• A few studies have reported that SOX2 is overexpressed in cervical squamous cell carcinoma (SCC), and plays an important role in the progression from squamous dysplasia to SCC. (biomedcentral.com)
  • Until now, squamous cell carcinoma (SQC) and adenocarcinoma (ADC) markers have not been thoroughly analyzed for pulmonary neuroendocrine carcinomas (NECs). (elsevierpure.com)
  • They established which miRNAs were differentially expressed regardless of cancer subtype, as well as signatures for both adenocarcinoma and squamous cell carcinoma specifically, after finding that the miRNAs strongly differed between those two groups. (genomeweb.com)
  • The researchers also identified a 27-miRNA predictive signature from only the adenocarcinoma samples, and a 17-miRNA signature from only those with squamous cell carcinoma. (genomeweb.com)
  • In a whole-genome sequencing in 17 Esophageal Squamous Cell Carcinoma cases and whole-exome sequencing in 71 cases, Song (2014), reported ASH1L alterations. (cancerindex.org)
  • Other types include squamous cell carcinoma (see the image below) and adenocarcinomas. (medscape.com)
  • Cross-section through the bladder, uterus, and vagina with squamous cell carcinoma of the bladder infiltrating through the bladder wall into the vaginal wall. (medscape.com)
  • Human Papillomavirus and Risk of Head and Neck Squamous Cell Carcinoma in Iran. (who.int)
  • however, CD200 expression has not been well-characterized in neuroendocrine neoplasms. (parallelpublicworks.com)
  • We examined CD200 expression in 391 neuroendocrine neoplasms from various anatomic sites. (parallelpublicworks.com)
  • Results: CD200 was expressed in 87% of the neuroendocrine neoplasms studied, including 60 of 72 (83%) pulmonary small cell carcinomas, 15 of 22 (68%) pulmonary carcinoids, three of four (75%) pulmonary large cell neuroendocrine carcinomas, 125 of 146 (86%) Merkel cell carcinomas, 79 of 83 (95%) gastrointestinal luminal carcinoids, and 56 of 60 (93%) pancreatic neuroendocrine tumors. (parallelpublicworks.com)
  • In gastrointestinal carcinoid and pancreatic neuroendocrine neoplasms, CD200 negativity correlated with higher grade. (parallelpublicworks.com)
  • Conclusions: CD200 is a relatively sensitive marker of neuroendocrine neoplasms and represents a potential therapeutic target in these difficult-to-treat malignancies. (parallelpublicworks.com)
  • CONTEXT: Gastric neuroendocrine tumors are rare neoplasms that originate from gastric enterochromaffin-like (ECL) cells in the oxyntic mucosa. (tum.de)
  • Colonic neuroendocrine neoplasms (NENs) are relatively rare tumors with an incidence rate of 0.11-0.21/100,000. (biomedcentral.com)
  • Neuroendocrine neoplasms (NENs) are rare tumors originating from neuroendocrine cells and include a series of heterogeneous tumors. (biomedcentral.com)
  • 18 With the exception of the ovarian neoplasms, the same carcinomas analyzed for gene expression were also examined for HE4 by immunohistochemistry on tissue microarrays (see below). (nature.com)
  • Gastroenteropancreatic High-Grade Neuroendocrine Neoplasms: Histology and Molecular Analysis, Two Sides of the Same Coin. (cdc.gov)
  • Pulmonary carcinoids are well differentiated low to intermediate grade lung neuroendocrine tumours (LNETs), that belong to the group of lung neuroendocrine neoplasms which also include highly aggressive lung neuroendocrine carcinomas (LNECs). (who.int)
  • These data have been combined with previously published LNET data to perform integrative analysis using multi-omics factor analysis (MOFA), resulting in a molecular map of lung neuroendocrine neoplasms for exploration. (who.int)
  • With the advent of improved immunohistochemical profiling, the tumor was reclassified as Merkel cell carcinoma because shared epithelial and neuroendocrine markers, along with ultrastructural features suggestive of neural crest origin, were observed in both the constituent tumor cell and the physiologic Merkel cell of the skin. (medscape.com)
  • [ 5 , 6 ] Furthermore, experiments have demonstrated that epidermal progenitors in the touch domes are capable of producing Merkel cell lines and that epithelial progenitor populations in adults have the capacity to give rise to both neuroendocrine and squamous lineages. (medscape.com)
  • SCLC is a neuroendocrine tumor derived from bronchial mucosal epithelial argentophilic cells. (hindawi.com)
  • Mutations in the epithelial cadherin (E-cadherin) gene have been shown to be associated with the occurrence of diffuse gastric carcinomas in affected families. (tum.de)
  • Jung Wook Park et al, Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage, Science (2018). (medicalxpress.com)
  • By definition, pseudomesotheliomatous carcinoma refers to an epithelial neoplasm that secondarily involves the pleura and encases the lung, thereby simulating the radiologic and macroscopic appearance of malignant mesothelioma. (medscape.com)
  • Methods: Tissue blocks containing pulmonary small cell carcinoma, pulmonary carcinoid, large cell neuroendocrine carcinoma, pancreatic neuroendocrine tumor, gastrointestinal carcinoid, and Merkel cell carcinoma were evaluated for CD200 expression by immunohistochemistry. (parallelpublicworks.com)
  • The authoritative source on Merkel cell carcinoma. (parallelpublicworks.com)
  • Merkel cell carcinoma is a rare primary cutaneous neuroendocrine carcinoma with growing incidence and high metastatic potential. (medscape.com)
  • [ 2 ] As neuroendocrine carcinomas were thought to be of neural crest origin, in 1978 Tang and Toker proposed that this carcinoma might be derived from Merkel cells. (medscape.com)
  • Merkel cells were thought to be of neural crest origin because they are excitable cells that secrete neuropeptides and stain positively for neuroendocrine markers. (medscape.com)
  • [ 6 ] As they are primarily postmitotic, Merkel cells putatively have low sensitivity to oncogenic stimuli, and they are found in the basal epidermis, whereas cutaneous neuroendocrine carcinomas arise in the dermis. (medscape.com)
  • Ultimately, it is unclear whether the eponymous Merkel cell is truly a histiogenic precursor of Merkel cell carcinoma. (medscape.com)
  • [ 7 , 8 ] Sunshine et al offer that perhaps there are multiple cell-line precursors of Merkel cell carcinoma. (medscape.com)
  • [ 9 ] Since our understanding of the histogenesis is still evolving, some authors choose to refer to Merkel cell carcinoma as neuroendocrine carcinoma of the skin or cutaneous neuroendocrine carcinoma. (medscape.com)
  • Also see Merkel Cell Tumors of the Head and Neck and Merkel Cell Carcinoma and Rare Appendageal Tumors . (medscape.com)
  • Even as the nature of the exact cell in which Merkel cell carcinoma oncogenesis occurs is controversial, there is strong support for the notion that Merkel cell carcinoma results from of one of two distinct pathways. (medscape.com)
  • Feng et al established in 2008 that approximately 80% of Merkel cell carcinomas in the Northern hemisphere occur after genomic integration by a ubiquitous skin commensal virus, Merkel cell polyoma virus (MCPyV). (medscape.com)
  • In 2017, avelumab became the first drug approved by the FDA for metastatic Merkel cell carcinoma in adults and children aged 12 years or older. (medscape.com)
  • [ 20 ] In 2018, another PD-1 inhibitor, pembrolizumab, was approved for adults and children with metastatic or recurrent, locally advanced Merkel cell carcinoma. (medscape.com)
  • Indicated for adults and children with metastatic or recurrent, locally advanced Merkel cell carcinoma. (medscape.com)
  • Merkel Cell Carcinoma of the Head and Neck: Recommendations for Diagnostics and Treatment. (medscape.com)
  • Effect of radiation therapy on survival in patients with resected Merkel cell carcinoma: a propensity score surveillance, epidemiology, and end results database analysis. (medscape.com)
  • Diagnosis and treatment of Merkel cell carcinoma. (medscape.com)
  • Available at https://www.mayoclinic.org/diseases-conditions/merkel-cell-carcinoma/symptoms-causes/syc-20351030 . (medscape.com)
  • Merkel cell carcinoma: prevention. (medscape.com)
  • Available at https://my.clevelandclinic.org/health/diseases/17971-merkel-cell-carcinoma/prevention . (medscape.com)
  • Merkel cell carcinoma: changing incidence trends. (medscape.com)
  • Uitentuis SE, Louwman MWJ, van Akkooi ACJ, Bekkenk M. Treatment and survival of Merkel cell carcinoma since 1993: a population-based cohort study in the Netherlands. (medscape.com)
  • Clonal integration of a polyomavirus in human Merkel cell carcinoma. (medscape.com)
  • Merkel cell polyomavirus expression in merkel cell carcinomas and its absence in combined tumors and pulmonary neuroendocrine carcinomas. (medscape.com)
  • MicroRNA Expression Patterns Related to Merkel Cell Polyomavirus Infection in Human Merkel Cell Carcinoma. (medscape.com)
  • Kwun HJ, Shuda M, Feng H, Camacho CJ, Moore PS, Chang Y. Merkel cell polyomavirus small T antigen controls viral replication and oncoprotein expression by targeting the cellular ubiquitin ligase SCFFbw7. (medscape.com)
  • Faust H, Andersson K, Ekström J, Hortlund M, Robsahm TE, Dillner J. Prospective study of Merkel cell polyomavirus and risk of Merkel cell carcinoma. (medscape.com)
  • Merkel cell carcinoma: two case reports focusing on the role of fluorodeoxyglucose positron emission tomography imaging in staging and surveillance. (medscape.com)
  • For MCPyV, which is present in ≈80% of rare but aggressive cutaneous Merkel cell carcinomas (MCCs) ( 17 , 25 - 27 ), seroprevalence among healthy persons was shown to be 42%-77% ( 20 , 21 , 28 , 29 ). (cdc.gov)
  • These posters to be presented at the AACR Meeting focus on the investigational nucleic acid platform, UNITE™ (UNiversal Intracellular Targeted Expression) for two vaccines, ITI-3000 for Merkel cell carcinoma (targeting the large T antigen of the Merkel cell polyomavirus) and Her2/Neu-LAMP DNA vaccine, both of which fuse a tumor associated antigen with lysosomal associated membrane protein 1 (LAMP-1). (biospace.com)
  • This presentation reports results of pre-clinical mouse studies of a cancer vaccine that promotes potent, antigen-specific CD4 T cell responses to MCPγV-LT. The majority of Merkel cell carcinomas (MCC), a rare and highly aggressive type of neuroendocrine skin cancer, are associated with Merkel cell polyomavirus (MCPyV) infection. (biospace.com)
  • Background Merkel cell carcinoma (MCC) is associated with high recurrence rates and poor survival when metastatic disease is present. (bmj.com)
  • Merkel cell carcinoma (MCC) is a rare and potentially aggressive neuroendocrine carcinoma of the skin with an incidence of around 0.5-0.8/100 000. (bmj.com)
  • Merkel cell carcinoma (MCC) is a rare neuroendocrine tumor that is highly aggressive in nature and indolent in progression. (e-jyms.org)
  • Moreover, Merkel cell polyomavirus has recently been characterized to be significantly associated with pathogenesis of MCC, including the expression of Cytokeratin 20 (CK20). (e-jyms.org)
  • Biopsy and IHC studies revealed findings consistent with Merkel Cell Carcinoma of neuroendocrine origin. (e-jyms.org)
  • Nasopharyngeal carcinoma (NPC) is a rare disease among Caucasians but one of the most prevalent malignant tumors and is the leading cause of death among all head and neck cancers in Southern China and Southeast Asia [ 6 , 7 ]. (hindawi.com)
  • The key finding: Prostate and lung cells have very different patterns of gene expression when they're healthy, but almost identical patterns when they transform into small cell cancers. (medicalxpress.com)
  • Cancers that become resistant to treatment often develop into small cell cancers-also known as small cell neuroendocrine carcinomas, or SCNCs-which generally have extremely poor prognoses. (medicalxpress.com)
  • Certain cancers can evade treatment in part by changing cell types-from aggressive adenocarcinoma to small cell carcinoma, for example. (medicalxpress.com)
  • The team also looked at large databases of gene expression, to compare the patterns of gene expression in their PARCB-SCNC cells to cancers of other organs. (medicalxpress.com)
  • They found that the pattern of gene expression in PARCB-SCNC cells was extremely similar to those of both prostate and lung small cell cancers. (medicalxpress.com)
  • This review describes current knowledge about the expression of distinct ORs in cancers, as well as the canonical and non-canonical signaling pathways induced by these ORs. (bmbreports.org)
  • In addition, OR expression pattern in various cancers were analyzed based on RNA-sequencing data reported in the Cancer Genome Atlas (TCGA), and the associations between patient survival outcomes and OR levels were analyzed to determine the clinical relevance and significances of OR expression in tumors. (bmbreports.org)
  • Primary gastric small cell carcinoma (GSCC) is a rare and the most poorly differentiated neuroendocrine tumor, accounting for less than 0.1% of all gastric cancers and 15% of all gastric neuroendocrine tumors [ 1 ]. (e-ce.org)
  • Biliary tree cholangiocarcinoma and pancreatic ductal carcinoma are highly aggressive cancers - both which are commonly diagnosed via endoscopic bile duct brushings. (swimacrossamerica.org)
  • RhoC over-expression has been reported in ductal pancreatic adenosarcoma (Suwa, 1998) and in inflammatory breast cancers (van Golen, 1999). (cancerindex.org)
  • Sclerotic cell carcinoma accounts for about 30% of all lung cancers, and about 9% are "large-cell carcinoma. (ccij-online.org)
  • Small cell carcinoma of the prostate is rare, accounting for less than 1% of all prostate cancers. (medscape.com)
  • Although pulmonary carcinoids show relatively good prognosis in comparison to carcinomas, metastatic disease and relapse do occur. (who.int)
  • We found that RhoA was expressed highly in large cell carcinoma cells but only weakly in adenocarcinoma cells. (nih.gov)
  • [ 2 ] Another 25-40% of cases are initially diagnosed as prostatic adenocarcinoma and recur as small cell carcinoma after hormonal therapy. (medscape.com)
  • The median interval between initial diagnosis of prostatic adenocarcinoma and recurrence of small cell carcinoma is 25 months. (medscape.com)
  • Unlike prostatic adenocarcinoma, small cell carcinoma of the prostate may present with metastases in up to 25% of patients. (medscape.com)
  • The distribution of prostatic small cell carcinoma is similar to that of prostatic adenocarcinoma. (medscape.com)
  • The risk factors for prostatic small cell carcinoma are related to those for prostatic adenocarcinoma and include age, race, and family history. (medscape.com)
  • this finding is not surprising, since many patients actually have prostatic adenocarcinoma with a component of small cell carcinoma. (medscape.com)
  • [ 3 , 4 ] The term "pseudomesotheliomatous carcinoma" was first applied by Harwood and colleagues in 1976 to 6 cases of peripheral lung adenocarcinoma that closely mimicked mesothelioma. (medscape.com)
  • High Cancer Susceptibility Candidate 8 Expression Is Associated With Poor Prognosis of Pancreatic Adenocarcinoma: Validated Analysis Based on Four Cancer Databases. (cdc.gov)
  • 2 Diagnosis of small cell (neuroendocrine) or mucinous adenocarcinoma of cervical cancer (ie, mucinous NOS, intestinal type, signet ring cell type, invasive stratified mucin producing carcinoma and gastric type) based on 2020 WHO classification of cervical cancer. (who.int)
  • According to the pathological type, it can be divided into non-small-cell lung carcinoma and small-cell lung carcinoma (SCLC) [ 2 ]. (hindawi.com)
  • Among all types of lung carcinoma, SCLC accounts for about 15%, and has the characteristics of high malignancy, short doubling time, extensive early metastasis, sensitivity to radiotherapy and chemotherapy, and easy recurrence and metastasis. (hindawi.com)
  • The tie-in between the level and the prognosis is to determine whether the blood lipid level during the initial treatment of small cell lung carcinoma affects the prognosis and to provide a theoretical basis for the clinical treatment of SCLC patients. (hindawi.com)
  • Background: Neuroendocrine tumors of the lung comprise typical (TC) and atypical carcinoids (AC), large-cell neuroendocrine cancer (LCNEC) and small-cell lung cancer (SCLC). (oncotarget.com)
  • Materials and Methods: Sixty representative FFPE-specimens (16 TC, 13 AC, 16 LCNEC and 15 SCLC) were used for mRNA expression analysis using the NanoString technique. (oncotarget.com)
  • Between SCLC and LCNEC CDK2 , CDKN1B , CDKN2A and PNN expression was significantly different with higher expression in SCLC. (oncotarget.com)
  • BCL2 expression increased over BAX expression with increasing malignancy of the tumor from TC to SCLC. (oncotarget.com)
  • In this Perspectives article, we review and synthesize these recent lines of evidence and propose a working nomenclature for SCLC subtypes defined by relative expression of these four factors. (cancerindex.org)
  • Background Extensive Stage Small Cell Lung Cancer (ES-SCLC) and Large Cell Neuroendocrine of the lung (LCNEC) are aggressive neuroendocrine carcinomas with an exceptionally poor prognosis. (bmj.com)
  • The patient population is adult subjects with histologically/cytologically confirmed unresectable small cell lung carcinoma (SCLC), large cell neuroendocrine lung carcinoma (LCNEC), combined SCLC, or combined LCNEC as per WHO 2021 criteria. (bmj.com)
  • We found that four of six small cell lung carcinoma (SCLC) cell lines exhibited a moderate to high activation rate of RhoA. (nih.gov)
  • Our results suggest that RhoA is activated in various lung cancer cells independent of its expression levels, and the high activation state of RhoA in SCLC cells mainly depends on a neuroendocrine peptide autocrine system which signals through Galpha12 coupled GPCR to RhoA. (nih.gov)
  • Distinct Clinical Characteristics in Young-Onset Pancreatic Neuroendocrine Tumor. (cdc.gov)
  • The first pancreatic neuroendocrine tumor in Li-Fraumeni syndrome: a case report. (cdc.gov)
  • We have seen in consultation a number of malignant melanomas with anomalous expression of keratin, other intermediate filaments, or synaptophysin, and therefore studied a large group of primary and metastatic melanomas to determine the frequency of these events. (elsevierpure.com)
  • Alternatively, univariate analysis revealed that SOX2 and HR-HPV RISH expression, either separately or in combination, predicted the poor prognosis of SCNEC patients. (biomedcentral.com)
  • Researchers from the Medical College of Wisconsin, the Mayo Clinic, and Washington University in St. Louis have identified two microRNA expression signatures predictive of prognosis in patients with stage I non-small cell lung cancer. (genomeweb.com)
  • With several recent studies correlating miRNA expression with outcome in lung cancer, the investigators set out to try to identify miRNA signatures that could accurately predict prognosis in what they claim is the largest study of its kind to date. (genomeweb.com)
  • However, the role and the pathways of lipid metabolism in the occurrence and development of lung carcinoma have not been fully studied, and the role of blood lipids in the prognosis of lung carcinoma is still unclear [ 5 ]. (hindawi.com)
  • OBJECTIVES: Optimal management of type 1 gastric neuroendocrine tumors (T1-GNETs) remains unknown, with few reports on their long-term prognosis. (bvsalud.org)
  • Xu F , Guan Y , Ma Y , Xue L , Zhang P , Yang X , Chong T , . Bioinformatic analyses and experimental validation of the role of m6A RNA methylation regulators in progression and prognosis of adrenocortical carcinoma. (aging-us.com)
  • This skin cancer has been called by several other names, including primary small-cell carcinoma of the skin, APUDoma, primary undifferentiated carcinoma of the skin, and the Toker tumor. (medscape.com)
  • Carcinogenic hypergastrinemia: signet-ring cell carcinoma in a patient with multiple endocrine neoplasia type 1 with Zollinger-Ellison's syndrome. (tum.de)
  • OBJECTIVE: In this study we investigated the histopathological and molecular findings in the gastrointestinal wall of a patient with multiple endocrine neoplasia type 1 with malignant duodenal gastrinoma and multiple gastric ECL cell tumors, who additionally developed a signet-ring cell carcinoma of the stomach. (tum.de)
  • CONCLUSION: Our immunohistochemical studies might suggest that the gastrinoma-associated excessive progastrin tissue concentrations led to diminished expression of E-cadherin within the gastric mucosa and promoted tumor development of a signet-ring cell carcinoma. (tum.de)
  • among these, gastric small cell carcinoma (GSCC) is extremely rare. (e-ce.org)
  • Small cell carcinoma of the prostate is a high-grade malignant neoplasm with neuroendocrine differentiation. (medscape.com)
  • Approximately 50% of patients have pure small cell carcinoma at initial presentation. (medscape.com)
  • [ 3 ] The overall risk of developing prostatic small cell carcinoma increases with age, with disease occurrence typically being in men older than 60 years. (medscape.com)
  • The genetic changes specific to prostatic small cell carcinoma have not been studied in great detail. (medscape.com)
  • Small cell carcinoma, classic type. (riken.jp)
  • Altered expression of the retinoblastoma (RB) gene in small-cell carcinoma of the lung. (riken.jp)
  • Mycotoxin Exposure and Renal Cell Carcinoma Risk: An Association Study in the EPIC European Cohort. (who.int)
  • Adrenocortical carcinoma (ACC) is a rare malignant tumor with an incidence rate of approximately 0.7/million to 2.0/million in the population [ 1 ]. (aging-us.com)
  • Cutaneous metastases of colonic neuroendocrine carcinomas (NECs) are very infrequent, while cases of scalp metastasis are even fewer. (biomedcentral.com)
  • RESULTS: Immunohistochemical studies of gastric ECL cell tumors showed a largely diminished E-cadherin expression in comparison to gastric surface mucosa cells and a loss of E-cadherin expression in the cells of the signet-ring carcinoma. (tum.de)
  • CONCLUSIONS: Type 1 gastric neuroendocrine tumors showed indolent nature and favorable long-term prognoses. (bvsalud.org)
  • According to the degree of differentiation, NENs have been divided into well differentiated NENs and poorly differentiated NENs in the 2010 World Health Organization classification of tumors of the digestive system, with the former being termed a neuroendocrine tumor (NET), and the latter, a neuroendocrine carcinoma (NEC) [ 1 ]. (biomedcentral.com)
  • DLL3 expression in large cell neuroendocrine carcinoma (LCNEC) and association with molecular subtypes and neuroendocrine profile. (bmj.com)
  • In contrast, CCNE1 and CDK6 showed elevated expression in carcinoids compared to carcinomas. (oncotarget.com)
  • Conclusion: Carcinoids have increased CDK4/6 and CCND1 expression controlling RB1 phosphorylation via this signaling cascade. (oncotarget.com)
  • How Reliable Are Gene Expression-Based and Immunohistochemical Biomarkers Assessed on a Core-Needle Biopsy? (lu.se)
  • Knowledge of the expression patterns of HE4 in our survey is useful for application in histopathologic diagnosis, and should be taken into consideration in future studies that examine the role of HE4 as a serological tumor biomarker or as a target for gene-based therapy. (nature.com)
  • This immunophenotype excluded a carcinoma, a lymphoid, melanocytic, germ cell, or neuroglial proliferation, and the diagnosis of sellar and suprasellar epithelioid angiosarcoma was made. (medscape.com)
  • In melanoma, i have focused in acral lentiginous melanoma for which we described KIT mutation and protein expression status in a large series of cases and described TERT amplification in progression to metastasis. (mdanderson.org)
  • Endoscopic ultrasound-guided biopsy revealed poorly differentiated neuroendocrine carcinoma of the esophagus with metastasis to a diaphragmatic lymph node. (biomedcentral.com)
  • DRAM2 was preferentially upregulated in NSCLC tissues and higher expression of DRAM2 in NSCLC correlated with tumor node metastases stage and lymph node metastasis. (cancerindex.org)
  • Additionally, DRAM2 overexpression promoted cell metastasis and proliferation in vitro, while knockdown of DRAM2 expression yielded opposite result. (cancerindex.org)
  • In front of an aggressive sellar and suprasellar lesion with a subacute clinical presentation, the main diagnoses are a pituitary carcinoma or aggressive adenoma, a pituitary metastasis of a carcinoma of unknown origin, or a solid craniopharyngioma. (medscape.com)
  • We analyzed the expression of 8 markers [p63, cytokeratin (CK) 5/6, SOX2, CK7, desmocollin 3, thyroid transcription factor-1 (8G7G3/1 and SPT24), and napsin A] in 224 NECs. (elsevierpure.com)
  • To investigate the involvement of stem cells in Epstein-Barr virus infection-related nasopharyngeal carcinoma (NPC), we used double immunofluorescence staining to examine several cancer stem/progenitor cell markers (CD44v6, CD24, and ALDH1A1) in NPC tissues and NPC cell lines. (hindawi.com)
  • High m6A risk not only can suppress immunotherapy-related biological processes, but also repress the expressions of immune-checkpoint markers. (aging-us.com)
  • However, the expression of NE markers is inconsistent because of the heterogeneity of NEPC. (biomedcentral.com)
  • Most small cell carcinomas usually arise from the lung and rarely from the gastrointestinal tract [ 1 , 2 ]. (e-ce.org)
  • GPR112 gene expression has been identified as a marker for neuroendocrine carcinoma cells. (wikipedia.org)
  • According to the study authors, gene expression analysis has failed to identify expression-based prognostic signatures in stage I NSCLC robust enough for clinical applications. (genomeweb.com)
  • Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
  • Our study revealed shared 'master gene regulators'-the key proteins that control expression of multiple genes in small cell cancer cells," Witte said. (medicalxpress.com)
  • Here, we examined the expression of the HE4 gene and protein in a large series of normal and malignant adult tissues by oligonucleotide microarray and tissue microarray, respectively. (nature.com)
  • In a series of 175 human adult tumors, gene expression was highest in ovarian serous carcinomas. (nature.com)
  • Using tissue microarrays and full tissue sections of normal and 448 neoplastic tissues, HE4 immunoreactivity was found in normal glandular epithelium of the female genital tract and breast, the epididymis and vas deferens, respiratory epithelium, distal renal tubules, colonic mucosa, and salivary glands, consistent with HE4 gene expression. (nature.com)
  • Here, we used oligonucleotide and tissue microarrays to survey HE4 gene and protein expression in a large group of malignant and normal tissues from adults. (nature.com)
  • HE4 is one of more than 8900 different human genes represented on U95a GeneChips (Affymetrix, Santa Clara, CA, USA), which we used previously to develop a molecular classification of 175 human carcinomas based on patterns of gene expression. (nature.com)
  • Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. (cusabio.com)
  • MicroRNAs are small evolutionarily conserved nucleotide sequences that regulate gene expression after transcription, by mRNA degradation or inhibition of translation. (ccij-online.org)
  • Expression levels of CD44v6 and ALDH1A1 were significantly increased in cancer cells of primary NPC specimens in comparison to chronic nasopharyngitis tissues. (hindawi.com)
  • Moreover, five pairs of clinical specimens were collected to confirm the overexpression of HNRNPC and non-ectopic expression of RBM15 in tumor tissues. (aging-us.com)
  • Results showed that nestin was expressed in various tissues of the embryo in patients with placenta previa, and nestin expression decreased as the embryo matured. (cusabio.com)
  • however, the expression in normal and malignant adult tissues has not been examined in detail. (nature.com)
  • Here, we describe the case and management of a previously healthy 67-year-old male in his fifth year of remission after treatment for poorly differentiated large cell neuroendocrine carcinoma of the esophagus. (biomedcentral.com)
  • One third of patients with cancer of unknown primary origin have poorly or undifferentiated carcinoma. (medscape.com)
  • International real-world study of DLL3 expression in patients with small cell lung cancer. (bmj.com)
  • In this study, we examined both the expression levels and the activation states of RhoA in various lung cancer cells by quantitative real-time reverse transcriptase-polymerase chain reaction and in vivo Rho guanine nucleotide exchange assay, respectively. (nih.gov)
  • DRAM2 acts as an oncogene in non-small cell lung cancer and suppresses the expression of p53. (cancerindex.org)
  • This clearly demonstrates that miRNA expression signatures combined with stage information has higher classification power than the staging method to predict survival," the authors wrote. (genomeweb.com)
  • Atieh T, Huang CH. Treatment of advanced-stage large cell neuroendocrine cancer (LCNEC) of the lung: A tale of two diseases. (bmj.com)
  • Overall, the results of the present study suggest that the co-expression of SOX2 with HR-HPV RISH in SCNEC may represent a specific subgroup exhibiting remarkably poorer prognostic outcomes compared with the expression of any one marker alone. (biomedcentral.com)
  • The associations of SOX2 and/or high-risk (HR)-HPV RNA in situ hybridization (RISH) levels with clinicopathological characteristics and prognostic outcomes for 88 neuroendocrine carcinoma (NEC) cases were analyzed. (biomedcentral.com)
  • El análisis de variación del número de copias para la indicación de terapias diana en pacientes con cáncer de pulmón: secuenciación masiva vs hibridación "in situ" fluorescente. (biopat.es)
  • The treatment of non-muscle-invasive bladder cancer (Ta, T1, carcinoma in situ [CIS]) begins with transurethral resection of bladder tumor (TURBT). (medscape.com)
  • SOX2 (76.2%) had the greatest expression for NECs. (elsevierpure.com)
  • We have also reviewed the literature concerning gastroenteropancreatic neuroendocrine carcinomas (GEP-NECs) in this article. (biomedcentral.com)
  • However, there is limited research on the immune microenvironment of adeno-neuroendocrine prostate cancer (NEPC). (biomedcentral.com)
  • Small cell neuroendocrine carcinoma of the uterine cervix (SCNEC) is a rare cancer involving the human papilloma virus (HPV), and has few available treatments. (biomedcentral.com)
  • The distinct characteristics of SMARCA4-dNSCLC were first proposed in 2017 by Agaimy et al ( 1 ) who highlighted the expression of cytokeratin 7 (CK7) and the loss of the BRG1 protein as the defining features of the disease. (spandidos-publications.com)
  • When lung carcinoma occurs, the proliferation of tumor cells is abnormally active, and the tumor cells continue to proliferate, and in this process, more energy and cell membrane synthesis are required. (hindawi.com)
  • When those cells grew in the mice, they displayed unique features of human small cell neuroendocrine carcinomas. (medicalxpress.com)
  • The team also identified that for small cell neuroendocrine carcinomas to develop in the prostate, two tumor suppressor genes, TP53 and RB1, which are known for protecting normal cells from transforming into cancer cells, had to be simultaneously inactivated when PARCB was introduced. (medicalxpress.com)
  • The present consensus statement was developed collaboratively by the North American Neuroendocrine Tumor Society (NANETS) and the Society of Nuclear Medicine and Molecular Imaging (SNMMI). (snmjournals.org)
  • His Swim Across America project aims to use RealSeqS to develop novel molecular diagnostics to reliably classify bile duct strictures, leading to correct treatment options for cholangiocarcinoma and pancreatic ductal carcinoma patients. (swimacrossamerica.org)
  • Caracterización molecular de biomarcadores para la indicación de inmunoterapia (PD-L1, Inestabilidad de Microsatélites y Tumor Mutational Burden) en una serie de carcinomas neuroendocrinos de pulmón. (biopat.es)
  • Therefore, the occurrence and development of lung carcinoma will be accompanied by abnormal lipid metabolism. (hindawi.com)
  • MCPyV integrates into the host genome, resulting in expression of a truncated form of the viral large T antigen (LT) in infected cells, and makes LT an attractive target for therapeutic cancer vaccines. (biospace.com)
  • However, adenocarcinomas of the lung, and occasional breast, transitional cell and pancreatic carcinomas had moderate or high levels of HE4 expression. (nature.com)