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  • threonine protein
  • Akt located at 14q32.3 in humans and sometimes called protein kinase B ([PKB] Online Mendelian Inheritance in Man no. 164730) is a multifunctional serine-threonine protein kinase that was initially identified as a mouse retrovirus oncogene in AK R t hymomas. (jci.org)
  • The brains of Wistar rat pups exposed to 0.2% lead acetate in their drinking water for three weeks after birth were analysed by AAS for the presence of lead and via Western blot for expression of tau, phosphorylated tau and various serine/threonine protein phosphatases (PP1, PP2A, PP2B and PP5). (spectroscopynow.com)
  • 1 , 2 In addition, over 200 other serine/threonine protein kinases are expressed in native collecting duct cells, 3 and some of these have been shown to play important roles in the response to vasopressin. (asnjournals.org)
  • stimulation
  • Using short-term cultures of large (normal human bronchial epithelial cells [NHBEs]), and small airway epithelial cells (SAECs) they showed that stimulation with nicotine and NNK in pharmacologically relevant concentrations (in the 100 nM range which is attained in the plasma of smokers) induced phosphorylation of Akt on physiologically relevant serine and threonine residues within minutes. (jci.org)
  • aquaporins
  • In this work, we investigated the role of phosphorylation of plasma membrane intrinsic protein (PIP) aquaporins in the Arabidopsis thaliana root by a combination of quantitative mass spectrometry and cellular biology approaches. (mcponline.org)
  • putative
  • To investigate a putative role of Ser 280 and Ser 283 phosphorylation in aquaporin subcellular trafficking, At PIP2;1 forms mutated at either one of the two sites were fused to the green fluorescent protein and expressed in transgenic plants. (mcponline.org)
  • activation
  • We are the first group to show that learning impairment by lead exposure involves over expression/over-activation of protein phosphatases, PP1 and PP2A," Rahman told SpectroscopyNOW. (spectroscopynow.com)
  • We have shown for the first time that over expression of PP1 by lead exposure is associated with learning and long-term memory impairment whereas PP2A over-activation is associated with short-term memory impairment. (spectroscopynow.com)
  • He adds that the team's aim is to fully investigate the pathway(s) that leads to the over-activation of these phosphatases and to find relevant therapeutic strategies to overcome the problem of learning and memory impairment by lead exposure which is widespread in many countries. (spectroscopynow.com)
  • Their activation by specific agonists leads to transient calcium fluxes, extracellular signal-regulated kinase (ERK) phosphorylation and chemotaxis. (mdpi.com)
  • treatments
  • The phosphorylation of At PIP2;1 at two C-terminal sites (Ser 280 and Ser 283 ) was monitored by an absolute quantification method and shown to be altered in response to treatments of plants by salt (NaCl) and hydrogen peroxide. (mcponline.org)
  • several
  • A novel phosphoproteomics procedure that involves plasma membrane purification, phosphopeptide enrichment with TiO 2 columns, and systematic mass spectrometry sequencing revealed multiple and adjacent phosphorylation sites in the C-terminal tail of several At PIPs. (mcponline.org)
  • previously
  • Tau phosphorylation by lead exposure was previously reported in a mouse model by Li et al (Acta Biol Hung 61(2):123-134)) and Rahman and colleagues showed in 2011 that human fetal neurons can be affected. (spectroscopynow.com)
  • Previously, we have reported that prolonged exposure to both DAMGO and morphine promotes desensitization of MOR signaling in transfected cells ( Koch et al , 1998 ). (embopress.org)
  • rats
  • Now, Abdur Rahman, Khalid Khan, Ghanim Al-Khaledi, Islam Khan and Sreeja Attur of Kuwait University Department of Family Sciences, College for Women have investigated the possible link between lead exposure and tau phosphorylation in Wistar rats. (spectroscopynow.com)
  • pathway
  • IKKβ is shown to phosphorylate NH 2 -terminal serines on IκBα, whereas IKKα regulates non-canonical pathway of NF-κB in response to a variety of inflammatory stimuli ( 33 , 43 , 53 ). (physiology.org)
  • events
  • We used tandem mass spectrometry to identify vasopressin-regulated phosphorylation events in isolated rat inner medullary collecting duct (IMCD) suspensions. (asnjournals.org)
  • found
  • Using a series of constructs harboring deletions, we found residues 136 to 206 of HDAC3 to be crucial in this interaction. (ahajournals.org)
  • 17 , 18 We also found a number of phosphorylation sites on the vasopressin-sensitive urea channel, UT-A. 17 However, because of the limited sensitivity of the experimental approach, we were unable to quantify changes in phosphorylation at these sites in UT-A, despite evidence for such sites on the basis of previous studies. (asnjournals.org)
  • changes
  • Thus, the present study documents stress-induced quantitative changes in aquaporin phosphorylation and establishes for the first time a link with plant aquaporin subcellular localization. (mcponline.org)
  • plasma
  • Confocal microscopy analysis of these plants revealed that, in resting conditions, phosphorylation of Ser 283 is necessary to target At PIP2;1 to the plasma membrane. (mcponline.org)
  • Among
  • Among serines in p53 protein immunoprecipitated from A549 cells treated with chrysotile, only Ser15 was markedly phosphorylated. (thefreelibrary.com)
  • damage
  • Upon a cell's exposure to stress, such as hypoxia or genomic damage, the p53 protein is expressed at high levels and is post-translationally modified. (miltenyibiotec.com)
  • known
  • It has long been known that exposure to the heavy metal lead early in life can be detrimental to cognitive development leading to a lower than expected IQ in some children. (spectroscopynow.com)