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  • tumors
  • Camptothecin and its derivatives inhibit topoisomerase I. Topotecan is an FDA-approved anti-cancer agent that acts as a radiation sensitizer of mammalian tumors. (biologists.org)
  • A drug containing a form of radioactive iodine called I 131 that is used to find or treat certain types of tumors, including pheochromocytomas and neuroblastomas. (pheopara.org)
  • The invention surprisingly found that antcin or an ester derivative, salt or a composition thereof in combination with an anti-tumor drug provides unexpected efficacy in inhibiting tumors, while retaining normal cells at high viability. (patentsencyclopedia.com)
  • Dose
  • However, that enthusiasm has been tempered by concern about the potentially high radiation dose received by patients. (healthcanal.com)
  • Using standard 64-detector row helical scanning as the benchmark, the effective radiation dose was reduced by 91 percent from 35.4 millisieverts (mSv) to 4.4 mSv using optimized 320-detector row volume scanning. (healthcanal.com)
  • According to Dr. Einstein, state-of-the-art CT technology emphasizes optimal image resolution with the ability to lower radiation dose through a variety of features and scan modes that adjust and modulate the dose based on the specific needs of the individual patient. (healthcanal.com)
  • As CT technology advanced from 16- to 64-slice capabilities, the radiation dose went up significantly," he said. (healthcanal.com)
  • Radiation Dose from Single-Heartbeat Coronary CT Angiography Performed with a 320-Detector Row Volume Scanner. (healthcanal.com)
  • Elimination is mainly via the kidneys, with excretion of the unchanged drug between 60% and 40% depending on the dose and method of administration [ 4 ]. (ecancer.org)
  • Major surgery within 4 weeks before first dose of study drug. (mayo.edu)
  • Requires or receiving anticoagulation with warfarin or equivalent vitamin K antagonists within 7 days of first dose of study drug. (mayo.edu)
  • The image intensifiers were interrogated for stored data of radiation dose and screening times. (omicsonline.org)
  • Previous studies have shown that atypical radiation dose during ureteroscopy is 1.13 mSv [ 4 ]. (omicsonline.org)
  • However, we use the latest low-dose equipment to reduce your risk of unnecessary exposure. (tuftsmedicalcenter.org)
  • tumor
  • The rationale for the development of histone deacetylase (HDAC) inhibitors as anticancer drugs resides in their ability to inhibit tumor growth, induce differentiation, and lower apoptotic threshold in transformed cells ( 1 ). (aacrjournals.org)
  • Obtaining a good therapeutic ratio for tumor versus normal tissue is essential, and hydroxamic acid-based drugs seem to inhibit tumor growth in animals at nontoxic doses ( 3 , 4 ). (aacrjournals.org)
  • A novel anticancer drug 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine (ECyd, TAS106) has been shown to radiosensitize tumor cells and to improve the therapeutic efficiency of X-irradiation. (biomedcentral.com)
  • Perform chemoembolization to deliver anti-cancer drugs directly into a tumor. (tuftsmedicalcenter.org)
  • 9. The combination of claim 1, wherein the anti-tumor drug is an antimitotic drug, an antimetabolite drug, an alkyling agent, a nitrogen mustard, a drug that targets DNA, a topoisomerase inhibitor, a hormone antagonist, or a tyrosine kinase inhibitor. (patentsencyclopedia.com)
  • 15. The method of claim 14, wherein the anti-tumor drug and the antcin or a salt or ester derivative or a composition thereof are administered separately, concurrently, or sequentially. (patentsencyclopedia.com)
  • susceptibility
  • In parallel, dysbiosis, candidiasis of the oral cavity combined with Hypo - and avitaminosis (especially groups b, B2, B6, PP). Imbalances vitamin metabolism lead to a change in the function of the oral mucosa: an increased susceptibility to oral background exposure. (medicalj-center.info)
  • therapeutic
  • Based on the evidence presented, it is proposed that cimetidine would synergise with a range of other drugs, including existing chemotherapeutics, and that further exploration of the potential of cimetidine as an anti-cancer therapeutic is warranted. (ecancer.org)
  • Radiation exposure from any diagnostic or therapeutic endourological intervention is variable. (omicsonline.org)
  • involves
  • This strategy involves delivering the drug via transdermal pathways, resulting in the death of cancerous cells. (hindawi.com)
  • antibody
  • The primary objective of this study is to evaluate the relationship between first influenza A virus exposure (inferred by age), vaccine history, and baseline serum antibody and Memory B cell (MBC) specificity, and the magnitude and breadth of the subsequent B cell response to seasonal influenza vaccine in healthy adults and children. (clinicaltrials.gov)
  • combinations
  • A number of possible combinations with other drugs are discussed in the supplementary material accompanying this paper. (ecancer.org)
  • widely
  • The original trade name was Tagamet (GlaxoSmithKline), but the drug is now widely available as a generic. (ecancer.org)
  • molecules
  • We developed a screen to identify, from the onset, molecules that act in vivo in conjunction with radiation, using Drosophila as a model. (biologists.org)
  • phase
  • Toxicity reached maximum levels at a drug concentration of ∼1 μmol/L, and cells in G 1 phase at the end of treatment were preferentially spared. (aacrjournals.org)
  • amount
  • In CT, numerous x-ray beams and a set of x-ray detectors rotate around the patient, measuring the amount of radiation being absorbed in the body. (healthcanal.com)
  • research
  • RSNA is an association of more than 44,000 radiologists, radiation oncologists, medical physicists and related scientists committed to excellence in patient care through education and research. (healthcanal.com)
  • Early research shows that taking a specific ginkgo leaf extract called EGb 761 (Dr. Willmar Schwabe Pharmaceuticals) daily for 22-24 weeks seems to be as effective as the drug donepezil (Aricept) for treating mild to moderate Alzheimer's disease. (webmd.com)
  • But, other research suggests that ginkgo leaf extract might be less effective than the conventional drugs donepezil (Aricept) and tacrine (Cognex). (webmd.com)
  • Treatment
  • By blocking the action of histamine on gastric parietal cells, the H 2 RAs are able to reduce the production of gastric acid, and indeed, CIM, the first drug in this class, was developed as a treatment for dyspepsia. (ecancer.org)
  • Journal
  • To receive news and publication updates for Journal of Drug Delivery, enter your email address in the box below. (hindawi.com)
  • analysis
  • In addition, his lab is exploring novel applications of biomedical informatics (such as medical image analysis and bioinformatics) and cheminformatics (such as structure-based rational drug design and in-silico drug screening) in systems biology and nanotechnology in translational medicine. (insightconferences.com)
  • cells
  • PCI-24781 pretreatment increased the fraction of cells with γH2AX foci 24 h after irradation but did not affect the initial rate of loss of radiation-induced γH2AX or the rate of rejoining of DNA double-strand breaks. (aacrjournals.org)