic culture models. (who.int)

ATF4, CHOP and VEGF mRNA expression levels were assessed using reverse transcription‑quantitative polymerase chain reaction. (spandidos-publications.com)
In addition, GSK2606414 treatment inhibited eIF2α phosphorylation and reduced CHOP and VEGF mRNA expression levels in RPE cells under TG‑induced ER stress. (spandidos-publications.com)
The level of CXCR4 mRNA expression, but not cell surface expression, increased on stimulation,vith It-lp or TNF-alpha. (elsevierpure.com)

The Nrf2-regulated antioxidant property plays a pivotal role in the anti-inflammatory mechanism underlying the inhibition of NF-κB activation in lycopene-treated ARPE-19 cells. (nih.gov)
Also, amniotic epithelial cells are known to promote natural wound healing as well as the inhibition of angiogenesis, which is the basic conversion of a tumor into malignant cancer. (wikipedia.org)
Koontongkaew S, Monthanapisut P, Saensuk T: Inhibition of arachidonic acid metabolism decreases tumor cell invasion and matrix metalloproteinase expression. (karger.com)

Distinct gene expression characteristics in epithelial cell- Porphyromonas gingivalis interactions by integrating transcriptome analyses. (bvsalud.org)
After 12 hours and 36 hours incubation, the cell pellets were collected for transcriptome analysis on the GeneChip HTA 2.0 array (Affymetrix platform) and the bioinformatic software were used for results evaluation. (aacc.org)

These microenvironments are classically defined as distinct cortex and medulla regions that each contain specialized subsets of stromal cells. (frontiersin.org)

Anatomy74

Organisms13

Diseases9

Chemicals and Drugs78

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Phenomena and Processes49

Disciplines and Occupations2

Information Science3

Retinal pigment epithelial cells1

Intestinal epithelial2

Genes21

Mammary epithelial cells4

Airway18

Proliferation10

Protein16

Mesenchymal21

Induces4

Thymic epithelial cells5

Bronchial epithelial cell2

Alveolar3

Tumor cells2

Cystic fibrosis1

Gastric epithelial2

Endometrial epithelial2

Colonic2

Corneal epithelial2

Methods3

Dendritic cells3

Differentiation4

Human17

Immune2

Lung11

Proteins4

Abstract1

Fibroblasts1

Macrophages1

Regulates1

Signaling pathway1

Progenitor cells1

Receptors2

Respiratory2

Receptor11

Gene expression profiles3

Tissues10

Squamous4

Antigen Expression2

Post-transcriptional1

Differentially expressed1

Epithelium5

Differential3

Phenotype1

Concentration4

Modulate1

Alterations4

Bone marrow1

Molecular2

Induction2

Infection6

Migration2

Thymus5

Tracheal1

Interestingly2

Vitro3

MRNA expression3

Inhibition3

Transcriptome2

Stromal cells1