• These comprise the Beta-coronaviruses OC43 and HKU-1, which have 38% and 35% amino acid homology with SARS-CoV-2, and the more distantly related Alpha-coronaviruses NL63 and 229E, each with around 31% homology 11 . (nature.com)
  • The capsid gene of the outbreak strain shares high amino acid homology with the Kashiwa645 GI.3 strain, previously shown to recognize nonsecretor saliva, as well as synthetic Lewis a. (cdc.gov)
  • Our results provide insights into the evolutionary history of the bZIP gene family in C. paliurus and the function of these genes during leaf development and in the response to drought stress. (biomedcentral.com)
  • In addition to the essential regulatory functions in plant growth and development, bZIP genes participate in the response to abiotic stress. (biomedcentral.com)
  • According to modern Darwinism, if two structures are similar because of common ancestry, each structure should be produced by similar genes and go through a similar pattern of development in the embryo. (answering-atheism.com)
  • But contrary to these predictions, biologists are learning that homologous structures can be produced by different genes and follow different patterns of development. (answering-atheism.com)
  • Darwinism predicts that these similarities should be due to the same gene but in fact different genes account for the development of body segments in these insects. (answering-atheism.com)
  • Mapping of the genes encoding human protein matches to pathways point to targets that could explain the observed presentation of symptoms in COVID-19 disease. (danielsolis.cz)
  • He describes homologies which are structures that indicate a shared ancestor: "the framework of bones being the same in the hand of a man, wing of a bird, fin of a porpoise, and leg of the horse - the same number of vertebrae forming the neck of the giraffe and of the elephant…at once explain themselves on the theory of descent with slow and slight successive modifications" (Darwin 391). (ostatic.com)
  • The high disparity of the mammalian autopod, reported here, is consistent with the higher potential of development to generate variation in more distal limb structures, as well as functional specialization of the distal elements. (elifesciences.org)
  • Homology is a central concept of comparative and evolutionary biology, referring to the presence of the same bodily parts (e.g., morphological structures) in different species. (asu.edu)
  • The existence of homologies is explained by common ancestry, and according to modern definitions of homology, two structures in different species are homologous if they are derived from the same structure in the common ancestor. (asu.edu)
  • Biologists define homology as similarity in structure between different organisms. (answering-atheism.com)
  • In research published today (August 20) scientists in Chile and Canada identify the substance in spontaneous ovulators: nerve growth factor beta (NGF-beta)-a neurotrophic protein involved in nerve development, which has the same chemical structure as OIF. (the-scientist.com)
  • Conversely, the transcription of COX-2 yields a 4.5-kb mRNA that encodes a 70-kd protein with roughly 70-75% homology to the COX-1 protein. (medscape.com)
  • Protein drugs are increasingly important in drug development worldwide due their high specificity, potency, and low toxicity. (lu.se)
  • Many protein drugs do, however, suffer from inherent physical instability limiting the manufacturability and formulation development, as well as short plasma half-lives that are incompatible with delivery of an efficacious dose within the appropriate dose regime[1,2]. (lu.se)
  • Homological algebra is a mathematical framework that initially emerged from classical simplicial topology, essentially as a crystallization product of the concepts of homology and cohomology groups of topological spaces. (zbmath.org)
  • Since the early 1940's, when S. Eilenberg , S. MacLane , and others discovered that the formalism of (co-)homology in topology could be axiomatized, and conveyed to more general algebraic systems, the development of abstract "homological" methods has undergone a rapid expansion, touching almost every area of algebra, geometry and topology. (zbmath.org)
  • And while the evidence for evolution itself remains persuasive -- especially the homologies that are found in comparative anatomy and molecular biology of many different species -- much of the empirical evidence that was formerly believed to support the neo-Darwinian mechanism of chance mutation coupled with natural selection has melted away like snow on a spring morning, through better observation and more careful analysis. (bibliotecapleyades.net)
  • Is Homology Evidence for Evolution? (answering-atheism.com)
  • Autopsies of Chinese citizens who have died from COVID-19 following SARS-CoV-19 infection show evidence of interstitial changes, suggesting the development of pulmonary fibrosis [ 1 ]. (danielsolis.cz)
  • Arguments often make use of simple, but profound, results from group theory or homology theory. (maa.org)
  • The evolutionary lines are completely distinct and yet we see a profound degree of homology. (answering-atheism.com)
  • They are classified into 5 groups according to substrate specificity and internal homology: collagenases, gelatinases, stromelysins, membrane-type MMPs, and others, including matrilysins 8 . (bvsalud.org)
  • Or just semantic explanations for structural homologies between noun and verb structure in general. (linguistlist.org)
  • Generative works, at least dating back to Chomsky's *Remarks, *explain structural homologies between noun and verb structure based on abstract formal schema (like X' theory). (linguistlist.org)
  • X-ray crystallography of OIF and NGF-beta confirmed their structural and sequence homology. (the-scientist.com)
  • Yet in recent years, evolutionary development, or Evo Devo, has taken biological inquiry beyond selection and heredity, toward a reconsideration of developmental causation, the non-adaptive constraints upon the possible evolution of forms, and the structural complexity that inheres in the generation of a single blade of grass. (byu.edu)
  • If all of the parts of the epitopes that are homologous to human proteins are excluded from consideration due to risk of pathogenic priming, the remaining immunogenic parts of the epitopes may be still immunogenic and remain as potentially viable candidates for vaccine development. (danielsolis.cz)
  • Discusses broader developmental and evolutionary issues and their implications for macroevolution, such as the links between phylogeny and ontogeny, homology and serial homology, normal and abnormal development, the evolution, variations, and birth defects of humans, and medicine. (routledge.com)
  • In accepting the view that texts are created with specific social goals in mind, I examined 127 twentieth-century high school biology textbooks for representations of animal development. (asu.edu)
  • The incredible development of comparative genomics during the last decade has required a correct use of the concept of homology that was previously utilized only by evolutionary biologists. (pasteur.fr)
  • This review brings back to the correct definition of homology and explains how this definition has been progressively refined in order to adapt it to the various new kinds of analysis of gene properties and of their products that appear with the progress of comparative genomics. (pasteur.fr)
  • The high susceptibility and mortality of these species, including limber pine ( Pinus flexilis ), creates an urgent need for the development and deployment of resistant germplasm to support recovery of impacted populations. (frontiersin.org)
  • He also explains how biologists characterize species into groups according to their characteristics within a species. (ostatic.com)
  • The development of non-invasive prenatal testing (NIPT) for AR disorders has proven challenging as it requires knowing which allele was transmitted to the fetus from each parent… We will investigate an indirect method that involves calculating the ratio of sequence reads for the two maternal beta-globin alleles and compareing this ratio from the maternal plasma DNA to the maternal whole blood DNA. (thalassemia.org)
  • These are cutting-edge investigations, extending from genomics and prenatal diagnosis to iron metabolism to red blood cell development to clinical studies, to fulfilling the promise of gene therapy. (thalassemia.org)
  • She will also be experimenting with homology directed recombination of JMML intron enhancer mutation into human erythroid progenitor HuDEP-2 cells to test the effect on erythroid differentiation and globin gene expression. (thalassemia.org)
  • The bZIP gene family has important roles in various biological processes, including development and stress responses. (biomedcentral.com)
  • The analysis of transcriptome data of the leaves in C. paliurus revealed the bZIP gene family was one of the most abundant TFs in this organism that regulate leaf development [ 26 ]. (biomedcentral.com)
  • Haeckel believed that the development of an embryo revealed the adult stages of the organism's ancestors. (asu.edu)
  • We are combining computational and experimental methods to explain biochemical, biological, and medical observations. (edu.pl)
  • The main objective of our work is the development of research tools that enable building the relationship between molecular structure and biological function. (edu.pl)
  • The first systematic account on homological algebra (as a now self- reliant, mature algebraic theory) was provided by the epoch-making textbook of H. Cartan and S. Eilenberg , published in 1956, which substantially influenced the further development of the subject itself as well as its increasingly far-reaching applications in other branches of mathematics. (zbmath.org)
  • During that period, from 1955 to the early 1980's, the development of homological algebra and its applications proceeded likewise tempestously. (zbmath.org)
  • Explain some important concepts of calculus (such as limit, continuity, derivative and integral). (uaeu.ac.ae)
  • We also constructed, by homology modeling, a theoretical structure of the pUL105 N-terminal domain which indicates that the mutated conserved amino acids in this domain could be involved in ATP hydrolysis. (frontiersin.org)
  • Ojeda's own work has identified a role for a different neurotrophic factor in the development and fertilization of oocytes. (the-scientist.com)
  • Evolutionary theory not only explains the production and variety of living forms without recourse to any higher order of intention, it seemingly does so in observable accordance with the mechanical principles of nature. (byu.edu)
  • I am aware of diachronic works that discuss the development of verbal alignment systems from (clausal) nominalizations. (linguistlist.org)
  • that they sought to use mechanistic reductionism to explain and predict systems that we now know are complexity-related, and cannot be explained as the sum of their parts. (bibliotecapleyades.net)
  • This will be the first book to synthesize, summarize, and provide high-quality illustrations to show what is known of the configuration, development, homology, and evolution of the muscles of all major extant chordate groups. (routledge.com)
  • Exploring the sensitivity of (13)Delta to possible respiratory isotope effects, we conclude that isotopic disequilibria between the gross fluxes of photosynthesis and day respiration can explain the high observed (13)Delta values during net photosynthetic gas exchange. (who.int)
  • This may to a certain degree explain why this type of CoV triggers severe inflammatory responses and immune damage and its associated complications. (spandidos-publications.com)
  • The RANK-RANKL-OPG system is a complex signaling pathway that plays a critical role in bone metabolism, mammary epithelial cell development, immune function, and cancer. (bvsalud.org)
  • As such, recent hCoV infection might presensitize children against SARS-CoV-2 infection and may explain cross-reactive SARS-CoV-2-neutralizing antibodies in some seronegative children 15 . (nature.com)
  • Additionally, OIF is important for development of the gland that produces progesterone, which is necessary for pregnancy. (the-scientist.com)
  • OThe molecules of the extracellular matrix play an important role during cell development and morphogenesis. (bvsalud.org)
  • Estrogens play an important role for the development and Authors' Affiliations: Departments of 1Oncology and 2Theoretical Physics, Lund progression of breast carcinoma. (lu.se)
  • In cancer cells, RANKL expression is often increased, which can lead to increased bone resorption and the development of bone metastases. (bvsalud.org)
  • It was the origin of the first single-celled organism in the primeval oceans, and its development into the plant and animal kingdoms of today by a strictly blind process of chance genetic mutation working with natural selection. (bibliotecapleyades.net)
  • In addition to better understanding the epigenetic underpinnings of the pathological disease process, detecting histone modifications can also aid in the development of histone modification-targeted drugs. (epigentek.com)
  • This study was conducted to review the literature about the role of metalloproteases in the development of odontogenic lesions. (bvsalud.org)
  • Thalassemias are some of the most common autosomal recessive (AR) disorders in the world," Dr. Carlberg explains. (thalassemia.org)
  • Similarly, the horned sphere and Antoine's necklace are explained well, but function primarily as motivation for introducing tameness hypotheses. (maa.org)
  • This is a project about medicine and the history of a condition called premenstrual syndrome (PMS), its "discovery" and conceptual development at both scientific and socio-cultural levels. (asu.edu)
  • bZIP TFs contain a bZIP domain, generally composed of 60-80 amino acids, with two functionally distinct parts, a highly conserved basic region and a variable leucine-zipper region (explaining the name bZIP) [ 2 , 3 ]. (biomedcentral.com)
  • The grand fact of the natural subordination of organic beings in groups under groups, which, from its familiarity, does not always sufficiently strike us, is in my judgment thus explained. (standardebooks.org)
  • Our goal is to identify specific interactions or combinations thereof that explain the observed effect. (edu.pl)
  • During the menstrual cycle, a small subset of follicles in an ovary will begin to grow and mature, with just a few achieving the potential to ovulate, Adams explains. (the-scientist.com)
  • The pattern of classification is analogous to the development of speciation. (ostatic.com)