Enzyme11beta-hydroxysteroiGlucocorticoidSteroid dehydrogenaseTypeInhibitorIsomeraseCorticosterone2017MitochondrialInactivationProgesteroneTissue-specificCortisolGenesVitroProtein expressionAKR1C1HepaticInhibitorsSignificantly reducedAntibodiesSyndromeMaturationProteinsInvolve0.05HumanAdipose tissueBrainHumansActivityMiceLevelsMales and femalesGene expression profilesFamilyCDNACholesterolPatternsStudyResultsCellsSpecificDifferencesCellFemale
Enzyme12
- 11β-Hydroxysteroid dehydrogenase type 1, also known as cortisone reductase, is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system. (wikipedia.org)
- Consistent with increase in serum T, piperine increased Leydig cell number, cell size, and multiple steroidogenic pathway proteins, including steroidogenic acute regulatory protein, cholesterol side-chain cleavage enzyme, 3β-hydroxysteroid dehydrogenase 1, 17α-hydroxylase/20-lyase, and steroidogenic factor 1 expression levels. (frontiersin.org)
- Piperine in vitro also increased androgen production and stimulated cholesterol side-chain cleavage enzyme and 17α-hydroxylase/20-lyase activities in immature Leydig cells. (frontiersin.org)
- 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a key enzyme that transform cortisone to cortisol, which activates the endogenous glucocorticoid function. (ijbs.com)
- Expression of steroidogenic enzymes, including steroidogenic acute regulatory protein, cholesterol side chain cleavage enzyme, and 3β-hydroxysteroid dehydrogenase type 1 messenger RNA, were examined by real-time polymerase chain reaction after 6 h of human chorionic gonadotropin treatment. (utoledo.edu)
- Expressions of phospho-ribosomal protein S6 kinase and cholesterol side chain cleavage enzyme were analyzed after 15 min and 24 h of human chorionic gonadotropin treatment, respectively. (utoledo.edu)
- Treatment with human chorionic gonadotropin increased the expression of downstream targets of mammalian target of rapamycin complex 1, as well as cholesterol side chain cleavage enzyme, 3β-hydroxysteroid dehydrogenase type 1 and steroidogenic acute regulatory protein messenger RNAs. (utoledo.edu)
- The neuroactive progestogen allopregnanolone (also known as 3,5-tetrahydroprogesterone or 3-hydroxy-5-pregnan-20-one) is synthesized from progesterone by isozymes on the enzyme 5alpha-reductase (5-reductase) and by the enzyme 3alpha-hydroxysteroid dehydrogenase (3-HSD). (deubiquitinaseinhibitor.com)
- Arterial hypertension is a major health problem affecting 1.13 billion people worldwide, of which 10% could be due to endocrine pathologies related to the mineralocorticoid receptor (MR) (i.e. primary aldosteronism, 11β-hydroxysteroid dehydrogenase type 2 enzyme (HSD11B2) deficiency). (endocrine-abstracts.org)
- Comment: Microsomal enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11-beta-HSD-1) required for cortisone conversion to its active metabolite, cortisol, in hepatic and adipose tissue. (sideload.com)
- To address the second, we investigated RNAs bound by the metabolic enzyme hydroxysteroid dehydrogenase 17-β 10 (HSD17B10). (nature.com)
- G6P availability directly modulates the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1), an ER-bound enzyme playing a key role in the development of the metabolic syndrome (MS). (biomedcentral.com)
11beta-hydroxysteroi6
- Anti-inflammatory effect of a selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitor via the stimulation of heme oxygenase-1 in LPS-activated mice and J774.1 murine macrophages. (ac.ir)
- 5. Itoi S, Terao M, Murota H, Katayama I. 11beta-Hydroxysteroid dehydrogenase 1 contributes to the pro-inflammatory response of keratinocytes. (ac.ir)
- Anti-inflammatory effects of levalbuterol-induced 11beta-hydroxysteroid dehydrogenase type 1 activity in airway epithelial cells. (ac.ir)
- Carbenoxolone prevents chemical eye ischemia-reperfusion-induced cell death via 11beta-hydroxysteroid dehydrogenase type 1 inhibition. (ac.ir)
- 11. Chapman KE, Coutinho AE, Zhang Z, Kipari T, Savill JS, Seckl JR. Changing glucocorticoid action: 11beta-hydroxysteroid dehydrogenase type 1 in acute and chronic inflammation. (ac.ir)
- Differential modulation of 3T3-L1 adipogenesis mediated by 11beta-hydroxysteroid dehydrogenase-1 levels. (bu.edu)
Glucocorticoid3
- Methods: Glucocorticoid production in H295R cells and cortisol inactivation by 11-hydroxysteroid dehydrogenase (11HSD) in CHO-K1 cells were assayed in the presence of Rooibos. (cput.ac.za)
- At the cellular level, the actions of glucocorticoids are mediated by a 94-kd protein, the glucocorticoid receptor (GR). The human (h) GR belongs to the steroid/thyroid/retinoic acid superfamily of nuclear receptors and functions as a ligand-dependent transcription factor that regulates the expression of glucocorticoid-responsive genes positively or negatively. (medscape.com)
- 7. Chapman K, Holmes M, Seckl J. 11beta-hydroxysteroid dehydrogenases: Intracellular gate-keepers of tissue glucocorticoid action. (ac.ir)
Steroid dehydrogenase2
- Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor and steroid dehydrogenase activity. (nih.gov)
- CHILD syndrome is inherited in an X-linked dominant fashion and involves a mutation in the NSDHL (NAD[P]H steroid dehydrogenase-like protein) gene. (medscape.com)
Type8
- Salicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and hence may explain why aspirin improves glycemic control in type 2 diabetes. (wikipedia.org)
- The GOIs are 17β-hydroxysteroid dehydrogenases type 14 (17β HSD14) and type 12 (17β HSD12), Niemann-Pick C type 2 (NPC2), Equistatin (EI), Complement component C3 (C3), Cathepsin L (CTSL), Patched domain-containing protein 3 (PTCH3), Smoothened (SMO), Desert Hedgehog (DHH), Zinc finger protein GLI2 (GLI2), and Vitellogenin (VTG). (sciencegate.app)
- 17beta-hydroxysteroid dehydrogenase Type 1, and not Type 12, is a target for endocrine therapy of hormone-dependent breast cancer. (ox.ac.uk)
- 17beta-HSD1 and 17beta-HSD12 mRNA and protein expression, and E2 production, were assayed in wild type breast cancer cell lines and in cells after siRNA and cDNA transfection. (ox.ac.uk)
- Expression levels of mRNA for neurosteroidogenic enzymes 17β-HSD, 5α-reductase, 3α-HSD and cytochrome P450 aromatase in the fetal wild type and SF-1 knockout mouse brain. (arnes.si)
- 6 observed that 17-β-hydroxysteroid dehydrogenase type 2 (17β-HSD2), the activity of which transforms oestradiol to less potent oestrogen (oestrone) and is stimulated by progesterone in endometrial glands, was significantly reduced in endometriotic tissue during the luteal phase, along with markedly repressed levels of immunoprecipitable PGR throughout the menstrual cycle. (emjreviews.com)
- However, the role of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which catalyzes the conversion of inactive cortisone into active cortisol, in inflammation remains unclear. (ac.ir)
- Recently developed unbiased high content techniques to identify RBPs in vivo yielded information on differences in cell type-specific expression and/or RNA-binding activity of RBPs in mammalian cells 2 , 3 . (nature.com)
Inhibitor2
- Cells were cultured for 72 h and treated with human chorionic gonadotropin (50 ng/ml) for different time periods with or without pretreatment with mammalian target of rapamycin complex 1 inhibitor, rapamycin, (20 nM) for 1 h. (utoledo.edu)
- Elevated levels of 11β-HSD1 contributed to the expression of inflammatory cytokines, whereas BVT.2733, a selective 11β-HSD1 inhibitor, ameliorated inflammatory responses, ROS, and mitochondrial damage in LPS-stimulated THP-1 cells. (ac.ir)
Isomerase1
- The enzymatic defects causing female virilization involve 3β-hydroxysteroid dehydrogenase Δ5-Δ4 isomerase (3β-HSD), P 450 C21 hydroxylase (21-OH), and P 450 C11 hydroxylase (11-OH). (health.am)
Corticosterone1
- Corticosterone suppresses IL-1beta-induced mPGE2 expression through regulation of the 11beta-HSD1 bioactivity of synovial fibroblasts in vitro. (ac.ir)
20171
- The following information was first published in Current Psychiatry , published September 2017, Vol. 16, No. 9, p. 20-28. (womensmentalhealth.org)
Mitochondrial1
- Analyses of the mitochondrial hydroxysteroid dehydrogenase (HSD17B10) uncover the RNA-binding specificity of an enigmRBP. (nature.com)
Inactivation1
- 17beta-hydroxysteroid dehydrogenases (17beta-HSDs) catalyse the pre-receptor activation/inactivation of hormones and other substrates. (ox.ac.uk)
Progesterone1
- Progesterone resistance due to suppressed progesterone receptor (PGR) expression and action is a general feature of endometriosis and is a cause of endometriosis-associated chronic pelvic pain, infertility, inflammatory disorders, and cancer. (emjreviews.com)
Tissue-specific1
- AKRs are tissue-specific hydroxysteroid dehydrogenases that interconvert weak steroid hormones to their more potent counterparts and regulate processes involved in development, homeostasis and reproduction. (biomedcentral.com)
Cortisol2
- Furthermore, cortisone and cortisol, which are the substrate and product of 11β-HSD1, respectively, showed biphasic responses and induced the expression of pro-inflammatory cytokines at a low concentration in both LPS-stimulated or untreated THP-1 cells. (ac.ir)
- The results of previous studies on the associations between elevated maternal cortisol, fetal growth, and gestational age at birth were inconsistent [7, 20-23]. (researchsquare.com)
Genes7
- Because we showed that integration neither affects the levels of viral genes, nor those of virally disrupted human genes, a genome-wide screen was performed to identify human genes which expression is influenced by viral integration and have clinical relevance. (cancerindex.org)
- Obese women showed a significantly higher expression of genes of the backdoor pathway and of CYP19 in visceral AT. (sciencegate.app)
- Therefore, towards this final end, we looked into the appearance of web host HDAC1 and its own function in chromatin modulation of web host protection genes and parasite success post-infection of macrophages with Bob (LdBob/stress/MHOM/SD/62/1SCL2D) [20, 21] obtained from Dr initially. (palomid529.com)
- It upregulated the declined level of serum testosterone and the expression of steroidogenic genes such as CYP11A1 and 17β3-HSD with an obvious histologic improvement of the testes with re-establishment of the normal spermatogenic series, Sertoli and Leydig cells. (biomedcentral.com)
- These duplicated genes maintain a high degree of sequence similarity, but differ greatly in their substrate specificity and tissue expression patterns. (biomedcentral.com)
- We sought to explore the expression of genes associated with depressive disorder in patients with depression compared to control patients. (omjournal.org)
- The independent t -test was used to check the significance of difference between the expression levels of target genes where the control was set at a reference level of 1.0. (omjournal.org)
Vitro1
- In vitro experiments showed the endogenous high expression of 11β-HSD1 lead to osteoclast formation and maturation. (ijbs.com)
Protein expression5
- Scope includes mutations and abnormal protein expression. (cancerindex.org)
- Gene and protein expression of reductases were determined using quantitative real-time polymerase chain reaction and Western blotting, respectively. (aspetjournals.org)
- Gene and protein expression of steroidogenic enzymes were determined. (sciencegate.app)
- The protein expression of IL-1β in cell supernatants was detected via ELISA. (ac.ir)
- After 48 hours of intervention under different experimental conditions, flow cytometry was used to measure the apoptosis of MPC5 cells, and quantitative real-time PCR and Western blot were used to measure the mRNA and protein expression of slit diaphragm-related proteins (nephrin, CD2AP, and synaptopodin) and the cytoskeleton-related protein transient receptor potential cation channel 6 (TRPC6). (zgddek.com)
AKR1C11
- Upregulation of AKR1C1 and AKR1C3 expression in OPSCC with integrated HPV16 and HPV-negative tumors is an indicator of poor prognosis. (cancerindex.org)
Hepatic3
- Chronic kidney disease (CKD) affects the nonrenal clearance of drugs by modulating the functional expression of hepatic drug-metabolizing enzymes and transporters. (aspetjournals.org)
- Collectively, these results suggest that the functional expression of hepatic reductases is selectively decreased in kidney disease. (aspetjournals.org)
- Conversely, 11β-HSD1 null mice exhibit a protective glycemic, lipid, and lipoprotein profile and show increased expression of hepatic mRNAs encoding regulators of fatty acid beta-oxidation. (biomedcentral.com)
Inhibitors1
- green tea is a complex mixture of various phenolics with contents varying with production and processing, and some of the phenolics are known HDAC inhibitors that alter genetic expression. (wikipedia.org)
Significantly reduced1
- have published their research findings on β-sitosterol wherein a 6-month administration of 20 mg of the compound significantly reduced the prostate size, increased the urine flow rate, and improved the mean voiding time and quality of life score in BPH patients. (thepeopleschemist.com)
Antibodies1
- d ) Validation of the yeast mRNA interactome using western blotting of input samples and eluate after interactome capture with specific antibodies (ADH1, alcohol dehydrogenase 1, PUB1) or against TAP-tagged proteins (PGK1, phosphoglycerate kinase 1, TDH1, triose phosphate dehydrogenase, TRX2, thioredoxine 2, SHE2, Swi5p-dependent HO Expression 2). (nature.com)
Syndrome1
- Exclusive expression of MeCP2 in the nervous system distinguishes between brain and peripheral Rett syndrome-like phenotypes. (cobblab.science)
Maturation1
- In the granulosa cells, under the action of 20β-hydroxysteroid dehydrogenase (20β-HSD), 17α-HP is converted to 17α, 20β-dihydroxyprogesterone (DHP), the maturation inducing hormone (MIH) in cyprinids, such as zebrafish and goldfish. (biomedcentral.com)
Proteins1
- Results MPC5 cells transfected by pEX-HBx had the highest expression of HBx mRNA at 48 hours after transfection (P P P P Conclusions INF-α can inhibit the apoptosis of podocytes induced by HBx, possibly through improving the abnormal expression of slit diaphragm-related proteins (CD2AP, nephrin, and synaptopodin) and cytoskeleton-related protein (TRPC6) induced by HBx. (zgddek.com)
Involve1
- The mechanisms involve both direct effects on target gene expression in the insulin signaling pathway and the alteration of other key transcriptional regulators of lipid homeostasis [ 4 ]. (biomedcentral.com)
0.051
- Cells inoculated into ovariectomised nude mice were stimulated using 0.05 or 0.1 microg E1 (s.c.) daily, and on day 35 the mice were dosed additionally with 20 mg/kg STX1040 s.c. daily for 28 days. (ox.ac.uk)
Human2
- The human gene for 11 beta-hydroxysteroid dehydrogenase. (wikipedia.org)
- mRNA expression signatures of human skeletal muscle atrophy identify a natural compound that increases muscle mass. (bodybuilding.com)
Adipose tissue1
- The objective of the present study was to investigate the association between the PPAR gamma expression in adipose tissue and intake of hydrogenated and non-hydrogenated vegetable oils and butter. (endocrine-abstracts.org)
Brain1
- In this study we examined whole-brain sex-biased gene expression through RNA-sequencing across four strains of zebrafish. (biomedcentral.com)
Humans1
- Recent studies in humans and rodents suggest a role of 11β-hydroxysteroid dehydrogenase (11β-HSD) in the development of idiopathic obesity and MS [ 2 ]. (biomedcentral.com)
Activity1
- On the other hand, PGR expression and activity in target cells is significantly dysregulated in both eutopic and ectopic tissues compared with control endometrium. (emjreviews.com)
Mice1
- In this study, we observed increased 11β-HSD1 expression in osteoclasts within an osteoporotic mice model (ovariectomized mice). (ijbs.com)
Levels2
- On the other hand, TGF-beta1 had no effect on mPR-alpha mRNA expression and increased FSHR mRNA levels. (biomedcentral.com)
- the expression levels of protein associated with apoptosis and endoplasmic reticulum stress (ERS) of SKO-007 cells in various groups were detected by Western blotting method. (researchgate.net)
Males and females1
- Other traits show sex bias in which they are displayed by both males and females but on average show higher expression in one sex (e.g. some behaviors, context-dependent hormone and gene regulation). (biomedcentral.com)
Gene expression profiles2
- Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
- However, sex differences in gene expression profiles in the brains of vertebrates are only beginning to be understood. (biomedcentral.com)
Family1
- It belongs to the family of short-chain dehydrogenases. (wikipedia.org)
CDNA1
- The hGR cDNA was isolated by expression cloning in 1985. (medscape.com)
Cholesterol2
- C3 expression can differentiate between exposures to BP-3 versus BBP as well as exposure to cholesterol versus sex hormones. (sciencegate.app)
- Researchers also noted decreases in fat mass, fasting blood glucose, plasma cholesterol and triglycerides, not to mention a decrease in atrophy-associated (muscle-wasting) skeletal muscle mRNA expression. (bodybuilding.com)
Patterns1
- 2014a), but females are expected to show comparable expression and colocalization patterns. (deubiquitinaseinhibitor.com)
Study1
- LVVB: study conception, nivel especializado en la atención de la mujer. (bvsalud.org)
Results1
- RESULTS: Twenty-nine thousand and seven consultations (0.81% of all consultations, 95% confidence interval [CI], 0.76-0.86) prescribed CVTA in 14,148 (1.36%) dogs. (bvsalud.org)
Cells1
- Series (Spanish-South American registry) comprised 25 patients,4 5 however, only the compound to break through cells were cotransfected with increasing concentrations of an expression vector for SRC-1 in the presence or absence of REA as indicated. (sideload.com)
Specific1
- PCR using primers specific for 20beta-hydroxysteroid dehydrogenase (20beta-HSD) which is involved in DHP production, follicle stimulating hormone receptor (FSHR), luteinizing hormone receptor (LHR), the two forms of membrane progestin receptor: mPR-alpha and mPR-beta, as well as GAPDH (control), were performed. (biomedcentral.com)
Differences1
- Despite differences in morphology, physiology, and behavior, there is limited sex-biased neural gene expression in zebrafish. (biomedcentral.com)
Cell1
- Administration of POS extract reversed the ACR-induced epididymides weight loss with improved semen quality and count, ameliorated the ACR-decreased testicular lesion scoring, testicular oxidative stress, testicular degeneration, Leydig cell apoptosis and the dysregulated PCNA and Caspase-3 expression in a dose-dependent manner. (biomedcentral.com)
Female1
- In the XX newborn, gonads are not palpable, which classically leads to the diagnosis of female pseudohermaphroditism. (health.am)