The adenosine A2B receptor, also known as ADORA2B, is a G-protein coupled adenosine receptor, and also denotes the human adenosine A2b receptor gene which encodes it. (wikipedia.org)
S1P(1R)-specific siRNA (S1P(1R) siRNA) reduced expression of S1P(1R) mRNA and protein, whereas scramble siRNA (SC siRNA) had no effect. (bvsalud.org)
Receptor16
The adenosine A2B receptor, also known as ADORA2B, is a G-protein coupled adenosine receptor, and also denotes the human adenosine A2b receptor gene which encodes it. (wikipedia.org)
Research into selective A2B ligands has lagged somewhat behind the development of ligands for the other three adenosine receptor subtypes, but a number of A2B-selective compounds have now been developed, and research into their potential therapeutic applications is ongoing. (wikipedia.org)
BAY 60-6583 NECA (N-ethylcarboxamidoadenosine) (S)-PHPNECA - high affinity and efficacy at A2B, but poor selectivity over other adenosine receptor subtypes LUF-5835 LUF-5845 - partial agonist Compound 38: antagonist, high affinity and good subtype selectivity ISAM-R56A: non-xanthinic high affinity selective antagonist (Ki: 1.50 nM) ISAM-140: non-xanthinic selective antagonist (Ki = 3.49 nM). (wikipedia.org)
1. Modulation of insulin release by adenosine A1 receptor agonists and antagonists in INS-1 cells: the possible contribution of 86Rb+ efflux and 45Ca2+ uptake. (nih.gov)
2. A1 and A2 adenosine receptor activation inhibits and stimulates renin secretion of rat renal cortical slices. (nih.gov)
4. A1 and A2 adenosine receptor modulation of contractility in the cauda epididymis of the guinea-pig. (nih.gov)
6. Adenosine A2A receptor agonists inhibit lipopolysaccharide-induced production of tumor necrosis factor-alpha by equine monocytes. (nih.gov)
7. Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes. (nih.gov)
10. K(ATP)-channel activation: effects on myocardial recovery from ischaemia and role in the cardioprotective response to adenosine A1-receptor stimulation. (nih.gov)
12. Adenosine A1 but not A2a receptor agonist reduces hyperalgesia caused by a surgical incision in rats: a pertussis toxin-sensitive G protein-dependent process. (nih.gov)
14. Repeated administration of selective adenosine A1 and A2 receptor agonists in the spontaneously hypertensive rat: tolerance develops to A1-mediated hemodynamic effects. (nih.gov)
15. Theophylline inhibits the differentiation of human monocyte into dendritic cell potentially via adenosine receptor antagonism. (nih.gov)
11. Adenosine receptors involved in modulation of noradrenaline release in isolated rat tail artery. (nih.gov)
13. Identification of A1 and A2 adenosine receptors in the rat spinal cord. (nih.gov)
17. Neutrophil adherence to endothelium is enhanced via adenosine A1 receptors and inhibited via adenosine A2 receptors. (nih.gov)
Purine1
Recent studies have built upon decades of evidence that adenosine, a purine nucleoside that can act as a neuromodulator, is involved in pain transmission and sensitization. (mdpi.com)