• In vivo, mock-transfected tumors are circumscribed with many large, open-lumened lymphatic vessels and contain intratumoral lymphatic vessels as well, while tumors overexpressing SEMA3F do not contain lymphatic vessels or have dilated surrounding lymphatics. (harvard.edu)
  • Gastric cancer is among the most common malignant tumors of the digestive system. (hindawi.com)
  • PURPOSE:Gastric cancer (GC) is still one of the most common malignancies with the majority of the tumors diagnosed at advanced stage. (duke.edu)
  • Subcutaneous tumor growth and tumor cell metastasis from primary tumors were also analyzed. (biomedcentral.com)
  • In cancer, tumors generate an immunosuppressive microenvironment that protects the tumor from host immunity, promotes tumor growth, and attenuates immunotherapeutic efficacy [ 15 ]. (biomedcentral.com)
  • Invasion of lymphatic vessels is a key step in the metastasis of primary tumors to draining lymph nodes. (ox.ac.uk)
  • These clinical studies clearly indicated that Nm23-H1 expression level in the tumors have a prognostic impact. (tmu.edu.tw)
  • This analysis platform of promoter activity will be applied for anticancer drugs screening and then provide a novel strategy for clinical practice to overcome metastasis and chemoresistance in the tumors. (tmu.edu.tw)
  • To better design treatments for cancer, it is important to understand the heterogeneity in tumors and how this contributes to metastasis. (pharmaceuticalintelligence.com)
  • used a single-cell triple omics sequencing (scTrio-seq) technique to examine the mutations, transcriptome, and methylome within colorectal cancer tumors and metastases from 10 individual patients. (pharmaceuticalintelligence.com)
  • This review article focuses on the role of honey in modulating the development and progression of tumors or cancers. (mdpi.com)
  • The article also underscores the various possible mechanisms by which honey may inhibit growth and proliferation of tumors or cancers. (mdpi.com)
  • These malignancies had been picked as inclusion criteria simply because they are really the most widespread cancers amongst the Chinese population and have been shown to reply to everolimus in non Chinese patient populations with advanced breast cancer, gastric cancer, NSCLC, or RCC, Patients had to have 1 measurable lesion as defined by Response Evaluation Criteria in Solid Tumors, ample bone marrow, liver, and renal functions. (mirnamimics.com)
  • Angiogenesis is essential in the process of carcinogenesis to facilitate tumor progression and metastasis. (spandidos-publications.com)
  • Profiling evidences of selectin demonstrate that they play an crucial role in cancer progression and metastasis. (biomedcentral.com)
  • The main cause of death in CRC includes tumor progression and metastasis. (biomedcentral.com)
  • Thus, identification of the distinct molecular genetic changes related to CRC progression and metastasis is extremely important. (biomedcentral.com)
  • However, the clinical significance of TFFs in colorectal cancer (CRC) patients remains unclear. (spandidos-publications.com)
  • Colorectal cancer (CRC) is the fourth leading cause of cancer-related mortality worldwide, accounting for over 600,000 deaths annually ( 1 ). (spandidos-publications.com)
  • Gastric cancer is the fifth most common malignant tumor and the fourth leading cause of cancer-related death worldwide, after lung cancer, colorectal cancer, and liver cancer [ 1 ]. (hindawi.com)
  • ZFAS1 has been found to be upregulated and function as oncogene in colorectal cancer and hepatocellular carcinoma, but its expression pattern, biological function and underlying mechanism in gastric cancer is still undetermined. (oncotarget.com)
  • OBJECTIVE: To investigate the effect of visceral fat area (VFA) on the accuracy of preoperative CT-N staging of colorectal cancer. (bvsalud.org)
  • METHODS: We retrospectively reviewed the clinical and imaging data of 385 CRC patients who underwent surgical resection for colorectal cancer between January 2018 and July 2021. (bvsalud.org)
  • Logistic regression analysis was used to evaluate the independent factors influencing the accuracy of preoperative N staging of colorectal cancer. (bvsalud.org)
  • Colorectal cancer susceptibility variants and risk of conventional adenomas and serrated polyps: results from three cohort studies. (cdc.gov)
  • Molecular profile in Paraguayan colorectal cancer patients, towards to a precision medicine strategy. (cdc.gov)
  • Another important mechanism for the progression of colorectal cancer is the ability of the transformed cells to invade and traverse the basement membrane, which in turn facilitates the conversion of adenomas into carcinomas and then metastases ( 1 ). (spandidos-publications.com)
  • The BRAF oncogene is an integral component of the MAP kinase pathway, and an activating V600E mutation occurs in 15% of sporadic colorectal cancer. (hindawi.com)
  • Recent studies have found that they have clinical and molecular features of both the BRAF mutant/MSI and the conventional BRAF wild-type cancers and comprise a distinct colorectal cancer subgroup. (hindawi.com)
  • This review highlights the importance of the BRAF mutation occurring in colorectal cancer stratified for molecular background and discusses its prognostic and clinical significance. (hindawi.com)
  • In colorectal cancer, the presence of a BRAF mutation can be associated with an aggressive phenotype and is a key prognostic biomarker for poor outcome particularly in late-stage disease. (hindawi.com)
  • The BRAF V600E mutation occurs early in tumourigenesis and is highly correlated with the serrated neoplasia pathway of colorectal cancer. (hindawi.com)
  • This pathway describes progression of a serrated precursor lesion, often followed by the onset of epigenetic instability involving promoter methylation and silencing of key tumour suppressor genes, and accounts for 15%-20% of sporadic colorectal cancer [ 1 , 2 ]. (hindawi.com)
  • BRAF mutant/MSS cancers form a distinct colorectal cancer entity that shares clinical and molecular features with both BRAF mutant/MSI serrated pathway cancers and the BRAF wild-type cancers of the conventional pathway [ 9 - 11 ]. (hindawi.com)
  • This latter pathway involves the previously well-defined series of genetic aberrations such as APC mutation and chromosomal instability and accounts for the majority of colorectal cancer [ 12 ]. (hindawi.com)
  • Although the relevance of mutant BRAF in the clinical setting is increasingly being acknowledged, the relatively low frequency of its occurrence requires further studies and larger experimental cohorts to secure its mutational status as a definitive biomarker for colorectal cancer. (hindawi.com)
  • Recently, especially in Japan, several researchers have suggested that colorectal cancer can develop not only through an adenoma-carcinoma sequence but also from normal mucosa via a de novo pathway, and that these de novo cancers have more aggressive malignant potential. (biomedcentral.com)
  • Immunohistochemical reevaluation showed the cervical lymph node biopsy specimen to be positive for CDX2 and CK20 and negative for CK7 expression, leading us to suspect the presence of a primary colorectal cancer. (biomedcentral.com)
  • In this case, immunohistochemical findings strongly suggested the existence of a colorectal cancer. (biomedcentral.com)
  • The non-polypoid gross appearance of the tumour suggested that it can originate de novo , thus providing a valuable case in support of the aggressive malignant potential of a de novo colorectal cancer pathway. (biomedcentral.com)
  • Colorectal cancer is the second leading cause of cancer deaths in men and women in Western countries [ 1 ], and its incidence is gradually increasing in Japan as well. (biomedcentral.com)
  • Laser microdissection (LMD) and microarray were used to identify genes associated with colorectal cancer. (elsevierpure.com)
  • Stanniocalcin 2 (STC2) expression and clinicopathological significance in 139 clinical colorectal cancer samples were specifically investigated using real-time quantitative reverse transcription-polymerase chain reaction. (elsevierpure.com)
  • A number of genes upregulated in colorectal cancer cells compared to normal colorectal epithelial cells were identified including STC2. (elsevierpure.com)
  • Furthermore, STC2 gene appeared to be associated with colorectal cancer progression and may be a useful prognostic indicator for colorectal cancer. (elsevierpure.com)
  • Colorectal cancer (CRC) is a common cancer worldwide. (biomedcentral.com)
  • The mRNA level of these genes was measured in 78 paired colorectal cancer samples by quantitative polymerase chain reaction (qPCR). (biomedcentral.com)
  • In 2012, an estimated 1.36 million people were diagnosed with colorectal cancer (CRC), including 746,300 men and 614,300 women. (biomedcentral.com)
  • Although genomic instability, epigenetic abnormality, and gene expression dysregulation are hallmarks of colorectal cancer, these features have not been simultaneously analyzed at single-cell resolution. (pharmaceuticalintelligence.com)
  • These effects of honey have been thoroughly investigated in certain cancers such as breast, liver and colorectal cancer cell lines. (mdpi.com)
  • The low expression or absence of stromal SPARC was an independent prognostic factor for poor prognosis of colon cancer. (nih.gov)
  • Cervical metastasis has a tremendous impact on the prognosis in patients with carcinomas of the head and neck. (medscape.com)
  • In view of poor prognosis at the time of future relapse, persons with primary lesions with more than 20% likelihood of metastasis should undergo either surgery or radiation therapy at the time of primary treatment. (medscape.com)
  • Then, the relationship between the expression level of the core genes and the prognosis of gastric cancer patients was analyzed using the Gene Expression Profiling Interactive Analysis (GEPIA) database. (hindawi.com)
  • Here, we reported that ZFAS1 expression is also overexpressed in gastric cancer, and its increased level is associated with poor prognosis and shorter survival. (oncotarget.com)
  • Advanced prostate cancer (PCa) has limited treatment regimens and shows low response to chemotherapy and immunotherapy, leading to poor prognosis. (thno.org)
  • The aim of this study was thus to clarify the correlation between expression of the hypoxic marker carbonic anhydrase-9 (CA9) and chemosensitivity to NAC as well as prognosis of breast cancer patients. (biomedcentral.com)
  • Nm23-H1 (also known as NME1 or Nm23A) was the first tumor metastasis-suppressor gene identified, and has the most data with regard to clinical prognosis. (tmu.edu.tw)
  • High expressions of Nm23-H1 are generally associated with improved prognosis for various carcinomas (breast, gastric, head/neck, hepatic cancer, melanoma, and NSCLC). (tmu.edu.tw)
  • In esophageal cancers, negative Nm23-H1 expression was correlated to poor prognosis (Wang et al. (tmu.edu.tw)
  • In conclusion, our findings show that CD44-positive ovarian cancer patients exhibit worse prognosis, which was associated with common clinicopathological features and poor prognostic factors. (geneticsmr.com)
  • High HMGB1 expression is an independent predictor of poor prognosis in patients with adenocarcinoma of the ampulla of Vater not treated with adjuvant chemotherapy. (biomedcentral.com)
  • Cutaneous squamous cell carcinoma (cSCC) is the second most common type of skin cancer, the prognosis for patients with metastatic cSCC remains relatively poor. (biomedcentral.com)
  • However, the prognosis for patients with metastasis cSCC remains relatively poor. (biomedcentral.com)
  • [ 5 ] It has been shown that histologic type is an independent prognostic factor in cervical cancer, with adenocarcinoma subtypes being associated with a poorer prognosis compared with SCC. (medscape.com)
  • CCR7-positive cancer cell expression has been associated with lymph node metastasis. (biolegend.com)
  • Knockdown of ZFAS1 impaired gastric cancer cells proliferation and induced apoptosis in vitro, and inhibited tumorigenicity of gastric cancer cells in vivo. (oncotarget.com)
  • DC-SIGNR knockdown inhibited the proliferation, migration and invasion of gastric cancer cells in vitro and suppressed the liver metastasis in vivo. (biomedcentral.com)
  • Upregulation of HK3 is associated with EMT in CRC and may be a crucial metabolic adaptation for rapid proliferation, survival, and metastases of CRC cells. (biomedcentral.com)
  • Expression of High-Mobility Group Box 1 (HMGB1), a multifunctional protein involved in DNA function as well as cell proliferation, inflammation, and the immune response, has been reported to be prognostic in several types of malignancies. (biomedcentral.com)
  • In this study, the significance of cancer cell behaviors, such as cell detachment, stromal invasion and lymphatic invasion on regional LN metastasis in gastric cancer was investigated by comprehensive immunohistochemistry. (toho-u.ac.jp)
  • Recent studies suggest that TFFs are involved in the development and progression of various types of cancer, including breast, lung, prostate, stomach and colon cancer ( 6 - 15 ). (spandidos-publications.com)
  • Prognostic Value of Lymphatic and Blood Vessel Invasion in Neuroendocrine Tumours of the Lung," The American Journal of Surgical Pathology, Vol. 29, 2005, pp. 324-328. (scirp.org)
  • The diagnostic value of circulating tumor cells and ctDNA for gene mutations in lung cancer. (cdc.gov)
  • In this study we show over-expression of cystatin C in melanoma cells is associated with reduced metastasis and increased apoptosis in lung tissues. (biomedcentral.com)
  • The most common site of metastasis of these cancers is the liver, followed by the lung. (biomedcentral.com)
  • Here, we show that an increase in the levels of GPR171 is crucial for lung cancer tumor progression in vitro and in vivo . (oncotarget.com)
  • Knockdown of GPR171 also inhibited migration and invasion of the lung cancer cell lines. (oncotarget.com)
  • Notably, inhibition of GPR171 synergistically enhanced the tumoricidal activity of an epidermal growth factor receptor (EGFR) inhibitor in lung cancer cells. (oncotarget.com)
  • Lung and bronchus cancers account for the greatest proportion of cancer deaths worldwide [ 1 , 2 ]. (oncotarget.com)
  • Moreover, improvement in survival over the past several decades is lower for lung cancer than all other cancers [ 2 ]. (oncotarget.com)
  • Therefore, considerable effort has been focused on the identification of effective drug targets for lung cancer. (oncotarget.com)
  • There are two clinical types of lung cancer: non-small cell lung carcinoma (NSCLC), which accounts for 85% of all cases, and small cell lung carcinoma (SCLC) [ 1 , 3 ]. (oncotarget.com)
  • and large cell carcinoma (5-15% of all lung cancers) [ 4 , 5 ]. (oncotarget.com)
  • EGFR (epidermal growth factor receptor), ALK (anaplastic lymphoma receptor tyrosine kinase), RET (ret proto-oncogene receptor tyrosine kinase), and BRAF (B-Raf proto-oncogene, serine/threonine kinase) are well-identified oncogenic driver mutations in lung cancer, and are targets for therapeutic application. (oncotarget.com)
  • Strategies Sufferers Eligible individuals had been aged 18 many years which has a histologi cally confirmed diagnosis of state-of-the-art breast cancer, gastric cancer, non little cell lung cancer, or RCC and have been unsuitable for regular anticancer ther apy because of treatment method refractory disease or other rea sons. (mirnamimics.com)
  • Patients with FTC are more likely to develop lung and bone metastases than are patients with papillary thyroid cancer. (medscape.com)
  • Older patients have an increased risk of developing bone and lung metastases. (medscape.com)
  • Other frequent sites of metastasis are lung, bone, skin, and central nervous system (CNS). (medscape.com)
  • Risk of lung cancer according to mild steel and stainless steel welding. (who.int)
  • Winter PD, Gardner MJ, Fletcher AC, Jones RD. A mortality follow-up study of pottery workers: preliminary findings on lung cancer. (who.int)
  • Lung, kidney, and brain cancer showed elevation in some studies but were not consistent. (who.int)
  • Our appreciation for the varied functions of lymphatic vessels has evolved from different scientific disciplines. (jci.org)
  • Traditionally, microcirculatory physiologists studied the essential transport functions of lymphatic vessels in removing fluid, molecules, and cells after leaking from blood vessels in the periphery and before returning them to the blood circulation. (jci.org)
  • Immunologists recognized the importance of lymphatic vessels as channels for leukocyte trafficking from peripheral sites to their draining LNs ( 4 - 6 ), and as conduits for soluble antigens that can be taken up directly by LN-resident B cells and immature DCs ( 7 - 10 ), which help regulate the kinetics of antigen presentation. (jci.org)
  • These new ideas, in turn, reveal a paradigm whereby the transport and immune functions of lymphatic vessels, which were previously considered separately, are in fact intimately coupled. (jci.org)
  • While we particularly focus on LEC interactions with DCs and T cells, we also highlight features that support immune regulation, including the structure and function of lymphatic vessels and the compartmentalization of the LN stroma, which help control the manner in which LECs can interface with immune cells. (jci.org)
  • The lymphatic vessels and secondary lymphoid organs (SLOs) are arranged in a manner that optimizes interactions among antigens, APCs, and innate and adaptive effector cells. (jci.org)
  • Activation of the VEGFA/VEGFR2 signaling and expression of blood vascular endothelial cell (BEC) markers, such as NRP1 and EphrinB2, further differentiate these precursor cells into BECs, which then form the hierarchical network of blood vessels 4 . (nature.com)
  • Therefore, this complex regulatory network requires precise control of gene expression patterns at both transcriptional and post-transcriptional levels in order to ensure proper maturation, differentiation, and formation of blood and lymphatic vessels. (nature.com)
  • There are two main routes by which tumor cells disseminate, through blood vessels (hematogenous spread) and through lymphatic vessels (lymphogenous spread). (harvard.edu)
  • Therapies targeted against lymphangiogenesis, the growth of new lymphatic vessels, are beginning to be explored. (harvard.edu)
  • Members of the vascular endothelial growth factor (VEGF) family, including VEGF-A and VEGF-C, stimulate the growth of blood vessels and lymphatic vessels. (harvard.edu)
  • A common receptor expressed on both adult blood vessels and lymphatic vessels is neuropilin 2 (NRP2). (harvard.edu)
  • Anti-angiogenic therapy is an old method to fight cancer that aims to abolish the nutrient and oxygen supply to the tumor cells through the decrease of the vascular network and the avoidance of new blood vessels formation. (mdpi.com)
  • The chemokine receptor CCR7 plays a pivotal role in the homing of naïve T cells and regulatory T cells to secondary lymphoid organs, and the migration of dendritic cells into afferent lymphatic vessels. (biolegend.com)
  • Absence of Lymphangiogenesis and Intratumoural Lymph Vessels in Human Metastatic Breast Cancer," The Journal of Pathology, Vol. 200, 2003, pp. 195-206. (scirp.org)
  • A critical initial step of metastasis is that tumor cells enter blood vessels or the lymphatic system by invasion of host basement membranes. (biomedcentral.com)
  • Cancer tissues were subjected to immunohistochemistry with antibodies against claudin-3, claudin-4, beta-catenin, matrix metalloproteinase (MMP)-1, and MMP-2, as well as endothelial markers of lymphatic vessel endothelial hyaluronan receptor-1 and von Willebrand factor for the objective discrimination between lymphatics and blood vessels. (toho-u.ac.jp)
  • Metastasis occurs via lymphatics and blood vessels. (msdmanuals.com)
  • If the melanoma does not show extraocular extension, it only can disseminate hematogenously, because the eye has no lymphatic vessels. (medscape.com)
  • Furthermore, among 134 patients with no clinical findings of metastasis at surgery, the patients with positive TFF3 experienced recurrence within one year more frequently than those with negative TFF3 (p=0.039). (spandidos-publications.com)
  • There are few reports on studies that investigated the clinical significance of TFFs expression using excised primary CRC specimens ( 19 ). (spandidos-publications.com)
  • High LYVE-1-Positive Lymphatic Vessel Numbers Are Associated with Poor Outcome in Breast Cancer," Clinical Cancer Research, Vol. 10, No. 21, 2004, pp. 7144-7149. (scirp.org)
  • Apart from these, the results from clinical studies have shown that Astragalus polysaccharides counteract against the side-effects of chemotherapeutic drugs, including a significant attenuation of myelosuppression in cancer patients ( 7 ). (spandidos-publications.com)
  • Recent studies have also found that presence of the BRAF mutation has direct implications for clinical management as along with TNM stage, BRAF mutational status was the only molecular variable that independently accounted for poor survival [ 13 ], and studies have found that BRAF mutant cancers are refractory to anti-EGRF therapy [ 14 , 15 ]. (hindawi.com)
  • The expression and clinical features of WDR5 were analyzed in two dependent cohorts. (thno.org)
  • Inappropriate gene expression in human cancer and its far-reaching biological and clinical significance. (ucsd.edu)
  • Cell and tissue interactions in carcinogenesis and metastasis and their clinical significance. (ucsd.edu)
  • Publications assessing the clinical or prognostic significance of CD44 expression in ovarian cancer were identified and reviewed until December 1, 2015. (geneticsmr.com)
  • A meta-analysis was then performed to examine the association between CD44 expression and clinical outcomes of ovarian cancer. (geneticsmr.com)
  • While clinical care focuses on the individual health, the public health policies aimed at breast cancer focus the attention on women from various countries. (bvsalud.org)
  • 1993). The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. (cancercentrum.se)
  • C) Multiple para-aortic lymph node metastases in the abdomen, the largest one measuring 43 mm in diameter (arrowhead). (biomedcentral.com)
  • In a study by Asari et al of 207 patients with FTC, the 127 patients with minimally invasive growth had no lymph node metastases. (medscape.com)
  • According to the authors, total thyroidectomy is recommended for all patients with FTC, but patients with widely invasive FTC need more aggressive surgery because of a higher tendency toward lymph node metastases. (medscape.com)
  • SPARC (secreted protein, acidic and rich in cysteine) is closely related with the progress, invasion and metastasis of malignant tumor and angiogenesis. (nih.gov)
  • SPARC maybe involved in the regulation of anti-angiogenesis by which it may serve as a novel target for colon cancer treatment as well as a novel distinctive marker. (nih.gov)
  • SEMA3F may inhibit angiogenesis and lymphangiogenesis by a novel mechanism, which is the repulsion of vascular and lymphatic endothelial cells (EC) expressing NRP2 similar to the way SEMA3F repels neurons. (harvard.edu)
  • Most of the anti-angiogenic agents approved for cancer treatment rely on targeting vascular endothelial growth factor (VEGF) actions, as VEGF signaling is considered the main angiogenesis promotor. (mdpi.com)
  • Tumour Angiogenesis and Metastasis-Correlation in Invasive Breast Carcinoma," The New England Journal of Medicine, Vol. 324, No. 1, 1991, pp. 1-8. (scirp.org)
  • In the present study, we aimed to further examine the potential of formononetin in controlling angiogenesis and tumor cell invasiveness in human colon cancer cells and tumor xenografts. (spandidos-publications.com)
  • These findings suggest that formononetin inhibits angiogenesis and tumor cell invasion, and thus support its use in the treatment of advanced and metastatic colon cancers. (spandidos-publications.com)
  • Additionally, the expression and activity of matrix metalloproteinases (MMPs) are increased in almost every type of human cancer, which may be associated with cell invasion, metastasis and angiogenesis. (spandidos-publications.com)
  • Relationship between inducible nitric oxide synthase expression and angiogenesis in primary gallbladder carcinoma tissue. (wjgnet.com)
  • Unbiased Phenotype-Based Screen Identifies Therapeutic Agents Selective for Metastatic Prostate Cancer. (harvard.edu)
  • Circulating tumor DNA alterations in patients with metastatic castration-resistant prostate cancer. (cdc.gov)
  • A key feature of metastatic cancer cells is their invasive ability. (biomedcentral.com)
  • Because elevated cysteine protease activity correlates well with highly invasive cancers, inhibition of this activity may be a target for anti-metastatic therapies. (biomedcentral.com)
  • We also discovered that the invasiveness of metastatic colon cancer cells was alleviated following drug treatment. (spandidos-publications.com)
  • Similarly, hepatic sinusoidal endothelial E-selectin expression is up regulated by highly metastatic cells entering the liver [ 10 ]. (biomedcentral.com)
  • Moreover, using an E-selectin-specific monoclonal antibody reduces liver metastasis, showing that E-selectin is involved in metastatic formation in this organ [ 11 ]. (biomedcentral.com)
  • Malignant lymphoma (ML) was first suspected, but aspiration cytology and biopsy of the lymph node suggested metastatic adenocarcinoma resulting from breast cancer. (biomedcentral.com)
  • Here we have addressed the question by comparing the RNA profiles of primary lymphatic endothelial cells (LEC) isolated from the vasculature of normal tissue and from highly metastatic T-241/vascular endothelial growth factor (VEGF)-C fibrosarcomas implanted in C57BL/6 mice. (ox.ac.uk)
  • For instance, the 5-year relative survival rate for patients with metastatic CRC is about 11%, while that for patients with stage III CRC ranges from 53% to 89% ( https://www.cancer.org ). (biomedcentral.com)
  • We propose that the regulatory mechanism of Nm23-H1 expression may play a crucial role in Nm23-H1 abundance and thus in modulating the metastatic behavior and chemosensitivity. (tmu.edu.tw)
  • 3) Using transfected cancer cell models to define the functional cis-acting regulatory elements during the treatment of anticancer drugs, and screen those drugs appropriate for highly metastatic and resistant phenotype. (tmu.edu.tw)
  • The NCCN recommends total thyroidectomy as the initial procedure only if invasive cancer or metastatic disease is apparent at the time of surgery, or if the patient wishes to avoid a second, completion thyroidectomy should the pathologic review reveal cancer. (medscape.com)
  • Metastasis to skin or internal organs may occur, and, occasionally, metastatic nodules or enlarged lymph nodes are discovered before the primary lesion is identified. (msdmanuals.com)
  • Using human colon adenocarcinoma tissues (hereinafter referred to as colon cancer) and their corresponding non-diseased colon from 114 patients' biopsies, the expression of SPARC and vascular endothelial growth factor (VEGF) were investigated by immunohistochemistry staining to assessment the relationship between SPARC and VEGF, as well as their prognostic significance in patients. (nih.gov)
  • Suppression of Tumour Lymphangiogenesis and Lymph Node Metastasis by Blocking Vascular Endothelial Growth Factor Receptor 3 Signaling," Journal of the National Cancer Institute, Vol. 94, No. 11, 2002, pp. 819-825. (scirp.org)
  • The results showed that formononetin downregulated the expression of the key pro-angiogenic factors, including vascular endothelial growth factor (VEGF) and matrix metalloproteinases. (spandidos-publications.com)
  • Therefore, we need to explore novel molecules to better understand the mechanism of hematogenous metastasis. (biomedcentral.com)
  • Here, we ask whether DC-SIGNR contributes to hematogenous metastasis from gastric carcinoma. (biomedcentral.com)
  • [ 6 , 7 ] When adenocarcinomas are present, they tend to be larger in size and have a propensity for early lymphatic and hematogenous metastasis. (medscape.com)
  • Cox Regression Analysis, SPARC emerged as an overall survival and disease-free survival independent prognostic factor for colon cancer. (nih.gov)
  • A multivariate analysis revealed that the expression of TFF3, lymph node metastasis, and vascular invasion were independent prognostic factors for disease-specific survival. (spandidos-publications.com)
  • The presence of neck metastasis is known to reduce survival by 50%, and the frequency of such spread is greater than 20% for most squamous cell carcinomas (SCCAs). (medscape.com)
  • In spite of the improvement in surgical techniques and targeted drug chemotherapy, the five-years overall survival rate remains unsatisfactory due to lots of patients were diagnosed at an advanced stage accompanied by lymphatic metastasis that limit the successful therapeutic strategies [ 3 ]. (oncotarget.com)
  • The correlation of claudin-4 tissue expression with patient overall survival survival (OS) or disease-free survival (DFS) was not statistically significant, as well as with age, gender, tumor N stage, grade, TNM stage, positive lymph node ratio or lymphovascular invasion. (duke.edu)
  • AKT1, also known as v-akt murine thymoma viral oncogene homolog 1, is involved in the regulation of cell-survival and anti-apoptotic activities, which may affect the pathogenesis of various cancers. (geneticsmr.com)
  • Its overall survival rate has shown rare substantial progress in spite of the improving diagnostic and treatment techniques for cancer in recent years. (bvsalud.org)
  • The Kaplan-Meier survival curve revealed a significant negative correlation (p = 0.013) between the disease-free survival (DFS) and the CA 9 expression in resected tissues after NAC. (biomedcentral.com)
  • This meta-analysis study aimed to investigate the correlation between CD44-positive cancer stem cells (CSCs) and clinicopathological features and its effect on the survival of ovarian cancer patients. (geneticsmr.com)
  • Multivariate analysis showed that transfusion, lymph-node metastasis, and high HMGB1 expression were independent predictors of poor overall survival. (biomedcentral.com)
  • However, the relationship between HMGB1 overexpression and survival in ampullary cancer has not yet been elucidated. (biomedcentral.com)
  • High levels of K17 expression were significantly associated with decreased patient survival. (medscape.com)
  • Thus, the goal of this study was to determine if K17 expression is a negative prognostic biomarker associated with decreased survival of patients with endocervical adenocarcinoma. (medscape.com)
  • In adenoid cystic carcinoma that is recurrent, is advanced, or has been resected with positive margins, neutron therapy can provide better local control than photon-based therapies, but it does not improve survival because of the excessive number of metastases that prevail in advanced stages. (medscape.com)
  • Despite methodological differences, findings evidence that although IBC presents particular features (lower survival rate and worse prognostics than most types of breast cancer), very few studies examine its epidemiology and specific risk factors in depth and use any other therapeutic approaches than those commonly used for other breast cancer subtypes. (bvsalud.org)
  • With an average survival rate of three years, IBC accounts for about 2.5% of all breast cancer types in the US. (bvsalud.org)
  • Predictive factors of cervical metastasis are primary site, primary tumor size, degree of differentiation of tumor, perineural invasion, perivascular invasion, inflammatory response, and tumor DNA content (ploidy). (medscape.com)
  • 1906: Crile developed the en bloc cervical lymphadenectomy known as the RND. (medscape.com)
  • Role of IL17A rs2275913 and rs3748067 polymorphisms in the risk cervical cancer. (geneticsmr.com)
  • Cervical cancer is a serious public health problem and is associated with high cancer-related mortality in females worldwide. (geneticsmr.com)
  • The expression of IL17A can increase the migration and invasiveness of cervical cancer cells by activating the NF-κB signal pathway. (geneticsmr.com)
  • Herein, we report a rare case of a small colon cancer with a depressed component and aggressive malignant potential with systemic metastasis, where the chief complaint was cervical lymph node swelling. (biomedcentral.com)
  • Uterine cervical cancer is a significant health concern, being the second most common cancer and the third leading cause of cancer mortality in women worldwide. (medscape.com)
  • Cervical cancer has multiple histologic subtypes, with squamous cell carcinoma (SCC) accounting for approximately 75% of cases and invasive adenocarcinoma accounting for 10% to 15% of cases. (medscape.com)
  • Thyroid cancers are found more often in patients with a history of low-dose or high-dose external irradiation to the cervical or thyroid area. (medscape.com)
  • Overall, about 5% of patients with thyroid cancer have metastases beyond the cervical or mediastinal area on initial presentation, as do 2-3% of patients with papillary thyroid cancer and 11% of patients with follicular thyroid cancer. (medscape.com)
  • MMPs have been implicated in these processes and a previous study has suggested that the plasma level of MMP-2 and MMP-9 may be viewed as a non-invasive indicator of invasiveness and metastasis in colon cancer ( 3 ). (spandidos-publications.com)
  • E-cadherin is a well-known tumor suppressor protein and loss of its expression in tumor cells is associated with increased tumor invasiveness and metastasis [ 18 , 19 ]. (biomedcentral.com)
  • Angiosarcomas Express Mixed Endothelial Phenotypes of Blood and Lymphatic Capillaries: Podoplanin as a Specific Marker for Lymphatic Endothelium," American Journal of Pathology, Vol. 154, 1999, pp. 385-394. (scirp.org)
  • Our previous studies had demonstrated that overexpression of Nm23-H1 was associated with suppression of lymphatic metastasis and chemosensitivity in oral squamous cell carcinoma (Wang et al. (tmu.edu.tw)
  • To determine the expression of tissue inhibitors of metalloproteinases (TIMP-2) in oral squamous cell carcinoma (OSCC) and the difference in its expression level between positive and negative HPV-16 (human papilloma virus- 16) OSCC patients. (bvsalud.org)
  • ABSTRACT Studies have suggested a possible link between breast cancer pathogenesis and human papillomavirus (HPV) infection. (who.int)
  • These events suggest that selectin play a key role in tumour metastasis to the target organs. (biomedcentral.com)
  • Current National Comprehensive Cancer Network (NCCN) guidelines recommend lobectomy plus isthmusectomy as the initial surgery for patients with follicular neoplasms, with prompt completion of thyroidectomy if invasive FTC is found on the final histologic section. (medscape.com)
  • At present, gene chip technology has a vital role in diagnosing gastric cancer and evaluating related gene expression [ 13 ]. (hindawi.com)
  • Deep RNA-DNA, RNA-protein interaction studies, and phenotype rescue analyses reveal that LETR1 is a nuclear trans-acting lncRNA modulating, via key epigenetic factors, the expression of essential target genes, including KLF4 and SEMA3C , governing the growth and migratory ability of LECs. (nature.com)
  • In this study, a data mining strategy was used to obtain 2 microarray datasets of gastric cancer from the GEO database to identify differentially expressed genes (DEGs) associated with gastric cancer occurrence and progression. (hindawi.com)
  • Search miRCancer for miR-107 associations with cancer and associated genes. (cancerindex.org)
  • Genome-wide gene expression microarrays have found widespread use because of their high throughput and ability to measure the expression of tens of thousands of genes simultaneously. (biomedcentral.com)
  • One approach to this problem is to create sets of genes with common biological characteristics, such as chromosomal location, biochemical function, or observed differential expression in some experimental condition, and then to determine whether the genes in these sets are coordinately induced or repressed. (biomedcentral.com)
  • Prevalence and characteristics of likely-somatic variants in cancer susceptibility genes among individuals who had hereditary pan-cancer panel testing. (cdc.gov)
  • We have demonstrated that fluid flow serves as a physical stimulus inducing expression of genes required for lymphatic valve development and identified a novel role for GATA2, an upstream transcriptional regulator of FOXC2. (umass.edu)
  • Correlation analysis between the change in the expression of genes involved in glycolysis and EMT was performed. (biomedcentral.com)
  • The results of correlation study showed that the expression of HK3 demonstrated a strong correlation with 7 of the 21 examined genes ( ZEB2, GREM1, TGFB3, TGFB1, SNAI2, TWIST1, and COL1A1 ) in CRC. (biomedcentral.com)
  • A study of differential gene expression profiling of aggressive and nonaggressive follicular carcinomas identified 94 genes that distinguish follicular carcinomas from follicular adenomas (including PBP and CKS2 ) and 4 genes that distinguish aggressive follicular carcinomas from nonaggressive follicular carcinomas ( NID2, TM7SF2, TRIM2, and GLTSCR2 ). (medscape.com)
  • A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility. (who.int)
  • TFF3 expression was significantly associated with the presence of distant metastasis (p=0.017), although neither TFF1 nor TFF2 expression was associated with the clinicopathological features. (spandidos-publications.com)
  • Twenty patients with distant metastasis who underwent a palliative resection of the tumor to release the disease-related symptoms were also included. (spandidos-publications.com)
  • Melanoma is the most lethal skin cancer with most deaths occurring from distant metastases. (harvard.edu)
  • Using optimized single-cell multiomics sequencing together with multiregional sampling of the primary tumor and lymphatic and distant metastases, we developed insights beyond intratumoral heterogeneity. (pharmaceuticalintelligence.com)
  • Patients who die from ciliary body melanoma die because of distant metastasis rather than local spread. (medscape.com)
  • In the present study, we evaluated the mRNA expression levels of TFF1, TFF2 and TFF3 in excised CRC specimens and assessed the correlation between TFF expression and the clinicopathological findings in CRC patients. (spandidos-publications.com)
  • In our study, we examined PKP1, PKP2, and PKP3 expression and their clinicopathological correlation with gastric cancer. (biomedcentral.com)
  • This study was an ecologic study in Asia for assessment of the correlation between age-specific incidence rate (ASIR) and age-specific mortality rate (ASMR) with HDI (life expectancy at birth, mean years of schooling and gross national income (GNI) per capita) Data about SIR and SMR for every Asian country for the year 2012 were obtained from the global cancer project. (waocp.com)
  • However, the regulatory roles of CDX2 have not been clarified in gastric cancer, and the correlation between CDX2 and Reg IV requires further study. (biomedcentral.com)
  • A positive correlation was observed between CDX2 and Reg IV expression at the mRNA and protein levels in gastric cancer tissues. (biomedcentral.com)
  • Moreover, we show similar induction of ESAM, Endoglin, and leptin receptor within tumor lymphatics in a series of human head and neck and colorectal carcinomas, and uncover a dramatic correlation between ESAM expression and nodal metastasis that identifies this marker as a possible prognostic indicator. (ox.ac.uk)
  • Cysteine proteases contribute to invasive properties of many cancer cell types. (biomedcentral.com)
  • Cysteine proteases help create an invasive phenotype at one or more steps in tumor progression to metastasis [ 7 ]. (biomedcentral.com)
  • Decreased PKP2 and PKP3 may be early prognostic markers and loss of PKP3 expression during gastric carcinoma progression may indicate an invasive phenotype. (biomedcentral.com)
  • RESULTS: Along with lymphatic invasion by cancer cells and gross tumor size, MMP-1 expression in cancer cells at the invasive front of the primary tumor was a significant, independent predictor of LN metastasis. (toho-u.ac.jp)
  • Tumor size, lymphatic invasion and MMP-1 expression level at the invasive front were the predictive factors of LN metastasis of gastric cancer. (toho-u.ac.jp)
  • IBC may be diagnosed by an imaging test and by a breast biopsy of an invasive cancer 7 . (bvsalud.org)
  • Recently we have demonstrated that one member of the class 3 semaphorins, Semaphorin 3F (SEMA3F), can inhibit human melanoma metastasis. (harvard.edu)
  • To analyze the contribution of cysteine proteases to metastasis we have over-expressed in B16 melanoma cells the natural cysteine protease inhibitor, cystatin C. We measured in vitro invasion of cystatin over-expression clones with Boyden chamber type assays. (biomedcentral.com)
  • Increased tumor cell apoptosis was found to be an important factor and may be related to the reduced tumor burden noted in this system of melanoma metastasis. (biomedcentral.com)
  • The expression of cystatin C-GFP fusion was observed in B16F10 melanoma cells following transient transfection of plasmid construct DNA. (biomedcentral.com)
  • A cytoplasmic expression was noted for GFP alone and cystatin C-GFP fusion when transiently expressed in B16 melanoma cells (Figure 1 ). (biomedcentral.com)
  • Investigation the biological effects of DC-SIGNR were verified by MTT, wounding and transwell in vitro and experiments on animals to confirm gastric cancer liver metastasis by IVIS. (biomedcentral.com)
  • In addition, CDX2 overexpression promoted the development of MDR in SGC-7901/DDP (cisplatin-resistant) and BGC-823/5-FU (5-fluorouracil-resistant) human gastric cancer cells in vitro and in vivo [ 18 ]. (biomedcentral.com)
  • Together these results indicate that SEMA3F is a potent metastasis inhibitor that targets both tumor and stromal cells and raise the possibility of SEMA3F having therapeutic potential. (harvard.edu)
  • This study explored the molecular mechanisms and potential therapeutic targets for gastric cancer occurrence and progression using bioinformatics. (hindawi.com)
  • These findings indicated potential therapeutic candidates for gastric cancer liver metastasis. (biomedcentral.com)
  • Role of the host stroma in cancer and its therapeutic significance. (ucsd.edu)
  • G protein-coupled receptors (GPCRs) are among the most significant therapeutic targets and some of them promote the growth and metastasis of cancer. (oncotarget.com)
  • Cutaneous squamous cell carcinoma (cSCC) is the second most common type of skin cancer, accounting for 20% of nonmelanoma skin cancers It is reported that approximately 1.8 million incidences of cSCC in a global context in 2017. (biomedcentral.com)
  • Expression of SPARC was significantly correlated with the expression of VEGF and MVD in colon cancer tissues. (nih.gov)
  • DC-SIGNR serum level was significantly increased in gastric cancer patients compared with healthy group. (biomedcentral.com)
  • In gastric cancer, PKP1 expression was unchanged but PKP2 and PKP3 were significantly decreased as compared to normal controls. (biomedcentral.com)
  • CDX2 silencing significantly downregulated Reg IV expression, and CDX2 overexpression significantly upregulated Reg IV expression in AGS and MKN-45 cells. (biomedcentral.com)
  • The CA9 expression in CNB specimens was significantly correlated with pathological response, lymph node metastasis, and lymph-vascular invasion. (biomedcentral.com)
  • Multivariate regression analyses indicated that the CA9 expression in resected tissues was an independent prognostic factor for DFS. (biomedcentral.com)
  • During development, the blood vascular system arises from endothelial cell progenitors that differentiate from mesodermal cells, mostly through the expression of the transcription factor (TF) ETV2. (nature.com)
  • Thereafter, a distinct subpopulation of endothelial cells lining the cardinal vein starts differentiating by expressing the TF PROX1, the master regulator of lymphatic endothelial cell (LEC) identity, via the TFs SOX18 and COUPTFII. (nature.com)
  • In experimental metastasis studies, researchers demonstrate that liver sinusoidal endothelial cell lectin (LSECtin) mediated colon cancer cells metastasis to liver displays enhanced abilities to the specific organ [ 8 ]. (biomedcentral.com)
  • This study identified new potential molecular targets closely related to gastric cancer occurrence and development via mining public data using bioinformatics analysis methods. (hindawi.com)
  • METHODS: A total of 210 cases with gastric cancer were selected. (toho-u.ac.jp)
  • Based on our observations, it is therefore important to study the expression regulatory mechanism of metastasis-suppressor factor contributing to early invasion/metastasis and chemoresistance in esophageal cancer. (tmu.edu.tw)
  • To help establish mechanism of cystatin C action in metastasis we have fused cystatin C to the N-terminus of green fluorescent protein. (biomedcentral.com)
  • However, this biological mechanism associated with both poor disease outcomes and adverse neuropsychiatric symptoms has received little attention in women with breast cancer. (biomedcentral.com)
  • Given the multifactorial consequences of increased tryptophan degradation in cancer outcomes and neuropsychiatric symptom manifestation, this biological mechanism deserves broader attention in women with breast cancer. (biomedcentral.com)
  • So far, the complex molecular mechanism of liver metastasis has still remained essentially unknown. (biomedcentral.com)
  • Histone modification is a vital mechanism of gene expression and a promising therapy target. (thno.org)
  • The quick growth of cancer cells in the priory location emerges the symptoms by destruction mechanism and filling the available space. (waocp.com)
  • If so such infection could either be a mechanism by which lead caused higher rates of stomach cancer, although it could also be a confounder. (who.int)
  • 3. State Key Laboratory of Oncology in South China & Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China. (thno.org)
  • The serum level of DC-SIGNR was evaluated in gastric cancer patients by ELISA. (biomedcentral.com)
  • Additionally, DC-SIGNR level was associated with an advanced pathological stage in gastric cancer patients. (biomedcentral.com)
  • Also, serum of soluble E-selectin (sE-selectin) concentration in gastric cancer patients are detected by ELISA, but increasing only in gastric cancer patients with peritoneal metastasis [ 9 ]. (biomedcentral.com)
  • A proportion of the BRAF mutant lesions remain as microsatellite stable (MSS), and in contrast to the MSI cancers, they have an aggressive phenotype and correlate with poor patient outcomes. (hindawi.com)
  • Subsequent study using multiple human cancer cell lines, including those of the colon, stomach and liver, further indicated the universal growth-inhibitory and pro-apoptotic effects of AST. (spandidos-publications.com)
  • However, DC-SIGNR as a family member of selectin participates in gastric cancer liver metastasis remains unknown. (biomedcentral.com)
  • DC-SIGNR promoted gastric cancer liver metastasis mediated with HNRNPKP2 which expression was regulated by STAT5A. (biomedcentral.com)
  • Despite surgical resection and chemoradiotherapy can control most cancer cells [ 5 ], a surgical resection has been rarely indicated for liver metastasis from gastric cancer [ 6 ]. (biomedcentral.com)
  • Lymphangiogenesis was quantified using lymphatic micro vessel density (LMVD) by counting the immunostained lymphatic microvessels at 200X. (scirp.org)