• CD147 , also known as Basigin (BSG) , or extracellular matrix metalloproteinase inducer (EMMPRIN) . (proteinkinase.biz)
  • Recombinant Human CD147 /EMMPRIN Protein (rhCD147), His Tag (CD7-H5222) is expressed from human 293 cells (HEK293). (proteinkinase.biz)
  • Cell surface EMMPRIN expression was measured by flow cytometry and Western blotting, and phospho-(p)-p38, p-JNK, nuclear NFκB p65, and phospho-p65 were measured by Western blotting. (biomedcentral.com)
  • Compared with BBR, dhBBR and Di-MeBBR significantly reduced EMMPRIN expression, which was associated with a greater inhibition of p-p38, p-JNK, nuclear NFκB p65 and phospho-p65 induced by oxLDL in macrophages. (biomedcentral.com)
  • dhBBR and Di-MeBBR reduced expression of EMMPRIN, CD68, and NFκB p65, and Di-MeBBR also reduced expression of matrix metalloproteinase-9, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in aortic plaques. (biomedcentral.com)
  • In this review of literature, we summarized five potential host cell receptors, as host-cell surface bindings, including angiotensin-converting enzyme 2 (ACE2), neuropilin 1 (NRP-1), dipeptidyl peptidase 4 (DPP4), glucose regulated protein-78 (GRP78), and cluster of differentiation 147 (CD147) related to the SARS-CoV-2 infection. (eurekaselect.com)
  • 1 2 Cell surface antigens CD38 and CD138 can be used to distinguish normal cells from clonal plasma cells, but more extensive use of immunophenotyping has been limited by a lack of universally accepted markers of MM. 3-5 Once diagnosed, the current standard-of-care for MM includes immunomodulatory drugs, proteasome inhibitors, steroids, and antibody therapies. (bmj.com)
  • human liver tissue were subjected to SDS PAGE followed by western blot with 11989-1-AP (CD147 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. (ptglab.com)
  • Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 11989-1-AP (CD147 antibody) at dilution of 1:200 (under 10x lens. (ptglab.com)
  • Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 11989-1-AP (CD147 antibody) at dilution of 1:200 (under 40x lens. (ptglab.com)
  • Our main goal is to identify new tumor antigens specifically expressed at the tumor cell surface and to validate their potential use as new therapeutic targets through the development of antibody-based immune-therapies. (hipi-lab-saint-louis.fr)
  • Each antibody is crafted with care according to rigorous protocols for immunogen design and preparation, presentation to host animal, and high-affinity purification against the antigen. (abcepta.com)
  • To validate the clinical significance of the CypA/CD147 interaction, we analyzed the expression levels of PPIA and BSG genes encoding CypA and CD147, respectively, in a wide range of tumor types using The Cancer Genome Atlas (TCGA) database. (bvsalud.org)
  • Because 10% of Sézary patients display malignant T cells that do not express KIR3DL2, we pursue our search for specific tumor antigens. (hipi-lab-saint-louis.fr)
  • Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. (wikidoc.org)
  • Among the tumor suppressor miRNAs, reduced let-7 expression occurs most frequently in cancer and typically correlates with poor prognosis. (encyclopedia.pub)
  • This protein is also identified as an ovarian-tumor-specific antigen. (childrensmercy.org)
  • Several receptors have been demonstrated for the interaction of spike (S) protein of SARS-CoV-2 with host cells, including angiotensin-converting enzyme (ACE2), ephrin ligands and Eph receptors, neuropilin 1 (NRP-1), P2X7, and CD147. (bvsalud.org)
  • The expression of these entry receptors in the central nervous system (CNS) may make the CNS prone to SARS-CoV-2 invasion, leading to neurodegenerative diseases. (bvsalud.org)
  • H. pylori cytotoxin associated antigen A (CagA) plays a crucial role in the development of gastric cancer. (bvsalud.org)
  • The CypA/CD147 interaction plays a crucial role in the progression of several diseases, including inflammatory diseases, coronavirus infection, and cancer, by activating CD147-mediated intracellular downstream signaling pathways. (bvsalud.org)
  • The JUN protein is a transcription factor that plays a crucial role in regulating gene expression in response to a variety of signals, including growth factors, cytokines, and stress. (cusabio.com)
  • Cyclophilin A (CypA), which has peptidyl-prolyl cis-trans isomerase (PPIase) activity, regulates multiple functions of cells by binding to its extracellular receptor CD147. (bvsalud.org)
  • Expression of extracellular matrix proteins and metalloproteases (MMPs) has been implicated in neoplasm recurrence. (jsurgmed.com)
  • Association between Human Leukocyte Antigen (HLA) DQB1*06 and HLA DQB1*03 and adverse outcomes in a group of critically ill patients with COVID-19 in Tunisia: a cross-sectional study. (cdc.gov)
  • Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. (abeomics.com)
  • Deoxyribonucleic acid damage caused by the irradiation caused higher level of poly- adenosinediphosphate-ribosylated Specific Protein 1(SP1), and translocation of SP1 from the nucleus, decreasing the expression of fucosyltransferase IV and Lewis Y. Conclusion: There was a significant role of glycosylation in radiation therapy for lung cancer. (bvsalud.org)
  • The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) has recently emerged as a leading candidate antigen against the blood-stage human malaria parasite. (nature.com)
  • However it has proved challenging to identify a heterologous expression platform that can produce a soluble protein-based vaccine in a manner compliant with current Good Manufacturing Practice (cGMP). (nature.com)
  • Scope includes mutations and abnormal protein expression. (cancer-genetics.org)
  • We observed that EGFRvIII expression alters the expression of EV-regulating genes (vesiculome) and EV properties, including their protein composition. (cancer-genetics.org)
  • MicroRNAs (miRNAs) serve a role in gene expression, primarily by interacting with messenger RNAs, and may be potential biomarkers for detecting cancer. (spandidos-publications.com)
  • Further analysis of the expression of these circulating miRNAs and their association with prognosis in patients with TNBC treated with immunotherapy should be assessed to evaluate their possible use as non‑invasive predictive biomarkers. (spandidos-publications.com)
  • The development of an effective vaccine against the merozoite has proved exceptionally challenging, hindered by substantial levels of polymorphism in the most widely studied candidate antigens 4 and redundant erythrocyte invasion pathways 5 . (nature.com)
  • As members of the immunoglobulin superfamily play fundamental roles in intercellular recognition involved in various immunologic phenomena, differentiation, and development, basigin is thought also to play a role in intercellular recognition and regulate several distinct functions, such as spermatogenesis, expression of the monocarboxylate transporter and the responsiveness of lymphocytes. (proteinkinase.biz)
  • Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). (ptglab.com)
  • Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol. (abcam.com)
  • After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). (cusabio.com)
  • Carcinoembryonic antigen (CEA) is a glycoprotein involved in cell adhesion . (wikidoc.org)
  • The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. (wikidoc.org)
  • RESULTS: The expressions of fucosyltransferase IV and Lewis Y were decreased after X-ray irradiation, thus inhibiting the proliferation of A549 lung cancer cells. (bvsalud.org)
  • Blood tests: Over expression of tumour markers like CD147 and fucosyltransferase 8. (omicsonline.org)
  • Furthermore, the expression of PPIA and BSG was positively correlated in many cancers. (bvsalud.org)
  • CD147 was determined to be positively correlated with WHO-defined grade ( P= 0.009). (jsurgmed.com)
  • HuNoV infection affects mainly secretor individuals where ABO(H) and Lewis histo-blood group antigens (HBGAs) are present in the small intestine. (bvsalud.org)
  • Nonsecretor individuals, who only express Lewis (Le) antigens, are less susceptible to HuNoV infection. (bvsalud.org)
  • Besides ACE2, CD147 was discovered as a novel SARS-CoV-2 receptor, CD147 appears to be an alternate receptor for SARSCoV- 2 infection. (eurekaselect.com)
  • Inhibition of mu-opioid receptor suppresses proliferation of hepatocellular carcinoma cells via CD147-p53-MAPK cascade signaling pathway. (e-century.us)
  • Expression of miRNA-9 was found higher in pro-inflammatory M1 than M2 macrophages, and promoted human M1 polarization [ 17 ] and miRNA-9 levels correlated with levels of peroxisome proliferator-activated receptor-δ (PPAR-δ, also known as PPAR-β) in M1 macrophages [ 18 ] . (encyclopedia.pub)
  • The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. (wikidoc.org)
  • Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. (cusabio.com)
  • These peptides can be used for antigen specific T-cell stimulation in T-cell assays or T-cell expansion. (abcepta.com)
  • Upon stimulation, the expression of IL-17A in CD8 T cells was higher in the BNT162b2 group than in the ChAdOx-1 boosting group. (biomedcentral.com)
  • Nine of these proteins were identified as potential immunotherapeutic targets, including five that were validated by FCM, confirming their expression on the cell surface of primary MM patient cells. (bmj.com)
  • Many studies have identified CypA and CD147 as potential therapeutic targets for cancer. (bvsalud.org)
  • Progress in this arena, however, is being made with a new generation of merozoite antigen targets identified in recent years that exhibit relatively low levels of polymorphism and against which functional neutralizing antibodies can be raised by vaccination. (nature.com)
  • VLP binding was observed for the three HuNoV genotypes in 10 of the 13 individuals, and competition experiments demonstrated that VLP recognition was driven by an interaction with the Lea antigen. (bvsalud.org)
  • This review aims to understand the biology and interaction of CypA and CD147 and to review the roles of the CypA/CD147 interaction in cancer pathology and the therapeutic potential of targeting the CypA/CD147 axis. (bvsalud.org)
  • Therefore, this review supports the hypothesis that targeting the CypA/CD147 interaction may improve treatment outcomes for patients with cancer. (bvsalud.org)
  • This two-part narrative review presents evidence for the widespread harms of novel product COVID-19 mRNA and adenovectorDNA vaccines and is novel in attempting to provide a thorough overview of harms arising from the new technology in vaccines that relied on human cells producing a foreign antigen that has evidence of pathogenicity. (gospanews.net)
  • Here, we leverage a set of genome-edited human PLIN2 reporter cell lines in a series of CRISPR-Cas9 loss-of-function screens, identifying genetic modifiers that influence PLIN2 expression and post-translational stability under different metabolic conditions and in different cell types. (stanford.edu)
  • Methods We established new patient-derived PA cell lines that preserve molecular features of the primary tumors and can be studied in OIS and proliferation depending on expression or repression of the SV40 large T antigen. (ibecbarcelona.eu)
  • Antigens on RBC membrane, and some of which might overlap with KLF1 mutations causing the fraction of hereditary persistence of fetal hemoglobin with CDA type IV. (wikipedia.org)
  • Although malignant cells were identified as a clonal expansion of CD4+ T cell with memory phenotype, their phenotypic detection relies on the loss of pan-T cell antigens such as CD26 or/and CD7. (hipi-lab-saint-louis.fr)
  • Let-7f expression was lower and IL-23R expression was higher in TH17-differentiated cells from women compared with men with severe asthma [ 16 ] . (encyclopedia.pub)
  • The expression of FasL in CD4 T cells, but not CD8 T cells, was higher in the BNT162b2-boosted group. (biomedcentral.com)
  • Gao H, Lan X, Li S, Xue Y. Relationships of MMP-9, E-cadherin, and VEGF expression with clinicopathological features and response to chemosensitivity in gastric cancer. (jsurgmed.com)
  • The study results demonstrated that CD147 could be a target for diagnosis, prognosis, and treatment of meningiomas. (jsurgmed.com)
  • Competition experiments using histo-blood group antigen (HBGA)-specific monoclonal antibodies (MAbs) demonstrate that GII.4 VLPs recognized the Lewis a (Lea) antigen. (bvsalud.org)
  • The Lea antigen also played a pivotal role in the recognition of GII.4 and GII.17 particles by inflammatory colon tissue from a nonsecretor Crohn's disease patient. (bvsalud.org)
  • Objective: To identify the mechanism of down-regulation of Lewis Y antigen caused by X-ray irradiation. (bvsalud.org)
  • Saliva binding assays showed that only GII.4 interacted with nonsecretor saliva via the Lewis a (Lea) antigen Surprisingly, the three genotypes interacted with nonsecretor enterocytes via the Lea antigen on duodenal tissue blocks, which were more relevant for HuNoV/HBGA studies. (bvsalud.org)
  • When individual members of the let-7 family were measured, the expression of let-7f was reported to be higher in cultured epithelial brushings from asthmatic donors [ 1 ] . (encyclopedia.pub)
  • data indicated that miR-139-5p was down-regulated in the hearts of Hypertrophic cardiomyopathy patients and that it inhibited cardiac hypertrophy by targetting c-Jun expression. (cusabio.com)
  • whilst another promising immunogen has included conserved regions III-V of the erythrocyte-binding antigen 175 kDa (PfEBA-175) 10 . (nature.com)
  • We determined expression of anti-apoptotic BCL-2 members in these models and primary PA. (ibecbarcelona.eu)