• Atrial natriuretic peptide (ANP) decreases plasma Na concentration and promtes seawater (SW) adaptation in eels. (bioone.org)
  • It is structurally similar to the atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP) and possesses biologic properties similar to these natriuretic peptides. (wikipedia.org)
  • Role of atrial natriuretic peptide in the suppression of lysophosphatydic acid-induced rat aortic smooth muscle (RASM) cell growth. (mcw.edu)
  • In the present study we investigated the possible role of atrial natriuretic peptide (ANP), a hormone affecting cardiovascular homeostasis and inducing antimitogenic effects in different cell types, on LPA-induced cell growth and reactive oxygen species (ROS) production in rat aortic smooth muscle (RASM) cells. (mcw.edu)
  • Atrial natriuretic peptide (ANP) has been shown to improve renal function in animal models of ischemic acute kidney injury, predominantly via afferent arteriolar dilatation. (medscape.com)
  • Dendroaspis natriuretic peptide (DNP) is a 38-residue peptide and a member of natriuretic peptide family. (wikipedia.org)
  • Brain natriuretic peptide (BNP) treatment increases heart function and decreases heart dilation after myocardial infarction (MI). (elifesciences.org)
  • Measurements were made of circulating levels of 25-hydroxyvitamin D [25(OH)D] and plasma B-type natriuretic peptide (BNP) levels in patients receiving chronic peritoneal dialysis. (nih.gov)
  • The hormone is known as brain natriuretic peptide. (scienceblog.com)
  • We're suggesting that transplanted bone marrow stromal cells may hasten recovery by releasing brain natriuretic peptide and other factors that improve blood flow to the brain and decrease swelling and pressure around the site of injury," said lead investigator Juan Sanchez-Ramos, MD, PhD, professor of neurology and research director at the USF Center for Aging and Brain Repair. (scienceblog.com)
  • The aim of the present study was to examine the effect of the synthetic endocannabinoid (eCB) analogue, arachidonyl-2′-chloroethylamide (ACEA), on calcitonin gene-related peptide (CGRP) release in the dura and trigeminal ganglion (TG), as cannabinoids are known to activate G i/o -coupled cannabinoid receptors type 1 (CB1), resulting in neuronal inhibition. (lu.se)
  • Changes in the expression of calcitonin gene-related peptide after exposure to injurious stretch-shortening contractions. (cdc.gov)
  • Professor Fabian Theis stated: "Deep learning, in particular the used recurrent neural networks need a lot of samples to be predictive, so I was very happy when Matthias approached me and we jointly were able to predict and interpolate biochemical properties of peptides based only on their sequence. (news-medical.net)
  • The resulting classifiers have application in a number of areas such as determination of peptide coverage for protein identification, pathway analysis, and protein quantification. (biomedcentral.com)
  • We demonstrate here the transcytosis ability of aprotinin and peptides derived from Kunitz domains using an in vitro model of the BBB and in situ brain perfusion. (aspetjournals.org)
  • In vitro, both peptides have the properties stimulating cell growth and division. (bodybasicswellness.com)
  • The role of Aβ as a toxic element in the disease has been widely explored through multiple techniques, including in vivo and in vitro application of synthetic peptides as well as in novel transgenic mouse models created to overexpress Aβ. (nature.com)
  • Improving this understanding likely will require expanding the types of characteristics measured for sense--antisense peptide complexes and hence the types of analytical methods applied to such interactions. (nih.gov)
  • Understanding the mechanism of sense--antisense peptide recognition also may provide insights into mechanisms of native (sense) peptide and protein interactions and protein folding. (nih.gov)
  • These include incomplete proteolytic digestion, small size, poor binding or elution from the type of LC column used, the limited mass range that can be detected by the mass spectrometer, bias toward detecting peptides with an intense MS signal in mixtures, the phenomenon of "ion suppression", the charge prior to ionization, and non-covalent interactions between peptides in the gas phase while in the mass spectrometer [ 1 ]. (biomedcentral.com)
  • SCFC calculations confirmed that interactions mediated by adsorbed layers of this peptide point to it being an excellent emulsion stabiliser. (bioinfor.com)
  • The objective of the current study was to examine the kinetics of amoxicillin and cefaclor interactions with human renal transporters human organic anion transporter 1 (hOAT1), human peptide transporter 1 (hPepT1), and human peptide transporter 2 (hPepT2) in detail, both as substrates and as inhibitors. (aspetjournals.org)
  • Hepatic uptake carriers of the organic anion-transporting peptide (OATP) family of solute carriers are more and more recognized as being involved in hepatic elimination of many drugs and potentially associated drug-drug interactions. (aspetjournals.org)
  • The ability to predict which peptides can and cannot potentially be observed for a particular experimental dataset has several important applications in proteomics research including calculation of peptide coverage in terms of potentially detectable peptides, systems biology analysis of data sets, and protein quantification. (biomedcentral.com)
  • The fact that most proteins in a complex mixture are represented by only a small number of proteolytic peptides presents several difficulties for proteomics researchers [ 2 ]. (biomedcentral.com)
  • De novo peptide sequencing algorithms have been widely used in proteomics to analyse tandem mass spectra (MS/MS) and assign them to peptides, but quality-control methods to evaluate the confidence of de novo peptide sequencing are lagging behind. (arxiv.org)
  • The Nature Communications paper describes CCS values measured on the timsTOF Pro as an essentially intrinsic property of the peptide ions, which can be used to improve confidence in peptide and protein group identification in 4D shotgun proteomics. (news-medical.net)
  • This is essential for high sensitivity proteomics where low levels of peptide signals need to be accurately measured in a complex mixture, e.g. in plasma proteomics, peptidomics, immunopeptidomics or metaproteomics. (news-medical.net)
  • Lead author Dr. Florian Meier, now an Assistant Professor in Functional Proteomics at the Jena University Hospital in Germany, said: "The scale and precision of peptide CCS values in our data from the timsTOF Pro was sufficient to train our deep learning model to accurately predict CCS values based only on the peptide sequence. (news-medical.net)
  • The need to keep track of protein modifications is readily recognized by the proteomics community, and few repositories of known peptide modifications have been created. (lu.se)
  • Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article. (aspetjournals.org)
  • Message Body (Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics. (aspetjournals.org)
  • BmK M7 crystallizes as a dimer in which the identical non-proline peptide bond between residues 9 and 10 exists either in the cis conformation or as a mixture of cis and trans conformations in either monomer. (rcsb.org)
  • We also determined the crystal structures of several mutants of BmK M1, a representative scorpion alpha-like toxin that contains an identical non-proline cis peptide bond as that observed in BmK M7, in which residues within or neighboring the cis peptide bond were altered. (rcsb.org)
  • Cis/trans interconversion of the switch residue at position 8 appears to be sequence-dependent as the peptide bond between residues 9 and 10 retains its wild-type cis conformation in the BmK M1 (K8Q) mutant structure. (rcsb.org)
  • Addition of multiple isocyanates to the peptide occurs via polymerization of the isocyanate at the N-terminus, rather than via addition of multiple isocyanate molecules to varied residues within the peptide. (cdc.gov)
  • Supporting Information: LC-MS characterization of GSH-MDI reaction products, Tables of peptides matched to albumin or modified albumin, and MS/MS data on the GSH-MDI modified albumin peptide containing residues 411-428. (cdc.gov)
  • Autoantibody response to MOG (35-55) has been observed in multiple sclerosis (MS) patients and MOG (35-55)-induced experimental autoimmune encephalomyelitis (EAE) C57/BL6 mice and Lewis rats. (anaspec.com)
  • Synthetic peptides corresponding to selected sequences from the nicotinic acetylcholine receptor (AChR) were employed to identify possible antigenic determinants within the receptor which can modulate the anti-AChR response and experimental autoimmune myasthenia gravis (EAMG). (openu.ac.il)
  • Successful recognition of antigenic peptides bound to Major Histocompatibility Complexes (pMHCs) requires specific binding of the TCR to these complexes ( 5 - 7 ), which in turn modulates the cell's fitness, clonal expansion, and acquisition of effector properties ( 7 ). (frontiersin.org)
  • Peptides have also been applied to self-assembly, and it is of interest to explore such short sequences as building blocks of large, designed complexes. (mdpi.com)
  • An experimental antibody therapy may help ease skin symptoms from the autoimmune disease lupus, a small preliminary trial suggests. (bio-peptide.com)
  • c) Frequency of peptide C-terminal amino acids. (news-medical.net)
  • This connection between the amino acids contained within a peptide sequence and its measured CCS has tremendous potential to increase the confidence of protein identification. (news-medical.net)
  • According to the European Medicines Agency guideline on environmental risk assessments for pharmaceuticals (EMA/CHMP/SWP/4447/00) vitamins, electrolytes, amino acids, peptides, proteins, carbohydrates, lipids proteins, vaccines and herbal medicinal products are exempted because they are unlikely to result in significant risk to the environment. (janusinfo.se)
  • In the therapeutic group, nicotinide was injected subcutaneously 0.5 mg/g body Wt/day for 40 days, 20 days before Stz injection up to 20 days after first Stz injection and then, on the 41st day after the first injection of the drug, the levels of fasting blood glucose (FBS), C-peptide, serum insulin, and inflammatory cytokines Il-1β, TNF-α and IFN-γ were studied. (ac.ir)
  • Sera from rats vaccinated with γ1TCR-I or γ2bTCR-I bind synthetic peptide 21-49 of human CD4. (biomedcentral.com)
  • Peptides encoded in the antisense strand of DNA have been predicted and found experimentally to bind to sense peptides and proteins with significant selectivity and affinity. (nih.gov)
  • The bacterial SH2 domains are not only capable of binding proteins or peptides in a Tyr phosphorylation-dependent manner, some bind pTyr itself with micromolar affinities, a property not observed for mammalian SH2 domains. (rcsb.org)
  • We employ new Natural Language Processing (NLP) based methods to predict whether any TCR and peptide bind. (frontiersin.org)
  • A set of standard tests are defined for the performance of peptide-TCR binding, including the detection of TCRs binding to a given peptide/antigen, choosing among a set of candidate peptides for a given TCR and determining whether any pair of TCR-peptide bind. (frontiersin.org)
  • Vitamin D deficiency in chronic renal failure may impair cardiac function, as manifested by elevated levels of B-type cardiac natriuretic peptides. (nih.gov)
  • During the past decade, experimental studies in animals and humans have focused on restoration of renal hemodynamics and tubule cell integrity. (medscape.com)
  • Data obtained so far on sequence and solvent dependence of interaction support a hydrophobic-hydrophilic (amphipathic) model of peptide recognition. (nih.gov)
  • Alignment of the amino acid sequence of aprotinin with the Kunitz domains of human proteins allowed the identification and design of a family of peptides, named Angiopeps. (aspetjournals.org)
  • Classification results with each dataset are used to compute informative percent amino acid coverage statistics for each protein in terms of the predicted detectable peptides in addition to the percent coverage of the complete sequence. (biomedcentral.com)
  • Furthermore, a route through foldable sequence-space between the simple peptide motif and extant protein fold is demonstrated. (fsu.edu)
  • This conclusion confirms the general finding that monoclonal antibodies and other biologics (protein or peptide) active pharmaceutical substances do not pose a risk to the environment. (janusinfo.se)
  • It correctly assigns peptides to 10% more spectra on an evaluation dataset containing 120 MS/MS spectra and decreases the false positive rate (FPR) of peptide identification. (arxiv.org)
  • However, for a particular protein, only a portion of the peptides are actually observed experimentally and the set of peptides that are observed from a single protein can vary substantially from one experiment to another. (biomedcentral.com)
  • Serum antibody to Fraction I capsular antigen, as measured by the passive hemagglutination (PHA) test, is correlated with resistance to Y. pestis infection in experimental animals. (cdc.gov)
  • The majority of protein architectures exhibit elements of structural symmetry, and "gene duplication and fusion" is the evolutionary mechanism generally hypothesized to be responsible for their emergence from simple peptide motifs. (fsu.edu)
  • Currents tools are based on conserved motifs and are applied to peptides with many known binding TCRs. (frontiersin.org)
  • Overall, these results suggest that these Kunitz-derived peptides could be advantageously used as a new brain delivery system for pharmacological agents that do not readily enter the brain. (aspetjournals.org)
  • Using patch-clamp electrophysiology in brain slices prepared from male rats, we reveal that opioid withdrawal abruptly reduces the ability of these peptides to inhibit neurotransmission, a direct consequence of a protein kinase A (PKA)-driven increase in the synaptic activity of peptidases. (jneurosci.org)
  • Although found in the brain, BNP belongs to a family of atrial natriuretic peptides, hormones made by the heart that exhibit powerful diuretic and blood pressure-lowering characteristics. (scienceblog.com)
  • In rat models of stroke, these atrial natriuretic peptides have been reported to decrease brain swelling or edema. (scienceblog.com)
  • Zasloff M ( 2015 ) Peer Review #3 of 'Cyclic mechanical stretch down-regulates cathelicidin antimicrobial peptide expression and activates a pro-inflammatory response in human bronchial epithelial cells (v0.2)' . (peerj.com)
  • Set up and perform experimental work including purification, concentration and separation of samples. (lu.se)
  • We combined large-scale TCR-peptide dictionaries with deep learning methods to produce ERGO (pEptide tcR matchinG predictiOn), a highly specific and generic TCR-peptide binding predictor. (frontiersin.org)
  • However, as many experimental settings provide, only beta chains, a binding prediction tool based on these chains is of importance. (frontiersin.org)
  • The source code is publicly available so that further developments can be accelerated for training and prediction models of the human peptide universe. (news-medical.net)
  • Informative report concerning the clinical experiment on oligopeptides peptides with the Humanofort product. (bodybasicswellness.com)
  • Kuwaba K, Kusubata M, Taga Y, Igarashi H, Nakazato K, Mizuno K. Dietary collagen peptides alleviate exercise-induced muscle soreness in healthy middle-aged males: a randomized double-blinded crossover clinical trial. (medlineplus.gov)
  • Experimental and clinical research papers adopting fresh conceptual approaches are encouraged. (iospress.com)
  • The overriding criteria for publication are novelty, significant experimental or clinical relevance and interest to a multidisciplinary audience. (iospress.com)
  • Another peptide, Box5 (a WNT5A derived antagonist) is currently in pre-clinical trials for malignant melanom. (lu.se)
  • Despite the central importance of the gene duplication and fusion hypothesis, experimental support for a plausible evolutionary pathway for a specific protein architecture has yet to be effectively demonstrated. (fsu.edu)
  • These results provide compelling experimental support for a plausible evolutionary pathway of symmetric protein architecture via gene duplication and fusion processes. (fsu.edu)
  • CIGB-500 Group (Experimental): 10 mg of the product will be received every 12 hours for 7-10 days (until completing a maximum of 20 administrations of the product), always in an intravenous bolus of 3 minutes (±20 seconds) duration. (who.int)
  • Experimental evidence suggests that vitamin D deficiency impairs cardiac structure and function. (nih.gov)
  • Our objective was to observe relationships between circulating levels of the cardiac natriuretic peptides and vitamin D levels in patients on chronic peritoneal dialysis. (nih.gov)
  • We also demonstrate the utility of predicted peptide observability for systems analysis to help determine if proteins that were expected but not observed generate sufficient peptides for detection. (biomedcentral.com)
  • We describe a statistical measure, Mass Distance Fingerprint, for automatic de novo detection of predominant peptide mass distances, i.e., putative protein mod- ifications. (lu.se)
  • The mitochondrial-derived peptide MOTS-c relieves hyperglycemia and insulin resistance in gestational diabetes mellitus. (bvsalud.org)
  • The combined use of cortistatin and other antiinflammatory peptides was very efficient treating murine septic shock. (rupress.org)
  • Indeed, the administration of the endotoxin LPS to experimental animals leads to pathophysiologic changes similar to human septic shock syndrome, and lethal endotoxemia has been extensively used as an experimental model of Gram-negative septic shock ( 1 ). (rupress.org)
  • Since the peptide CCS values are entirely determined by their linear amino acid sequences, they should be predictable with high accuracy and our deep learning model accurately predicted CCS values even for previously unobserved peptides. (news-medical.net)
  • The method's focus is to globally detect mass differences, not to assign peptide sequences or modifications to individual spectra. (lu.se)
  • The goal is to assign acquired spectra to known peptide sequences and potential co- and post-translational modifica- tions. (lu.se)
  • We have developed a methodology for constructing artificial neural networks that can be used to predict which peptides are potentially observable for a given set of experimental, instrumental, and analytical conditions for 2D LC MS/MS (a.k.a Multidimensional Protein Identification Technology [MudPIT]) datasets. (biomedcentral.com)
  • This peptide is used to block β-Catenin (6B3) Rabbit mAb #9582 and β-Catenin Antibody (Carboxy-terminal Antigen) #9587 reactivity in dot blot protocols. (cellsignal.com)
  • The peptide blocks β-Catenin (6B3) Rabbit mAb #9582 and β-Catenin Antibody (Carboxy-terminal Antigen) #9587 by dot blot. (cellsignal.com)
  • The survival of peptide-preimmunized rabbits injected with AChR seemed to correlate with the antibody specificities in immunoblots. (openu.ac.il)
  • Following the primary series of 3 injections, about 7% of individuals do not produce PHA antibody, and a few fail to develop a titer of 128, the level correlated with immunity in experimental animals. (cdc.gov)
  • In addition, are substantial differences in the peptides observed due to variations in the protein extraction and or solublization methods, tissue types, prefractionation, LC separation conditions, and differences between gradients even when the same LC separation conditions are used. (biomedcentral.com)
  • It covers degradation and experimental methods to study denaturation, and evaluates stabilizers and the use of stabilizing excipients. (pda.org)
  • The anions preferentially interact with the cis conformers of the peptide models, which is rationalized by the respective electrostatic potential surfaces. (uni-koeln.de)
  • In each case, the isocyanates react preferentially with the N-terminus of the peptide. (cdc.gov)
  • The affinity of a TCR for a given peptide epitope and the specificity of the binding are governed by the heterodimeric αβ T-cell receptors ( 2 ). (frontiersin.org)
  • However, in current practice, the efficacy of therapies such as dopamine, fenoldopam, and natriuretic peptides for the treatment of established acute kidney injury remains unproven and their routine use is not recommended. (medscape.com)
  • The GP method along with RF and SVR, each is used for post-processing the results of peptide identification by PEAKS, a commonly used de novo sequencing method. (arxiv.org)
  • Oral Ingestion of AP Collagen Peptide Leads to Systemic Absorption of Gly-Pro-Hyp, Alleviating HO-Induced Dermal Fibroblast Aging. (medlineplus.gov)
  • Such sense--antisense peptide recognition has been observed in many systems, most often by detecting binding between immobilized and soluble interaction partners. (nih.gov)
  • We demonstrate that the procedure we have developed for building a classifier based on an individual experimental data set results in classifiers with accuracy comparable to those reported in the literature based on large training sets collected from multiple experiments. (biomedcentral.com)
  • Here, we propose a genetic programming (GP) based method, called GP-PSM, to learn a PSM scoring function for improving the rate of confident peptide identification from MS/MS data. (arxiv.org)
  • We acquired data from whole-proteome digests of five organisms, which resulted in the measurement of over two million CCS values, including about 500,000 unique peptides, making it by far the most comprehensive CCS data set to date. (news-medical.net)
  • On the other hand, there are experimental data suggesting that the pharmacologically active moiety of Pegasys, IFN α2a, will be rapidly biodegraded. (janusinfo.se)
  • Rats with chronic aortocaval (AV) fistula, an experimental model of congestive heart failure, display high plasma levels of atrial natriuretic factor (ANF) and a blunted natriuretic response to ANF infusion. (elsevierpure.com)
  • The manuscript demonstrates that a mechanical stretch down-regulates cathelicidin antimicrobial peptide expression and activates a pro-inflammatory response in the human bronchial epithelial cell line model VA10. (peerj.com)
  • Thus, despite an intact capacity of glomeruli to generate cGMP in response to ANF, the ANF-induced increase in U(cGMP)V in vivo is attenuated in experimental heart failure. (elsevierpure.com)
  • Streptococcus pneumoniae, a major cause of human disease, produces a 17-mer autoinducer peptide pheromone (competence-stimulating peptide [CSP]) for the control of competence for genetic transformation. (unibo.it)
  • Hemostatic parameters in rats 24 h after single administration of this peptide did not differ from the control level observed in animals receiving 0.85% NaCl. (unboundmedicine.com)
  • The laboratory study was published in the January 2004 issue of the journal Experimental Neurology. (scienceblog.com)
  • The structural interconversion of the isomeric states of the BmK M1 non-proline cis peptide bond may relate to the conversion of the scorpion alpha-toxins subgroups. (rcsb.org)
  • Ingestion of a collagen peptide containing high concentrations of prolyl-hydroxyproline and hydroxyprolyl-glycine reduces advanced glycation end products levels in the skin and subcutaneous blood vessel walls: a randomized, double-blind, placebo-controlled study. (medlineplus.gov)
  • To learn more about our Blocking Peptides, including pricing or custom products, please submit a product inquiry request. (cellsignal.com)
  • This paper, written by Drs. John Wang and Musetta Hanson, is a review of concerns in formulating injectable products containing peptides and proteins. (pda.org)
  • Following specific binding of T cell receptors to viral and bacterial-derived peptides bound to MHC ( 5 ), or from neo-antigens ( 8 - 10 ), the appropriate T cells expand, resulting in the increased frequency of T cells carrying such receptors. (frontiersin.org)
  • In contrast, many TCR responses are characterized by a high level of cross-reactivity with single TCRs binding a large number of MHC-bound peptides, and single peptides binding a large number of TCRs ( 16 , 17 ). (frontiersin.org)