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  • postnatal muscle
  • We have previously reported that postmitotic expression of a local isoform of insulin-like growth factor 1 (mIGF-1) induces myocyte hypertrophy ( 16 ), increases mass and strength of postnatal muscle, and preserves regenerative capacity in senescent and dystrophic mice ( 17 - 19 ). (pnas.org)
  • gene
  • Gene Expr Patterns. (washington.edu)
  • Regulation of gene expression occurs primarily at the level of transcription. (els.net)
  • a) In a hypothetical example, the gene is represented by a horizontal line and the transcription start site by the bent red arrow. (els.net)
  • The transcription of the foxD3 gene in the neural crest of chickens (shaded blue area of schematised chick embryo, anterior to the right) is controlled by two regulatory modules, NC1 and NC2. (els.net)
  • Regulatory modules are short stretches of sequence that contain binding sites for transcription factors that determine whether transcription of the gene they control is initiated. (els.net)
  • mice
  • We observed a massive reduction, but not complete loss, of Pax7-positive SCs on isolated myofibers of Pax7CE/loxP-Gu mice already 1211441-98-3 1 day after the end of the TAM treatment (Figure 1N). (a-443654.com)
  • Concomitant with the loss of Pax7-positive SCs, we also noted a rapid decline of Pax7 mRNA concentrations in TAM-treated Pax7CE/loxP-Gu mice (Figures S3A and S3F) and a rapid decline of SCs as assessed by the expression of calcitonin receptor (Calcr), a marker. (a-443654.com)
  • regeneration
  • Our results revealed an essential function of Pax7 in maintenance of heterochromatin and expansion of SCs, giving rise to a new model of the regulatory network between myogenic genes and that drives muscle regeneration. (a-443654.com)
  • bHLH
  • However, neither the expression of the neurogenic bHLH factors including Ngn2, Mash1, and NeuroD1 nor subsequent generation of new neurons could be detected in injured tissue. (jneurosci.org)
  • mouse
  • Indeed, the transplantation of bone marrow-derived SCs into the mdx dystrophic mouse model had a limited impact on muscle cell replacement ( 10 ), suggesting that the poor recruitment of circulating SCs is one of the limiting factors for tissue repair ( 10 , 11 ). (pnas.org)