• Is Adipocyte Differentiation the Default Lineage for Mesenchymal Stem/Progenitor Cells after Loss of Mechanical Loading? (scirp.org)
  • Mesenchymal stem/progenitor cells (MSC/MPC) are found in many tissues and fluids including bone marrow, adipose tissues, muscle, synovial membranes, synovial fluid, and blood. (scirp.org)
  • Hart, D. (2014) Is Adipocyte Differentiation the Default Lineage for Mesenchymal Stem/Progenitor Cells after Loss of Mechanical Loading? (scirp.org)
  • Hart, D.A. (2014) Why Mesenchymal Stem Cell/Progenitor Cell Heterogeneity in Specific Environments? (scirp.org)
  • Wu, Y. and Zhao, R.C. (2012) The Role of Chemokines in Mesenchymal Stem Cell Homing to the Myocardium. (scirp.org)
  • Li, L. and Jiang, J. (2011) Regulatory Factors of Mesenchymal Stem Cell Migration into Injured Tissues and Their Signal Transduction Mechanisms. (scirp.org)
  • Fehrer, C. and Lepperdinger, G. (2005) Mesenchymal Stem Cell Aging. (scirp.org)
  • Batsali, A.K., Kastrinaki, M.C., Papadaki, H.A. and Pontikoglou, C. (2013) Mesenchymal Stem Cells Derived from Wharton's Jelly of the Umbilical Cord: Biological Properties and Emerging Clinical Applications. (scirp.org)
  • Sources of exogenous stem/progenitor cells that are currently under evaluation in the context of acute lung injury repair include embryonic stem cells, bone marrow- or fat-derived mesenchymal stem cells, circulating endothelial progenitors, and, recently, amniotic fluid stem/progenitor cells. (nih.gov)
  • WNT, R-spondin, epidermal growth factor, and mammalian target of rapamycin are secreted by Paneth cells or mesenchymal cells. (wjgnet.com)
  • In the present study we examined the protective potential of exogenously administered human umbilical cord derived mesenchymal stem cells (UCMSCs) against Dextran Sulfate Sodium (DSS) induced acute colitis in immunodeficient NOD.CB 17 - Prkdc scid /J mice with particular attention to endoplasmic reticulum (ER) stress. (biomedcentral.com)
  • The current study aimed to investigate the effect of mesenchymal stem cells (MSCs) transplantation as a new strategy for treatment of diabetes in Streptozotacin (STZ) induced diabetic male albino rats. (alliedacademies.org)
  • From several pathological mechanisms involved in T2DM-DKD, we focused on mitochondria damage induced by hyperglycemia-driven reactive species oxygen (ROS) accumulation and verified whether mesenchymal stem cells (MSCs) anti-oxidative, anti-apoptotic, autophagy modulation, and pro-mitochondria homeostasis therapeutic potential curtailed T2DM-DKD progression. (bvsalud.org)
  • The therapeutic potential of systemically or locally injected bone marrow cells (BMC) or mesenchymal stem cells in myocardial infarction (MI) is a very controversial issue. (uni-muenchen.de)
  • Four months post-MI, we found that the mesenchymal cells in the scar tissue were almost exclusively of local origin. (uni-muenchen.de)
  • We previously showed that human first trimester fetal blood mesenchymal stem cells (MSCs) transplanted into a murine OI model (oim mice) improved the phenotype. (ox.ac.uk)
  • Hematopoietic stem cell transplantation (HSCT) results in the alteration of several components of the immune system. (medscape.com)
  • Transplantation can result in granulocytopenia as well as impairment of barrier defenses, cell-mediated immunity, and humoral immunity. (medscape.com)
  • In conclusion: treatment with MSC.s transplantation as a cell-therapy could restore pancreatic β-cell function and improved liver and kidney functions in diabetes as a new strategy for diabetes treatment. (alliedacademies.org)
  • Stem cell transplantation is a promising strategy for therapeutic cardiac regeneration, but current therapies are limited by inefficient interaction between potentially beneficial cells (either exogenously transplanted or endogenously recruited) and the injured tissue. (regenerativemedicine.net)
  • Here we apply targeted nanomedicine to achieve in vivo cell-mediated tissue repair, imaging and localized enrichment without cellular transplantation. (regenerativemedicine.net)
  • WO 2001/046401 discloses embryonic or stem-like cells produced by cross species nuclear transplantation. (justia.com)
  • Thus, transplantation of stem cells pre-cultivated on nanostructured implants might improve the clinical outcome by support of the graft adherence and acceleration of the regeneration process. (uni-bielefeld.de)
  • The two main strategies described in literature are exogenous stem cells transplantation and enhancement of endogenous neurogenesis. (unifesp.br)
  • In this study, we evaluated polylactic acid (PLA) polymeric nanofibers (PNF) as carriers for cell transplantation and evaluated two formulations of poly(lactic-co-glycolic acid) (PLGA) for local delivery of CXCL12, a powerful chemokine to recruit neural stem cells (NSC). (unifesp.br)
  • We conclude that the PNF are viable scaffolds for cell transplantation, MS and NP are suitable for soluble factor, such as CXCL12, delivery in two different brains injury model. (unifesp.br)
  • We also discussed the advantage and challenges of mitochondrial transfer strategies, including cell-based mitochondrial transplantation, extracellular vesicle-based mitochondrial transplantation, and naked mitochondrial transplantation, for the treatment of cardiovascular disorders. (frontiersin.org)
  • The mix of induced pluripotent stem (iPS) cell technology and targeted gene adjustment by homologous recombination (HR) represents a promising new method of generate genetically corrected patient-derived cells that might be useful for autologous transplantation therapies. (biomasswars.com)
  • Despite initial successes, this approach has largely proved disappointing, with most individuals requiring exogenous insulin therapy within 5 years of transplantation. (medscape.com)
  • A more appealing strategy involves the transplantation of beta cells grown from stem cells, particularly with recent advances in generating large numbers of beta cells from human stem cells. (medscape.com)
  • Accumulated data indicate that hematopoietic stem cell transplantation may be effective under optimal conditions in preventing the progression of central nervous system symptoms in neuronopathic forms of lysosomal storage diseases (such as Krabbe disease), including some of the mucopolysaccharidoses, oligosaccharidoses, sphingolipidoses, and lipidoses as well as peroxisome disorders such as X-linked adrenoleukodystrophy. (medscape.com)
  • Although longitudinal natural history data are limited, published guidelines are available to assist with decisions related to the pursuit of transplantation and whether to use bone marrow or umbilical cord blood-derived cells. (medscape.com)
  • Some evidence indicates that at least in certain disorders, combination ERT and hematopoietic stem cell transplantation together might be superior to hematopoietic stem cell transplantation alone in patients who are appropriate candidates. (medscape.com)
  • The availability of both ERT and hematopoietic stem cell transplantation has prompted ongoing consideration of newborn screening efforts to diagnose lysosomal storage diseases. (medscape.com)
  • Residual pools of adult stem cells are hypothesized to be the source of lung regeneration and repair. (nih.gov)
  • Furthermore, endogenous HMGB1 enhances angiogenesis and restores cardiac function inside a murine style of Rabbit polyclonal to Coilin myocardial infarction (11), as well as the exogenous administration of HMGB1 after myocardial infarction prospects towards the recovery of remaining ventricular function through the regeneration of cardiomyocytes (12). (exposed-skin-care.net)
  • We show that non-ionizing, low-power laser (LPL) treatment can instead be used as a minimally invasive tool to activate an endogenous latent growth factor complex, transforming growth factor-β1 (TGF-β1), that subsequently differentiates host stem cells to promote tissue regeneration. (impactlab.com)
  • According to researchers at the Center for Genomic Regulation, disruption of the circadian rhythm (the body's natural biological clock) increases skin cells' susceptibility to forming tumors and aging quicker due to the lack of cell regeneration. (nmmra.org)
  • Abstract Osteogenic differentiation of various adult stem cell populations such as neural crest-derived stem cells is of great interest in the context of bone regeneration. (uni-bielefeld.de)
  • They use endogenous stem cells to regenerate transparent lens in situ, the first-of-its-kind human physical tissue and organ regeneration with physiological functions. (gzzoc.com)
  • The development of stem cell technologies brings hope in tissue and organ regeneration. (gzzoc.com)
  • Professor Yizhi Liu's team has used endogenous stem cells to achieve in situ regeneration of lens and applied the therapy for infants with congenital cataract. (gzzoc.com)
  • In today's regular cataract surgery, a big incision into the capsular bag damages endogenous epithelial stem cells and leads to the failure of lens regeneration. (gzzoc.com)
  • To solve these problems, his team has created a brand new minimally invasive cataract surgery to eliminate pathological tissues and protect basilar membrane and regeneration microenvironment beneficial to cell growth. (gzzoc.com)
  • What's more, this research provides a brand new strategy for cataract therapy and creates a new direction for tissue regeneration and clinical application of stem cells. (gzzoc.com)
  • Nevertheless, strong correlations have been found between heart disease, atherosclerosis, hypertension, fibrosis, and regeneration efficiency with senescent cell burden and its proinflammatory sequelae. (oaepublish.com)
  • This review discusses the current controversy about the role that endogenous and exogenous progenitor cells have in cardiac homeostasis and myocardial regeneration following injury. (johnshopkins.edu)
  • Still missing from these approaches is any attempt to induce regeneration or replication of endogenous beta cells in the pancreas, an approach that would be physiologically desirable. (medscape.com)
  • My lab focuses on understanding the role of the extracellular environment for endogenous and exogenous lung tissue regeneration in healthy and diseased lung. (lu.se)
  • Such cells from different sources can proliferate and differentiate into different lineages (e.g. osteogenic, chondrogenic and adipogenic) after suitable stimulation. (scirp.org)
  • The crypts generate a constant stream of new cells that differentiate and migrate upward into the villi. (wjgnet.com)
  • However, current ex vivo cell manipulations common to most regenerative approaches create a variety of technical and regulatory hurdles to their clinical translation, and even simpler approaches that use exogenous factors to differentiate tissue-resident stem cells carry significant off-target side effects. (impactlab.com)
  • Validating the pluripotent status (ability to differentiate into specialized cells of all three germ layers) of your culture is a critical step in stem cell research. (takarabio.com)
  • The Pluripotency Check PCR Kit can be used to validate the pluripotent status (ability to differentiate into specialized cells of all three germ layers) of your stem cell culture. (takarabio.com)
  • During the development of multicellular organisms, precursor cells for specialized organs need to differentiate in reproducible proportions and in spatially coherent domains. (biologists.com)
  • Both exogenous (inflammation, chemoradiotherapy, and diet) and endogenous factors (mitochondrial dysfunction, extracellular matrix, and enteric nervous system) have vital effects on stem cell fate modulation. (wjgnet.com)
  • High-mobility group package-1 (HMGB1) is usually a nuclear proteins that functions as a cytokine when released in to the extracellular milieu by necrotic and inflammatory cells, and it is involved with inflammatory reactions and tissue restoration (4). (exposed-skin-care.net)
  • Exosomes are small extracellular vesicles (30-100 nm in size) released by all types of cells and originate from the endosomal compartment. (decodeage.com)
  • Epithelial cells adjacent to the area of the defect flatten, lose their hemidesmosome attachments, and migrate on transient focal contact zones that are formed between cytoplasmic actin filaments and extracellular matrix proteins. (medscape.com)
  • Ideally, exogenous differentiation should mimic an endogenous differentiation process, which is partly mediated by topological cues. (uni-bielefeld.de)
  • The system is regulated by feedback loops partly mediated by endogenous and exogenous EPO and G-CSF. (health-atlas.de)
  • Strategies to enhance endogenous alveolar epithelial repair could include protection of epithelial progenitors from injury and/or stimulation of endogenous progenitor cell function. (nih.gov)
  • Further work will be needed to translate stem/progenitor cell therapy for the lung. (nih.gov)
  • Here we report that aged Aldh2(-/-) Fancd2(-/-) mutant mice that do not develop leukaemia spontaneously develop aplastic anaemia, with the concomitant accumulation of damaged DNA within the haematopoietic stem and progenitor cell (HSPC) pool. (ox.ac.uk)
  • WO 2016/135723 to the present inventors discloses mammalian bone marrow cells enriched with mitochondria for treatment of mitochondrial diseases. (justia.com)
  • The method involves microinjecting heterologous mitochondria into an oocyte or embryonic cell wherein the heterologous mitochondria are capable of achieving at least normal levels of mitochondrial membrane potential in the oocyte or embryonic cell. (justia.com)
  • Nuclear transfer efficiency is enhanced by introduction of compatible cytoplasm or mitochondrial DNA (same species or similar to donor cell or nucleus). (justia.com)
  • US 20130022666 provides compositions comprising a lipid carrier and mitochondria as well as methods of delivering exogenous mitochondria to a cell and methods of treating or reversing progression of a disorder associated with mitochondrial dysfunction in a mammalian subject in need thereof. (justia.com)
  • Studies have shown that cell-to-cell mitochondrial transfer plays an essential role in regulating cardiovascular system development and maintaining normal tissue homeostasis under physiological conditions. (frontiersin.org)
  • Given the complexity of the biological function of mitochondria, researchers have begun to consider rescuing the injured cells through mitochondrial transfer, that is, replacing damaged mitochondria with healthy mitochondria from donor cells. (frontiersin.org)
  • CONCLUSIONS 476310-60-8 The outcomes of this research display that endogenous HMGB1 is vital for ischemia-induced angiogenesis in diabetic mice which HMGB1 proteins administration enhances security blood circulation in the ischemic hind limbs of diabetic mice through a VEGF-dependent system. (exposed-skin-care.net)
  • Certainly, vessel-associated stem cells (mesoangioblasts), injected in to the general blood circulation of dystrophic mice, migrate to sites of injury in response towards the HMGB1 transmission, with 476310-60-8 a nuclear factor-BCdependent system (10). (exposed-skin-care.net)
  • Using these mice we demonstrated that our UCMSCs have a direct preventive effect other than the T-cell immunomodulatory properties which are already known. (biomedcentral.com)
  • In BTBRob/ob mice, a robust model of T2DM-DKD and obesity, MSC therapy (1 × 106 cells, two doses 4-weeks apart, intra-peritoneal route) led to functional and structural kidney improvement in a time-dependent manner. (bvsalud.org)
  • Researchers at the Center for Genomic Regulation conducted the study on samples of skin stem cells from mice. (nmmra.org)
  • In studies with mice, this method helped to regrow some hair cells, but the cells did not grow back quite right, and the mice went from being totally deaf to getting some hearing back - but not all. (hearingdoctors.net)
  • Mice with combined inactivation of aldehyde catabolism (through Aldh2 knockout) and the Fanconi anaemia DNA-repair pathway (Fancd2 knockout) display developmental defects, a predisposition to leukaemia, and are susceptible to the toxic effects of ethanol-an exogenous source of acetaldehyde. (ox.ac.uk)
  • This team showed that injection of just three genes- Neurog3, Mafa, and Pdx1 -into the pancreatic parenchyma of mice leads to conversion of exocrine cells to functional beta cells, a process popularly known as "reprogramming. (medscape.com)
  • Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients. (cdc.gov)
  • However, the mechanism through which RAD18 influences triple-negative breast cancer (TNBC), especially the interaction between tumor cells and the tumor microenvironment, remains elusive. (nature.com)
  • Hydrogels can remodel the hostile stroke microenvironment to aid endogenous and exogenous regenerative repair processes. (nih.gov)
  • Stroke is an unmet clinical need with a paucity of treatments, at least in part because chronic stroke pathologies are prohibitive to 'first-generation' stem cell-based therapies. (nih.gov)
  • Stem cell therapies are regulated differently in various countries around the world, with some countries offering stem cell therapies that are not available elsewhere. (nationalacademies.org)
  • In the United States, stem cell therapies are regulated as biologics and are subject to premarket approval under the risk-based approach to approving cellular and tissue-based products. (nationalacademies.org)
  • The Japanese government has made innovation, including innovation in stem cell research, a national priority, and new laws regarding regenerative medicine products are expected to provide a more efficient path to the translation of these therapies to the clinic. (nationalacademies.org)
  • While stem cell therapies offered in China must be registered, there are not yet approved quality control guidelines available. (nationalacademies.org)
  • If regulations for stem cell therapies were only just now being developed in the United States, they would look much different than the ones that exist today, said Margaret Foster Riley, professor of law at the University of Virginia School of Law. (nationalacademies.org)
  • The present invention provides stem cells enriched with healthy functional mitochondria, and therapeutic methods utilizing such cells for the alleviation of debilitating conditions, including aging, and age-related diseases as well as the debilitating effects of anti-cancer therapies in subjects in need thereof. (justia.com)
  • Therefore, the therapeutic use of appropriate populations derived from stem and progenitor cells has been considered for cell-based therapies for neurodegenerative diseases, primarily Parkinson's disease, and brain injuries. (ehu.eus)
  • Although a few FDA-approved therapies for type 2 diabetes (meglitinides, sulfonylureas, incretin-based drugs) directly enhance beta-cell function, no therapies for any form of diabetes lead to the growth of healthy, new beta cells to replace those that were lost or dysfunctional. (medscape.com)
  • The data presented in this thesis may serve as valuable resources to help optimize future cell replacement therapies for patients suffering from PD. (lu.se)
  • This brings as oral dopamine therapies with the advantage that with it continued infective risks for the patients the cells can be targeted to the site where dopamine with DBS which is not so for patients with trans- is most needed, namely the striatum. (lu.se)
  • In some cases, offering a particular stem cell therapy can have a positive economic impact for the country in which it is offered because patients are willing to travel in hopes of finding effective therapeutic options. (nationalacademies.org)
  • The microgravity environment onboard the ISS promotes superior 3-D cell growth conditions, enabling evaluations (using this cell line) that may better mimic the cellular response of human tissues. (issnationallab.org)
  • Mitochondria not only serve as power plants in cells but also act as crucial regulators in many biological processes, including reactive oxygen species (ROS) signaling, redox balance, calcium homeostasis, protein quality control, and programmed cell death ( 3 , 4 ). (frontiersin.org)
  • High expression of RAD18 facilitated a highly stem-cell phenotype through the Hippo/YAP pathway, which supports the proliferation of TNBC. (nature.com)
  • The signaling network in the niche establishes the baseline for self-renewal, fate determination, proliferation, and differentiation of intestinal stem cells. (wjgnet.com)
  • Additional processes in which mitochondria are involved include heat production, storage of calcium ions, calcium signaling, programmed cell death (apoptosis) and cellular proliferation. (justia.com)
  • Conditioned medium from these M2-like macrophages presented lower levels of proinflammatory cytokines and higher levels of proangiogenic factors and promoted endothelial cell proliferation, migration, and tube formation. (biomedcentral.com)
  • Pharmacodynamic models are based on ordinary differential equations describing proliferation and maturation of haematopoietic cells. (health-atlas.de)
  • For this purpose, a cell kinetic model of bone marrow erythropoiesis was developed that is based on a set of differential compartment equations describing proliferation and maturation of erythropoietic cell stages. (health-atlas.de)
  • A sufficient supply of progenitor stem cells to facilitate epithelial cell proliferation is important for the cornea. (medscape.com)
  • The present invention relates to stem cells enriched with functional mitochondria, and therapeutic methods utilizing such cells to diminish the debilitating effects of various conditions, including aging and age-related diseases as well as the debilitating effects of anti-cancer therapy treatments. (justia.com)
  • Mitochondria are found in nearly all eukaryotic cells and vary in number and location depending on the cell type. (justia.com)
  • Mitochondria perform numerous essential tasks in the eukaryotic cell such as pyruvate oxidation, the Krebs cycle and metabolism of amino acids, fatty acids and steroids. (justia.com)
  • The majority of this ATP production by non-photosynthetic eukaryotes takes place in the mitochondria, which can make up nearly 25% of the total volume of a typical cell. (justia.com)
  • WO 2013/002880 describes compositions and methods comprising bio-energetic agents for restoring the quality of aged oocytes, enhancing oogonial stem cells or improving derivatives thereof (e.g., cytoplasm or isolated mitochondria) for use in fertility-enhancing procedures. (justia.com)
  • MSCs prevented these cells from apoptosis-induced cell death, ROS accumulation, and mitochondria membrane potential impairment. (bvsalud.org)
  • In pathological conditions, damaged cells transfer dysfunctional mitochondria toward recipient cells to ask for help and take up exogenous functional mitochondria to alleviate injury. (frontiersin.org)
  • They demonstrated that transferring functional mitochondria of bone marrow-derived stem cells to defective parenchymal cells increases the aerobic respiration capacity of recipient mitochondria ( 7 ). (frontiersin.org)
  • Studies have shown that cells can eliminate defective mitochondria by delivering them to recipient cells (such as macrophages) to maintain homeostasis. (frontiersin.org)
  • And the released mitochondria can also act as a distress signal to activate the rescue properties of recipient cells ( 12 , 13 ). (frontiersin.org)
  • Gimble, J.M., Bunnell, B.A. and Guilak, F. (2012) Human Adipose-Derived Cells: An Update on the Transition to Clinical Translation. (scirp.org)
  • More broadly, this work outlines a mechanistic basis for harnessing resident stem cells with a light-activated endogenous cue for clinical regenerative applications. (impactlab.com)
  • Additionally, they have applied the therapy in clinical treatment for congenital cataract, creating a new approach to applying stem cells to tissue and organ repair. (gzzoc.com)
  • In the interdisciplinary consortium HaematoSys partners from leading clinical haematooncological study groups, pathologists, geneticists, cell biologists as well as mathematicians, statisticians and bioinformaticians have joined forces. (health-atlas.de)
  • [ 3 ] Clinical trials are currently under way on the safety, tolerability, and efficacy of transplanting such cells in encapsulated forms in persons with type 1 diabetes, with results to be announced in the coming years. (medscape.com)
  • Today, clinical trials using stem cell-derived dopaminergic progenitors have commenced. (lu.se)
  • Next, in order to study the potential of autologous cell replacement therapy we transplanted progenitors derived from a PD patient into a pre-clinical rat model. (lu.se)
  • DBS is a widely used FDA-approved treatment and stem cell-derived dopamine neuron replacement has now evolved to the first in-human clinical trials. (lu.se)
  • One strategy for correction is to use homologous recombination (HR) with an exogenous DNA donor template to modify specific genomic sequences. (biomasswars.com)
  • This approach MF498 would retain regulation by endogenous genomic elements a key advantage for genes that must be expressed in a staged fashion through differentiation or development. (biomasswars.com)
  • The successful treatment of diabetes is how to regenerate pancreatic islets β-cells. (alliedacademies.org)
  • during the evening and night, when the skin is no longer being exposed to possible damage, the cycle allows the cells to divide, regenerate, and replace damaged cells with healthy ones. (nmmra.org)
  • Liu pointed out that in the near future, with efforts of scientists, human could regenerate a healthy tissue or organ by using their own stem cells after the surgical excision of pathological one. (gzzoc.com)
  • Haematopoietic stem cells (HSCs) regenerate blood cells throughout the lifespan of an organism. (ox.ac.uk)
  • OBJECTIVE High-mobility group package-1 (HMGB1) proteins is a nuclear DNA-binding proteins released from necrotic cells, inducing inflammatory reactions and promoting cells restoration and angiogenesis. (exposed-skin-care.net)
  • M2 macrophages and exosomes from adipose-derived stem cells (ASCs) are both reported to promote angiogenesis. (biomedcentral.com)
  • Above the stem cell zone is the lineage-committed progenitor cells, also known as the transit amplifying zone, divided to fuel the rapid epithelial cell turnover. (wjgnet.com)
  • After 24-30 hours, mitosis begins to restore epithelial cell population. (medscape.com)
  • ALDH1, which has a role in the early differentiation of stem cells through its function in the oxidation of retinol to retinoic acid, is suggested to be a strong candidate for cancer stem cells in the breast. (hindawi.com)
  • First, we utilized single cell sequencing to dissect the differentiation of stem cells to midbrain dopaminergic neurons. (lu.se)
  • Gene expression-based prognostic signatures have a significant effect on predicting the survival of patients with malignant tumors, such as non-small cell lung cancer [ 7 ] and pediatric acute myeloid leukemia [ 8 ]. (aging-us.com)
  • Moreover, exosomes also act as vehicles for the transfer of nucleic acids (DNA, mRNA transcripts, miRNA, and non-coding RNAs) between cells, potentially influencing gene expression in target cells. (decodeage.com)
  • Significantly, HMGB1 is usually a chemotactic agent in vitro and in vivo for endothelial precursor cells (EPCs) (13), and latest results demonstrate that HMGB1 administration considerably increases degrees of development elements including vascular endothelial development factor (VEGF), fundamental fibroblast 476310-60-8 development element, and insulin-like development element-1 released by cultured human being cardiac fibroblasts (14). (exposed-skin-care.net)
  • Nowadays, more and more studies have revealed that cells in the cardiovascular system (such as cardiomyocytes, vascular smooth muscle cells, endothelial cells, et al. (frontiersin.org)
  • The stem cell source may be bone marrow, peripheral blood, or umbilical cord blood. (medscape.com)
  • Borlongan, C.V., Glover, L.E., Tajiri, N., Kaneko, Y. and Freeman, T.B. (2011) The Great Migration of Bone Marrow-Derived Stem Cells towards the Ischemic Brain: Therapeutic Implications for Stroke and Other Neurological Disorders. (scirp.org)
  • We treat acute myocardial infarction by targeting exogenous bone marrow-derived stem cells (expressing CD45) or endogenous CD34-positive cells to injured cardiomyocytes (expressing myosin light chain. (regenerativemedicine.net)
  • The influx of bone marrow-derived cells during tissue repair was monitored in wild-type inbred Fischer 344 rats reconstituted with bone marrow from transgenic F344 rats expressing hPLAP under the control of the ubiquitous R26 promoter. (uni-muenchen.de)
  • Intravenous administration of 1x107 BMC from hPLAP transgenic donors administered 1 week post-MI profoundly reduced the infiltration of the infarction site by bone marrow-derived cells, and also the infarction area. (uni-muenchen.de)
  • This positive autoregulation of FGF signaling, coupled with the repression of BMP signaling, may contribute to the specification of reproducible and coherent cohorts of cells with the same identity via a community effect, both in the embryo and in synthetic embryo-like systems. (biologists.com)
  • For example, RAD18 plays a vital role in regulating the DNA stability of embryonic stem cells and cellular homeostasis in highly prolific cells [ 6 ]. (nature.com)
  • Wang Z, Qu YJ, Cui M. Modulation of stem cell fate in intestinal homeostasis, injury and repair. (wjgnet.com)
  • ER stress induces activation of the unfolded protein response (UPR), a signaling network that is required to resolve stress, restoring ER homeostasis and promoting cell survival and adaptation. (biomedcentral.com)
  • The majority of the biologic markers that are proven to have an association with TNBC resistance against therapy are found in the cytoplasm of TNBC cells. (hindawi.com)
  • however, regulations for treating patients with cells and tissues that are based on evidence could help to address challenges relating to therapy, safety, and efficacy. (nationalacademies.org)
  • The GOLD 2023 report recommends that triple therapy be considered as an initial treatment only for patients with blood eosinophils ≥300 cells/μL and who have had ≥2 moderate or ≥1 severe exacerbation. (com.ng)
  • Recent evidence indicates that patients already receiving therapy and with blood eosinophils of between 100 and 300 cells/μL, particularly those who have experienced a hospitalization, may also benefit from the addition of an ICS to their existing treatment regimens.35 Further research is needed to explore the use of lower thresholds for triple therapy initiation, thus extending the benefits of this treatment to a broader population. (com.ng)
  • In type 1 diabetes , beta cells succumb to autoimmunity, leaving individuals with significantly reduced beta-cell mass and a lifelong dependence on insulin replacement therapy. (medscape.com)
  • Because of this local degeneration of a relatively small population of dopaminergic neurons in the midbrain, PD has been considered an especially interesting candidate for cell-replacement therapy. (lu.se)
  • Transplantations of fetal tissue in the 1980s and 1990s provided proof-of-concept for the potential of cell replacement therapy for PD and some patients benefitted greatly from their transplants. (lu.se)
  • The overall aim of this thesis has been to assess the potential of autologous grafting in cell replacement therapy for PD. (lu.se)
  • The transplant procedure requires the harvesting of hematopoietic stem cells from a donor. (medscape.com)
  • In a previous report we used gene targeting in murine iPS cells to correct the sickle cell anemia mutation in a mouse model of this disease.7 However in contrast to mouse cells efficiencies of gene targeting in human iPS and embryonic stem cells are low8-12 or require the construction of large donor templates 13 14 thereby rendering this approach difficult to practice. (biomasswars.com)
  • In recent years, we have come to appreciate that loss or dysfunction of insulin-producing islet beta cells underlies virtually all major forms of diabetes mellitus. (medscape.com)
  • Ando, W., Heard, B., Nakamura, N., Frank, C.B. and Hart, D.A. (2012) Ovine Synovial Membrane-Derived Mescenchymal Progenitor Cells Retain the Phenotype of the Original Tissue That Was Exposed to in Vivo Inflammation: Evidence for a Suppressed Chondrogenic Differentiation Potential of the Cells. (scirp.org)
  • Inflammation can be induced directly by UPR pathways in stressed cells, or indirectly through interaction with immune cells recruited by inflammatory cytokines released from stressed cells [ 11 ]. (biomedcentral.com)
  • Numerous cytokines and growth factors that are up-regulated in corneal cells further contribute to tissue inflammation. (medscape.com)
  • Stimulation with exogenous FGF boosts the expression of endogenous Fgf genes while repressing Bmp ligand genes. (biologists.com)
  • The use of stem cell-derived dopamine neurons or deep brain stimulation (DBS) represents two alternative approaches to treat Parkinson's Disease. (lu.se)
  • Laser-activated TGF-β1 was capable of differentiating human dental stem cells in vitro. (impactlab.com)
  • In vitro experiments withcardiac fibroblasts and H9c2 cells confirmed the exceptional biocompatibilityof BC-Ppy composites. (ibecbarcelona.eu)
  • The investigators showed that a class of antimalarial drugs known as artemisinins, typified by the FDA-approved drug artemether , were capable of inhibiting ARX levels, reducing glucagon, and increasing insulin in an in vitro alpha-cell model. (medscape.com)
  • Specifically, the employment of BC-Ppy compositesdrives partial H9c2 differentiation toward a cardiomyocyte-like phenotype.The scaffolds increase the expression of functional cardiac markersin H9c2 cells, indicative of a higher differentiation efficiency,which is not observed with plain BC. (ibecbarcelona.eu)
  • This article challenges this established, static view of cardiac growth and favors the notion that the mammalian heart has the inherent ability to replace its cardiomyocytes through the activation of a pool of resident primitive cells or the administration of hematopoietic stem cells. (johnshopkins.edu)
  • Among others are the breast cancer stem cells (BCSCs), which are believed to have a contribution to tumorigenesis, metastasis, and resistance against chemotherapy. (hindawi.com)
  • Chemotherapy is modelled by depletion of cells. (health-atlas.de)
  • In response to endogenous and exogenous insults, malignant cells mostly have an intensive DNA repair capacity that allows them to proliferate and survive. (nature.com)
  • At least two populations of epithelial stem/progenitor cells give rise to the lung anlage, comprising the laryngo-tracheal complex versus the distal lung below the first bronchial bifurcation. (nih.gov)
  • Here, we address these questions by analyzing the effects of targeted signaling manipulations in differentiating stem cell populations at single-cell resolution. (biologists.com)
  • Although the main cell-cell communication systems that drive and coordinate differentiation in cell populations have been identified, how these systems interact in signaling networks is still not well understood. (biologists.com)
  • The study showed that when a circadian rhythm is interrupted, the stem cells lose their capacity to replace dead skin cells because the genes Bmal1 and Period 1/2 prevent the cells from knowing when to execute the appropriate functions. (nmmra.org)
  • It includes 16 prevalidated forward and reverse primer mixes, based on nine genes expressed in pluripotent stem cells and two control genes. (takarabio.com)
  • The Pluripotency Check PCR Primer Set consists of 16 forward and reverse primer mixes, based on nine genes expressed in pluripotent stem cells, plus two control genes. (takarabio.com)
  • It includes 16 forward and reverse primer mixes, based on nine genes expressed in pluripotent stem cells and two control genes, plus the reagents necessary for RNA extraction, first-strand cDNA synthesis, and PCR. (takarabio.com)
  • Gene-corrected cells maintained complete MF498 pluripotency and a standard karyotype subsequent removal of reprogramming drug-resistance and factor genes. (biomasswars.com)
  • Here, we show that intraperitoneal injection of e-CSC in oim neonates reduced fractures, increased bone ductility and bone volume (BV), increased the numbers of hypertrophic chondrocytes, and upregulated endogenous genes involved in endochondral and intramembranous ossification. (ox.ac.uk)
  • Exogenous cells preferentially homed to long bone epiphyses, expressed osteoblast genes, and produced collagen COL1A2. (ox.ac.uk)
  • For example, how can genes be delivered at the precise dose to cells in humans? (medscape.com)
  • Hart, D.A. (2014) Perspectives on Endogenous and Exogenous Tissue Engineering Following Injury to Tissues of the Knee. (scirp.org)
  • Because stem cells regulate cell replacement in tissues, they constantly reproduce cells to replenish those that have deteriorated through daily use. (nmmra.org)
  • Skin grafts showed that neonatal exposure of wild-type F344 rats to hPLAP transgenic F344 cells results in lifelong tolerance to hPLAP expressing tissues and cells. (uni-muenchen.de)
  • Aging changes in the musculoskeletal system, such as cell senescence and alterations in the matrix of joint tissues, can increase the susceptibility to OA. (decodeage.com)
  • The study revealed that a disturbance in the circadian rhythm produces an increased number of latent cells and a decreased number of differentiated cells. (nmmra.org)
  • However, the possible synergistic effects between exogenous exosomes and endogenous M2 macrophages are poorly understood. (biomedcentral.com)
  • However, the factors that damage DNA and the protective mechanisms that operate in these cells are poorly understood. (ox.ac.uk)
  • Direct neuronal reprogramming of a somatic cell into therapeutic neurons, without a transient pluripotent state, provides new promise for the large number of individuals afflicted by neurodegenerative diseases or brain injury. (lu.se)
  • This approach could be potentially applied directly in the brain by targeting resident cells as a source of new neurons. (lu.se)
  • The first part of the thesis (Paper I, II, III) shows the development and improvement of a hESC-based system of for virus-mediated direct reprogramming of human glial progenitor cells into both induced dopaminergic neurons (iDANs) and GABAergic interneurons. (lu.se)
  • Study shows that Aging is a process marked by the steady accumulation of cellular and tissue damage due to various endogenous and exogenous stressors. (decodeage.com)
  • They therefore represent a more realistic cellular environment for modeling the cell biology and pathology of the nervous system. (ehu.eus)
  • This delay is required for preparatory cellular changes prior to rapid cell movement. (medscape.com)
  • The cysteine thiol acts as a nucleophile in reactions with both exogenous and endogenous electrophilic species. (drcalapai.com)
  • Since both strategies pose problems, there is increasing research on the use of biomaterial to try to optimize cell engraftment and delivery of soluble factors that can increase neurogenesis. (unifesp.br)
  • The research team has found that lens exists in endogenous epithelial stem cells and proved that Pax6 and Bmil are core factors in maintaining self-renewal and differentiation. (gzzoc.com)
  • The low endogenous regenerative capacity of the heart,added tothe prevalence of cardiovascular diseases, triggered the advent ofcardiac tissue engineering in the last decades. (ibecbarcelona.eu)
  • In particular, due to the limited regenerative capacity of the adult nervous system, the therapeutic potential of stem cells has opened up new perspectives for development of treatment strategies for brain repair after injury or disease. (ehu.eus)
  • Unconventional strategies have consequently been investigated, proposing the use of cells as an effective alternative approach to IBD. (biomedcentral.com)
  • Multiple strategies to replace beta cells in individuals with diabetes have been considered. (medscape.com)
  • Instead, for sporadic patient cells alternative strategies need to be evaluated. (lu.se)
  • Alternatively, exogenous stem/progenitor cells can be delivered into the lung either intravenously, intratracheally, or by direct injection. (nih.gov)
  • Within minutes after a small corneal epithelial injury, cells at the edge of the abrasion begin to migrate centripetally to cover the defect rapidly at a rate of 60-80 µm/h. (medscape.com)
  • BCSC is a subset of tumor cells that has stem cell-like characteristics, such as a high capacity for self-renewal and tumor initiation, which implies that BCSC may cause aggressiveness of TNBC. (hindawi.com)
  • Breast cancer stem cell is a subset of tumor cells that has a characteristic of stem cells, having a high capacity of self-renewal and tumor initiations, which imply that BCSC may cause aggressiveness of TNBC [ 5 ]. (hindawi.com)
  • The targeting event displaced the introns and coding regions and replaced the endogenous 3' UTRs (which contribute to mRNA destabilization and to Arc mRNA dendritic trafficking) with an exogenous SV40 polyadenylation signal (to promote high-level expression). (jax.org)
  • Because the study was not performed on skin stem cells of humans, there is room for speculation. (nmmra.org)
  • Exogenous application of SA and some other chemicals including: polyacrylic acid, acetyl salicylic acid, 2, 6-dichloroisonicotinic acid, methyl salicylate, jasmonic acid and jasmonic methyl ester, benzothiadiazole derivatives, DL-B-aminobutyric acid and oxalic acid, can induce accumulation of pathogenensis-related proteins and lead to reduced incidence of several diseases on many crops (Gozzo, 2003). (scialert.net)
  • However, post-mortem analysis of transplanted tissue revealed accumulation of pathological Lewy bodies in a small subset of transplanted cells over time, revealing a host-to-graft disease propagation. (lu.se)
  • The Pluripotency Check PCR Kit contains all the necessary reagents to confirm that your mouse embryonic stem (ES) or induced pluripotent (iPS) cells are indeed pluripotent. (takarabio.com)
  • In particular, the advent of human embryonic stem cells followed by reprograming technologies for generation of induced pluripotent stem cells have instigated studies into modeling human brain development and disease by providing a means to simulate a human tissue otherwise completely or largely inaccessible to researchers. (ehu.eus)
  • These progenitors which are derived from either embryonic stem cells (ESCs) or healthy induced pluripotent stem cells (iPSCs) express wild-type levels of a-syn, thus making them equally susceptible to developing Lewy bodies over time. (lu.se)
  • A recent study has revealed the importance of the body's circadian rhythm in the aging process and the regenerative capacity of skin stem cells. (nmmra.org)
  • This method uses the body's own dormant stem cells to regrow new hair cells. (hearingdoctors.net)
  • To elucidate the osteoinductive potential of porous substrates with different pore diameters (30 nm, 100 nm), human neural crest-derived stem cells isolated from the inferior nasal turbinate were cultivated on the surface of nanoporous titanium covered membranes without additional chemical or biological osteoinductive cues. (uni-bielefeld.de)
  • Cultivation of human neural crest-derived stem cells on 30 nm pores resulted in osteogenic differentiation as demonstrated by alkaline phosphatase activity after seven days as well as by calcium deposition after 3 weeks of cultivation. (uni-bielefeld.de)
  • Stem cell technologies have opened up new avenues in the study of human biology and disease. (ehu.eus)