Expression cell line tumor. Medical search. Frequent questions

The hsa-miR-371-373 cluster (counteracting cellular senescence and linked with differentiation potency), as well as hsa-miR-520c/-520h (inhibiting the tumor suppressor p21) were 3.9-16.3 fold up-regulated in two of the three cisplatin resistant cell lines. (biomedcentral.com)
Loss of DKK3 gene is associated with a possible tumor suppressor role in human cancers. (amrita.edu)
The chromosome 22 area contains the hSNF5/INI1 gene that appears to function as a classic tumor suppressor gene. (wikipedia.org)
INI1/hSNF5, a component of the chromatin remodeling SWI/SNF complex, is a critical tumor suppressor biallelically inactivated in rhabdoid tumors. (wikipedia.org)
Identification of INI1 as a tumor suppressor has facilitated accurate diagnosis of rhabdoid tumors. (wikipedia.org)
AT/RT is the first pediatric brain tumor for which a candidate tumor suppressor gene has been identified. (wikipedia.org)
In conclusion, SCARA5 inhibited the proliferation and EMT and induced the apoptosis of OSCC cells through the inhibition of STAT3 and PI3K/AKT signaling pathways, thereby exerting a tumor suppressor effect. (degruyter.com)
Specifically, CD8+ cells, also known as cytotoxic T cells, burst onto the scene, while other immune system suppressor cells drop off, Dr. Hermann tells GEN . (genengnews.com)
This may include oncomir (oncogenic miRNA) inhibition, or tumor suppressor-miRNA replacement therapies [ 6 , 9 ]. (hindawi.com)
Overexpression of XAF1 impairs tumor progression whereas knockdown of XAF1 promotes tumor growth, suggesting that XAF1 may be a candidate tumor suppressor in neuroblastoma and its associated pathway may be important for developing future interventions. (nus.edu.sg)
Results of mechanistic studies demonstrated that inhibiting KDM1 increased the expression of tumor suppressor p53 target genes through epigenetic modifications, according to Sareddy. (medindia.net)
Frequency of myeloid suppressor cells (MDSC). (who.int)

Agents that induce apoptosis may inhibit tumor growth and provide therapeutic benefit. (nih.gov)
The authors investigated the effect of a homeopathic treatment regimen containing Conium maculatum, Sabal serrulata, Thuja occidentalis, and a MAT-LyLu Carcinosin nosode on the expression of cytokines and genes that regulate apoptosis. (nih.gov)
The therapeutic effect of homeopathic treatments observed in the in vivo experiments cannot be explained by mechanisms based on distinct alterations in gene expression related to apoptosis or cytokines. (nih.gov)
Elimination of BCR/ABL-dependent intracellular signals triggers apoptosis, but it is unclear whether this activates additional cell survival and/or death pathways. (lu.se)
Treatment of carfilzomib followed by selinexor caused selinexor-sensitive and selinexor-resistant cell lines to be more sensitive to selinexor as determined by an increase in apoptosis. (aacrjournals.org)
Pretreatment with the proteasome inhibitor carfilzomib can further stabilize IκB, which is sequestered in the nucleus to inhibit transcriptional activity of NFκB and suppresses expression of survivin, thereby inducing apoptosis. (aacrjournals.org)
Its roles include regulation of proliferation, promotion of immune system and activation of apoptosis in B cells. (intechopen.com)
In these cells, IL-21 does not promote proliferation but enhances apoptosis and chemotaxis. (intechopen.com)
Translation elongation factor 1A2 (TEF1A2) is a tumor marker and an inhibitor of cadmium -induced apoptosis. (cdc.gov)
Transgenic CHO cells permanently overexpressing TEF1A2 were developed and used to investigate the role of TEF1A2 in apoptosis induced by cadmium - a well-known human chemical carcinogen. (cdc.gov)
Exposure of CHO cells to 2.5 and 10 um cadmium chloride for 24-hours resulted in significant apoptosis in all cell lines at 24- and 48-hours following the exposure. (cdc.gov)
However, the cadmium -induced apoptosis was significantly lower in the transgenic CHO cells permanently overexpressing TEF1A2 compared with the vector-alone transfected control cells. (cdc.gov)
Niclosamide targets not only the energy production in the cells but also triggers other processes that result in what is called, Apoptosis, (self-killing) in the cells. (nottingham.ac.uk)
SCARA5 overexpression significantly inhibited cell proliferation and induced apoptosis of CAL-27 and SCC-9 cells. (degruyter.com)
Our results indicated that AST inhibits cell proliferation through phase-specific cell cycle arrest and caspase-dependent apoptosis. (spandidos-publications.com)
E very day, billions of our cells die quietly and in an orderly fashion by activating a cell suicide program known as apoptosis. (the-scientist.com)
Importantly, these animals survived significantly longer than mice that had received injections of cancer cells that had apoptosis-inducing enzymes activated instead. (the-scientist.com)
Triggering necroptosis is considered an attractive strategy over inducing apoptosis because many tumors develop ways to block or evade apoptosis, he writes. (the-scientist.com)
An aberrant miRNA expression could contribute to cancer development and progression [ 6 , 7 ] and could affect their target genes that are involved in many biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, and development [ 8 ]. (hindawi.com)
Doxorubicin- and platinum-based agents are most commonly used with the platinum-based agents that induce apoptosis versus the doxorubicin-based drugs that promote cell arrest. (medscape.com)
A new form of 5-fluorouracil called fluoropyrimidine that has increased activity against malignant cells and while having fewer gastrointestinal side effects has shown to be efficacious against malignant salivary cancers and to potentiate the effects of radiotherapy by increasing apoptosis. (medscape.com)
When DNA becomes damaged, p53 helps determine whether the DNA will be repaired or the cell will self-destruct ( undergo apoptosis ). (medlineplus.gov)

The understanding of such tumor evasion mechanisms and the complex interactions that take place in the tumor microenvironment is essential to obtain successful treatments. (aacrjournals.org)
Preclinical tests show that the inhibitor can change the microenvironment of a tumor by increasing populations of antitumor immune cells in the area. (genengnews.com)
Recent evidence, however, supports a dual role for macrophages in the regulation of tumour proliferation and immune control 10 , 16 , and indicates that the local tissue microenvironment plays a critical role in determining cell phenotypes. (ersjournals.com)
However, target identification warrants a better understanding of the surfaceome and how it is modulated by the tumor microenvironment. (lu.se)
The development of CRC is highly influenced by the tumour microenvironment. (lu.se)

Future research should explore subtle modulations in the expression of multiple genes in different biological pathways. (nih.gov)
We further demonstrated that suppression of autophagy using either pharmacological inhibitors or RNA interference of essential autophagy genes enhanced cell death induced by IM in cell lines and primary CML cells. (lu.se)
Although epigenetically silenced, endogenous retroviral (ERV) genes become activated in tumors and function to ignite immune responses. (frontiersin.org)
Single-cell transcriptome RNA sequencing coupled with functional T-cell proteomics analysis uncovers the top-upregulated genes that might be critical for the persistence of polyfunctional CAR-T cells in mice. (nature.com)
In contrast, the previously established ER-negative TMX2-28 cell line has decreased expression of both DOK7 and ELF5 and increased DNA methylation in the transcriptional start site region of these genes. (umass.edu)
Activation of the Wnt pathway stabilizes beta-catenin, allowing it to move into the cell nucleus and control the expression of many different genes. (eurekalert.org)
This study aimed to evaluate the expression levels of miR-34a and 11 of its bioinformatically selected target genes and proteins to test their potential dysregulation in RCC. (hindawi.com)
In the present studies, we examined the expression of two PDGF receptor genes in human tumor cell lines derived from neural crest. (jci.org)
Gene-expression patterns used to differentiate four type cause heart damage, and markable finding that genes cur- types of SRBCT. (lu.se)
Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
Sarcoma tissue samples and cell lines are subjected to a multiplatform genome-wide characterization of expression of protein-coding genes and microRNAs, DNA copy number changes, activating mutations, gene rearrangements and methylation profiling. (mskcc.org)
To identify potential therapeutic targets, our lab screens the genes and microRNAs in these signatures for involvement in proliferation, differentiation, and survival of sarcoma cell lines. (mskcc.org)
The interactome is significantly enriched with genes differentially expressed in MPM tumors compared with normal pleura and with other thoracic tumors, genes whose high expression has been correlated with un-favorable prognosis in lung cancer, genes differentially expressed on crocidolite exposure, and ex-osomederived proteins identified from malignant mesothelioma cell lines. (cdc.gov)
Cancers occur when genetic mutations build up in critical genes, specifically those that control cell growth and division (proliferation) or the repair of damaged DNA. (medlineplus.gov)
Somatic mutations in many different genes have been found in lung cancer cells. (medlineplus.gov)
The EGFR and KRAS genes each provide instructions for making a protein that is embedded within the cell membrane. (medlineplus.gov)

We showed that overexpression of DKK3 can decrease cell invasion, proliferation, and colony forming ability of GBC cells. (amrita.edu)
Extracellular ST6GAL1, present in cancer exosomes or the freely soluble recombinant sialyltransferase, compensates for insufficient intrinsic ST6GAL1 by boosting cancer cell proliferation and increasing invasiveness. (nature.com)
Our data indicate that extracellular ST6GAL1 from remote sources can compensate for cellular ST6GAL1-mediated aggressive tumor cell proliferation and invasive behavior and has great clinical potential for extracellular ST6GAL1 as these molecules are in the extracellular space should be easily accessible targets. (nature.com)
Cell proliferation and invasion were assayed using the kidney cell lines HEK293 with wild-type p53 and a ccRCC cell line MZ1257RC mutated for p53. (frontiersin.org)
MZ1257RC showed induction of ERV-K113 expression and significantly increased both proliferation and invasion in the presence or absence of Aza. (frontiersin.org)
HEK293 cells demonstrated a restriction of ERV-K113 env expression and invasion with no changes in proliferation in the absence of Aza. (frontiersin.org)
However, in the presence of Aza despite increased ERV-K113 env expression, an inhibition of HEK293 proliferation and a further restriction of invasion was found. (frontiersin.org)
In vitro studies based on MCF-7 cell proliferation and induction of vitellogenin in primary culture of rainbow trout hepatocytes. (cdc.gov)
Beta-catenin is a central component of the Wnt signaling pathway that controls cell proliferation and differentiation. (eurekalert.org)
Among its different constituents, Astragalus polysaccharides have been most widely studied particularly for their immunopotentiating properties, such as stimulation of murine B cell proliferation and cytokine production ( 6 ). (spandidos-publications.com)
A hallmark of the disease is the proliferation of cells that have not completely matured. (genengnews.com)
We demonstrate that CD117+ cells display increased proliferation and migration. (biorxiv.org)
Further, in cell lines, CD117 activation by SCF promotes faster proliferation and invasiveness, while blocking CD117 activation with tyrosine kinase inhibitors (TKIs) decreased progression in a context-dependent manner. (biorxiv.org)
When these proteins are turned on (activated) by binding to other molecules, signaling pathways are triggered within cells that promote cell proliferation. (medlineplus.gov)
The altered protein cannot regulate cell proliferation effectively and allows DNA damage to accumulate in cells. (medlineplus.gov)
Further screening showed increased cell proliferation. (who.int)

Gliomas are the most common primary brain tumors. (scirp.org)
Malignant gliomas remain aggressive and lethal primary brain tumors in adults. (oncotarget.com)
Brain tumors are the abnormal growth of brain cells that may be benign or metastatic. (medindia.net)
Brain tumors account for about 2.4% of all the tumor diagnosesandare most challenging due to their critically delicate location. (medindia.net)
Gliomas, the deadliest form of primary central nervous system neoplasms, represent about 70 percent of brain tumors, according to Sareddy. (medindia.net)
I'm a board certified neuro-oncologist who treats both primary brain tumors as well as metastatic disease to the brain and nervous system. (stanford.edu)

A and B ) MCT1 was detected by western blot ( A ) and confocal microscopy ( B ) in human tumor cell lines and control tissues. (jci.org)
We assessed miR-637 expression in 98 and 16 gliomas and non-tumoral brain tissues, respectively, using in situ hybridization. (scirp.org)
We found that cytoplasmic linker protein 170 (CLIP170) was overexpressed in HNSCC tissues and cells compared to normal controls. (nih.gov)
Presently, we have investigated the expression profile of TEF1A2 using a panel of human cancer cell lines and tumor tissues. (cdc.gov)
Up to a 2000-fold overexpression of TEF1A2 was detected in 90% (nine out of 10) of the cancer cell lines derived from various human tissues compared to their corresponding controls. (cdc.gov)
Hsa_circ_001242 expression levels in 40 paired OSCC tissues and four OSCC cell lines were selected using real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). (hindawi.com)
We first confirmed that hsa_circ_001242, which is located at chr10: 17157441-17168917 (Figure 1 ), was significantly downregulated in OSCC cell lines and OSCC tissues. (hindawi.com)
Its expression levels in tissues at various stages of OSCC were then explored, and the potential relationship between hsa_circ_001242 expression levels and patients' clinicopathological factors were investigated. (hindawi.com)
The tumor size and the number of proliferating cells were reduced in the tumor tissues obtained from the formononetin-treated group. (spandidos-publications.com)
Just like members of an orchestra are active at different times although playing the same piece of music, every cell in our body contains the same genetic sequence but expresses this differently to give rise to cells and tissues with specialised properties. (embl.org)
The analysis used data collected from 163 laboratories worldwide involving 5,372 human samples from various tissues, cell types and diseases. (embl.org)
We found RCC tissues displayed significantly higher miR-34a expression level than their corresponding noncancerous tissues, particularly in chromophobic subtype. (hindawi.com)
MIR-34A has its own transcript and is expressed at higher levels than MIR-34B/C in most tissues, and this expression could be dysregulated in multiple diseases, especially in cancers [ 11 ]. (hindawi.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
We analyse two comprehensive transcriptome datasets from human tissues and human-derived cell lines in terms of the expression profiles of the SLC and ABC families of membrane transporters. (biorxiv.org)
The Gini index (coefficient) characterises inequalities of distributions, and is used in a novel way to describe the distribution of the expression of each transporter among the different tissues and cell lines. (biorxiv.org)
Similar trends hold true for the expression profiles of transporters in different cell lines, suggesting that cell lines exhibit largely similar transport behaviour to that of tissues. (biorxiv.org)
By contrast, the Gini coefficients for ABC transporters tend to be larger in cell lines than in tissues, implying that some kind of a selection process has taken place. (biorxiv.org)
The lowest four in tissues are FAM32A, ABCB7, MRPL21 and PCBP1, while the lowest three in cell lines are SF3B2, NXF1 and RBM45. (biorxiv.org)
PCBP1 is both reasonably highly expressed and has a low Gini coefficient in both tissues and cell lines, and is an excellent novel housekeeping gene. (biorxiv.org)
We have also found that smg p25A is mainly detected inneural tissues by use of its specific monoclonal antibody, and that the levels of smg p25A mRNA increase in PC12 cells after their differentiation into neuron-like cells. (nii.ac.jp)
These results suggest that smg p21 and smg p25A can be used as potential tumor markers for tumors derived from hematopoietic and neural tissues, respectively. (nii.ac.jp)
But for the most part, normal tissues and 9 cell lines). (lu.se)
These include gamma-knife stereotactic radiosurgery and brachytherapy (radioactive seeds or sources are placed in or near the tumor itself, giving a high radiation dose to the tumor while reducing the radiation exposure in the surrounding healthy tissues). (medscape.com)

World Health Organization (WHO) grade IV glioma, which includes glioblastoma multiform (GBM), is a highly invasive and fatal malignant tumor [1]. (scirp.org)
It is known that arsenic trioxide (ATO) is able to inhibit the migration and invasion of solid malignant tumors, but its exact molecular mechanism remains unclear. (nih.gov)
Objective -To analyze the expression of versican and hyaluronan in melanocytomas and malignant melanomas of dogs, to correlate their expression with expression of the hyaluronan receptor CD44, and to identify enzymes responsible for the synthesis and degradation of hyaluronan in canine dermal fibroblasts and canine melanoma cell lines. (avma.org)
Versican and, to a lesser extent, hyaluronan were significantly overexpressed in malignant melanomas, compared with expression in melanocytomas. (avma.org)
No significant difference was found between malignant tumors from oral or cutaneous origin. (avma.org)
Surgery is the primary treatment of malignant tumors of the salivary glands. (medscape.com)
Benign neoplasms occur more frequently in women than in men, but malignant tumors are distributed equally between the sexes. (medscape.com)
Almost half of all submandibular gland neoplasms and most sublingual and minor salivary gland tumors are malignant. (medscape.com)
Malignant pleural mesothelioma (MPM) is an aggressive cancer affecting the outer lining of the lung, with a median survival of less than one year. (cdc.gov)

It is within the cell-autonomous context that ST6GAL1 involvement in cancer progression has been interpreted. (nature.com)
Cancer cell-extrinsic mechanisms, which are poorly understood, are also believed to contribute to disease progression and the heterogeneous genetic mutations with diverse presentations. (nature.com)
Cell cycle progression was also affected. (frontiersin.org)
Angiogenesis is essential in the process of carcinogenesis to facilitate tumor progression and metastasis. (spandidos-publications.com)
Another important mechanism for the progression of colorectal cancer is the ability of the transformed cells to invade and traverse the basement membrane, which in turn facilitates the conversion of adenomas into carcinomas and then metastases ( 1 ). (spandidos-publications.com)
There is increasing interest in the role played by the innate and adaptive immune systems in the regulation of tumour development and progression 2 , 3 and it is anticipated that a better understanding of the molecular and cellular immunology of NSCLC will lead to the identification of novel targets for immunotherapy. (ersjournals.com)
The role of macrophage phenotypes in tumour progression has been extensively reviewed 6 - 10 . (ersjournals.com)
Cancer stem-like cells (CSCs) are associated with cancer progression, metastasis, and recurrence, and may also represent a subset of circulating tumor cells (CTCs). (biorxiv.org)
In this study, we show that CD117 expression in prostate cancer patients is associated with decreased overall and progression-free survival and that activation and phosphorylation of CD117 increases in prostate cancer patients with higher Gleason grades. (biorxiv.org)
GBM stem-like cells (GSCs) represent a subpopulation of the tumor which is responsible for tumor initiation, progression, and re-growth after chemoradiation [ 5 , 6 ], as well as supporting tumor vessel growth and function [ 7 ]. (oncotarget.com)
These ANN ment, cell-cycle progression, drug treat- with different dyes. (lu.se)
S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. (cancerindex.org)

Neuroblastoma is an aggressive, relapse-prone childhood tumor of the sympathetic nervous system. (nus.edu.sg)

Stably fluorescence protein (FP) expressing cell clones of colorectal carcinoma and germ cell tumor lines were generated by lentiviral transduction using the FPs eGFP, dsRed2, TurboFP635, and mPlum. (nih.gov)
A similar switch from lactate-fueled respiration to glycolysis by oxygenated tumor cells in both a mouse model of lung carcinoma and xenotransplanted human colorectal adenocarcinoma cells was observed after administration of CHC. (jci.org)
8] when using sequence analysis of human colorectal cells. (scirp.org)
Uncovering key kinases in tumor growth and invasion is crucial for improving targeted therapies in advanced-stage colorectal cancer. (medindia.net)

Unlike other testicular tumors, spermatocytic tumors does not appear to be linked to cryptorchidism and is not associated with intratubular germ cell neoplasia, unclassified type (IGCNU), or other testicular germ cell tumor subtypes. (medscape.com)
Sixteen histological tumor subtypes exist and the most common are papillary, chromophobe and clear cell renal cell carcinoma (ccRCC) representing 85% of all RCC. (frontiersin.org)
In this investigation a human RCC tissue microarray (TMA) (n=374) predominantly consisting of the most common histological tumor subtypes was hybridized with an ERV-K env antibody and correlated with patient clinical data. (frontiersin.org)
TMA results showed the highest amount of ERV-K env protein expression and the strongest significant membrane expression in ccRCC versus other RCC subtypes. (frontiersin.org)
High ERV-K env total protein expression of all tumor subtypes significantly correlated with low tumor grading and a longer disease specific survival using multivariable analyses. (frontiersin.org)
although it is derived from cells of the renal tubular epithelium, it has several histological subtypes which differ in their clinical outcome and biological features. (hindawi.com)
To tailor CRC treatment, it is essential to first model this heterogeneity by defining subtypes of patients with homogeneous biological and clinical characteristics and second match these subtypes to cell lines for which extensive pharmacological data is available, thus linking targeted therapies to patients most likely to respond to treatment. (tudelft.nl)
Methods We applied a new unsupervised, iterative approach to stratify CRC tumor samples into subtypes based on genome-wide mRNA expression data. (tudelft.nl)
By applying this stratification to several CRC cell line panels and integrating pharmacological response data, we generated hypotheses regarding the targeted treatment of different subtypes. (tudelft.nl)
Results In agreement with earlier studies, the two dominant CRC subtypes are highly correlated with a gene expression signature of epithelial-mesenchymal-transition (EMT). (tudelft.nl)
Application of this stratification to four CRC cell line panels comprising 74 different cell lines, showed that the tumor subtypes are well represented in available CRC cell line panels. (tudelft.nl)
Pharmacological response data for targeted inhibitors of SRC, WNT, GSK3b, aurora kinase, PI3 kinase, and mTOR, showed significant differences in sensitivity across cell lines assigned to different subtypes. (tudelft.nl)
By matching the identified subtypes to cell line panels that have been pharmacologically characterized, it opens up new possibilities for the development and application of targeted therapies for defined CRC patient sub-populations. (tudelft.nl)
The authors used artificial neural croarrays is to study changes in gene ex- .nature organ the tumor arose from, how big it networks (ANNs) to identify gene-ex- pression that accompany changes in is, and what it looks like after it has pression signatures associated with spe- cell physiology, such as during develop- been imbedded in wax and colored cific subtypes of tumors. (lu.se)
0 gene-expression profiling to tinct subtypes of SRBCTs (Fig. 1). (lu.se)
These data are then used to identify both genetically distinct subtypes of sarcoma and molecular signatures associated with tumor morphology, grade, recurrence, and survival. (mskcc.org)
Non-small cell lung cancer is divided into three main subtypes: adenocarcinoma, squamous cell carcinoma, and large cell lung carcinoma. (medlineplus.gov)

Carefully planned and executed surgical excision is the primary treatment for all primary salivary gland tumors. (medscape.com)
An estimated 700 deaths (0.4 per 100,000 for males and 0.2 per 100,000 for females) related to salivary gland tumors occur annually. (medscape.com)
Successful diagnosis and treatment of patients with salivary gland tumors require a thorough understanding of tumor etiology, biologic behavior of each tumor type, and salivary gland anatomy. (medscape.com)

This study supports ERV-K env as a single prognostic indicator for better survival of RCC, which we propose represents a new tumor antigen. (frontiersin.org)
Rational design of chimeric antigen receptor T (CAR-T) cells based on the recognition of antigenic epitopes capable of evoking the most potent CAR activation is an important objective in optimizing immune therapy. (nature.com)
Our results highlight the importance of the specific target antigen epitope in governing optimal CAR-T activity and provide a nanobody-based B7-H3 CAR-T product for use in solid tumor therapy. (nature.com)
That necroptotic cells don't have to carry any tumor antigen to have this effect was a remarkable finding to senior author Andrew Oberst , a cancer immunologist at the University of Washington. (the-scientist.com)
Monocytes activated by tumour-derived microvesicles from pancreatic, colon and lung cancer cell lines have been found to show increased expression of human leukocyte antigen (HLA)-DR and a resulting increase in production of reactive oxygen intermediates and TNF-α 11 . (ersjournals.com)
These cells are reported to express the CD163 antigen 7 , 8 . (ersjournals.com)
[ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)

In August 2016, KEYTRUDA (pembrolizumab) (2 mg/kg every three weeks) was approved in Europe for previously-treated patients with locally advanced or metastatic NSCLC whose tumors express PD-L1 (TPS of 1 percent or more) and who have received at least one prior chemotherapy regimen. (merck.com)
The data demonstrate that KEYTRUDA provided meaningful improvements in survival versus the current standard of care in patients whose tumors express high levels of PD-L1," said Dr. Luis Paz-Ares, chair of the medical oncology department, Hospital Universitario Doce de Octubre, Madrid, Spain. (merck.com)

Research has intensified to understand ERV protein function and their role as tumor antigens and targets for cancer (immune) therapy. (frontiersin.org)
Selinexor, a small molecule that inhibits nuclear export protein XPO1, has demonstrated efficacy in solid tumors and hematologic malignancies with the evidence of clinical activity in sarcoma as a single agent. (aacrjournals.org)
A protein that helps prevent a woman's body from rejecting a fetus may also play an important role in enabling pancreatic cancer cells to evade detection by the immune system, allowing them to spread in the body. (sciencedaily.com)
Researchers found that the metastatic pancreatic cancer cells in the lymph nodes produce enough of the protein, IDO, to wall-off the immune system's T-cells and recruit cells that suppress the immune response to the tumor. (sciencedaily.com)
In every case, they found greater expression of the IDO protein in the cancerous lymph nodes. (sciencedaily.com)
In solid tumors, the B7-H3 transmembrane protein is an emerging target that harbours two distinct epitope motifs, IgC and IgV, in its ectodomain. (nature.com)
It can directly bind to the 3'-untranslated region of the target mRNA through its seed sequence and inhibit the expression of the encoded protein at the post-transcriptional level [3]. (scirp.org)
ATO at non-cytotoxic level (1 μM) inhibited the migration and invasion of HNSCC cells by displacing zinc in the zinc finger motif of CLIP170, which is a key protein that controls microtubule dynamics. (nih.gov)
This study characterizes the expression of hormone receptors, and the mRNA and DNA methylation levels of docking protein 7 (DOK7), and E74-like factor 5 (ELF5), in 21 novel tamoxifen-resistant cell lines and extends the findings to primary and recurrent human breast tumors. (umass.edu)
The parent (MCF-7) and tamoxifen-selected cell lines were characterized for protein expression of ER, progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) using immunohistochemistry (IHC). (umass.edu)
Researchers reveal a new way in which cells restrain beta-catenin and potentially suppress tumor metastasis: the protein can be ejected from cells in small vesicles called exosomes. (eurekalert.org)
To investigate the effects of necroptotic cells on tumors, doctoral student Annelise Snyder at the University of Washington along with her colleagues engineered cancer cells in which the RIPK3 protein-an enzyme that triggers the necroptotic pathway-was activated. (the-scientist.com)
Myeloid related protein (MRP) 8/14 expression by macrophages is associated with the release of TNF-α 12 . (ersjournals.com)
and cell differentiation ( SOX2 and TGFB3 ) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens. (hindawi.com)
The advanced pathological grade was associated with strong TGFB1, VEGFA, and Ki67 protein expression and absent Tp53 staining. (hindawi.com)
C57BL/KaLwRij mice were implanted subcutaneously with unilateral murine green fluorescent protein-expressing 5TGM1 tumors and divided into 3 independent groups: untreated, treated beginning week 2 after tumor implantation, and treated beginning week 3 after tumor implantation. (snmjournals.org)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
Before and after treatment, serum neuron specific enolase (NSE), tumor necrosis factor-α(TNF-α), interleukin-8(IL-8), hypersensitive C-reactive protein (CRP), Birmingham Cognitive Screen test (BCoS) score, serum soluble intercellular adhesion molecule-1(ICAM-1), serum endothelin-1(ET-1), vascular endothelial growth factor (VEGF) levels, and endothelium-dependent vasodilation function (FMD) in the two groups were compared. (bvsalud.org)
CD47 is involved in crosstalk between colon cancer cells and macrophages by interacting with its ligand signal-regulatory protein α on macrophages. (lu.se)
Novel PPIs were predicted by applying the HiPPIP algorithm, which computes features of protein pairs such as cellular localization, molecular func-tion, biological process membership, genomic location of the gene, and gene expression in microar-ray experiments, and classifies the pairwise features as interacting or noninteracting based on a random forest model. (cdc.gov)
The TP53 gene provides instructions for making a protein, called p53, that is located in the nucleus of cells throughout the body, where it attaches (binds) directly to DNA. (medlineplus.gov)
The protein regulates cell growth and division by monitoring DNA damage. (medlineplus.gov)

The most potent nanobody-based CAR-T cells show inhibition of large tumor xenografts in mice with rigorous T-cell signaling and significant T-cell infiltration into the tumor. (nature.com)
As MCT1 was found to be expressed by an array of primary human tumors, we suggest that MCT1 inhibition has clinical antitumor potential. (jci.org)
Exosomal release of beta-catenin and inhibition of Wnt signaling may explain why CD82 and CD9 suppress tumor metastasis. (eurekalert.org)
We found that KDM1 expression is upregulated in gliomas and have preclinical evidence that suggests pharmaceutical inhibition of the KDM1 axis could have therapeutic implications for the treatment of gliomas," said Sareddy. (medindia.net)

4SC-202 also appears to increase the expression of tumor-associated antigens and immunomodulatory molecules in cancer cell lines. (genengnews.com)
In the first experiment, the injected necroptotic cells were derived from the same cell line as the tumors, and carried the same cell surface antigens. (the-scientist.com)
To him, it suggests that the necroptotic cells don't direct T cells to target tumors by displaying particular antigens, but rather by secreting particular cytokines and chemokines that activate local T cells that reside around the tumor and are already primed to attack those cancer cells, but need an external nudge to become active. (the-scientist.com)
Immunotherapies with antibody-drug-conjugates (ADC) and CAR-T cells, targeted at tumor surface antigens (surfaceome), currently revolutionize clinical oncology. (lu.se)

This study indicates that treatment with the highly diluted homeopathic remedies does not alter the gene expression in primary prostate tumors or in lung metastasis. (nih.gov)
Only the has-miR-10b involved in breast cancer invasion and metastasis and has-miR-512-3p appeared to be up-regulated (2-3-fold) in all three cell lines. (biomedcentral.com)
CD82 and CD9 are both suppressors of metastasis whose expression is lost in several types of late stage tumor. (eurekalert.org)
Additionally, the expression and activity of matrix metalloproteinases (MMPs) are increased in almost every type of human cancer, which may be associated with cell invasion, metastasis and angiogenesis. (spandidos-publications.com)
Combined, these data indicate that CD117 expression potentially promotes tumor initiation and metastasis. (biorxiv.org)

A case of a seven-month-old child with a primarily spinal tumor that presented with progressive paraplegia and abnormal feeling in the legs was reported. (wikipedia.org)
Interleukin-21 (IL-21) is produced by activated T cells and it plays many diverse roles by regulating the functions of normal and abnormal cells. (intechopen.com)
Lung cancer is a disease in which certain cells in the lungs become abnormal and multiply uncontrollably to form a tumor . (medlineplus.gov)

CONCLUSIONS: The distinct ELF5 methylation of PR-positive primary tumors from women who had a PR-negative recurrence indicates the possibility of stratification of women for tailored treatment in the early stages of disease. (umass.edu)
GBM stem-like cells (GSCs) present in tumors are felt to be highly tumorigenic and responsible for tumor recurrence. (oncotarget.com)

2014). genetic StudieS are carried out, uSing tuMour SaMPleS froM PatientS with excellent clinical data that have been collected at a PoPulation level or internationally, to Provide unique data coMbining the Pathology, geneticS, clinical featureS, and ePideMiology of tuMourS. (who.int)

However, the successful application of these emerging cell-based therapies in solid tumors remains limited. (nature.com)
That helps to eradicate the cells that are at the root of the leukemia, something conventional therapies can't do, Dr. Lee says. (genengnews.com)
I think the future of oncology, in terms of treating solid tumors , will be these combination therapies," Dr. Hermann says. (genengnews.com)
Such tumor profiles can subsequently be applied to exclusively tailor cancer therapies to directly target a causative mutation for a malignancy, ultimately achieving a personalized and precise approach to cancer treatment. (biomedcentral.com)
It focuses on how precision oncology has shaped advances in the impact of non-coding RNAs in epigenetics and cancer, immunotherapy and tumor biology, and the clinical significance of various therapies in a range of cancers. (biomedcentral.com)
In the last decade, the availability of autologous stem cell transplantation and combination therapies consisting of immunomodulatory drugs, proteasome inhibitors, and other chemotherapeutics has improved median 5-y survival from 34.6% in 2004 to 49.6% in 2013 ( 3 , 4 ). (snmjournals.org)

Research has shown that lysine-specific histone demethylase 1 (LSD1) plays an essential role in the self-renewal of these "leukemic stem cells," Incyte principal investigator Sang Hyun Lee, Ph.D., tells GEN . Building on this finding, Dr. Lee and colleagues developed an LSD1 inhibitor called INCB059872, which spurs myeloid cell differentiation. (genengnews.com)
It is involved in p53 pathways and is implicated in cell death/survival signaling, the cell cycle, and differentiation, thereby playing a regulatory role in carcinogenesis [ 12 ]. (hindawi.com)
These findings suggest that PDGF isoforms are involved not only in the promotion of the neuroblastoma cell growth, but also in neuronal cell migration, growth, and differentiation in human brain development. (jci.org)
Evidence is accumulating that small G proteins are involved in the regulation of cell growth and differentiation. (nii.ac.jp)
We have found that the levels of smg p21 mRNA increase in hematopoietic leukemiae cells after their differentiation into hematopoietic cells. (nii.ac.jp)

We compared microRNA expression patterns in three cisplatin resistant sublines derived from paternal cisplatin sensitive germ cell tumor cell lines in order to improve our understanding of the mechanisms of cisplatin resistance. (biomedcentral.com)
Three cisplatin resistant sublines (NTERA-2-R, NCCIT-R, 2102EP-R) showing 2.7-11.3-fold increase in drug resistance after intermittent exposure to increasing doses of cisplatin were compared to their parental counterparts, three well established relatively cisplatin sensitive germ cell tumor cell lines (NTERA-2, NCCIT, 2102EP). (biomedcentral.com)
Moreover, we describe for the first time an association of the up-regulation of micro-RNA species such as hsa-miR-512-3p/-515/-517/-518/-525 and down-regulation of hsa-miR-99a/-100/-145 with a cisplatin resistant phenotype in human germ cell tumors. (biomedcentral.com)
We created an in vitro model of acquired cisplatin resistance by long term exposure of three well established germ cell tumor cell lines to cisplatin, resulting in sublines with significantly increased resistance to cisplatin. (biomedcentral.com)
The paternal cell lines are (1) the p53-wt (wild type) pluripotent gonadal germ cell tumor cell line NTERA-2, (2) the p53-mutated pluripotent extragonadal nonseminomatous germ cell tumor cell line NCCIT and (3) the p53-wt nullipotent embryonal cell carcinoma 2102EP, derived from a primary human testicular teratocarcinoma. (biomedcentral.com)
Our approach was designed to characterize the role of micro-RNAs on the presumably multifactorial phenomenon of acquired cisplatin resistance in germ cell tumors. (biomedcentral.com)
Spermatocytic tumor has an annual incidence of approximately 0.2 per 100 000, comprising no more than 2% of all testicular germ cell tumors (TGCTs), with no clear rise during recent decades. (medscape.com)
Patients with spermatocytic tumors are usually older than patients with other testicular germ cell tumors, with most cases presenting in the sixth decade. (medscape.com)
therefore, spermatocytic tumor should be considered in the differential diagnosis of testicular germ cell tumors presenting in young adults. (medscape.com)
[ 13 ] An immunohistochemical and molecular study supports that these tumors are likely to originate in a cell farther along the developmental pathway than those that give rise to other germ cell tumors. (medscape.com)

We observed low expression of DKK3 in gallbladder adenocarcinoma tumors and highly invasive GBC cell lines. (amrita.edu)
She injected the cells into mouse melanoma or adenocarcinoma tumors the animals carried on their flanks. (the-scientist.com)

We found that shRNA knockdown of intrinsic ST6GAL1 expression resulted in decreased ST6GAL1 cargo in the exosome-like vesicles as well as decreased breast tumor cell growth and invasive behavior in 3D in vitro cultures. (nature.com)
The mechanistic effects of selinexor in sarcomas as a monotherapy and in combination with proteasome inhibitor, carfilzomib, across a panel of cell lines in vitro and few in xenograft mouse models were investigated. (aacrjournals.org)
Both LCRF-0004 and BMS-777607 demonstrated significant anti-tumor efficacy in vitro , however BMS-777607 was far superior to LCRF-0004. (frontiersin.org)
They silenced KDM1 expression with siRNA or inhibited it with pargyline or NCL-1 and found that reducing its expression or inhibiting it pharmacologically reduced glioma cell line growth in vitro. (medindia.net)
In addition, inhibiting KDM1 pharmacologically reduced the growth of patient-derived primary glioblastoma multiforme cells in vitro and the growth of a human glioma cell line in mice. (medindia.net)
Human fibroblast monocultures were found to be insufficient to fully replicate in vivo fibrosis outcomes suggesting in vitro predictive potential depends upon more advanced cell culture in vitro models. (cdc.gov)

Tumor-native ST6GAL1 promotes tumor cell behaviors such as invasion and resistance to cell stress and chemo- and radio-treatments. (nature.com)

Translation factors are essential for cells to synthesize proteins, and their aberrant expression may result in pathological conditions including cancer. (cdc.gov)
Expression and effective removal of Cas9 and vector components are monitored using fluorescent reporter proteins. (aacrjournals.org)
Researchers have begun to home in on these proteins, looking for drugs that inhibit their actions in the cell. (genengnews.com)

Inactivating immune system checkpoints such as PD-1 and treating cells with 4SC-202 can inhibit tumor growth. (genengnews.com)

Cisplatin (cis-diamminedichloroplatinum II, CDDP) is a chemotherapeutic agent widely used in the treatment of several solid tumors, among them testicular cancer, lung cancer, breast cancer, and bladder cancer. (biomedcentral.com)
1991. Promotion of mouse lung tumors by bioaccumulated polychlorinated aromatic hydrocarbons. (cdc.gov)
The approval of KEYTRUDA as a first treatment instead of chemotherapy for patients who express high levels of PD-L1 has the potential to transform the way metastatic non-small cell lung cancer is treated," said Dr. Roy Baynes, senior vice president, head of clinical development, and chief medical officer, Merck Research Laboratories. (merck.com)
Single cell RNA sequencing identifies TGFbeta as a key regenerative cue following LPS-induced lung injury. (nationaljewish.org)
Am J Physiol Lung Cell Mol Physiol. (nationaljewish.org)
SPDEFending the Lung through Mucin Expression. (nationaljewish.org)
Preclinical studies also suggest INCB059872 could help combat small-cell lung cancer and Ewing Sarcoma, and clinical trials are currently underway to test the drug's efficacy in patients with sickle-cell disease, as well as its safety in patients with advanced malignancies. (genengnews.com)
There is a marked survival advantage for patients with nonsmall cell lung cancer (NSCLC) expressing high numbers of macrophages in their tumour islets. (ersjournals.com)
Macrophages infiltrating the tumour islets in nonsmall cell lung cancer were predominantly of the M1 phenotype in patients with extended survival. (ersjournals.com)
Nonsmall cell lung cancer (NSCLC) is the most common cause of cancer-related death worldwide. (ersjournals.com)
The FORESEE Study is a multi-center, prospective clinical trial enrolling patients with Breast or Non-Small Cell Lung Cancer (NSCLC) who have suspicious or confirmed Leptomeningeal Metastases (LM). (stanford.edu)
Lung cancer is generally divided into two types, small cell lung cancer and non-small cell lung cancer, based on the size of the affected cells when viewed under a microscope. (medlineplus.gov)
Non-small cell lung cancer accounts for 85 percent of lung cancer, while small cell lung cancer accounts for the remaining 15 percent. (medlineplus.gov)
Large cell carcinoma encompasses non-small cell lung cancers that do not appear to be adenocarcinomas or squamous cell carcinomas. (medlineplus.gov)
In nearly all cases of lung cancer, these genetic changes are acquired during a person's lifetime and are present only in certain cells in the lung. (medlineplus.gov)

Consequently, we aimed to assess miR-637 expression in gliomas to determine the effects of miR-637 on glioma cell migration and invasion, as well as to explore the possible signaling pathways involved. (scirp.org)
Gliomas are the most common primary brain tumours and originate from the glial cells of the brain. (nottingham.ac.uk)
They showed widespread LDLR expression in adult and paediatric cohorts, and, importantly, also categorized the intra-tumour variation observed between the core and either rim or invasive regions of adult High-Grade Gliomas. (nottingham.ac.uk)
Through immunohistochemical analysis, they found that KDM1 expression was elevated in gliomas. (medindia.net)

The M1 phenotype (classically activated) macrophages are thought to be induced by interferon-γ, with or without lipopolysaccharide and tumour necrosis factor (TNF)-α, and exert a cytotoxic effect against cancer cells. (ersjournals.com)

Aggressive breast cancer is a highly heterogeneous disease caused by a variety of distinct cell-intrinsic genetic alterations in mammary epithelial cells, leading to vastly heterogenic disease manifestation in individual patients and predominantly affecting patient prognosis and treatment options [ 14 ]. (nature.com)
Tumors contain oxygenated and hypoxic regions, so the tumor cell population is heterogeneous. (jci.org)
Due to the heterogeneous nature of tumors, molecular profiling is crucial to our understanding of how genomics plays a role in the cause or development of an individual cancer. (biomedcentral.com)
Future work will explore additional MM cell lines with heterogeneous LAT1 expression and response to melphalan therapy. (snmjournals.org)

We have also demonstrated that PDGF receptors on the human neuroblastoma cell lines were biologically functional. (jci.org)
The neuroblastoma cell lines also expressed the transcripts of PDGF A- and B-chains. (jci.org)
In addition, expression of IGF-II and HIF-2α correlates in neuroblastoma cell lines, tumors and in sympathetic neuroblasts during embryonic week 6.5, but not later, suggesting that these IGF-II and HIF-2α expressing neuroblastomas originate from sympathetic pre-ganglia at developmental week 6.5 or earlier. (lu.se)

In this chapter, we will focus on IL-21's biological effects and signaling pathways as well as discuss the potential implications and applications of IL-21 in leukemia cells. (intechopen.com)
Importantly, some of these differences in sensitivity were in concordance with high expression of the targets or activation of the corresponding pathways in primary tumor samples of the same subtype. (tudelft.nl)

Ex vivo drug screening refers to the out-of-body assessment of drug efficacy in patient derived vital tumor cells. (biomedcentral.com)
In addition, they find that making tumor cells produce a necroptosis-inducing enzyme is enough to kickstart the tumor-stunting process-a strategy the authors think could boost the efficacy of existing immunotherapies. (the-scientist.com)

Hypoxic tumor cells primarily use glucose for glycolytic energy production and release lactic acid, creating a lactate gradient that mirrors the oxygen gradient in the tumor. (jci.org)

Here, we generate dromedary camel nanobodies targeting B7-H3 and demonstrate that CAR-T cells, based on the nanobodies recognizing the IgC but not IgV domain, had potent antitumour activity against large tumors in female mice. (nature.com)
These cells form tumors in syngeneic models, upon subcutaneous and systemic (i.v.) injection, in immunocompetent mice. (genoway.com)
Humanized CD3 C57/Bl6 mice were injected (s.c.) with 1x10 6 EL4-hCD19-LZ cells. (genoway.com)
The reduction in tumor volume as well as pro-apoptotic and anti-proliferative effects in HT-29 nude mice xenograft are comparable to those produced by 5-FU. (spandidos-publications.com)
The inoculation of engineered tumor cell lines in immunocompetent mice results in either tumor rejection or an aberrant response to immunotherapy, making the experiments technically impossible in the first case or providing inconsistent results in the latter. (aacrjournals.org)

Conclusions and Clinical Relevance -Versican may be useful as a diagnostic marker for melanocytic tumors in dogs. (avma.org)

The use of radiation in T1 and T2 parotid gland tumors found that 5-year disease-free survival increased from 70% to 92% with postoperative radiation. (medscape.com)
The most common tumor of the parotid gland is the pleomorphic adenoma , which represents about 60% of all parotid neoplasms, as seen in the image below. (medscape.com)

Thus, increasing numbers of macrophages within the tumour islets conferred a marked survival advantage, while increased numbers of macrophages in the tumour stroma were associated with worse prognosis. (ersjournals.com)

Clinical signs and symptoms depend on the location of the tumor. (wikipedia.org)
Dr Ruman Rahman from the University of Nottingham's School of Medicine led the study and said: "Brain tumours can be very hard to treat with the current techniques available, this is because many of the drugs or nanoparticles that have been shown to work in cells, when used in tests of clinical treatments cannot penetrate the blood brain barrier that many tumours sit behind. (nottingham.ac.uk)
However, the lack of durable clinical responses due in part to the resistance mechanisms that tumors exhibit in a significant proportion of patients urges novel approaches to find the right therapeutic strategies. (aacrjournals.org)
His research has involved both translational research and clinical trials including the role of B cell depletion and mesenchymal stem cells in systemic lupus erythematosus. (rochester.edu)

Next, the effects of miR-637 on glioma cell migration and invasion were determined by using the transwell assay. (scirp.org)
In addition, miR-637 suppressed glioma cell migration and invasion. (scirp.org)
3) Tumour invasion and dissemination. (qub.ac.uk)
These findings suggest that formononetin inhibits angiogenesis and tumor cell invasion, and thus support its use in the treatment of advanced and metastatic colon cancers. (spandidos-publications.com)
The enhanced levels of MMP-7 and -9 mRNA expressions and increased cell invasion into matrigel were observed in colon cancer cells upon stimulation with TAM-conditioned medium. (lu.se)

Imatinib mesylate (IM), a potent inhibitor of the BCR/ABL tyrosine kinase, has become standard first-line therapy for patients with chronic myeloid leukemia (CML), but the frequency of resistance increases in advancing stages of disease. (lu.se)
We found that DKK3 expression levels were low in GBC patients and cell lines. (amrita.edu)
Multidrug resistance parameters, tissue infiltration parameters, receptors for colony-stimulating factors (CSFr) and cell cycle parameters were analyzed using flow cytometry in 145, 109 initial and 36 relapsed or refractory, acute nonlymphoblastic leukemia (ANLL) patients to find out clinically more reliable functional parameters. (karger.com)
Dr. Brody, Charles Yeo, M.D., Samuel D. Gross Professor and chair of Surgery at Jefferson Medical College and their co-workers analyzed IDO expression in 14 lymph nodes to which pancreatic cancer cells had spread and compared them to the primary tumors that had not spread in the same patients. (sciencedaily.com)
The researchers examined tissue microarrays from intra- and inter-tumour regions of 36 adult and 133 paediatric patients to confirm LDLR as a therapeutic target. (nottingham.ac.uk)
CNSide can detect and quantify tumor cells in the CSF from patients with Breast Cancer or NSCLC having a suspicious or confirmed LM. (stanford.edu)
We are studying components of blood, tumor tissue, normal tissue, and other fluids, such as urine, cerebrospinal fluid, abdominal or chest fluid in patients with cancer. (stanford.edu)
PATIENTS AND METHODS: Tumor samples from MONALEESA-2, -3, -7 underwent PAM50-based subtyping. (bvsalud.org)
RESULTS: Overall, 990 tumors (among 2066 patients) from ribociclib (n=580) and placebo (n=410) arms were profiled. (bvsalud.org)

There are also some emerging mouse models of the AT/RT cancer as well as experimental cell lines derived from tumors. (wikipedia.org)
Dublin, May 26, 2023 (GLOBE NEWSWIRE) -- The "Squamous-Cell Carcinoma of the Larynx in the United States, 2022-2042: Cancer Populations USA Report and Data Dashboard" report has been added to ResearchAndMarkets.com's offering. (globenewswire.com)
The findings might mean not only a better way to detect pancreatic cancer spreading to lymph nodes, but also could enhance tumor immune therapy strategies against the fast-moving, deadly disease. (sciencedaily.com)
According to Jonathan Brody, Ph.D., assistant professor of Surgery at Jefferson Medical College of Thomas Jefferson University, one way that metastatic cancer cells can survive in nearby lymph nodes is by avoiding the immune system. (sciencedaily.com)
The Jefferson scientists wanted to know if metastatic pancreatic cancer cells residing in the lymph nodes expressed IDO to avoid being found, and if so, could they target this enzyme with available drugs to prevent the cancer cells from hiding from the immune system. (sciencedaily.com)
These data point to the fact that IDO may play a role in helping cancer cells avoid the immune system. (sciencedaily.com)
The group also examined pancreatic cancer cell lines in the laboratory for IDO expression. (sciencedaily.com)
The immune system appears to have a balance that can allow cancer cells to grow but also can detect and destroy them, Brody explains. (sciencedaily.com)
An inhibitor might be able to activate T-cells to kill cancer cells, for example. (sciencedaily.com)
Note the plasma membrane expression of the lactate transporter in WiDr, FaDu, SiHa, and PC-3 cancer cells. (jci.org)
The key now is to use drug and prodrug nanoparticles to target these receptors and cut off the energy supply of the cancer cells. (nottingham.ac.uk)
David Needham, Professor of Translational Therapeutics in the School of Pharmacy at the University of Nottingham and Professor of Mechanical Engineering and Materials Science at Duke University has been working on developing new, more clinically-effective, formulations of a common metabolic inhibitor (niclosamide) that cuts off the energy of cells and could be modified as a treatment for a number of diseases - including cancer. (nottingham.ac.uk)
Professor Needham, who has been investigating this drug as a possible treatment for cancer for a number of years and has been driving research in this area and is co-author on this study, said: "We know that niclosamide works by turning down the dimmer switch on host cells in the body, like in the nose as a preventative for COVID19 and other infections. (nottingham.ac.uk)
Oral squamous cell carcinoma (OSCC) is the third most common cancer in developing countries and ranks sixth among systemic cancers worldwide [ 1 , 2 ]. (hindawi.com)
Our previous findings demonstrated that formononetin initiates growth-inhibitory and pro-apoptotic activities in human colon cancer cells. (spandidos-publications.com)
In the present study, we aimed to further examine the potential of formononetin in controlling angiogenesis and tumor cell invasiveness in human colon cancer cells and tumor xenografts. (spandidos-publications.com)
We also discovered that the invasiveness of metastatic colon cancer cells was alleviated following drug treatment. (spandidos-publications.com)
In recent years, we focused on investigating the anti-carcinogenic properties of total Astragalus saponins (AST) in human colon cancer cells and tumor xenografts. (spandidos-publications.com)
Subsequent study using multiple human cancer cell lines, including those of the colon, stomach and liver, further indicated the universal growth-inhibitory and pro-apoptotic effects of AST. (spandidos-publications.com)
However, in vivo genetic screens require stable expression of several components that in most cases are not derived from murine cells, which represents a major obstacle in the context of cancer immunology. (aacrjournals.org)
Together, the one-two punch could spur the body's own immune system to attack cancer cells. (genengnews.com)
Together, the drugs appear to prevent cancer cells from evading detection. (genengnews.com)
Introducing either necroptotic cells or an enzyme that triggers necroptosis can wipe out cancer. (the-scientist.com)
In recent years, biologists have begun to investigate whether activating necroptosis in cancer cells could similarly coax the immune system into attacking tumors. (the-scientist.com)
That necroptotic cancer cells produce an immune response was already known-as his lab and others have shown -but the mechanisms involved were largely unexplored, he says. (the-scientist.com)
To determine how CD117 expression and activation by its ligand stem cell factor (SCF, kit ligand, steel factor) alter prostate cancer aggressiveness, we used LNCaP-C4-2 and PC3-mm human prostate cancer cells, which contain a CD117+ subpopulation. (biorxiv.org)
We demonstrate that CD117 expression and activation drives prostate cancer aggressiveness through the CSC phenotype and TKI resistance. (biorxiv.org)
Multiple myeloma (MM) is a cancer of terminally differentiated plasma B cells that originates in the hematopoietic bone marrow and accounts for 15%-20% of all hematologic malignancies ( 1 , 2 ). (snmjournals.org)
Multifunctional magnetic iron-oxide nanoparticles (IONPs) can be directly imaged by magnetic resonance imaging (MRI) and designed to therapeutically target cancer cells. (oncotarget.com)
Critical to sub-classify SRBCTs, Khan et al .6 used to measure genome-wide gene expres- .com decisions in cancer therapeutics are to microarrays to monitor the expression sion for a variety of biological samples. (lu.se)
The aim of this study was to examine whether Annexin A2 and S100A10 expression can be used as prognostic markers for epithelial ovarian cancer (EOC). (cancerindex.org)
M2 macrophages derived from human monocyte cell line THP-1 secreted high levels of IL-8 and leukotriene D4 (LTD4), which induced colon cancer cell migration, and Th2 cytokines (IL-4, IL-10) to maintain a tumoral immunosuppressive environment. (lu.se)
CD47, as a key regulator of crosstalk between colon cancer cells and TAMs, could thus be a therapeutic target for CRC. (lu.se)
Neuroblastoma is a childhood tumor of the developing sympathetic nervous system (SNS) and is the most commonly diagnosed form of cancer in children before one year of age. (lu.se)
Mattias Höglund and his staff have drawn up a classification system for bladder cancer based on information on genetic mutations and changes in gene expression in both the genome and the epigenome. (lu.se)

It is also known that TEF1A2 is oncogenic and its overexpression can result in cell transformation and tumorigenesis. (cdc.gov)

ELF5 methylation was lower in second versus primary tumors in women who received anti-estrogen treatment, in PR-negative versus PR-positive tumors, and in the subset of PR-positive first tumors from the group of women who had second PR-negative tumors as compared to those who had second PR-positive tumors. (umass.edu)
Tumors include Ewing sarcoma (EWS), neu- while Ewing sarcomas are aggres- roblastoma (NB), rhabdomyosarcoma (RMS) and Burkitt lym- rently used in tumor diagnosis do sive enough to warrant treatment phomas (BL, subset of non-Hodgkin lymphoma). (lu.se)
Mantle cell lymphoma (MCL) is a lymphoproliferative disorder derived from a subset of naive pregerminal center cells localized in primary follicles or in the mantle region of secondary follicles. (medscape.com)
In a subset of peri-vascularly located immature neural crest-like neuroblastoma cells, aggressiveness and growth promoting charasteristics have been reported to be instigated by HIF-2α, a key element of the oxygen-sensing machinery. (lu.se)

Renal cell carcinoma (RCC) is one of the ten most common cancers for men and women with an approximate 75% overall 5-year survival. (frontiersin.org)
Additionally, elevated expression levels of MST1 also correlated with better survival. (frontiersin.org)
Here, we showed that XAF1 low expression correlates with poor survival and disease status. (nus.edu.sg)

Additionally, M2 macrophages have been traditionally thought of as being the predominant macrophage phenotype in solid tumours (tumour-associated macrophages). (ersjournals.com)
Two tumours that look the same in terms of gene expression can nonetheless develop differently. (lu.se)

Around 17% of all pediatric cancers involve the CNS, making these cancers the most common childhood solid tumor. (wikipedia.org)

A continuous monitoring of the whole tumor burden of individuals in orthotopic tumor models is a desirable aim and requires non-invasive imaging methods. (nih.gov)
Highly invasive GBM cells are known to infiltrate the surrounding normal brain, making complete resection impossible [ 3 , 4 ]. (oncotarget.com)

Furthermore, IL-21 promotes differential expression of many cytokines including interleukins and chemokines. (intechopen.com)
His lab's previous research has shown that the RIPK3 enzyme can drive cells to generate inflammatory chemokines and cytokines during cell death, which can stimulate T killer cells. (the-scientist.com)
For instance, when the researchers treated the necroptotic cells to curtail the production of those cytokines, and then injected them into tumors, they didn't see the slowdown in growth they had observed in earlier experiments. (the-scientist.com)

The expression of both markers correlated to histological subtype, histological grading, International Federation of Gynecology and Obstetrics (FIGO) stage, and macro-radical surgery. (cancerindex.org)

Regulation of MUC5B Expression in Idiopathic Pulmonary Fibrosis. (nationaljewish.org)
moreover, normal cell regulation can be disrupted by tumor-suppressive or oncogenic miRNAs. (scirp.org)
ELF5 and DOK7 regulation in anti-estrogen treated cells and tumors. (umass.edu)

These tumour-associated macrophages (TAMs) were of the M2 phenotype (CD206+). (lu.se)

In this report on squamous-cell carcinoma of the larynx (SCC-L), forecast estimates are provided of incident cases by stage, age and gender, race-ethnicity, anatomical subsite, and PD-1/PD-L1 status. (globenewswire.com)
We identified monocarboxylate transporter 1 (MCT1) as the prominent path for lactate uptake by a human cervix squamous carcinoma cell line that preferentially utilized lactate for oxidative metabolism. (jci.org)
Here, we report a novel molecular target and antimetastatic mechanism of ATO in head and neck squamous cell carcinoma (HNSCC). (nih.gov)
However, there is limited information on the function of circRNA in oral squamous cell carcinoma (OSCC). (hindawi.com)
Oral squamous cell carcinoma (OSCC) is a common tumor in the world. (degruyter.com)
Excretory stem cells give rise to squamous cell and mucoepidermoid carcinomas, while intercalated stem cells give rise to pleomorphic adenomas, oncocytomas, adenoid cystic carcinomas, adenocarcinomas, and acinic cell carcinomas. (medscape.com)
Squamous cell carcinomas arise from excretory duct cells, pleomorphic adenomas arise from the intercalated duct cells, oncocytomas arise from the striated duct cells, and acinic cell carcinomas arise from acinar cells. (medscape.com)

Collectively, these results indicated that: 1) TEFA12 is significantly overexpressed in human tumor cell lines and tumor tissue samples, 2) the cellular expression level of TEF1A2 may be used as a tumor marker, and 3) the anti-apoptotic role of TEF1A2 may potentially be responsible for its oncogenic function. (cdc.gov)
Expression of DOK7 and ELF5 is significantly up-regulated in half of the tamoxifen-selected cell lines as compared to the parental MCF-7. (umass.edu)
Hsa_circ_001242 expression levels were significantly downregulated in four OSCC cell lines (SCC-9, SCC-15, SCC25, and CAL-27) than in human normal oral keratinocyte (HOK) cell lines. (hindawi.com)
Previous research showed that scavenger receptor class A member 5 (SCARA5) was one of the potential biomarkers of OSCC, and its expression is significantly low in OSCC. (degruyter.com)

This effect can be further enhanced in relatively selinexor-resistant sarcoma cell lines by pretreatment with the proteasome inhibitor carfilzomib. (aacrjournals.org)
Subsequently, the effect of an additional small molecular inhibitor, BMS-777607 (which targets MST1R (RON), MET, Tyro3, and Axl) also resulted in a decreased proliferative capacity of MPM cells. (frontiersin.org)

We have shown here that IM induces autophagy in CML blast crisis cell lines, CML primary cells, and p210BCR/ABL-expressing myeloid precursor cells. (lu.se)
The primary tumor site is limited to the testis and, unlike classic seminoma, spermatocytic tumors have never been reported as primary at extragonadal sites. (medscape.com)
If cells are escaping the primary tumor and going into another environment such as the lymph nodes, what are they doing to evade detection by the immune system? (sciencedaily.com)
MCT1 is expressed in a variety of different human tumor cell lines and primary human tumor biopsies. (jci.org)
Sample Population -35 biopsy specimens from melanocytic tumors of dogs, canine primary dermal fibroblasts, and 3 canine melanoma cell lines. (avma.org)
The relationship between hormone receptor status and promoter methylation of DOK7 and ELF5 was further examined using available methylation array data (Illumina HM450) from a set of paired primary and second breast tumors from 24 women. (umass.edu)

Canine fibroblasts and melanoma cell lines expressed hyaluronan synthase 2 and 3 (but not 1) and hyaluronidase 1 and 2. (avma.org)

Using antibodies to IDO, they didn't find any IDO expression until they treated the cells with interferon to mimic the conditions in the lymph nodes. (sciencedaily.com)
Doses as high as of 60 Gy (1 Gy=100 rad) were needed in stage 3 or 4 tumors that have invaded bone, nerves, or lymph nodes. (medscape.com)

Recent trends suggest that the rate of overall CNS tumor diagnosis is increasing by about 2.7% per year. (wikipedia.org)
Most spermatocytic tumors present with painless testicular enlargement, which can be referred to several years before the diagnosis. (medscape.com)
Although researchers have learned much from the study of this diverse group of tumors over the years, the diagnosis and treatment of salivary gland neoplasms remain complex and challenging problems for the head and neck surgeon. (medscape.com)

Mostafa MM, Bansal A, Michi AN, Sasse SK, Proud D, Gerber AN , Newton R. Genomic determinants implicated in the glucocorticoid-mediated induction of KLF9 in pulmonary epithelial cells. (nationaljewish.org)
CD47 binding to α2β1 integrin could regulate cyclooxygenase-2 expression and cell migration on collagen I surface in intestinal epithelial cells. (lu.se)
Large cell carcinoma arises from epithelial cells that line the lungs. (medlineplus.gov)

We utilized a quantitative RT-PCR (RTQ-PCR) based platform for detection of almost all currently known (738) human micro-RNA species on these 6 cell lines. (biomedcentral.com)
The sialyltransferase ST6GAL1 that adds α2-6 linked sialic acids to N-glycans of cell surface and secreted glycoproteins is prominently associated with many human cancers. (nature.com)
Specifically, ERV-K members were originally identified due to their similarity to the Mouse Mammary Tumor Virus (MMTV) and are subdivided into ten so-called human MMTV-like clades (HML1-10) ( 2 , 3 ). (frontiersin.org)
1999. Transactivation activity of human, zebrafish, and rainbow trout aryl hydrocarbon receptors expressed in COS-7 cells: Greater insight into species differences in toxic potency of polychlorinated dibenzo- p -dioxin, dibenzofuran, and biphenyl congeners. (cdc.gov)
The first-in-human testing of scFv-based B7-H3 CAR-T cells has shown antitumor response against anaplastic meningioma and childhood diffuse intrinsic pontine glioma without severe side effects 16 , 17 . (nature.com)
We generated an EL4-hCD19-LZ clonal cell line expressing high levels of human CD19 (NCBI GeneID: 930), and an optimized dual fusion reporter luciferase-ZsGreen (LZ). (genoway.com)
Human CD19 expression was assessed in EL4 parental cell line (left), human control cells - PBMC (center), and EL4-hCD19-LZ cell line (right). (genoway.com)
Corynebacterium tuberculostearicum, a human skin colonizer, induces the canonical nuclear factor-kappaB inflammatory signaling pathway in human skin cells. (nationaljewish.org)
Human glioma cell lines, U373 and U251 cells, were purchased from the China Academia Sinica Cell Repository (Shanghai, China) and cultured in Dulbecco's Modified Eagle Medium (Gibco) that contained 10% fetal bovine serum (Gibco). (scirp.org)
Interleukin-21 (IL-21) was first identified in 2000 through screening of a cDNA library from CD3+ human T cells [ 1 ]. (intechopen.com)
In this study, we found that the SCARA5 expression was lower in CAL-27 and SCC-9 cells than that in human normal oral epithelial keratinocytes. (degruyter.com)
By integrating gene expression data from an unprecedented variety of human tissue samples, Alvis Brazma and his team at the European Bioinformatics Institute, an outstation of the European Molecular Biology Laboratory (EMBL), and their collaborators have for the first time produced a global map of gene expression. (embl.org)
Renal cell carcinoma (RCC) accounts for approximately 3% of human malignancies, and its incidence appears to be increasing globally [ 1 ]. (hindawi.com)
Human neuroblastoma cells express alpha and beta platelet-derived growth factor receptors coupling with neurotrophic and chemotactic signaling. (jci.org)
The expression of alpha and/or beta PDGF receptors was detected in a wide variety of neural crest-derived human tumor cell lines such as neuroblastoma, primitive neuroectodermal tumor, and Ewing's sarcoma by RNA blot analysis, and confirmed by immunoblot analysis. (jci.org)
Recognition of the human vulvar tumor line A431. (who.int)

For example, analysis of the continents showed that cell lines are usually more similar to each other than to their tissue of origin. (embl.org)
Immunohistochemistry was performed on representative tissue from all groups for LAT1 and glucose transporter 1 (GLUT1) expression. (snmjournals.org)
Altogether there are four main datasets, namely 409 "SLCs" in 59 tissue types and 56 cell lines, and 48 ABCs in the same tissue types and cell lines. (biorxiv.org)
Expression of Annexin A2 and S100A10 was evaluated in EOC tissue samples (n=303) by immunohistochemistry. (cancerindex.org)
He used it to mean the unexplained process of development from fertilised egg to fully grown individual, or the mystery of how the same DNA can lead to different gene expression, tissue and organs. (lu.se)

Here we investigated whether quantification of a xenograft tumor intrinsic fluorescence signal can be used to evaluate tumor growth and response to chemotherapy. (nih.gov)

Anatomy23

Organisms12

Diseases68

Chemicals and Drugs55

Analytical, Diagnostic and Therapeutic Techniques and Equipment45

Phenomena and Processes58

Disciplines and Occupations1

Information Science4

Health Care4

Suppressor12

Apoptosis22

Microenvironment5

Genes16

Proliferation16

Brain tumors6

Tissues24

Malignant9

Progression12

Childhood tumor of the sympathetic nervou1

Colorectal4

Subtypes17

Salivary gland tumors3

Antigen7

Whose tumors express2

Protein22

Inhibition4

Antigens4

Metastasis5

Abnormal3

Recurrence2

Pathology1

Therapies6

Differentiation5

Germ10

Adenocarcinoma tumors2

Vitro6

Promotes tumor cell1

Proteins3

Inhibit tumor growth1

Lung15

Gliomas4

Necrosis factor1

Heterogeneous4

Neuroblastoma cell lines3

Pathways2

Efficacy2

Hypoxic tumor1

Mice5

Conclusions1

Parotid gland2

Prognosis1

Clinical4

Invasion5

Patients9

Cancer35

Overexpression1

Subset4

Survival3

Tumours2

Solid tumor1

Invasive2

Cytokines3

Markers1

Regulation3

Phenotype1

Squamous7

Significantly4

Inhibitor2

Primary6

Melanoma1

Lymph nodes2

Diagnosis3

Epithelial cells3

Human16

Tissue5

Xenograft tumor1