• Target genes expression after combined YAP/TAZ inhibition was analyzed. (biomedcentral.com)
  • YAP and TAZ activation is not uncoupled from cell density in CCA cells and both factors cooperatively contribute to proliferation and expression of CIN-associated genes. (biomedcentral.com)
  • Mechanistically, the complex consisting of YAP and transcription factors promotes the expression of genes involved in DNA replication, cell cycle regulation, chromosomal segregation, but also in the control of cellular stemness. (biomedcentral.com)
  • Wnt signaling pathway is mediated by Wnt family of 19 secreted glycoproteins (bearing22 or 24 cysteine residues) which are essential for cell proliferation, embryonic development, cell polarity, and tissue homeostasis [ 9 ]. (biomedcentral.com)
  • Recent studies indicate that aberrant MMP expression, localization and function may contribute to synaptic plasticity deficits associated with such disorders. (nature.com)
  • Deficits in synaptic remodelling are associated with psychiatric and neurological disorders, and aberrant MMP expression or function may contribute to the molecular mechanisms underlying these deficits. (nature.com)
  • WNT1-inducible-signaling pathway protein 3 (WISP3, also named CCN6) is a matricellular protein that in humans is encoded by the WISP3 gene. (wikipedia.org)
  • We also perform microarray transcriptomics experiments to characterize the gene expression states of the MSC-treated is- chemic tissues, and compare the results with those of non-ischemic tissues, as well as ischemic tissues from a saline-treated control group. (thno.org)
  • It is a member of the CCN family (CCN intercellular signaling protein) of secreted, extracellular matrix (ECM)-associated signaling matricellular proteins. (wikipedia.org)
  • The CCN acronym is derived from the first three members of the family identified, namely CYR61 (cysteine-rich angiogenic inducer 61, or CCN1), CTGF (connective tissue growth factor, or CCN2), and NOV (nephroblastoma overexpressed, or CCN3). (wikipedia.org)
  • These proteins, together with WISP1 (CCN4), and WISP2 (CCN5) comprise the six-member CCN family in vertebrates. (wikipedia.org)
  • In contrast, both proteins were jointly detectable in most CCA cell lines and showed nuclear/cytoplasmic shuttling in a cell density-dependent manner. (biomedcentral.com)
  • Loss of WISP3 expression is associated with aggressive inflammatory breast cancer and breast cancer with axillary lymph node metastasis, suggesting that WISP3/CCN6 may function as a suppressor of breast cancer growth and metastasis. (wikipedia.org)
  • We serially evaluate several facets of the recovery process, including α V β 3 -integrin expression (a marker of angiogenesis), blood perfusion, and muscle function. (thno.org)
  • 1. Aberrant expression of Cyr61, a member of the CCN (CTGF/Cyr61/Cef10/NOVH) family, and dysregulation by 17 beta-estradiol and basic fibroblast growth factor in human uterine leiomyomas. (nih.gov)
  • 5. Regulation of angiogenesis and endothelial cell function by connective tissue growth factor (CTGF) and cysteine-rich 61 (CYR61). (nih.gov)
  • 16. Comparison of prostaglandin F2alpha, bimatoprost (prostamide), and butaprost (EP2 agonist) on Cyr61 and connective tissue growth factor gene expression. (nih.gov)
  • The CCN acronym is derived from the first three members of the family identified, namely CYR61 (cysteine-rich angiogenic inducer 61, or CCN1), CTGF (connective tissue growth factor, or CCN2), and NOV (nephroblastoma overexpressed, or CCN3). (wikipedia.org)
  • Interestingly, NOV/CCN3, a founder member of the family of matricellular proteins called CCN (CYR61/CCN1, CTGF/CCN2, NOV/CCN3), has been involved in the regulation of cytokines, chemokines and MMP in several cell systems and therefore represents an attractive candidate for this role. (biomedcentral.com)
  • It is a member of the CCN family (CCN intercellular signaling protein) of secreted, extracellular matrix (ECM)-associated signaling matricellular proteins. (wikipedia.org)
  • 0.001) in the expression of 2,010 genes in arsenic-exposed liver samples and in the expression of 2,540 genes in arsenic-induced HCC. (nih.gov)
  • The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. (cancerindex.org)
  • We used human embryonic lung (HEL) cells, which respond with an altered expression of a broad spectrum of genes. (ijpsr.com)
  • Despite the opinion that small changes in gene expression represent noise and are not relevant 3 , we measured moderate changes in expression of key genes which might influence metabolic pathways and result in altered cell phenotypes. (ijpsr.com)
  • CCN proteins characteristically contain an N-terminal secretory signal peptide followed by four structurally distinct domains with homologies to insulin-like growth factor binding protein (IGFBP), von Willebrand type C repeats (vWC), thrombospondin type 1 repeat (TSR), and a cysteine knot motif within the C-terminal (CT) domain. (wikipedia.org)
  • 18. Estrogen receptor gene expression in human uterine leiomyomata. (nih.gov)
  • To explore further the molecular mechanisms of transplacental arsenic hepatocarcinogenesis, we conducted a second arsenic transplacental carcinogenesis study and used a genomewide microarray to profile arsenic-induced aberrant gene expression more extensively. (nih.gov)
  • Ingenuity Pathway Analysis revealed that significant alterations in gene expression occurred in a number of biological networks, and Myc plays a critical role in one of the primary networks. (nih.gov)
  • Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
  • Then, mRNA expression of Epithelial-mesenchymal transition (EMT) marker SNAIL and CYP enzymes were measured by PCR and determinate specific drug metabolites, associated with CYP enzymes by LC/MS. Our results demonstrated an epigenetic shift in HepG2 cells towards PHH after exposure to 5-AZA and Vitamin C which resulted in a higher expression and activity of specific drug metabolizing CYP enzymes. (cancerindex.org)
  • Moreover, knocking down lincRNA-p21 could elevate the expression of Yes associated protein (YAP), the core effector of Hippo signaling, by elevating mRNA levels and increasing its nucleus translocation instead of the canonical Hippo pathway. (oncotarget.com)
  • The mRNA expression of NOV and pro-inflammatory factors were measured with real-time quantitative PCR, CCL2 protein expression was assessed using ELISA, MMP-2 and -9 activities using zymography. (biomedcentral.com)
  • 6. Differential expression of G-protein-coupled estrogen receptor-30 in human myometrial and uterine leiomyoma smooth muscle. (nih.gov)
  • 8. Differential expression of caveolin-1 in human myometrial and uterine leiomyoma smooth muscle. (nih.gov)
  • These proteins, together with WISP1 (CCN4), and WISP2 (CCN5) comprise the six-member CCN family in vertebrates. (wikipedia.org)
  • 17. Expression of the fibroblast growth factor receptor in women with leiomyomas and abnormal uterine bleeding. (nih.gov)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • The abnormal expression of follistatin‑like protein 1 (FSTL1) in various tumors is a crucial regulator of the biological process of tumorigenesis. (spandidos-publications.com)
  • The effects of abnormal expression of FSTL1 on cervical cancer cells were assessed using colony formation, MTT, wound‑healing, Transwell, apoptosis, and nude mouse tumorigenicity assays. (spandidos-publications.com)
  • 19. Ovarian steroid hormones modulate the expression of progesterone receptors and histone acetylation patterns in uterine leiomyoma cells. (nih.gov)
  • Extracellular hormones can modulate LATS1/2 kinase activity via G-protein-coupled receptors to regulate the Hippo pathway 19 , 23 . (nature.com)
  • Follistatin-like protein 1 (FSTL1), a type of secretory glycoprotein, is expressed in most mammalian cells, with the exception of peripheral lymphocytes. (spandidos-publications.com)
  • A ) As a result of liver injury, quiescent vitamin-A-rich hepatic stellate cells undergo 'activation' towards proliferative, fibrogenic and contractile myofibroblasts. (medscape.com)
  • 2. CCNs, fibulin-1C and S100A4 expression in leiomyoma and myometrium: inverse association with TGF-beta and regulation by TGF-beta in leiomyoma and myometrial smooth muscle cells. (nih.gov)
  • Finally, we observed that 5-AZA and Vitamin C led to an increased expression of Hepatocyte nuclear factor 4α (HNF4α) and E-Cadherin and a significant down regulation of Snail1 (SNAIL), the key transcriptional repressor of E-Cadherin. (cancerindex.org)
  • Overexpression experiments verified the regulation role of lincRNA-p21 in YAP expression. (oncotarget.com)
  • ID1, inhibitor of DNA binding, are up-regulated as a rapid response after 2 h with a factor 3.8 and RPS2, ribosomal protein S2 , is down-regulated to nearly 50 % after 24 hours. (ijpsr.com)
  • It is well-known that epigenetics is strongly modified in tumor cells and that epigenetic regulators influence the expression and function of Cytochrome P450 (CYP) enzymes through altering crucial transcription factors responsible for drug-metabolizing enzymes. (cancerindex.org)
  • They interact normally with DNA binding proteins under heterodimer formation and are considered as negative regulators of transcription. (ijpsr.com)
  • NOV-reduced expression was restored after treatment of CFA rats with dexamethasone. (biomedcentral.com)
  • The expression of FSTL1 in normal and cervical cancer tissues was examined using quantitative reverse transcription‑polymerase chain reaction and immunohistochemistry assays. (spandidos-publications.com)
  • Therefore we performed a systematic analysis of the genetic expression behaviour, using the established whole genome microarray-technology which should be able to reveal the cellular effects. (ijpsr.com)
  • 10. Expression of connexin-43 in human myometrium and leiomyoma. (nih.gov)
  • The results indicated that the expression of FSTL1 was downregulated in cervical cancer tissues and that its downregulation was associated with tumor differentiation, pathologic type, and infiltration depth. (spandidos-publications.com)
  • The expression levels of lincRNA-p21 in tissue samples and cell lines were detected by qRT-PCR. (oncotarget.com)
  • MGC-803 and MKN-45 cells were transfected with siRNAs targeting lincRNA-p21 or control siRNAs to determine the effect of reduced lincRNA-p21 expression on tumorigenesis. (oncotarget.com)
  • In vitro , results based on cultured DRG neurons showed that siRNA-mediated inhibition of NOV enhanced IL-1β- and TNF-α-induced MMP-2, MMP-9 and CCL2 expression whereas NOV addition inhibited TNF-α-induced MMP-9 expression through β 1 integrin engagement. (biomedcentral.com)
  • 12. Decreased expression of early growth response-1 and its role in uterine leiomyoma growth. (nih.gov)