Expressed in fetal and adult brain mrna and protein fetal proteins. Medical search. Frequent questions

In H. sapiens, THAP3 gene is expressed ubiquitously throughout different tissues, and expression is greatest in the kidneys. (wikipedia.org)
It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. (thermofisher.com)
Analysis of human gut fetal tissues with a KIAA0586 mutation showed strikingly similar findings compared to the animal models demonstrating conservation of TALPID3 and its necessary role in human GI tract development and patterning. (bvsalud.org)
We report here the expression of this gene in tissues, particularly in different parts of the brain. (nih.gov)
They are also involved in the repair of adult tissues after injury and may mediate the cross-talk between different cell types in the brain. (biopsychiatry.com)
ZNF804A is highly expressed in brain tissues. (biomedcentral.com)
Its clinical presentation clearly differs from other forms of GSD, because it is caused by the deficiency of the lysosomal enzyme, alpha-1,4-glucosidase, leading to the pathologic accumulation of normally structured glycogen within the lysosomes of most tissues, differs Three forms of the disease exist: infantile-onset, late-onset juvenile and adult onset. (medscape.com)
The study examined the expression of Neuroglobin (Ngb) and Hypoxia-inducible factor-1α (Hif-1α) in adult and young yak brain tissues, and provided researchers with meaningful insight into the anatomy, physiology, and biochemistry of this mammal. (scielo.br)
0.05) expressed in the cerebellar cortex, piriform lobe, medulla, and corpus callosum of the adult yak while in the young yak brain tissues, the protein expressions were significantly found in the white matter of the cerebellum, pineal gland, corpus callosum, and cerebellar cortex. (scielo.br)
The findings documented that Ngb and Hif-1α are commonly expressed in various adult and young yak brain tissues. (scielo.br)
Multiple roles in the brain tissues of the adult and young yaks are involved in the expression and distribution and are proposed to play a significant role in the adaptation of the yak to the high altitude environment. (scielo.br)
This study provides meaningful data to understand the adaptive mechanism to hypoxia and recommended researchers to expand on the adaptive mechanism and brain tissues that are not recorded. (scielo.br)
Using immunohistochemistry, we observed HOXD9 protein expression in human brain tumor tissues, including astrocytomas and glioblastomas. (123dok.net)
Here, we used microarray analysis to profile the previously annotated lncRNAs and mRNAs expressed in various mouse tissues, including testis. (biomedcentral.com)
By comparing the lncRNA and mRNA expression profiles among the tissues, we identified lncRNAs and mRNAs that showed differential expression in each tissue. (biomedcentral.com)
The ECS, which is sensitive to phytocannabinoids, plays a fundamental physiological role in the brain and peripheral tissues, as well as in many pathological conditions [ 14 ]. (biomedcentral.com)

2) lilli mutation strongly suppresses the rough eye phenotype of ectopically expressed phyllopod (Tang, 2001), and (3) lilli was identified in a screen for genes that enhance the embryonic lethal phenotype of dpp alleles (Su, 2001). (sdbonline.org)
They have potent effects during embryonic, fetal and child development, and can modify the size and structure of particular brain regions. (biopsychiatry.com)
ABSTRACT Teleost eggs contain an abundant store of maternal thyroid hormones (THs) and early in zebrafish embryonic development all the genes necessary for TH signalling are expressed. (pharmaceuticalintelligence.com)

These results suggest that polycystin's major role is in the maintenance of renal epithelial differentiation and organization from early fetal life. (ox.ac.uk)

The secretion of inflammatory factors as well as the marker proteins in the mitogen-activated protein kinase (MAPK) pathway were detected by Western blot. (frontiersin.org)

Nanos1A was strongly expressed in brain and also localized in all germ cell types in the polarized testis. (nature.com)
We performed microarray analysis of transcripts from mouse brain, heart, kidney, liver and testis. (biomedcentral.com)
Genomic analysis identified 250 protein-coding genes located near (≤ 10 kb) 194 of the loci encoding testis-specific lincRNAs. (biomedcentral.com)
Analysis of male germ cell-related cell lines (F9, GC-1 and GC-2) revealed that some of the testis-specific lncRNAs were expressed in each of these cell lines. (biomedcentral.com)
Our results revealed that all of them were expressed exclusively in the testis, and 23 of the 26 showed germ cell-specific expression. (biomedcentral.com)
However, although numerous studies have investigated the protein-coding genes that show tissue-specific expression and play important roles during spermatogenesis, no previous study has comprehensively identified and characterized the mouse testis-specific lncRNAs. (biomedcentral.com)
Cannabis action is mediated by the endocannabinoid system (ECS), which expression is well established in the brain but unknown in the developing testis. (biomedcentral.com)
The fetal testis, whose endocrine function orchestrates the masculinization of many distant organs, is particularly sensitive to disruption by xenobiotics. (biomedcentral.com)
In this context, we aimed to determine whether cannabis exposure has the potential to directly impact the human fetal testis. (biomedcentral.com)
We determined the expression of components of the ECS in the human fetal testis from 6 to 17 developmental weeks and assessed the direct effects of phytocannabinoids Δ9-trans-tetrahydrocannabinol (THC) and cannabidiol (CBD) on the testis morphology and cell functions ex vivo. (biomedcentral.com)
We demonstrate the presence in the human fetal testis of two key endocannabinoids, 2-arachidonylglycerol (2-AG) and to a lower level anandamide (AEA), as well as a range of enzymes and receptors for the ECS. (biomedcentral.com)
Transcriptomic analysis on 72 h-exposed fetal testis explants revealed 187 differentially expressed genes (DEGs), including genes involved in steroid synthesis and toxic substance response. (biomedcentral.com)
Our study is the first to evidence the presence of the ECS in the human fetal testis and to highlight the potential adverse effect of cannabis consumption by pregnant women onto the development of the male gonad. (biomedcentral.com)

In vertebrate brains, GABA A receptors are the principal mediators of inhibitory synaptic transmission. (jneurosci.org)
All vertebrate brains contain a hypothalamus. (cloudfront.net)

Neoepitope antibodies distinguish smaller cleaved fragments or processed forms of proteins versus the intact full-length or precursor by using a designed peptide purification process to maximize immunoreactivity to a specific cleavage site. (thermofisher.com)
Expression of the PKD1 protein, polycystin, was assessed in kidney using monoclonal antibodies to a recombinant protein containing the C terminus of the molecule. (ox.ac.uk)
But a disadvantage is that those who have been exposed to natural forms of the adenovirus have antibodies to the virus that will likely block the synthesis of the spike protein, and therefore not afford protection against SARS-CoV-2. (theepochtimes.com)
Just as in the case of antibiotic resistance, new strains evolve within an infected immune-compromised person's body that produce a version of the spike protein that no longer binds with the acquired antibodies. (theepochtimes.com)
At the time, Mikovits warned that fertility rates may drop thanks to the SARS-CoV-2 spike protein creating antibodies that attack syncytium, and indeed, we're now starting to see that. (fromthetrenchesworldreport.com)

The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. (thermofisher.com)
Almost half of the genes expressed in adults showed reduced expression, supporting a broad role for the three tested genes in steady-state transcript abundance. (sdbonline.org)
PTP- NP-2 mRNA expression is highly restricted, with a 5.5-kb specific transcript in human fetal and adult brain and 5.5 and 3. (wikigenes.org)

Expression of nucleoside diphosphate kinase, mitochondria-associated adenylate kinase, and several mitochondria-associated creatine kinase isozymes was highest in the outer retina, whereas expression of cytosolic adenylate kinase and brain creatine kinase was higher in the cones, horizontal cells, and amacrine cells indicating the diversity of ATP-buffering strategies among retinal neurons. (molvis.org)
ZNF804A is localized in the cytoplasm and neurites in the human cortex and is expressed in various types of neurons, including pyramidal, dopaminergic, GABAergic, and Purkinje neurons in mouse brain. (biomedcentral.com)
Epilepsy is a common neurological disorder, featuring an enduring predisposition to epileptic seizures due to hyperexcitability and hypersynchrony in brain neurons (Devinsky et al. (frontiersin.org)

In the adult brain, the lack of these proteins can induce apoptotic neuronal death (7, 8). (sld.cu)
Smac/Diablo is a recently identified protein that is released from mitochondria after apoptotic stimuli. (biomedcentral.com)
In view of the possible role of Smac in cervical carcinogenesis and its potential as a therapeutic target, we have investigated the expression of this apoptotic protein in cervical cancer patients. (biomedcentral.com)
Many studies have documented differences between childhood and adult medulloblastomas in terms of location, proliferation, and apoptotic indices. (surgicalneurologyint.com)

Scholars@Duke publication: Selection of a subset of mRNAs from combinatorial 3' untranslated region libraries using neuronal RNA-binding protein Hel-N1. (duke.edu)
As a means to identify cellular RNA targets for these proteins, we devised combinatorial shape libraries representing naturally derived 3' untranslated regions and were able to select a structurally related subset of transcripts that bound to Hel-N1. (duke.edu)
Approximately 10% of the proteins encoded by these subset mRNAs were identifiable in the data bases and most are implicated in cell growth regulation. (duke.edu)
Thus, transcriptional profiles suggest that Lilliputian and Suppressor of Triplolethal are obligatory cofactors in the adult and that they can also function with Cyclin-dependent kinase 9 at a subset of loci. (sdbonline.org)
Smac is expressed de novo in a subset of cervical cancer patients, reflecting a possible heterogeneity in the pathways leading to cervical cancer. (biomedcentral.com)

They can bind to the 3′ untranslated region (3′UTR) of target messenger RNAs (mRNAs) in order to regulate gene expression post-transcriptionally with no sequence specificity but by potential electrostatic interactions with the phosphate backbone of RNA 2 , 3 . (nature.com)

Fixed-frozen retinas from adult C57BL/6N mice were used for immunohistochemistry, laser scanning confocal microscopy, and enzymatic histochemistry. (molvis.org)
Interestingly, polycystin expression, monitored at the mRNA level and by immunohistochemistry, appears higher in cystic epithelia, indicating that the disease does not result from complete loss of the protein. (ox.ac.uk)

To determine the factors mediating these phenotypes, interestingly, three binding proteins of ZNF804A, galectin 1 (LGALS1), fasciculation and elongation protein zeta 1 (FEZ1) and ribosomal protein SA (RPSA), show different effects on reversing the deficits. (biomedcentral.com)

In addition, FACL4 was highly expressed in both adult and newborn mouse brain especially in the granule cells of the dentate gyrus and the pyramidal cell layer of CA1 in hippocampus, and the granular cell layer and Purkinje cells of the cerebellum. (nih.gov)
The HOXD9 gene was highly expressed in a side population (SP) of SK-MG-1 cells that was previously identified as an enriched-cell fraction of glioma cancer stem-like cells. (123dok.net)

THAP3 mRNA is 1.3x. more abundant in H. sapiens fetal brain tissue than in H. sapiens adult kidney tissue. (wikipedia.org)
We have studied PKD1 mRNA, with an RNase protection assay, and found widespread expression in adult tissue, with high levels in brain and moderate signal in kidney. (ox.ac.uk)
The study relied on microarray analysis of 32 post-mortem brain samples - the microarray method can simultaneously measure the level of activity of tens of thousands of genes that are functional in a given tissue. (biopsychiatry.com)
Bone marrow stromal cells (BMSC) are multipotent stem cells and are considered good candidates for cell restoration in injured brain tissue. (sld.cu)
Smac mRNA expression was below the detection limit in the normal cervical tissue samples. (biomedcentral.com)
Critically, in these conditions, the underlying retinal tissue, including the cells that give rise to the optic nerves that convey the sight-information to the brain, remain intact. (thenakedscientists.com)

In addition, Nanos1B protein was predominantly located in the nuclei of male germinal cells. (nature.com)

These turned out to be mRNAs for four different FGF molecules and two receptors that bind to FGF and are key to their function. (biopsychiatry.com)
Neonatal exposure to a Type-I pyrethroid (bioallethrin) induces dose-response changes in brain muscarinic receptors and behaviour in neonatal and adult mice. (cdc.gov)

Similarly the effect of expressing a dominant negative Cyclin-dependent kinase 9 allele was analyzed. (sdbonline.org)

Hel-N1, a human RNA-binding protein, shares significant homology with Drosophila protein ELAV, which is essential for fly neuronal development. (duke.edu)
Multiple elongation complexes exist, but the role of specific components in adult Drosophila is underexplored. (sdbonline.org)

Mutations in the gene encoding the neuronal transmembrane protein stargazin bring about recessively inherited epilepsy and ataxia in "stargazer" mice. (healthcarecoremeasures.com)

This approach provides a means to gain access to novel genes expressed in various cell types by partitioning mRNAs containing common sequence elements using RNA-binding proteins. (duke.edu)

H. sapiens THAP3 interacts with proteins involved in various cellular processes, like transcription regulation and neuronal development. (wikipedia.org)
Our previous interactomic study revealed that ZNF804A interacts with multiple proteins to control protein translation and neural development. (biomedcentral.com)

THAP domain-containing protein 3 (THAP3) is a protein that, in Homo sapiens (humans), is encoded by the THAP3 gene. (wikipedia.org)

Polycystin, the polycystic kidney disease 1 protein, is expressed by epithelial cells in fetal, adult, and polycystic kidney. (ox.ac.uk)
In fetal and adult kidney, staining is restricted to epithelial cells. (ox.ac.uk)

Two (the Moderna vaccine and the Pfizer/BioNTech vaccine) are based on mRNA technology, whereas the other two (produced by Johnson & Johnson and AstraZeneca) are based on a double-stranded DNA recombinant viral vector. (theepochtimes.com)
Hansen (26) showed that coexpression of γ6 significantly decreased currents through recombinant T-type Ca2+ channels (CaV3.1) in HEK-293 cells and native T-type Ca2+ channels in atrial HL-1 cells and that this effect did not accompany any decrease in the level of CaV3.1 mRNA or protein. (healthcarecoremeasures.com)

Absence of maternal THs did not affect early specification of the neural epithelia but profoundly modified later dorsal specification of the brain and spinal cord as well as specific neuron differentiation. (pharmaceuticalintelligence.com)

20 weeks) and adult kidney, strong staining persists in cortical tubules with moderate staining detected in the loops of Henle and collecting ducts. (ox.ac.uk)

Our goals were twofold: 1) to characterize the gene expression, protein expression, and activity of key synthesizing and regulating enzymes of energy metabolism in the whole mouse retina, retinal compartments, and/or cells and 2) to provide an integrative analysis of the results related to function. (molvis.org)
The implants also faithfully reproduced flashes of light, which were presented at rates varying from twice to twenty times per second, producing similar brain responses to a healthy retina, and the system worked for at least 6 months following implantation. (thenakedscientists.com)

The THAP3 protein is as known as MGC33488, LOC90326, and THAP domain-containing, apoptosis associated protein 3. (wikipedia.org)
Homeobox proteins are master regulators of develop-ment and control many cellular processes, including proliferation, apoptosis, cell shape, and cell migration. (123dok.net)
Inhibitors of Apoptosis Proteins (IAPs) are the most important regulators of caspases. (biomedcentral.com)
In cells undergoing apoptosis, IAPs are inactivated by interaction with proteins containing the so-called IBM (IAP-binding motif) [ 4 , 5 ]. (biomedcentral.com)

Here, removal of intact α 6 protein from cerebellar granule cells allowed perturbations in other subunit levels to be studied. (jneurosci.org)
For example, cerebellar granule cells express six subunit genes abundantly (α 1 , α 6 , β 2 , β 3 , γ 2 , and δ), and so they probably have several distinct GABA A receptor subtypes of unknown subunit stoichiometry. (jneurosci.org)
Brain magnetic resonance imaging (MRI) showed an intra-axial left hemisphere cerebellar lesion causing midline shift tonsilar herniation. (surgicalneurologyint.com)
Brain magnetic resonance imaging (MRI) showed an intra-axial left hemisphere cerebellar lesion. (surgicalneurologyint.com)

Microarray analysis was performed to screen aberrantly expressed mRNAs and activated signaling pathways between epileptic rats and normal controls. (frontiersin.org)

Human HTT caspase cleavage sites generate fragment-specific forms of the protein. (thermofisher.com)

But I think maybe the most disturbing thing is they actually modified the [RNA] code so that it doesn't produce a normal version of the spike protein. (fromthetrenchesworldreport.com)
So, the spike protein binds to the ACE2 receptor once it's produced by the human cell … but it's a modified version of the spike protein. (fromthetrenchesworldreport.com)

Another growth factor, called Brain Derived Neurotrophic Factor, has been hypothesized to play a role in the effects of stress on the brain and in the mode of action of antidepressants. (biopsychiatry.com)
The aim of this study is to learn if rat BMSC express brain-derived neurotrophic factor (BDNF) and glia-derived nerve factor (GDNF) and determine if this expression varies according to the number of culture passages. (sld.cu)

Some authors propose that serum thyroid hormone abnormalities are due to inhibition of thyroid hormone binding to proteins, thus preventing tests from appropriately reflecting free hormone levels. (medscape.com)
Cervical cancer cell lines (HeLa, SiHa, CaSki and CaLo) were obtained from ATCC and cultured as monolayers in Dulbecco Modified Eagle's Medium (DMEM) containing 10% (V/V) fetal bovine serum (GIBCO, Bethesda, MD, USA) at 37°C in a humidified atmosphere of 5% (V/V) CO 2 . (biomedcentral.com)

Gliomas, especially glioblastomas (GBMs), are the most malignant primary brain tumors[1]. (123dok.net)
Medulloblastoma is an embryonal neoplasm and accounts for 1% of all adult intracranial tumors. (surgicalneurologyint.com)
In the pediatric group, MB is the most common malignant brain tumor, but accounts for less than 1% of all adult intracranial tumors,[ 11 5 ] with an annual incidence of approximately only 0.5 per million individuals. (surgicalneurologyint.com)

The mRNA in these vaccines codes for the spike protein normally synthesized by the SARS-CoV-2 virus. (theepochtimes.com)
It produces a version that has a couple of prolines in it, side by side at the critical place where this spike protein normally would fuse with the cell that it's infecting. (fromthetrenchesworldreport.com)

The analysis was conducted on samples from two areas of the brain involved in the coordination of thinking and emotion: the dorsolateral prefrontal cortex and the anterior cingulate cortex. (biopsychiatry.com)
2001. Subchronic dermal application of N,N-diethyl m-toluamide (DEET) and permethrin to adult rats, alone or in combination, causes diffuse neuronal cell death and cytoskeletal abnormalities in the cerebral cortex and the hippocampus, and purkinje neuron loss in the cerebellum. (cdc.gov)

Iodide is transported across the basement membrane of the thyroid cells by an intrinsic membrane protein called the Na/I symporter (NIS). (pharmaceuticalintelligence.com)
Free T4 measurements were primarily used for assessing thyroid function despite the technical difficulties in free thyroid hormone measurements owing to abnormal binding proteins, changes in binding protein concentrations, and the effects of drugs and illness on thyroid hormone binding. (pharmaceuticalintelligence.com)
Eight years later, Gull related dry skin, sparse hair, puffiness of the face and hands, and a swollen tongue to myxedema, the pathological deficiency of thyroid function in adults (goiter). (medscape.com)

Transcription of the THAP3 gene can result in 11 different mRNA variants, of which 8 are alternatively spliced and 3 are unspliced. (wikipedia.org)
This may be described if loss of γ2 is functionally rescued by compensating proteins or alternatively if γ2 is not required as a Ca2+ channel subunit and (18-20). (healthcarecoremeasures.com)

The pathology is caused by a mutation in the huntingtin gene which results in the production of an abnormal protein, mutant huntingtin (mHtt). (bmj.com)

The δ subunit mRNA was present at wild-type levels in the mutant granule cells, indicating a post-translational loss of the δ subunit. (jneurosci.org)

2001. Effects of daily dermal application of DEET and permethrin, alone and in combination, on sensorimotor performance, blood-brain barrier, and blood- tests barrier in rats. (cdc.gov)
1998. Cypermethrin increases apo A-1 and apo B mRNA but not hyperlipidemia in rats. (cdc.gov)

These results suggest that transcriptional elongation control is especially important for rapidly expressed genes to support digestion and metabolism, many of which have sex-biased function. (sdbonline.org)

This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. (thermofisher.com)
The huntingtin gene is widely expressed and is required for normal development. (thermofisher.com)

The Affymetrix data revealed varied gene expression patterns of the ATP synthesizing and regulating enzymes found in the muscle, liver, and brain. (molvis.org)

The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. (thermofisher.com)
Ablation of senescent cells in the brain prevents disease progression and improves cognition in murine models of neurodegenerative conditions. (bvsalud.org)
ANN ARBOR, MI - The brains of people with severe depression have lower levels of several related molecules that are key to the development, organization, growth and repair of the brain than the brains of people without the disease, or those with the bipolar form of depression, a new study finds. (biopsychiatry.com)
As a result, they can be seen as mediators of the property that neuroscientists call "neural plasticity" - the ability of the brain to adapt to stress, experience, disease and the effects of drugs. (biopsychiatry.com)
Schizophrenia (SZ) is a devastating brain disease that affects about 1% of world population. (biomedcentral.com)
It's a monkey virus coming out of a monkey cell line and that's the problem, but the spike protein is clearly [causing] the disease. (fromthetrenchesworldreport.com)
In her paper, " Worse Than The Disease: Reviewing Some Possible Unintended Consequences of mRNA Vaccines Against COVID-19 ," published in the International Journal of Vaccine Theory, Practice and Research in collaboration with Dr. Greg Nigh, 2 Seneff explains that a significant part of the problem is that while the natural spike protein is bad, the spike protein your body produces in response to the vaccine is even worse. (fromthetrenchesworldreport.com)
The therapeutic potential of BMSC for the treatment of cerebral ischemia (2, 3), traumatic brain injury (4), and Parkinson´s disease (5) has been evaluated. (sld.cu)
We found no correlation between the presence of Smac mRNA and histology, menopause, WHO stage or disease status. (biomedcentral.com)
The studies related to tumor biological and clinical features in adults are limited due to the low incidence of the disease in this age group. (surgicalneurologyint.com)
Three forms of the disease exist: infantile, juvenile, and adult. (medscape.com)
Initial signs of the disease usually develop in adolescents or adults. (medscape.com)

We report that Hel-N1 and a related form, Hel-N2, are expressed in human medulloblastoma cells, but their ratio differs significantly from that in adult brain and fetal brain. (duke.edu)
These data indicate that human FOXP2 exerts a greater neurogenic effect, which is perhaps significant for the construction of the brain, including neural circuits involved in language processing. (comparative-cognition-and-behavior-reviews.org)
The development of the human blood-CSF-brain barrier. (cdc.gov)

This protein contains the Thanatos-associated protein (THAP) domain and a host-cell factor 1C binding motif. (wikipedia.org)
Through single cell transcriptomics, we identify a population of tumor-associated macrophages that express a unique array of pro-tumorigenic SASP factors and surface proteins and are also present in normal aged lungs. (bvsalud.org)
In this review, we discuss recent findings supporting the role of cell senescence in the pathogenesis of neurodegenerative diseases and in brain tumours. (bvsalud.org)
Nanos are RNA-binding proteins playing crucial roles in germ cell development and maintenance. (nature.com)
The Nanos proteins family regroups highly conserved RNA-binding proteins in higher eukaryotes implicated in germ cell development and maintenance. (nature.com)
However, both the mRNA and the protein it produces have been changed from the original version in the virus with the intent to increase rate of production of the protein in an infected cell and the durability of both the mRNA and the spike protein it codes for. (theepochtimes.com)
The reason for this is because the synthetic RNA has been manipulated in such a way as to create a very unnatural spike protein that result in it not collapsing on itself into the cell once it attaches to the ACE2 receptor, as it normally does. (fromthetrenchesworldreport.com)
This protein is ubiquitously expressed and known to confer toxicity to multiple cell types. (bmj.com)
We also profiled lncRNA and mRNA expression in three mouse male germ cell-related cell lines (F9, GC-1 and GC-2). (biomedcentral.com)

Many proteins involved in transcription regulation are influenced by phosphorylation and glycosylation sites, which corroborates THAP3's function. (wikipedia.org)

Unexpectedly the mechanism of inhibition in this case appeared to be a reduction of α1 subunit protein expression by γ7 rather than modulation of existing channels (25). (healthcarecoremeasures.com)

THAP3 is ubiquitously expressed in H. sapiens, though expression is highest in the kidneys. (wikipedia.org)

Hel-N1 has been shown to bind in vitro to 3' untranslated regions of mRNAs encoding c-myc, c-fos, granulocyte/macrophage colony-stimulating factor, and transcriptional repressor, Id. (duke.edu)

The expansion of protein families through gene and whole genome duplication provides raw material for adaptive evolution via mutation and selection and is considered a driving force in the development of biological novelty and complexity (28-30). (healthcarecoremeasures.com)

FACL4 was expressed in early stages of development with a significant amount of FACL4 mRNA detected in an E7 mouse embryo. (nih.gov)
The samples expressing Smac were distributed equally among the stages (5 in stage I, 4 in stage II and 4 in stage III) with similar expression levels. (biomedcentral.com)

A role of this gene in Germinal Stem Cells maintenance may be evolutionarily conserved as Nanos2 is specifically expressed both in oogonia and in spermatogonia of adult medaka 11 and in a subpopulation of undifferentiated A spermatogonia in juvenile and spermiating male trout 12 . (nature.com)
Taken together, these data identify Nanos as primordial genes with highly conserved functions for both, the migration of the germinal cells and their maintenance in adults. (nature.com)
Additional experiments proven that γ2 coimmunoprecipitates with GluR1 -2 and -4 AMPAR subunits indicated in heterologous COS cells which the postsynaptic denseness proteins PSD-95 must translocate the γ2-AMPAR complicated to neuronal postsynaptic membranes (10). (healthcarecoremeasures.com)
are all expressed in fetal and adult brain and some members of this group (7) reported that γ4 altered the steady state inactivation of the P/Q-type Ca2+ channel although γ5 accelerated the kinetics of current activation and inactivation of the T-type calcium channel in HEK-293 cells (7). (healthcarecoremeasures.com)
Bone marrow stromal cells (BMSC) are adult stem cells with characteristics that make them an attractive candidate in cellular therapy for neurological diseases (1). (sld.cu)

Variant 1 is the predominant variant and encodes THAP3 protein isoform 1. (wikipedia.org)

In the juvenile and adult form, the involvement of the skeletal muscle dominates the clinical presentation. (medscape.com)
In the juvenile and adult forms, the involvement of skeletal muscles dominates the clinical presentation. (medscape.com)

A better understanding of senescence is likely to result in the development of novel and efficacious anti-senescence therapies against these brain pathologies. (bvsalud.org)
Copy number variants (CNVs) of ZNF804A have been observed in patients with autism spectrum disorders (ASDs), anxiety disorder, and BD, suggesting that ZNF804A is a dosage sensitive gene for brain development. (biomedcentral.com)
Over the last 10 years, researchers at Bristol University have followed almost 7000 children to find out, comparing their balance skills, which reflects brain development, with self-reported alcohol consumption logged by the childrens' mothers ten years previously while they were pregnant. (thenakedscientists.com)

Combined exposure to DEET (N,N-diethyl- m -toluamide) and permethrin-induced release of rat brain mitochondrial cytochrome c. (cdc.gov)

Gene ontology (GO) analysis showed that these protein-coding genes were enriched for transcriptional regulation-related terms. (biomedcentral.com)

Oxidative stress generated during such stressful conditions may damage DNA and proteins, and as a consequence the cellular processes are disturbed. (springer.com)

Anatomy57

Organisms19

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Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Psychiatry and Psychology9

Phenomena and Processes61

Disciplines and Occupations1

Information Science4

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Tissues16

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Testis13

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Immunohistochemistry2

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Interacts2

Humans1

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Version of the spike protein2

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Serum2

Tumors3

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