Germ-Line MutationGerm CellsOogenesisCaenorhabditis elegansCaenorhabditis elegans ProteinsMicronucleus, GermlineDNA Mutational AnalysisDrosophila ProteinsMutationPedigreeHamartoma Syndrome, MultipleNeoplastic Syndromes, HereditaryColorectal Neoplasms, Hereditary NonpolyposisImmunoglobulin Variable RegionAnimals, Genetically ModifiedDrosophila melanogasterBase SequenceGenes, BRCA1Molecular Sequence DataStem CellsDrosophilaGenetic Predisposition to DiseaseGenes, ImmunoglobulinAllelesImmunoglobulin Heavy ChainsLi-Fraumeni SyndromeParagangliomaOvaryPhenotypeMutS Homolog 2 ProteinAdenomatous Polyposis ColiArgonaute ProteinsGene Expression Regulation, DevelopmentalGenes, BRCA2SpermatogenesisBRCA2 ProteinGenetic TestingMosaicismGonadsSpermatogoniaAntibody DiversityMeiosisDisorders of Sex DevelopmentTestisSex Determination ProcessesExonsLoss of HeterozygosityPolymerase Chain ReactionRNA, HelminthGametogenesisNuclear ProteinsImmunoglobulin kappa-ChainsRNA-Binding ProteinsMutation, MissenseGene Rearrangement, B-Lymphocyte, Heavy ChainOocytesDNA, NeoplasmAmino Acid SequenceImmunoglobulin epsilon-ChainsDNA Mismatch RepairPolymorphism, Single-Stranded ConformationalGenes, HelminthSpermatozoaProto-Oncogene Proteins c-retGenes, APCGenes, InsectImmunoglobulin gamma-ChainsDNA-Binding ProteinsStem Cell NichePeutz-Jeghers SyndromeCell DifferentiationMicrosatellite RepeatsSuccinate DehydrogenaseSequence Analysis, DNADNA Transposable ElementsInsect ProteinsImmunoglobulin Class SwitchingRNA-Induced Silencing ComplexEmbryo, NonmammalianNoonan SyndromeTumor Suppressor ProteinsGene Rearrangement, B-Lymphocyte, Light ChainTransgenesDEAD-box RNA HelicasesImmunoglobulin Light ChainsFrameshift MutationDNA MethylationSequence DeletionPenetranceGene RearrangementRNA InterferenceMultiple Endocrine Neoplasia Type 2aTranscription FactorsGenotypeAge of OnsetFamily HealthBRCA1 ProteinHelminth ProteinsIntestinal PolyposisFumarate Hydratase