• As the precursor of other non-essential amino acids such as cysteine and taurine, versatile compounds such as SAM-e, and the important antioxidant glutathione, methionine plays a critical role in the metabolism and health of many species, including humans. (wikipedia.org)
  • Cysteine and methionine are the two sulfur-containing proteinogenic amino acids. (wikipedia.org)
  • The CcpA regulon comprises genes involved in sugar uptake, fermentation and amino acids metabolism, confirming the role of CcpA as a link between carbon and nitrogen pathways. (studyres.com)
  • Methionine is also involved in angiogenesis and various processes related to DNA transcription, epigenetic expression, and gene regulation. (wikipedia.org)
  • To understand these processes through comprehensive analyses of microbial ecology, evolution and metabolism, sequenced reference genomes of representative native prokaryotes are crucial. (biomedcentral.com)
  • This is in contrast to cysteine residues, where the thiol group has a catalytic role in many proteins. (wikipedia.org)
  • We now report that the signal transduction mechanism controlling CymR activity in response to cysteine availability involves the formation of a stable complex with CysK, a key enzyme for cysteine biosynthesis. (pasteur.fr)
  • Based on GO and KEGG annotations, we identified transcripts related to sulfur metabolism, sterol biosynthesis, trehalose synthesis, and hydrolysis. (biomedcentral.com)
  • The ability of B. subtilis CysK to bind to CymR appears to be correlated to the loss of its capacity to form a cysteine synthase complex with CysE. (pasteur.fr)
  • The main backbone is derived from aspartic acid, while the sulfur may come from cysteine, methanethiol, or hydrogen sulfide. (wikipedia.org)
  • Our in-depth analysis identified sulfation pathways in L. luymesi , and sulfate activation might be an important detoxification pathway for promoting sulfur cycling, reducing byproducts of sulfide metabolism, and converting sulfur compounds to sulfur-containing organics, which are essential for symbiotic survival. (biomedcentral.com)
  • Moreover, sulfide can serve directly as a sulfur source for cysteine synthesis in L. luymesi . (biomedcentral.com)
  • Several enzymes have evolved as sensors in signal transduction pathways to control gene expression, thereby allowing bacteria to adapt efficiently to environmental changes. (pasteur.fr)
  • Methionine is also involved in angiogenesis and various processes related to DNA transcription, epigenetic expression, and gene regulation. (wikipedia.org)
  • Contrary to the previous analysis, two pathways for cysteine synthesis and the cycloartenol-C-24-methyltransferase gene were identified in animals for the first time. (biomedcentral.com)
  • This symbiosis has received much attention, and studies have examined the energy metabolism, host-microbe interactions, and adaptation to deep-sea chemosynthetic environments to reveal unique mechanisms associated with chemical ecology and metabolic evolution. (biomedcentral.com)
  • We also showed that O-acetylserine plays a dual role as a substrate of CysK and as an effector modulating the CymR-CysK complex formation. (pasteur.fr)
  • The existence of two pathways for cysteine synthesis might ensure its participation in the formation of proteins, heavy metal detoxification, and the sulfide-binding function of haemoglobin. (biomedcentral.com)