• The results of these analyses revealed that the differentially expressed exosomal miRNAs participate in multiple biological processes, such as gene expression, synthesis of biomolecules, cell development, differentiation, and signal transduction, among others. (hindawi.com)
  • Moreover, we found that these differentially expressed exosomal miRNAs connect osteogenic differentiation to processes such as axon guidance, MAPK signaling, and Wnt signaling. (hindawi.com)
  • This study confirms that alterations in the expression of exosomal miRNAs can promote osteogenic differentiation of ADSCs, which also provides the foundation for further research on the regulatory functions of exosomal miRNAs in the context of ADSC osteogenesis. (hindawi.com)
  • MicroRNAs (miRNAs) are a group of endogenous non-coding RNAs, which are single-stranded and ~21 nucleotides (~21 nt) in length. (nature.com)
  • Accumulating studies have suggested that miRNAs are frequently dysregulated in tumors compared with normal tissues, resulting in aberrant expression of target genes or proteins and cancer progression 13 . (nature.com)
  • MicroRNAs (miRNAs) are brief noncoding RNAs that bind to focus on mRNAs and inhibit their manifestation (11, 12). (baxkyardgardener.com)
  • However, the entire effect and range of aberrant miRNA manifestation in PKD remain unfamiliar, whether miRNAs regulate additional areas of PKD pathogenesis specifically, like the cyst microenvironment. (baxkyardgardener.com)
  • miRNAs are a family of small non-coding RNAs that emerged as significant and versatile regulators involved in regulation of immune responses. (frontiersin.org)
  • MicroRNAs (miRNAs) are highly conserved, single-stranded, small non-coding RNAs that have been shown to act as essential regulators of gene expression at the posttranscriptional level. (frontiersin.org)
  • MicroRNAs (miRNAs) are the most altered subset of ncRNAs, followed by long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs). (ersjournals.com)
  • Wound healing is a complex physiological process necessitating the coordinated action of various cell types, signals and microRNAs (miRNAs). (molcells.org)
  • Accumulating evidence suggests that microRNAs (miRNAs) are key regulators of this network, with the capacity to target multiple messenger RNAs involved in the EndMT process as well as in the regulation of disease progression. (bmbreports.org)
  • This review highlights the current fund of knowledge regarding the known links between miRNAs and the EndMT process, with a focus on the mechanism that regulates associated signaling pathways and discusses the potential for the EndMT as a therapeutic target to treat many diseases. (bmbreports.org)
  • Recently, there has been strong interest in exploring the roles of non-coding RNAs, including circular RNAs (circRNAs), long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), in the process of GC [ 2 - 4 ]. (archivesofmedicalscience.com)
  • Moreover, circRNAs have four major functions, including as competing endogenous RNAs (ceRNAs) to sponge microRNAs (miRNAs), interaction with RNA binding proteins to regulate the cell cycle and proliferation and the management of gene transcription and protein translation [ 8 , 9 ]. (archivesofmedicalscience.com)
  • Molecular mechanistic investigation has demonstrated that circRNAs mainly function as miRNA sponges to neutralize miRNAs levels and regulate their downstream targets in the tumorigenesis of cancer, including GC [ 2 ]. (archivesofmedicalscience.com)
  • miRNAs are small, non-coding and single-stranded RNAs (approximately 22 nucleotides) and function as post-transcriptional regulators to modulate gene expression by sequence-specific interaction with their 3′-untranslated regions (3′-UTRs) [ 14 ]. (archivesofmedicalscience.com)
  • EBV is the first human virus that has the capability to encode microRNAs (miRNAs). (ijbs.com)
  • EBV miRNAs also inhibit the expression of viral antigens, thereby enabling infected cells to escape immune recognition. (ijbs.com)
  • microRNAs (miRNAs) are a large class of small non-coding RNAs with a length of 21-23 nucleotides (nt) [ 11 ]. (ijbs.com)
  • Exceptionally, a minority of miRNAs are derived from RNA Pol III transcripts. (ijbs.com)
  • For example, murine gammaherpesvirus 68 (MHV-68)-encoded miRNAs are located downstream of viral tRNAs and transcribed by RNA Pol III [ 2 ]. (ijbs.com)
  • miRNAs are able to post-transcriptionally control gene expression by binding to target mRNAs [ 15 ]. (ijbs.com)
  • miRNAs comprise a large group of endogenous non-coding RNAs that can block mRNA translation or negatively regulate mRNA stability and thereby play a central role in regulating gene expression [10] , [11] . (plos.org)
  • CircRNAs exert their biological effects by 4 different mechanisms: serving as sponges of microRNAs (miRNAs), serving as sponges of RNA binding proteins (RBPs), modulating parental gene transcription, and encoding functional proteins. (techscience.com)
  • MicroRNAs (miRNAs) are small noncoding RNAs (~22 nucleotides in length) that regulate gene expression post-transcriptionally by imperfect binding to the 3′ untranslated region of target mRNAs in a wide variety of cell types. (biomedcentral.com)
  • The recent publication by Wagh and colleagues sought to identify the novel miRNAs regulating cardiac-specific transcription factors that determine left versus right ventricular determination [ 1 ]. (biomedcentral.com)
  • MicroRNAs (miRNAs) have been identified as important posttranscriptional regulators involved in various biological and pathological processes of cells, but their association with tumor chemoresistance has not been fully understood. (biomedcentral.com)
  • MicroRNAs (miRNAs) are a class of small noncoding RNA molecules that negatively regulate the expression of target genes by either mRNA degradation or translational inhibition. (biomedcentral.com)
  • microRNAs (miRNAs) are important regulators in plant growth and development. (biomedcentral.com)
  • Plant microRNAs (miRNAs) are 20-24 nucleotides (nt) long and widely exist as gene regulators. (biomedcentral.com)
  • Altering expression of miRNAs can result in multiple visible phenotypes of a plant. (biomedcentral.com)
  • Additionally, as competitive endogenous RNAs (ceRNAs), lncRNAs and messenger RNAs (mRNAs) can regulate one other by competing for the shared microRNAs (miRNAs/miRs) ( 14 , 15 ). (spandidos-publications.com)
  • that asthma is intensively regulated by a variety of microRNAs (miRNAs). (cdc.gov)
  • MiRNAs are approximately 19- to 25-nucleotide estimated about 250,000 and mortality does not appear single-stranded, noncoding RNAs that exist in both to correlate well with prevalence. (cdc.gov)
  • Th)1 cells.5 Meanwhile, the function and immunity of with genetic predisposition, involving multiple cells, DCs are closely regulated by miRNAs. (cdc.gov)
  • We hypothesized that a high fat diet in non-human primates would induce changes in hepatic chromatin structure resulting in altered expression of fetal genes critical to the development of childhood and adult obesity. (nih.gov)
  • Microarray datasets of HF were downloaded from the Gene Expression Omnibus (GEO) database and differentially expressed genes (DEGs) were selected by using R software. (researchsquare.com)
  • Hub genes were selected by a protein-protein interaction (PPI) network, and competitive endogenous RNA (ceRNA) networks were constructed by Cytoscape. (researchsquare.com)
  • The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
  • The discovery of the antioxidant response element (ARE) have led to the conclusion that the battery of genes, including glutamate-cysteine ligase (GCL), thioredoxin reductase 1 (Txnrd1), NAD(P)H-quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HMOX1) is regulated through Nrf2 binding to this consensus binding sequence [ 3 ]. (springer.com)
  • Although high-throughput analysis of liquid biopsies has uncovered many differentially expressed genes in the context of cancer, the functional connection between these genes is not investigated in depth. (frontiersin.org)
  • WGCNA tries to find genes that have correlated expressions and aims to build sets of such genes which are named modules. (frontiersin.org)
  • In comparison to the frequently used differential gene expression analysis the approach offers additional insights by incorporating information about the relationship between genes detected in a given sample. (frontiersin.org)
  • Overexpression and silencing of YBX1 were performed to assess the expression of CORO1C , one of the differentially regulated genes from the transcriptomic analysis. (biomedcentral.com)
  • Global gene expression profiling in the YBX1 silenced MDA-MB-231 cells identified differential expression of several genes, including CORO1C (which encodes for an actin binding protein, coronin-1C) as a potential downstream target of YB-1. (biomedcentral.com)
  • Moreover, down-regulation of let-7c expression is accompanied by up-regulation of Bcl-2 expression and down-regulation of Bax expression, both of which are the downstream genes of HSP70. (molcells.org)
  • Four latency types (0, I, II, III) are defined depending on the expression pattern of EBV latent genes, and at the same time are linked to a particular tumor type [ 6 , 7 ]. (ijbs.com)
  • Our analysis revealed subsets of genes, whose expression is positively associated with H3K27me3, different to the otherwise reported negative association with gene expression in many other organisms. (uni-frankfurt.de)
  • This study is to explore the biogenesis mechanism of a secondary hepatocellular carcinoma (HCC) based on the function of RNA binding proteins (RBPs)-encoding genes in the physiological microenvironment (PM). (peerj.com)
  • The differentially expressed RBPs-encoding genes (DERs) and differentially expressed DERs-associated genes (DEDs) were screened to undergo GO and KEGG analysis. (peerj.com)
  • The genes encoding RBPs and the relevant genes are involved in the transformation from PM to PTM, then constructing the TM by regulating protein synthesis. (peerj.com)
  • These novel findings were confirmed by real-time polymerase chain reaction analysis: higher expression of HAND genes correlated with lower expression of miR-363, miR-367, miR-181a and miR-181c. (biomedcentral.com)
  • In this study, expression of mature miR159 was successfully suppressed by STTM which resulted in the increased expressions of its two targets genes, OsGAMYB and OsGAMYBL1 (GAMYB-LIKE 1). (biomedcentral.com)
  • Gene Ontology (GO) enrichment analysis of differentially expressed genes between wild type plants and STTM159 transgenic plants showed that genes involved in cell division, auxin, cytokinin (CK) and brassinosteroids (BRs) biosynthesis and signaling are significantly down-regulated in STTM159 plants. (biomedcentral.com)
  • Further analysis from the RNA-seq data showed that the decreased cell divisions in STTM159 transgenic plants may result, at least partly from the lower expression of the genes involved in cell cycle and hormone homeostasis, which provides new insights of rice miR159-specific functions. (biomedcentral.com)
  • Using the GSE2223 and GSE59612 datasets, and RNA sequencing data of GBM from The Cancer Genome Atlas, differentially expressed (DE) genes including DE messenger RNAs (DEmRNAs) and DElncRNAs between GBM and normal controls were identified. (spandidos-publications.com)
  • Stably introduced into cancer cell lines, the system reports on elevated endogenous ADAR1 editing activity induced by interferon as well as knockdown of ADAR1 and ADAR2. (cancerindex.org)
  • Circular RNAs (circRNAs) have been identified as competing endogenous RNAs (ceRNAs) to mediate gene expression participating in the progression of multiple cancers, including gastric carcinoma (GC). (archivesofmedicalscience.com)
  • In our study, hsa_circ_0017728 as a potential oncogene competing endogenous RNA (ceRNA) was investigated in the progression and development of gastric carcinogenesis. (archivesofmedicalscience.com)
  • CircRNAs are a novel class of endogenous noncoding RNA and are characterized by single-stranded, covalently closed circular molecules without 5′ to 3′ polarity and a polyadenylated tail [ 5 , 6 ]. (archivesofmedicalscience.com)
  • Further, we developed a pipeline to characterise novel genome-wide endogenous short interfering RNAs (endo-siRNAs). (uni-frankfurt.de)
  • Based on the competing endogenous RNA hypothesis, DElncRNA‑micro RNA (miRNA)‑DEmRNA interactions were obtained by target gene prediction. (spandidos-publications.com)
  • It may act as a competing endogenous RNA and influence tumorigenesis of GBM. (spandidos-publications.com)
  • By transporting "cargos" such as proteins, RNAs, DNAs, and lipids [ 26 ], exosomes regulate the eventual fate of recipient cells. (hindawi.com)
  • 1) Characterize novel families of oncoproteins (Pbx and Meis) that dimerize with and regulate the DNA binding properties of Hox proteins. (stanford.edu)
  • RNA-binding proteins in leukemia and cancer. (ucla.edu)
  • A relatively new addition to the repertoire of gene expression regulatory molecules are the so-called RNA binding proteins, defined as proteins whose function is to bind ribonucleic acids (RNA). (ucla.edu)
  • These proteins participate in gene expression by binding to and regulating messenger RNA (mRNAs), which in turn are translated into proteins. (ucla.edu)
  • For the purpose of this study we selected a set of proteins that were misregulated following silencing of TDP-43 and analysed their expression in a TDP-43-aggregation model cell line HEK293 Flp-in Flag-TDP-43-12x-Q/N F4L. (nature.com)
  • In conclusion, by identifying a common set of proteins that are differentially expressed in a similar manner in these two different conditions, we show that TDP-43 aggregation has a comparable effect to TDP-43 knockdown. (nature.com)
  • Abstract Scaffold proteins are crucial regulators of signaling networks, and their abnormal expression may favor the development of tumors. (techscience.com)
  • 18 DERs and DEDs were identified in the PTM vs. PM, 87 in the TM vs. PTM, and 87 in the TM vs. PM. Those DERs and DEDs participated in the regulation of gene expression at the levels of chromatin conformation, gene activation and silencing, splicing and degradation of mRNA, biogenesis of piRNA and miRNA, ribosome assemble, and translation of proteins. (peerj.com)
  • Through domain-mapping experiments and high throughput characterization of IGF2BP3 binding sites in mRNA, we determined that RNA-binding is necessary for the function of this protein. (ucla.edu)
  • Their function is based on their sequence homology-based binding to and regulation of mRNA targets, thereby modulating gene expression. (ucla.edu)
  • MiRNA usually binds directly to the 3′-untranslated region (3′-UTR) of target gene mRNA through the RNA-induced silencing complex (RISC) [ 15 , 16 ]. (ersjournals.com)
  • Correlation analysis revealed that mRNA TNF receptor associated factor 4 (TRAF4) was associated with DLEU1 expression. (spandidos-publications.com)
  • We have discovered a set of lncRNAs that are differentially regulated in leukemia and particularly in poor-prognosis B-ALL with translocations of the mixed lineage leukemia (MLL) gene. (ucla.edu)
  • This study investigated the role of long non‑coding RNAs (lncRNAs) in glioblastomagenesis progression. (spandidos-publications.com)
  • Further investigation has identified heat shock protein 70 as a direct target of let-7c and has demonstrated that the expression of HSP70 in fibroblasts is negatively correlated with let-7c levels. (molcells.org)
  • Here we used droplet-based single-cell sequencing for multi-omic profiling of PBMCs obtained from female patients and sex-matched healthy individuals and performed multimodal single-cell analyses including single-cell-level unbiased transcriptome, surface protein expression, pseudotemporal trajectory analysis, cell-cell interaction analysis, and T-cell receptor repertoire. (nycu.edu.tw)
  • Gene expression profiling using Affymetrix GeneChip® Human Transcriptome 2.0 array was subsequently carried out in YB-1 silenced MDA-MB-231 cells. (biomedcentral.com)
  • We find that the small RNA transcriptome is altered, even if a gene unrelated to RNAi pathway is targeted. (uni-frankfurt.de)
  • Although more and animals and plants and regulate gene/protein expression more progressions have been made about the through direct complementarity between their 5' region pathogenesis of asthma in recent years, the increasing and the 3' untranslated region of target mRNAs. (cdc.gov)
  • SNHG16-miR-23-3p/miR-103-5p/HAPLN1 and XIST-miR-23-3p/ miR-103-5p/HAPLN1 might regulate the disease progression of HF at the transcriptional level. (researchsquare.com)
  • TDP-43 protein plays an important role in regulating transcriptional repression, RNA metabolism and splicing. (nature.com)
  • Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
  • We reasoned that miR-214 functions in the cyst microenvironment and regulates PKD progression. (baxkyardgardener.com)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • In our lab, we identified that one particular RNA-binding protein, IGF2BP3, was responsible for driving a highly aggressive leukemia, based on patient materials, cell lines, and mouse models. (ucla.edu)
  • BALR-2 knockdown leads to activation of apoptosis pathways through the pro-apoptotic protein BIM. (ucla.edu)
  • Its major distinguishing features are the ability to bind RNA in a very specific manner through two RNA recognition motifs (RRM) and the C-terminal portion of the protein, which includes a glycine-rich domain that is involved in most of the protein interactions described 3 . (nature.com)
  • Liquid biopsy represents a promising alternative to invasive tissue biopsies in particular for cancer diagnosis as it enables the study of cell-free (cf) nucleic acids in the blood, which includes cfDNA and various cfRNAs (e.g., protein-coding, lncRNA, microRNA, etc. (frontiersin.org)
  • This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. (cancerindex.org)
  • Furthermore, pumilio homolog 2 (PUM2), a RNA-binding protein, mediated the packaging of miRNA-130a into exosomes. (dovepress.com)
  • Y-box binding protein-1 is an evolutionary conserved transcription and translation regulating protein that is overexpressed in various human malignancies, including breast cancer. (biomedcentral.com)
  • Silencing the YBX1 gene (which encodes the YB-1 protein) by small interfering RNA (siRNA) was performed in MDA-MB-231 and Hs578T breast cancer cell lines, followed by phenotypic assays including cell migration and invasion assays. (biomedcentral.com)
  • In addition, gene expression and protein levels in GC tissues and cell lines were measured using RT-qPCR and western blotting, respectively. (archivesofmedicalscience.com)
  • They are usually generated from either exons or introns of both protein-coding and non-coding transcripts that are processed by RNA polymerase II (Pol II) [ 12 - 14 ]. (ijbs.com)
  • Next we explored the roles of miR-27a and its target Raf Kinase Inhibitory Protein (RKIP) in regulating cisplatin resistance and metastasis in lung adenocarcinoma. (biomedcentral.com)
  • In recent years, noncoding RNAs (ncRNAs), especially microRNAs, long noncoding RNAs and circular RNAs, have been found to be associated with abnormalities of the ASMCs. (ersjournals.com)
  • Circular RNAs (circRNAs) are noncoding RNAs with a covalently closed loop structure. (techscience.com)
  • The recently discovered novel class of non-coding RNA, termed long non-coding RNA (lncRNA), play important roles in gene expression regulation, development and cancer. (ucla.edu)
  • We have also completed studies of a second long non-coding RNA, CASC15, in B-cell leukemia and B-cell development. (ucla.edu)
  • Notably, the knockdown of HSP70 by HSP70 siRNA apparently abrogates the stimulatory effect of let-7c inhibitor on heat-denatured fibroblasts proliferation and migration. (molcells.org)
  • We developed a generic automated eukaryotic short interfering RNA (siRNA) analysis tool, called RAPID. (uni-frankfurt.de)
  • Our tool captures diverse siRNA characteristics from small RNA sequencing data and provides easily navigable visualisations. (uni-frankfurt.de)
  • We also introduced a normalisation technique to facilitate comparison of multiple siRNA-based gene knockdown studies. (uni-frankfurt.de)
  • In vitro , the sprouting and migratory properties of primary endothelial cell cultures were reduced by inhibiting EZH2 through up-regulation of miR-101, siRNA-mediated knockdown of EZH2, or treatment with 3-Deazaneplanocin-A (DZNep), a small molecule inhibitor of EZH2 methyltransferase activity. (plos.org)
  • Based on our preliminary data, the focus of this proposal is to apply developed high throughput technology (comparative epigenomics and metabolomics) to decipher the primate epigenome and metabolome in the obese maternal environment and then measure the impact of supplementation on the differentially altered epigenome and resultant disease. (nih.gov)
  • Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)
  • RESULTS: We discovered that PFKFB3 expression in tumor tissues was slightly higher than that in tumor adjacent normal tissues but that PFKFB4 expression was significantly higher in the tumor tissues of oral cancer patients. (bvsalud.org)
  • The overexpression and knockdown of PUM2 promoted and inhibited tumor growth of xenograft mice, respectively. (dovepress.com)
  • Cancer-associated fibroblasts (CAFs) have been demonstrated to be essential stromal components in the tumor microenvironment, regulating cancer cell growth, migration, invasion, and chemo-response through various mechanisms. (dovepress.com)
  • Increased miR-27a expression was also detected in tumor tissues sampled from lung adenocarcinoma patients treated with cisplatin-based chemotherapy and was proved to be correlated with low expression of RKIP, decreased sensitivity to cisplatin, and poor prognosis. (biomedcentral.com)
  • MicroRNAs participate in the regulation of asthma, the goal of this study is to summarize recent researches on the roles of microRNAs in the pathogenesis of asthma. (cdc.gov)
  • Most of these paracrine secretions include soluble factors and exosomes, which regulate the repair and regeneration processes at sites of damage by affecting cell proliferation, migration, and differentiation [ 22 , 23 ]. (hindawi.com)
  • Our results demonstrated that the hsa_circ_0017728 expression level was up-regulated in GC tissues and cell lines and closely associated with poor overall survival and pathological differentiation, higher TNM stage and lymph node metastasis. (archivesofmedicalscience.com)
  • MicroRNAs regulate target gene expression post-transcriptionally in a myriad of cell types and play critical roles in diverse physiological and pathological processes, including cardiomyocyte development, differentiation, and regeneration. (biomedcentral.com)
  • To this end, the authors performed miRNA expression profiling in undifferentiated hESCs and CMs at day 8 and day 14 after differentiation. (biomedcentral.com)
  • MicroRNAs not only participate in determining DCs phenotype and then naive T lymphocyte differentiation, but also participate in the regulation of airway inflammation and airway remodeling in asthma. (cdc.gov)
  • The RNAs play important roles in the pathological and physiological tissues including cancer. (peerj.com)
  • The results of the present study indicate that microRNAs play important roles in regulating asthma immune responses. (cdc.gov)
  • High-throughput sequencing was used to determine differentially expressed circRNAs in GC tissues and corresponding non-cancerous tissues. (archivesofmedicalscience.com)
  • RT‑PCR demonstrated that the expression levels of DLEU1 and TRAF4 were increased in GBM tissues. (spandidos-publications.com)
  • For example, lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) is highly expressed in GBM tissues and perturbed expression of NEAT1 suppresses cell proliferation and invasion ( 10 ). (spandidos-publications.com)
  • CircRNAs are predominantly generated in eukaryotes via four cyclized models: back-spliced exons, circular intronic RNAs, exon-intron circRNAs and intergenic circRNAs [ 7 , 8 ]. (archivesofmedicalscience.com)
  • Current work involves, first, understanding the molecular mechanisms that underlie the specificity of binding and downstream effects on gene expression. (ucla.edu)
  • In the present study, we show that let-7c miRNA is decreased in heat-denatured fibroblasts and that inhibiting let-7c expression leads to the increased proliferation and migration of dermal fibroblasts, whereas the overexpression of let-7c exerts an opposite effect. (molcells.org)
  • Knockdown of hsa_circ_0017728 had the ability to cause inhibition of cell proliferation and migration and elevate the cell apoptosis rate in GC cells. (archivesofmedicalscience.com)
  • We have initiated an ambitious research study, using gene expression profiling to characterize the expression of lncRNA in B-lymphoblastic leukemia (B-ALL). (ucla.edu)
  • miR-214, an evolutionarily conserved miRNA, is derived from a long noncoding RNA (lncRNA) called dynamin 3 opposite strand (are upregulated in multiple PKD models. (baxkyardgardener.com)
  • High expression of lncRNA H19 promotes cell migration and enhances angiogenesis ( 11 , 12 ). (spandidos-publications.com)
  • The expression of HOX transcript antisense RNA lncRNA is increased in GBM and is significantly associated with high grade brain tumors ( 13 ). (spandidos-publications.com)
  • LncHERG is an lncRNA that acts as a competing RNA of miR-940. (spandidos-publications.com)
  • MicroRNAs have broad biological functions in cancers and may serve as ideal biomarkers. (nature.com)
  • Previous research showed that scavenger receptor class A member 5 (SCARA5) was one of the potential biomarkers of OSCC, and its expression is significantly low in OSCC. (degruyter.com)
  • The novel innovation and significance resides within its potential to provide (1) an expanded understanding of the mechanism through which a maternal high fat diet reprograms primate gene expression and (2) a simple intervention (essential nutrient supplementation with neither diet nor behavioral modification) with tremendous potential impact given the current obesity epidemic and the lack of efficacious therapeutics. (nih.gov)
  • Objectives: RNA therapeutics is an emerging field that widens the range of treatable targets and would improve disease outcome through bypassing the antibiotic bactericidal targets to kill Mycobacterium tuberculosis (M.tb). (nycu.edu.tw)
  • This review highlights findings concerning noncoding RNAs (ncRNAs) in asthmatic ASMCs so far and proposes a schematic diagram that helps us to better understand how ncRNAs are involved in pathophysiological behavioural changes in asthmatic ASMCs. (ersjournals.com)
  • Many noncoding RNAs (ncRNAs) have been identified in asthmatic ASMCs in recent years [ 5 ]. (ersjournals.com)
  • Moreover, exosomal miRNA-130a was transferred from CAFs to recipient NSCLC cells and knockdown of miRNA-130a reversed the effect of CAFs-derived exosomes during chemoresistance of NSCLC cells. (dovepress.com)
  • Our results suggest that up-regulation of miR-27a could suppress RKIP expression and in turn contribute to chemoresistance of lung adenocarcinoma cells to cisplatin. (biomedcentral.com)
  • Zhang et al cytokines, mediators and signals and closely related to demonstrated that microRNA let-7i was upregulated immune regulation. (cdc.gov)
  • We detected miR-27a expression in two lung adenocarcinoma cell lines, A549 and A549/CDDP, and then investigated the effects of miR-27a on the metastasis and the chemosensitivity of cancer cells, using both gain- and loss-of-function studies. (biomedcentral.com)
  • In this study, the gene expression profile in GBM was analyzed using a microarray dataset and RNA-sequencing (RNA-Seq) datasets. (spandidos-publications.com)
  • We previously showed that VEGF signaling in primary endothelial cell cultures caused overexpression of VEGFR2 in a positive feed-forward loop, which is at least partly regulated by loss of miRNA-mediated control of VEGF receptor degradation. (plos.org)
  • Small interfering RNA-mediated RKIP knockdown revealed similar effects as that of ectopic miR-27a expression, while overexpression of RKIP attenuated the function of miR-27a in lung adenocarcinoma cells. (biomedcentral.com)
  • The samples were analyzed using the technology of RNA-seq and bioinformatics. (peerj.com)
  • MicroRNAs are small non-coding RNA molecules that are critical in physiology and pathology. (ucla.edu)
  • Further, using RAPID, we investigated the aberrations of endo-siRNAs, and their respective transcriptomic alterations caused by an RNAi pathway triggered by feeding small RNAs against a target gene. (uni-frankfurt.de)
  • Small interfering RNA demonstrated that silencing DLEU1 downregulated TRAF4. (spandidos-publications.com)
  • Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
  • We found that lipopolysaccharide and Vibrio anguillarum significantly upregulated the expression of fish miR-21. (frontiersin.org)
  • miR-27a was significantly up-regulated in cisplatin-resistant lung adenocarcinoma A549/CDDP cells compared with parental A549 cells. (biomedcentral.com)
  • The viability of GBM cells was significantly decreased following RNA interference with DLEU1 and TRAF4 production. (spandidos-publications.com)
  • Thus, to maintain a balance between host preservation and inflammatory pathology, the immune response and inflammation need to be tightly regulated. (frontiersin.org)
  • We have recently published a paper on defective marginal zone B-cell development in miR-146a deficient mice, and collaborated on a manuscript that describes roles for miR-146a in regulating T-cell activation. (ucla.edu)
  • Therefore, specific roles of miR159 in rice could be explored by down regulating miR159 through STTM. (biomedcentral.com)
  • In rice, studies on miR159 were either based upon genome-wide expression analyses focused upon responses to different nitrogen forms and abiotic stress or upon phenotypic studies of transgenic plants overexpressing its precursor. (biomedcentral.com)
  • In vitro experiments of transfections with miR-431-3p mimic/miR-1303 short interfering RNA in THP-1 cells under ESAT-6 stimuli showed that miR-431-3p and miR-1303 were capable to augment and suppress autophagy/apoptosis/phagocytosis of macrophage via targeting MDR1/MMP16/RIPOR2 and ATG5, respectively. (nycu.edu.tw)
  • The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treat- ment. (lu.se)
  • Methods: We screened for microRNA with immune-regulatory functions against M.tb by next generation sequencing of peripheral blood mononuclear cells, followed by validation in an independent cohort. (nycu.edu.tw)
  • Wang M, Yu F, Wu W, Wang Y, Ding H, Qian L. Epstein-Barr virus-encoded microRNAs as regulators in host immune responses. (ijbs.com)
  • METHODS: We compared the gene expression levels of PFKFB family members and analyzed their clinical significance in oral cancer patients, whose clinical data were obtained the Cancer Genome Atlas database. (bvsalud.org)
  • High PFKFB3 and PFKFB4 expression had different effects on the prognosis of oral cancer patients with different clinicopathological outcomes. (bvsalud.org)
  • Gene expression is a finely tuned, intricate process that normally regulates cellular identity, and becomes disrupted in cancer. (ucla.edu)
  • In this study, by data mining of the Cancer Genome Atlas database, we screened out 4 differentially-expressed microRNAs (DEmiRNAs) between TNBC and normal samples: miR-135b-5p, miR-9-3p, miR-135b-3p and miR-455-5p. (nature.com)
  • By employing microRNA expression profiling and functional knockdown studies on human embryonic stem cell-derived cardiomyocytes, the authors identified miR-363 as an upstream negative regulator of left ventricular specification transcription factor HAND1 . (biomedcentral.com)
  • Studies of how miR-146a regulates B-cell activation and autoimmunity are future focuses of this area of research in the laboratory. (ucla.edu)
  • By applying multiple filtering strategies, we selected common single-cell blood features across the patients to reveal a unique T-cell state wherein GIMAP7 was up-regulated and NFKBIA was down-regulated. (nycu.edu.tw)
  • Sequencing cell-free RNA derived from liquid biopsies has been very promising for the diagnosis of several diseases. (frontiersin.org)
  • Our study thus demonstrates the feasibility of performing gene co-expression network analysis from cell-free RNA data and its utility in studying hepatocellular carcinoma. (frontiersin.org)
  • To date, many studies have focused on WGCNA analysis of bulk or single-cell RNA (scRNA) sequencing data from tissue samples. (frontiersin.org)
  • Identification of PARD3 signature on PARD3 deficient H157 cell line, reconstituting the expression of PARD3 gene, with a wt and a mutant form. (nih.gov)
  • It would appear that YB-1 could regulate cell invasion and migration via downregulation of its indirect target coronin-1C. (biomedcentral.com)
  • In addition, SCARA5 repressed OSCC cell epithelial-mesenchymal transformation (EMT), evidenced by increased E-cadherin expression and reduced N-cadherin expression. (degruyter.com)
  • Our data suggests that in rice, miR159 positively regulates organ size, including stem, leaf, and grain size due to the promotion of cell division. (biomedcentral.com)