• This aquaporin is regulated in two ways by the peptide hormone vasopressin: short-term regulation (minutes) through trafficking of AQP2 vesicles to the apical region where they fuse with the apical plasma membrane long-term regulation (days) through an increase in AQP2 gene expression. (wikipedia.org)
  • Lithium, which is often used to treat bipolar disorder, can cause acquired diabetes insipidus (characterized by the excretion of large volumes of dilute urine) by decreasing the expression of the AQP2 gene. (wikipedia.org)
  • The expression of the AQP2 gene is increased during conditions associated with water retention such as pregnancy and congestive heart failure. (wikipedia.org)
  • Background: Vasopressin induced trafficking of aquaporin-2 (AQP2) containing vesicles has been studied in kidney cell lines using conventional fluorescent proteins as tags. (johnshopkins.edu)
  • Here we provide laboratory data that suggests imatinib affects aquaporin 2 (AQP2) expression proposing a theory behind imatinib associated FR. (asn-online.org)
  • In the kidney aquaporin-2 (AQP2) provides a target for hormonal regulation of water transport by vasopressin. (uniba.it)
  • Data for functional involvement of the SNARE vesicle-associated membrane protein 2 in AQP2 targeting has recently been provided. (uniba.it)
  • Changes in AQP2 expression/trafficking are of particular importance in pathological conditions characterized by both dilutional and concentrating defects. (uniba.it)
  • More precisely, recent data support the hypothesis that, in vivo external calcium, through activation of calcium-sensing receptors, modulates the expression/trafficking of AQP2. (uniba.it)
  • One member, CAMK2δ (CAMK2D), has been proposed to be involved in vasopressin signaling in the renal collecting duct, which controls water excretion through regulation of the water channel aquaporin-2 (AQP2). (bvsalud.org)
  • Aquaporin-1 ( AQP1 ), located in proximal tubules (PT) and descending thin limbs of Henle ( DTL ), and aquaporin-2 ( AQP2 ), located in collecting ducts (CD), are channels involved in water transport across renal tubule epithelia. (transhumanist.ru)
  • Using antibodies against AQP1 and AQP2 , we here show expression of AQP1 and AQP2 in normal human developing and adult kidneys and in autosomal dominant polycystic kidney disease (ADPKD). (transhumanist.ru)
  • Western blot analysis showed maximal expression of AQP1 and AQP2 in normal adult kidneys, lower levels in fetal kidneys, and decreases associated with degree of cystic progression in ADPKD. (transhumanist.ru)
  • This review focuses on emerging topics encompassing the functional involvement of aquaporin channel proteins (AQPs) and membrane transport systems, also allowing permeation of NO and hydrogen peroxide, a major ROS, in oxidative stress physiology and pathophysiology. (hindawi.com)
  • This notion has been challenged by the discovery of new membrane transport functions, especially those exerted by aquaporins (AQPs), a family of membrane channel proteins widespread in nature [ 10 , 11 ]. (hindawi.com)
  • Aquaporins (AQPs) facilitate transport of water and small solutes across cell membranes and play an important role in different physiological processes in plants. (biomedcentral.com)
  • The present study reports the identification and structural and expression analysis of the AQPs found in the diploid progenitor genomes of A. hypogea i.e. (biomedcentral.com)
  • The global expression profile of AQPs in A. hypogea revealed a similar pattern of AQP expression regardless of the subfamilies or the genomes. (biomedcentral.com)
  • The tissue-specific expression of AQPs suggests an important role in the development and function of the respective organs. (biomedcentral.com)
  • Aquaporins (AQPs) are small (21-34 kD) integral membrane proteins, which form channels facilitating movement of water and other small solutes across the cell membrane. (biomedcentral.com)
  • Various recent studies suggest that membrane channel proteins, named aquaporin (AQPs), by affecting stomatal conductance behavior could be involved in plant responses to stress conditions. (ac.ir)
  • مطالعات متعدد اخیر نشان می-دهد که پروتئین-های کانال غشایی به نام Aquaporin (AQPs) با تأثیر بر رفتار هدایت روزنه می- توانند در پاسخ گیاهان به شرایط تنش نقش داشته باشند. (ac.ir)
  • Choroid plexus epithelial cells (CPECs) secrete most of the CSF through poorly understood mechanisms that involve aquaporins (AQPs) and various solute transport proteins like the Na+-K+-2Cl- cotransporter 1 (NKCC1). (wright.edu)
  • Because of their relatively high transcript expression the present work addresses the cellular and subcellular location of AQPs 4, 7 and 9 proteins in CPECs and EP cells, using immunolabeling with validated antibodies and confocal immunofluorescence. (wright.edu)
  • Takata K, Matsuzaki T, Tajika Y. Aquaporins: water channel proteins of the cell membrane. (benthamscience.com)
  • This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. (antibodies-online.com)
  • Ca2+/Calmodulin-dependent protein kinase 2 (CAMK2) family proteins are involved in the regulation of cellular processes in a variety of tissues including brain, heart, liver, and kidney. (bvsalud.org)
  • Aquaporin (AQP) 4 is a member of the AQP gene family of water-selective transport proteins. (elsevierpure.com)
  • It is the only aquaporin regulated by vasopressin. (wikipedia.org)
  • When it is needed, vasopressin binds to the cell surface vasopressin receptor thereby activating a signaling pathway that causes the aquaporin 2 containing vesicles to fuse with the plasma membrane, so the aquaporin 2 can be used by the cell. (wikipedia.org)
  • Fasting reduces expression of this aquaporin independently of vasopressin. (wikipedia.org)
  • Cell biological aspects of the vasopressin type-2 receptor and aquaporin 2 water channel in nephrogenic diabetes insipidus" (PDF). (wikipedia.org)
  • North WG, Fay MJ, Longo KA, Du J: Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide. (hmdb.ca)
  • Fay MJ, Du J, Yu X, North WG: Evidence for expression of vasopressin V2 receptor mRNA in human lung. (hmdb.ca)
  • The data show that tolvaptan inhibits the expression of mRNAs that were previously shown to be increased in response to vasopressin including aquaporin-2, but also reveals mRNA changes that were not readily predictable and suggest off-target actions of tolvaptan. (bvsalud.org)
  • We studied the effect of water deprivation on AQP4 gene expression in chickens. (elsevierpure.com)
  • The nucleotide sequence of a chicken aquaporin 4 (AQP4) cDNA that encodes a protein of 335 amino acids showed high homology to mammalian AQP4. (elsevierpure.com)
  • Quantitative analysis by real-time RT-PCR analysis showed that the mRNA expression of AQP4 in the hypothalamus significantly increased after dehydration. (elsevierpure.com)
  • On the other hand, the mRNA expression of AQP4 in the kidney significantly decreased after dehydration. (elsevierpure.com)
  • AQP4 expression in CPECs is debatable. (wright.edu)
  • Preliminary study on the association of AQP4 promoter polymorphism with anti-aquaporin-4 antibody positivity in southern Han Chinese patients with idiopathic demyelinating disorders of central nervous system. (cdc.gov)
  • Acutely and chronically, lithium salts produce a natriuresis that is associated with an impaired regulation of the expression of the epithelial sodium channel in the cortical collecting tubule. (medscape.com)
  • Transcriptional regulation of aquaporins in accessions of Arabidopsis in response to drought stress. (lu.se)
  • Aquaporin 2 is in kidney epithelial cells and usually lies dormant in intracellular vesicle membranes. (wikipedia.org)
  • In this issue of JCI Insight, Glisinski and colleagues report that the inflammatory cytokine IL-13 markedly altered self-renewal and differentiation of type 2 alveolar epithelial cells (AEC2s), resulting in ectopic expression of bronchial cell-associated markers and a hyperplastic phenotype. (jci.org)
  • Pathogenesis of dry skin in type 2 diabetes mellitus (T2DM) rises from the chronic hyperglycemia causing an increase in advanced glycation end-products (AGEs), proinflammatory cytokines, and oxidative stress. (hindawi.com)
  • However, it is unclear whether neuron populations in the human PVN are involved in the development of type 2 diabetes mellitus (T2DM). (nin.nl)
  • However, contrasting findings of greater SARS-CoV-2 presence in the choroid plexus of the organoids have also been reported. (news-medical.net)
  • On the contrary, SARS-CoV-2 S was abundantly present within the choroid plexus of the cortical hemorrhage specimens. (news-medical.net)
  • Vella J, Zammit C, Di Giovanni G, Muscat R, Valentino M. The central role of aquaporins in the pathophysiology of ischemic stroke. (benthamscience.com)
  • Aquaporin-2 (AQP-2) is found in the apical cell membranes of the kidney's collecting duct principal cells and in intracellular vesicles located throughout the cell. (wikipedia.org)
  • Igarashi H, Huber VJ, Tsujita M, Nakada T. Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema. (benthamscience.com)
  • Preincubation in 0.1 mM HgCl(2), a standard aquaporin inhibitor, prevented such cell swelling. (wikigenes.org)
  • CD44 is one of the well-known surface markers for hepatocellular carcinoma, and its expression level is related to poor survival and a high recurrence rate. (fabad.org.tr)
  • Purification and characterization of two protein kinases acting on the aquaporin SoPIP2;1. (lu.se)
  • También se discuten las perspectivas futuras con respecto a la evaluación y el diagnóstico temprano de lesión renal en estos pacientes. (revistanefrologia.com)
  • We demonstrate that while Rspo3 from myofibroblasts maintains colonic Lgr5 + cells during homeostasis, during injury its main function is not to maintain Lgr5 + cells but to interact with more differentiated cells that express Lgr4 but not Lgr5 and are able to regain expression of Wnt target genes and generate new crypts. (nature.com)
  • Furthermore, miR-543 upregulation promotes the expression of genes related to drug metabolism, including CYP3A4, which is involved in ruxolitinib metabolism. (jci.org)
  • In a previous report using the resources of the New Hampshire Birth Cohort Study (NHBCS), we found that low-to-moderate i n utero exposure to arsenic, a highly toxic and widespread pollutant, was associated with altered expression of several key developmental genes in the fetal portion of the placenta. (biomedcentral.com)
  • Using NanoString technology, we further analyzed the fetal placenta samples from the NHBCS for the expression of genes encoding arsenic transporters and metabolic enzymes. (biomedcentral.com)
  • Moreover, AQP9 expression associated with that of a subset of female-specific arsenic-responsive genes. (biomedcentral.com)
  • Based on these results and prior studies, increased AQP9 expression may lead to increased arsenic transport in the female fetal placenta, which in turn may alter the expression patterns of key developmental genes that we have previously shown to be associated with arsenic exposure. (biomedcentral.com)
  • Overexpression of a plasma membrane aquaporin in transgenic tobacco improves plant vigor under favorable growth conditions but not under drought or salt stress. (ac.ir)
  • The expression of AQP1 in the basolateral membrane is a subject of debate. (wright.edu)
  • its expression in the basolateral membrane of mouse CPECs is undetectable. (wright.edu)
  • 2) AQP 7 expression was found to be restricted to the apical membrane of CPECs and EPCs. (wright.edu)
  • At the cellular and whole organ level, degenerative changes that are a hallmark of natural aging (shorter telomeres, increased expression of cellular senescence markers, increased DNA damage, oxidative stress, and apoptosis, accompanied by diminished elasticity) reach pathological levels in aging humans in the form of chronic respiratory disease. (karger.com)
  • Aquaporins are multifunctional water and solute transporters highly divergent in living organisms. (benthamscience.com)
  • Expression of aquaporins-1 and -2 during nephrogenesis and in autosomal dominant polycystic kidney disease. (transhumanist.ru)
  • The response of a plant to drought stress is positively related to physiological traits and gene expression. (ac.ir)
  • However, there was not any clear relationship between physiological traits and expression of sunTIP7 gene in all six sunflower inbred lines. (ac.ir)
  • Here, we demonstrate that miR-543 targets the dioxygenases ten-eleven translocation 1 (TET1) and 2 (TET2) in patients and in vitro, causing increased levels of global 5-methylcytosine, while decreasing the acetylation of histone 3, STAT3, and tumor protein p53. (jci.org)
  • The basic job of aquaporin 2 is to reabsorb water from the urine while its being removed from the blood by the kidney. (wikipedia.org)
  • Mouse Models of Kidney Fibrosis Unilateral ureteral obstruction (UUO) CAL-101 (GS-1101, Idelalisib) was performed in adult (8 to 12 weeks) C57BL6 wild-type or Coll-GFP mice as described previously.2 Briefly, the left ureter was ligated twice using 4-0 nylon surgical sutures at the level of the lower pole of kidney. (holyexperiment.org)
  • Kidney Single-cell Transcriptomes Predict Spatial Corticomedullary Gene Expression and Tissue Osmolality Gradients. (mhh.de)
  • Vaccination of cattle with synthetic peptides corresponding to predicted extracellular domains of Rhipicephalus (Boophilus) microplus Aquaporin-2 reduces the number of ticks feeding to repletion. (usda.gov)
  • Unexpected complexity of the Aquaporin gene family in the moss Physcomitrella patens. (lu.se)
  • In the cortical regions of the hemorrhagic specimens, blood vessels situated proximal to erythrocyte clusters showed significantly lower claudin-5 expression compared to away from vessels located far from the erythrocyte clusters. (news-medical.net)
  • Increased expression of TGF-1 was detected predominantly in injured epithelium after unilateral ureteral obstruction, whereas downstream signaling from the TGF-1 receptor increased in both injured epithelium and pericytes. (holyexperiment.org)
  • Increasing incidence of diabetes creates a growing healthcare financial burden in Indonesia as it is expected to cost 1.2 million US dollar by 2020 [ 1 , 2 ]. (hindawi.com)
  • Phosphorylation events and the modulation of aquaporin 2 cell surface expression. (massgeneral.org)
  • Activation of Abl tyrosine kinases increases cell surface expression of EGFR. (asn-online.org)
  • Lgr5 is a well-established marker of these basal stem cells in the gastrointestinal tract 1 and lineage tracing experiments have demonstrated that Lgr5 + cells give rise to clonal cell populations establishing entire colonic crypts 2 . (nature.com)
  • Expression of Lgr5 is controlled by Wnt signaling, which plays a critical role for stem cell turnover in the gastrointestinal tract 2 . (nature.com)
  • At the cellular level, aging is marked by depletion of adult stem cell reservoirs, the inability to maintain baseline homeostasis, a reduced response to stress, an increased accumulation of damaged DNA leading to telomere shortening, and mitochondrial dysfunction [ 1,2 ]. (karger.com)
  • DTL (Cdc10-dependent transcript 2) is a critical regulator of cell cycle progression and genomic stability. (transhumanist.ru)
  • The Plant Cell 15(2): 439-447. (ac.ir)
  • In our previous study, the upregulation of DTL expression in aggressive HCC correlated positively with tumor grade and poor patient survival. (transhumanist.ru)
  • Structural mechanism of plant aquaporin gating. (lu.se)
  • The encoded protein is the predominant aquaporin found in brain. (antibodies-online.com)
  • In a recent study published in BRAIN , researchers evaluated the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections on fetal brain health. (news-medical.net)
  • Previous studies have reported that maternal SARS-CoV-2 infections and immunological responses elevate the risk of altered fetal brain development, fetal death, growth restrictions and severe pathologies such as intraventricular hemorrhages and pneumonia. (news-medical.net)
  • SARS-CoV-2 presence was detected in the initial- and subsequent-trimester fetal brain associated with hemorrhage in the cortex. (news-medical.net)
  • Molecular Brain Research , 141 (2), 193-197. (elsevierpure.com)
  • Moreover, a specific subpopulation of astrocytes characterized by aquaporin 4 expression was overrepresented in T2DM patients. (nin.nl)
  • Sunflower lines had different fold change expression of sunTIP7 gene under drought stress. (ac.ir)
  • The cells are starved in 1 ml/well plain DMEM F12 medium for 2 hours prior to treatment. (asn-online.org)
  • After treatment, cells are washed, fixed, permeablized, and incubated with anti-aquaporin 2 antibody and Alexa Flor Goat anti-rabbit IgG 488. (asn-online.org)
  • Western blot analysis detected expression of alpha amylase and aquaporin 5 protein, suggesting that primary cells were acinar in origin. (cdc.gov)
  • Compared to control-treated cells, CD44 (3.2- fold) and p-STAT3 (2.44-fold) protein expressions were upregulated in PEITC-treated cells. (fabad.org.tr)
  • Furthermore, SARS-CoV-2 spike (S) protein expression was investigated in cells of the placenta, amnion, and umbilical cord. (news-medical.net)
  • SARS-CoV-2 spike (S) expression was sparse in cortical microtubule-associated protein 2 (MAP2)-positive and HuC/D-positive neurons and the nestin-positive and Hopx (homeodomain-only protein)-positive radial glial, and Sox2 (sex-determining region Y-box 2)-positive ventricular zone and subventricular zone progenitor cells. (news-medical.net)
  • Growth rates were severely decreased, to approximately 50% of those of wild type cells, depending on the expression levels of dCas9. (web.app)
  • Structure and Stability of the Spinach Aquaporin SoPIP2;1 in Detergent Micelles and Lipid Membranes. (lu.se)
  • Genetics 2018 2 4 (1): e213. (cdc.gov)
  • In addition, SARS-CoV-2 was present sparsely in the placental, umbilical cord and amniotic tissues, indicating SARS-CoV-2 presence in maternal and fetal tissues. (news-medical.net)
  • We found that maternal arsenic exposure was strongly associated with expression of the AQP9 gene, encoding an aquaglyceroporin transporter, in female but not male fetal placenta. (biomedcentral.com)
  • Mechanistically, we found that activation of STAT3 by JAKs epigenetically controls miR-543 expression via binding the promoter region of miR-543. (jci.org)
  • The greatest degree of conservation between homologues is found in TMSs 1 and 2 of the Thermotoga maritima protein. (tcdb.org)
  • Nature genetics, 48(2), pp. 159-166. (unibe.ch)