Pregnancy, delivery, and the puerperium are associated with increased rates of iron deficiency and anemia, which correlates with worse maternal and fetal outcomes and places pregnant women at increased risk of obstetric hemorrhage. (karger.com)
These fetal growth patterns are also associated with blood flow and nutrient transfer by the placenta, demonstrating a complex interaction between maternal and fetal nutrition early in pregnancy that influences postnatal weight and eventually adult health. (ox.ac.uk)
Expression of hepcidin2
The present study suggests that knowledge of the regulatory expression of hepcidin as well as TGF-ß family signaling obtained in murine and human cells is not always applicable to bovine cells. (bvsalud.org)
Hypoxia downregulates the expression of hepcidin, which leads to both increased intestinal iron absorption and increased release of recycled iron from the reticuloendothelial system [ 21 , 22 ]. (hindawi.com)
Bovine6
We evaluated the effect of iron administration on plasma hepcidin concentrations in calves and the expression of bovine hepcidin by the BMP pathway in a cell culture study. (bvsalud.org)
Treatment with BMP6 increased hepcidin expression in human liver-derived cells but not in bovine liver-derived cells. (bvsalud.org)
The reporter activity of hepcidin was lower in the cells transfected with bovine Smad4 than in those transfected with murine Smad4. (bvsalud.org)
The lower expression levels of bovine Smad4 were responsible for the lower activity of the hepcidin reporter, which might be due to the instability of bovine Smad4 mRNA. (bvsalud.org)
We revealed the unique regulation of bovine hepcidin expression and the characteristic TGF-ß family signaling mediated by bovine Smad4. (bvsalud.org)
Cells were resuspended in growth media (GM Ham's F-10 containing 20% fetal bovine serum 2.5 ng/ml bFGF 100 ug/ml streptomycin and 100 IU/ml penicillin) and myogenic cells were enriched over 8-12 passages by gentle trypsinization and brief preplating. (academicediting.org)
Systemic iron3
Hepcidin negatively regulates systemic iron levels by inhibiting iron entry into the circulation. (bvsalud.org)
Hepcidin production is increased in response to an increase in systemic iron via the activation of the bone morphogenetic protein (BMP) pathway. (bvsalud.org)
AIM: The aim of the study was to investigate the respective roles of iron excess and hepcidin, the systemic iron regulator, in the development of iron-related osteoporosis. (bvsalud.org)
Outcomes2
There was limited data reporting on prevalence of anaemia and direct maternal and foetal outcomes. (biomedcentral.com)
The paper complements work published by the same groups in 2021 that identified fetal head growth trajectories that are associated with different developmental, behavioural, visual and growth outcomes at 2 years of age. (ox.ac.uk)
Pregnancy7
In order to supply adequate iron during pregnancy, the levels of the iron regulatory hormone hepcidin in the maternal circulation are suppressed, thereby increasing dietary iron absorption and storage iron release. (bvsalud.org)
In 2018, the prevalence of exposure to malaria infection in pregnancy in sub-Saharan Africa was 29% (equivalence of 11 million pregnancies) [ 4 ]. (biomedcentral.com)
Pregnant women who need to accommodate the haemodynamic demands of pregnancy may be at higher risk for anaemia, which is increased by exposure to synergistic inflammatory and infective conditions. (biomedcentral.com)
Discussion: Our study provides a unique resource for the planned analyses given the range of potentially disadvantageous exposures (including poor nutrition, pregnancy complications and infections) in geographically diverse populations worldwide. (ox.ac.uk)
Supported by a grant from the Bill & Melinda Gates Foundation, the INTERBIO-21st Study monitored the growth inside the womb of over 3,500 babies in six countries (Brazil, Kenya, Pakistan, South Africa, Thailand, and the United Kingdom) using serial fetal ultrasound scans throughout pregnancy, and analysed blood samples taken from the women early in pregnancy and from the umbilical cord at birth. (ox.ac.uk)
They found that maternal fat metabolism as early as the 5th month of pregnancy, and the growth of the fetal abdomen growth patterns of fetal abdominal growth associated with maternal lipid metabolites that track newborn growth, adiposity and development into childhood. (ox.ac.uk)
Very importantly, in both studies, the same critical time period close to the 5th month of pregnancy is the starting point for accelerated or decelerated fetal growth that is sustained into early childhood. (ox.ac.uk)
Deficiency2
MATERIAL AND METHODS: We used mice models with genetic iron overload (GIO) related to hepcidin deficiency (Hfe-/- and Bmp6-/- ) and secondary iron overload (SIO) exhibiting a hepcidin increase secondary to iron excess. (bvsalud.org)
A Prospective, Randomized, Interventional Study of Oral Iron Supplementation Comparing Daily Dose with Alternate Day Regimen Using Hepcidin as a Biomarker in Iron Deficiency Anemia. (mcmaster.ca)
Regulator1
The master regulator of iron balance in humans is hepcidin, a peptide produced by the liver [ 20 ]. (hindawi.com)
Nutrition1
Phase II aims to improve the functional classification of the highly heterogenous preterm birth and fetal growth restriction syndromes through a better understanding of how environmental exposures, clinical conditions and nutrition influence patterns of human growth from conception to childhood, as well as specific neurodevelopmental domains and associated behaviors at 2 years of age. (ox.ac.uk)
Growth2
Molecular alterations in prostate carcinomas that associate with in vivo exposure to chemotherapy: identification of a cytoprotective mechanism involving growth differentiation factor 15. (biovendor.com)
Regulation of hepcidin expression by iron status has been proposed on the basis of evidence mainly from rodents and humans. (bvsalud.org)
Although intramuscular administration of iron increased iron-related parameters, plasma hepcidin concentrations were unaffected. (bvsalud.org)
The osteoblastic MC3T3 murine cells that are able to mineralize were exposed to iron and/or hepcidin. (bvsalud.org)
CONCLUSION: Together, these data suggest that iron in excess alone is not sufficient to induce osteoporosis and that low hepcidin levels also contribute to the development of osteoporosis. (bvsalud.org)
Risk1
Mycotoxin Exposure and Renal Cell Carcinoma Risk: An Association Study in the EPIC European Cohort. (who.int)
Cells1
Hepcidin supplementation of cells had a rescue effect on the collagen 1 and alkaline phosphatase expression level decrease. (bvsalud.org)
Model1
Alterations in bone microarchitecture in the Bmp6-/- model were positively correlated with hepcidin levels (BV/TV (ρ = +.481, p (bvsalud.org)
Effect1
Exposure to exogenous arachidonic acid had no effect on ERK2 phosphorylation but exposure to lysophosphatidylcholine the other metabolite of PLA2 caused a dose-dependent increase in ERK2 phosphorylation. (academicediting.org)
Renal1
6. Bone marrow iron distribution, hepcidin, and ferroportin expression in renal anemia. (nih.gov)
Serum1
We collected 200 μL from the blood culture bottle to inoculate a 5-mL Ellinghausen, McCullough, Johnson, and Harris media supplemented with 5% fetal bovine serum. (ox.ac.uk)
Systemic2
Nemeth has received numerous awards for her work, including the International BioIron Society Presidential Award for seminal work on the mode of action of hepcidin and the molecular basis of systemic ironhomeostasis, was featured in the 2016 Cell Metabolism series on women leaders in the field of metabolism, and is the president-elect of the International Bioiron Society. (uclahealth.org)
This demonstrated that personal care products containing triclosan were the dominant, but not the only, source of systemic exposure to triclosan. (researchgate.net)
Innate2
Nemeth identified IL-6 as the main driver of hepcidin and defined the structural basis of the hepcidin-ferroportin interaction, developed hepcidin-like agonists and delineated the role of hepcidin in innate immunity against gram-negative bacteria. (uclahealth.org)
LPS tolerization refers to the absence of an inflammatory response after repeated or prolonged exposure to this microbial endotoxin as re-challenged "tolerant" innate immune cells are incapable of immunological activation. (frontiersin.org)
Maternal6
10. Expression of Hepcidin and Ferroportin in the Placenta, and Ferritin and Transferrin Receptor 1 Levels in Maternal and Umbilical Cord Blood in Pregnant Women with and without Gestational Diabetes. (nih.gov)
Placental nitric oxide (NO) is critical for maintaining perfusion in the maternal-fetal-placental circulation during normal pregnancy. (nih.gov)
NO and its many metabolites are also increased in pregnancies complicated by maternal inflammation such as preeclampsia, fetal growth restriction, gestational diabetes, and bacterial infection. (nih.gov)
Effects of supervised aerobic and strength training in overweight and grade I obese pregnant women on maternal and foetal health markers: the GESTAFIT randomized controlled trial. (medscape.com)
Maternal iron deficiency (ID) and environmental lead (Pb) exposure are co-occurring insults that both affect the neurodevelopment of offspring. (bvsalud.org)
Although as noted above, there are significant maternal-fetal implications even with mild reductions in hemoglobin. (glowm.com)
8. Pharmacological inhibition of prolyl hydroxylase protects against inflammation-induced anemia via efficient erythropoiesis and hepcidin downregulation. (nih.gov)
Concentrations1
The concentrations were significantly higher in plasma than in milk, indicating that infant exposure to triclosan via breast milk is much less than the dose in the mother. (researchgate.net)
Model1
16. Prenatal Alcohol Exposure Alters Fetal Iron Distribution and Elevates Hepatic Hepcidin in a Rat Model of Fetal Alcohol Spectrum Disorders. (nih.gov)
Human2
NIEHS research uses state-of-the-art science and technology to investigate the interplay between environmental exposures, human biology, genetics, and common diseases to help prevent disease and improve human health. (nih.gov)
Triclosan has previously been found in human plasma and milk, but neither the primary source of human exposure nor the efficiency of triclosan transfer to human milk is known. (researchgate.net)