• In a nut shell, as a stimulus, such as an allergen comes into contact with an asthma patient, it activates various types of immune cells leading to an inflammatory response, causing bronchial hyperresponsiveness, bronchoconstriction, excessive mucus secretion, airflow obstruction and an asthma attack. (wikipedia.org)
  • These vasoactive amines such as histamine, heparin and serotonin released from the mast cell granules cause vasodilation, increased vascular permeability, smooth muscle contraction and increased mucus secretion. (wikipedia.org)
  • A positive correlation is found between secretion of histamine and the extent of membrane folds on the mast cell surface. (rupress.org)
  • Because of its potential importance in acinar cell digestive enzyme secretion Rab3 is an important subject for review. (pancreapedia.org)
  • Rab3 isoforms have been identified in different tissues and cell types where it has been suggested to play a role in secretion (Table 1). (pancreapedia.org)
  • Considerable attention has been paid to understanding how Rab3A regulates secretion from neurons and neuroendocrine cells. (pancreapedia.org)
  • exocytosis mast cell mucin mucus Munc18 secretion Peritoneal MCs were isolated. (silverchair.com)
  • The secretion of histamine from mast cell and basophil granules by exocytosis. (bvsalud.org)
  • Stimulus-secretion coupling in these exocrine cells may thus by mechanistically similar to that found at the neuromuscular junction and the squia giant synapse. (silverchair.com)
  • For example, the constitutive secretion of IL-6 and IL-8 from senescent cells seems to involve the forming of a specific cellular website termed the TOR-autophagy spatial coupling area (TASCC). (buyresearchchemicalss.net)
  • For example, deficiency in particular essential autophagy protein may actually impair controlled secretion from Aliskiren hemifumarate your intestinal Paneth cell9,10, bone tissue marrow produced mast cells11, pancreatic -cells12,13, melanocytes14, osteoclasts15 and vestibular epithelial cells16. (buyresearchchemicalss.net)
  • Local cytokine activity enables cells to self-regulate their expression and secretion with many feed-forward and negative feedback loops existing in most cytokine systems/hierarchies. (encyclopedia.pub)
  • Cytokines are also able to act in a manner independent of secretion and can act as cell surface ligands. (encyclopedia.pub)
  • They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. (lookformedical.com)
  • Plasma cells are short-lived cells that differentiate from B lymphocytes and are specialized for the abundant secretion of specific antibodies (immunoglobulins). (mhmedical.com)
  • Because ZKSCAN5 improved the secretion of VEGFC by breast cancer cells, the effects of the conditioned medium on HLEC proliferation and migration were investigated in ZKSCAN5 knockdown stable cell lines. (bms-911543.com)
  • As specialized, inducible cytoplasmic organelles, lipid droplets have functions beyond the regulation of lipid metabolism, in cell signalling and activation, membrane trafficking and control of inflammatory mediator synthesis and secretion. (microbiologyresearch.org)
  • The Ca2+ level surge results in cytoskeletal rearrangement, allowing exocytosis and degranulation of intracellular granules, thus releasing vasoactive amines and proteases. (wikipedia.org)
  • Rab3d, a small GTPase, is localized on mast cell secretory granules and translocates to the plasma membrane upon exocytosis. (chkd.org)
  • Mast cells are cells that reside in the connective tissue and contain a large number of granules, rich in histamine, heparin, chymase, serotonin, and also cytokines. (bvsalud.org)
  • Azouz, N.P., Rab5 is a novel regulator of mast cell secretory granules: impact on size, cargo, and exocytosis. (riken.jp)
  • Particular secretory granules inside the endothelial cell referred to as Weibel-Palade body (WPBs) contain several biologically active substances, although von Willebrand element (VWF) is definitely the most abundant17,18. (buyresearchchemicalss.net)
  • Mast cells also originate from blood cell precursors and are filled with granules for the release of various vasoactive agents and other substances during inflammatory and allergic reactions. (mhmedical.com)
  • citation needed] Mast cells degranulation also results in the release of eosinophil chemotactic factors and neutrophil chemotactic factors. (wikipedia.org)
  • Localized mast cell degranulation induced by concanavalin A-sepharose beads. (rupress.org)
  • Concanavalin A (Con A) covalently linked to Sepharose 4B beads induced localized degranulation of sensitized rat peritoneal mast cells in regions of contact between beads and cells. (rupress.org)
  • This degranulation was Ca2+ dependent and was not seen when sensitized mast cells bound to beads conjugated with a nonstimulating lectin, wheat germ agglutinin, or when unsensitized mast cells bound to Con A-Sepharose. (rupress.org)
  • The results suggest that, if an influx of Ca2+ is the mechanism for initiating mast cell degranulation, then the opening of Ca2+ channels in the plasma membrane of activated mast cells is a localized event and that Ca2+ acts locally within the cell to initiate exocytosis. (rupress.org)
  • Electromagnetic radiation of ultra-high frequency in fracture treatment was proved to stimulate secretory activity and degranulation of mast cells, to produce the increase in microcirculatory bed vascular permeability, endotheliocyte migration phenotype expression, to ensure endovascular endothelial outgrowth, to activate reparative osteogenesis and angiogenesis while fracture reparation becomes one of the primary type and of a short-term duration. (heraldopenaccess.us)
  • The reactions in both patients were morphologically and biochemically similar to the cutaneous late-phase allergic reactions that occur after IgE-mediated, antigen-provoked mast cell degranulation. (northwestern.edu)
  • The source of the membrane required for fold formation is probably secretory granule membrane incorporated into the plasma membranene as a result of exocytosis. (rupress.org)
  • A single form of Rab3 exists in C. elegans and is believed to play a role in neurotransmitter release (47), while in sea urchin eggs a Rab3 is believed to play a role in cortical granule exocytosis (13). (pancreapedia.org)
  • 2) the medium granule cell type (granule diameter = 3-6 μm) displays only delayed rectification and (3) the small granule cell type (granule diameter = 1-2 μm) displays fast rise time, short duration action potentials whose inward current is also carried primarily by Ca 2+ ions. (silverchair.com)
  • In vivo research showed that the tiny GTPase Rab27a regulates azurophilic granule exocytosis. (cancerdir.com)
  • We discovered that both Rab27b and Rab27a deficiencies impaired azurophilic granule exocytosis. (cancerdir.com)
  • In those studies, using human neutrophils, Rab27a effector-downregulated granulocytes and Munc13-4-deficient murine neutrophils, we exhibited that Munc13-4 function is usually important for the exocytic mechanism of a variety of structurally and functionally different secretory organelles in neutrophils while JFC1 plays a more specific role in regulating azurophilic granule exocytosis (10, 19). (cancerdir.com)
  • In this work, using unique genetically altered mouse models, we analyze the role of Rab27b and Rab27a in neutrophil function and demonstrate that they play key, yet different, jobs in the legislation of neutrophil granule exocytosis. (cancerdir.com)
  • Cytotoxic T cells (CTL) secrete perforin from lysosomes. (biology-pages.info)
  • The result of cytotoxic complement reaction may be beneficial for the body (elimination of the infectious agent or damaged cells) or harmful (damage to autologous normal cells by immunopathological reactions). (dadamo.com)
  • gene (type 2 Griscelli symptoms, GS) develop an immunodeficiency disorder seen as a malfunctioning cytotoxic T-lymphocytes and by impaired organic killer cell function (21, 22). (cancerdir.com)
  • [ 15 ] The surface of the APC contains 2 peptide-binding proteins (ie, major histocompatability complex [MHC] classes I and II), which can stimulate cytotoxic T (T C ) cells, regulatory T (Treg) cells, and helper T (T H ) cells. (medscape.com)
  • Mast cells are immune cells usually located at tissues exposed to the environment, such as the skin, respiratory tract mucosa and digestive tract mucosa. (wikipedia.org)
  • METHODS: Quantitative real-time PCR, western blotting or immunohistochemistry to detect expression of PER2 and PD-L1 in OSCC tissues and cells. (bvsalud.org)
  • RESULTS: In OSCC tissues and cells, PER2 expression was reduced and PD-L1 expression was increased, the expression of PER2 was significantly negatively correlated with PD-L1. (bvsalud.org)
  • Immunostaining is a long-standing method that utilizes antibodies to label biological targets in live and fixed cells and tissues. (echelon-inc.com)
  • There are, however, potential pitfalls in this interpretation, since exocrine tissues are composed of cells which may communicate electrically with one another via low resistance junctions (e.g. (silverchair.com)
  • Histiocytoses encompass a group of diverse proliferative disorders characterized by the accumulation and infiltration of variable numbers of monocytes, macrophages, and dendritic cells in the affected tissues. (medscape.com)
  • The complement system influence the activity of numerous cells, tissues and physiological mechanism of the body. (dadamo.com)
  • Thus, while Rab27a is usually widely expressed and has been demonstrated to play a role in the regulation of exocytosis in many tissues with secretory function (29), Rab27b has been shown to play a significant role in Ki16425 inhibitor exocytosis in a limited number of cellular systems including platelets (30), pituitary gland (31), pancreatic acinar cells (32), parotid acinar cells (33) and mast cells (34). (cancerdir.com)
  • Dendritic cells display a large amount of MHC-peptide complexes at their surface and can increase the expression of costimulatory receptors and migrate to the lymph nodes, spleen, and other lymphoid tissues, where they activate specific T cells. (medscape.com)
  • The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. (lookformedical.com)
  • Connective tissue is specialized to physically support and connect other tissues and maintain the water required for metabolite diffusion to and from cells. (mhmedical.com)
  • Connective tissues all consist primarily of extracellular material rather than cells. (mhmedical.com)
  • All adult connective tissues are derived from an embryonic form of connective tissue called mesenchyme , which contains uniformly undifferentiated cells scattered in a gel-like matrix. (mhmedical.com)
  • Link to discussion of how antigens are taken up by macrophages and B cells and degraded in their lysosomes. (biology-pages.info)
  • however, significant amounts are also produced by monocytes, macrophages, and epithelial cells in the gastrointestinal and genitourinary tracts. (dadamo.com)
  • Besides macrophages and plasma cells, other leukocytes normally wander through all types of connective tissue proper, providing surveillance against bacterial invaders and stimulating tissue repair. (mhmedical.com)
  • Lipid bodies: cytoplasmic organelles important to arachidonate metabolism in macrophages and mast cells. (microbiologyresearch.org)
  • In inflammatory conditions, mast cells are activated by cytokines and release pro-inflammatory mediators. (iranpath.org)
  • The mechanism by which mast cell mediated angiogenesis has been attributed to synthetizing pro-angiogenic micro-molecules including heparin, histamine, basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF) and various cytokines such as tumor necrosis factor-a (TNF-a) and interleukin (IL)-8 (9-11). (iranpath.org)
  • In this review, we discuss the dualistic effects of histamine: how histamine affects inflammation of the immune system through the activation of intracellular pathways that induce the production of inflammatory mediators and cytokines in different immune cells and how histamine exerts regulatory functions in innate and adaptive immune responses. (hindawi.com)
  • Cytokines are small proteins with well characterised effects on cell survival, migration and activation in a range of biological systems and cell types. (encyclopedia.pub)
  • Cytokines are small, soluble proteins weighing thirty kilodaltons or less that are synthesized and secreted by a range of cells, including both immune cells, such as neutrophils, B-, and T-cells, and stromal cells, such as endothelial cells and fibroblasts [ 1 ] . (encyclopedia.pub)
  • While soluble cytokines may promote unidirectional signalling into the target cells, cell surface cytokines can initiate bi-directional outside-in signalling [ 7 ] . (encyclopedia.pub)
  • The conditioned medium from these cells re-expressing ZKSCAN5 could rescue these effects ( Figures?2A, B ). A similar tendency was also detected in HLEC migration analysis ( Figures?2C, D ). Open in a separate window Figure?2 VEGFC secreted by cancer cells, under the influence of ZKSCAN5, regulates HLEC proliferation, migration, and tube formation. (bms-911543.com)
  • Once released, histamine binds to a number of different target cell receptors and exerts a wide variety of effects. (bvsalud.org)
  • Adherence occurred at threefold log concentrations less of A23187 and Ag than required for histamine release in a selective subpopulation comprising 20 to 30% of the total cells. (aai.org)
  • Treatment of cells with dibutyryl cAMP, which activates protein kinase A, inhibited both adherence and histamine release induced by Ag or calcium ionophore. (aai.org)
  • Treatment of cells with staurosporin, which inhibits protein kinase C, also inhibited adherence and histamine release induced by calcium ionophore, but was not significantly active against either adherence or histamine release induced by Ag. (aai.org)
  • Histamine and its receptors represent a complex system of immunoregulation with distinct effects mediated by four GPCRs (G protein-coupled receptors HRs 1-4) and their differential expression, which changes according to the stage of cell differentiation and microenvironmental influences. (hindawi.com)
  • Once secreted, VWF multimers can assemble into lengthy strings that may become tethered towards the root connective cells while concurrently ensnaring circulating platelets. (buyresearchchemicalss.net)
  • Fibroblasts (fibrocytes), the major cells of connective tissue proper, are elongated, irregularly shaped cells with oval nuclei that synthesize and secrete most components of the ECM. (mhmedical.com)
  • In particular, Owen is studying the ability of B cells to activate natural killer cells, complement system, and other inflammatory mediators during pregnancy. (portlandpress.com)
  • Mast cells secrete some of their many mediators of inflammation from modified lysosomes. (biology-pages.info)
  • Each category of histiocytosis can be traced to reactive or neoplastic proliferation in one of these cell lineages. (medscape.com)
  • ZKSCAN5-Regulated VEGFC Promotes the Proliferation, Migration, and Tube Formation of HLECs Cancer cell-secreted VEGFC markedly enhanced the proliferation and migration of lymphocyte endothelial cells. (bms-911543.com)
  • The ZKSCAN5 knockdown ZR75-1 or MDA-MB-231 cell-conditioned medium decreased HLEC proliferation. (bms-911543.com)
  • A, B) Cell proliferation and colony formation assays in HLECs cultured in conditioned medium come from ZR75-1 or MDA-MB-231 cells stably infected with lentivirus carrying ZKSCAN5 shRNA or ZKSCAN5 shRNA plus ZKSCAN5-R. The representative Western blot displays the expression of ZKSCAN5. (bms-911543.com)
  • While the chronic high-dose exposure of epithelial cells to a carcinogen such as 4-NQO leads to tumor development, its effect on other cells has not been explored yet. (bvsalud.org)
  • Altogether, our results indicated that in addition to the genotoxicity of oral epithelial cells, 4-NQO potentiates long-range effects on specific immune cells to induce cell death to cause very-early immunosuppressive response during oral carcinogenesis, and thus immunosuppression and tumor development are coevolved. (bvsalud.org)
  • They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules. (lookformedical.com)
  • Plasma membrane folds on the mast cell surface and their relationship to secretory activity. (rupress.org)
  • Mast cell secretory activity stimulation and endovascular angiogenesis activation is one of the therapeutic action mechanisms of ultra-high frequency electromagnetic radiation during fracture treatment. (heraldopenaccess.us)
  • neutrophils demonstrated upregulation of Rab27b appearance which didn't make up for the secretory flaws seen in Rab27a-lacking cells recommending that Rab27 isoforms play indie jobs in neutrophil exocytosis. (cancerdir.com)
  • So far, a possible role of Rab27b in neutrophil exocytosis is currently unknown. (cancerdir.com)
  • As the FceRI receptors on mast cells capture the IgE antibodies produced by Th2 cells, they become sensitive to the specific allergen. (wikipedia.org)
  • The finding that sensitized mast cells which had adhered to Con A-Sepharose beads degranulated in regions of the cell away from the area of bead contact if exposed to soluble Con A excluded the possibility that the localized release was due to a redistribution of the IgE receptors or putative Ca2+ channels to the region of bead contact. (rupress.org)
  • This can be initiated by a number of factors, all of which involve binding of IgE, cross-linked by antigen, to the mast cell or basophil's Fc receptors. (bvsalud.org)
  • Different fragments, released from individual components during complement activation, operate by a non-cytolytic mechanism through specific receptors present on various cell types. (dadamo.com)
  • The direction and intensity of the biological response depend on the state of the receptors (affinity and density) and on the function of cells bearing receptors. (dadamo.com)
  • Adherent receptors mediate adherence of cells and other particles with bound C3b or C4b fragments and are known as CR1 to CR5. (dadamo.com)
  • These receptors, present on the other cells of the immune system, are involved in a variety of immunoregulatory reactions. (dadamo.com)
  • Histoplasma capsulatum cell wall {beta}-glucan induces lipid body formation through CD18, TLR2, and dectin-1 receptors: correlation with leukotriene B4 generation and role in HIV-1 infection. (microbiologyresearch.org)
  • An asthma attack is usually mediated by an inflammatory pathway, where a trigger such as an allergen could lead to a series of immune response mediated by various types of immune cells. (wikipedia.org)
  • The pathophysiology for asthma mainly involves the inflammatory pathway, associated with several types of immune cells in the body, mainly T helper 2 cells (Th2 cells), B cells and mast cells. (wikipedia.org)
  • Since the immunosuppression due to aberrant immunological profile is recognized as a significant cause in tumors, here we determine the interaction between 4-NQO and immune cells both in vivo and in vitro, and its effect on oral squamous cell carcinoma (OSCC) progression in a murine model. (bvsalud.org)
  • These results suggested that 4-NQO induced tumor transition from pre-malignant lesions to OSCC by altering certain immune cells systemically. (bvsalud.org)
  • The aim of this study was to evaluate the impact of smoking on angiogenesis by assessing mast cells density and VEGF expression in chronic periodontitis. (iranpath.org)
  • Mast cells isolated from the rat peritoneal cavity have folds of plasma membrane that form snake-like ridges on their surfaces. (rupress.org)
  • The finding that morphologically distinct cell types display distinct electrical activity may indicate that different secretory products are released only under a specific set of conditions associated with changes in membrane potential. (silverchair.com)
  • The exocytosis of lysosomes provides the additional membrane needed to quickly seal wounds in the plasma membrane. (biology-pages.info)
  • EVs may for example be released by the direct blebbing of the cell membrane and in doing so, may encapsulate cellular contents. (encyclopedia.pub)
  • Hydrosol suppressed the activation of SNARE proteins in DNP-BSA-stimulated RBL-2H3 cells and inhibited ROS and NO in LPS-stimulated RAW264.7 cells. (ncsu.edu)
  • The complement system consists of more than 35 soluble and cell-bound proteins, 12 of which are directly involved in the complement pathways. (dadamo.com)
  • They filter bacteria and small foreign proteins out of the blood, and dispose of worn out red blood cells. (lookformedical.com)
  • It has been shown that cigarette smoking stimulates chemokines in mast cells and upregulates vascular endothelial growth factor in lung tissue of pulmonary disease (13-14). (iranpath.org)
  • Exocytosis from endothelial cells represents among the 1st lines of protection following vascular damage. (buyresearchchemicalss.net)
  • Because of the presence of multiple forms of Rab3 in neuronal cells, the group of T. Sudhof prepared a mouse model in which all four isoforms of Rab3 were deleted. (pancreapedia.org)
  • transcriptional FCER2 transcription C( SFTPC), amongst several presequences, produces a exocytosis of erasure, a crucial vitro that is supplement project building in features. (familie-vos.de)
  • Cells propagated in vitro in special media conducive to their growth. (lookformedical.com)
  • In vitro studies focus on the strength and specificity of the interaction, while our in vivo studies are elucidating the cell fate and signaling of Opa liposomes. (umich.edu)
  • Flow cytometric analysis of human peripheral blood mononuclear cells pre-gated on the lymphocyte population using Granzyme H (E3H7W) Rabbit mAb (Alexa Fluor ® 488 Conjugate) (right) or concentration-matched Rabbit (DA1E) mAb IgG XP ® Isotype Control (Alexa Fluor ® 488 Conjugate) #2975 (left), co-stained with CD3 (UCHT1) Mouse mAb (violetFluor ™ 450 Conjugate) #61347. (cellsignal.com)
  • The aim of the present study was to locate mast cells in chronic periapical lesions (granulomas and cysts) by using histochemical techniques and toluidine blue staining. (bvsalud.org)
  • They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (lookformedical.com)
  • Fibronectin was identified as a target of mMCP-5, and the exocytosis ofmMCP-5from theMCs in the mouse's peritoneal cavity resulted in the expression of metalloproteinase protease-9, which has been implicated in arthritis. (johnshopkins.edu)
  • First, during the sensitization phase, where T cells interact with dendritic cells, the dendritic cells will present a specific antigen from the allergen to Th2 cells, leading to their development. (wikipedia.org)
  • Pluripotent stem cells can also be committed to produce dendritic cells. (medscape.com)
  • The importance of dendritic cells in presenting antigens to T and B lymphocytes is increasingly recognized. (medscape.com)
  • Dendritic cells appear to develop in several pathways. (medscape.com)
  • [ 11 ] Immature dendritic cells respond to GM-CSF (not to macrophage colony-stimulating factor [M-CSF]) and become committed to generating dendritic cells, which are "professional" antigen-presenting cells (APCs). (medscape.com)
  • [ 13 ] Dendritic cells are also efficient stimulators of B-cell lymphocytes. (medscape.com)
  • Effective induction of antigen-specific T-cell responses requires interaction between the dendritic cells and T lymphocytes to prime the latter cells for expansion and subsequent immune responses. (medscape.com)
  • Costimulatory interaction (i.e., second signal) is between CD80(B7.1)/CD86(B7.2) on the dendritic cell, and CD28 on the T cells. (medscape.com)
  • While polyclonal antibodies are secreted by many different B cell clones and recognize multiple antigenic epitopes, monoclonals originate from a single B cell clone and are specific for just one epitope. (cellsignal.com)
  • Normal histiocytes originate from pluripotent stem cells, which can be found in bone marrow. (medscape.com)
  • Cytokine release is possible in any organ and compartment throughout the body and has far reaching effects on cell survival, differentiation, and activation [ 4 ] . (encyclopedia.pub)
  • The focus of this review is to highlight the role of statins in modulating the function and differentiation of various blood cells. (archivesofmedicalscience.com)
  • The innate immune system comprises physical, chemical, and biological barriers (e.g., the skin , gastric acid , commensal organisms ) and both cellular (e.g., granulocytes , natural killer cells , mast cells ) and humoral ( complement system ) defense mechanisms . (amboss.com)
  • The plasma cells will then extensively produce allergen-specific IgE antibodies, which are captured by a type of receptor, FceRI, on the mast cells. (wikipedia.org)
  • As an allergen binds to the IgE antibodies on the mast cell surface, clustering and cross-link formation of FceRI takes place. (wikipedia.org)
  • Traditional polyclonal and monoclonal antibodies are the product of normal B cell development and genetic recombination. (cellsignal.com)
  • Where polyclonal antibodies are purified directly from the serum of the immunized host, and monoclonals are purified from either hybridoma-derived tissue culture supernatant or ascites, recombinant antibodies are instead purified from the tissue culture supernatants of transfected host cell lines. (cellsignal.com)
  • The cells must then be permeabilized using a detergent solution for the antibodies to gain access to the intracellular compartment. (echelon-inc.com)
  • Reduced gingival bleeding in smokers has been associated with decreased blood vessel density and inflammatory cells infiltration in gingiva (5-6). (iranpath.org)
  • Such a description excludes diseases in which infiltration of these cells occurs in response to a primary pathology. (medscape.com)
  • In the periapical granuloma cases, mast cells were found in eight cases (50%), located in the granulation tissue. (bvsalud.org)
  • Mast cells were detected in both cysts and periapical granuloma, located in the capsule and granulation tissue, respectively. (bvsalud.org)
  • She later continued to study MRes in Cell Biology at UCL, during which she investigated how attenuated mutations in the envelope protein of pathogenic simian immunodeficiency virus affect virological synapse formation and envelope sorting during infection, under the supervision of Prof. Mark Marsh and Dr. Scott Lawrence. (portlandpress.com)
  • D) Cytoplasmic and nuclear ZKSCAN5 protein levels in two types of breast cancer cell lines, ZR75-1 and MDA-MB-231. (bms-911543.com)
  • Upon exocytosis, the nonhelical ends of the procollagen subunits are removed, forming trimeric collagen molecules that aggregate and become covalently bound together in large collagen fibrils . (mhmedical.com)
  • TRAIL expression in astrocytes is repressed by molecules produced by T cells and microglia in the context of inflammation. (nature.com)
  • however, culture of mast cells with TGF-beta 1 was determined to enhance IgE-mediated adherence to laminin. (aai.org)
  • Hence, the high-affinity IgE-R on the mast cell functions not only in exocytosis but also facilitates the process of mast cell adherence to laminin. (aai.org)
  • In this study, we demonstrate that the cross-linking of cell surface high-affinity IgE-R on mast cells derived from mouse bone marrow cultured for 3 wk in the presence of WEHI-3-conditioned media acts as a highly sensitive physiologic stimulus for this attachment and that receptor activation is also induced by calcium ionophore A23187. (aai.org)
  • Here we investigate the role and molecular mechanism of the core clock gene Period2 (PER2) in regulating PD-L1 expression and its role in the combination therapy of oral squamous cell carcinoma (OSCC). (bvsalud.org)
  • The exact mechanism associated with this growth and expansion remains unclear, although it is known that several types of cells, including mast cells, do play a role in such phenomena 4 . (bvsalud.org)
  • These examples of programmed cell death (PCD) or apoptosis take place by an entirely different mechanism. (biology-pages.info)
  • Afterward, the activated Th2 cells would release interleukine-4, a type of cytokine to promote B cells, another type of immune cell to differentiate intoallergen-specific memory B cells and plasma cells. (wikipedia.org)
  • Pathogens, including fungi, viruses, parasites, or intracellular bacteria can induce and may benefit from lipid droplets in infected cells. (microbiologyresearch.org)
  • Zweytick D , Athenstaedt K , Daum G . Intracellular lipid particles of eukaryotic cells. (microbiologyresearch.org)
  • Langerhans cell histiocytosis (LCH) can be localized and manifest as pain or may even be asymptomatic, as is the case in isolated bone lesions. (medscape.com)
  • The constitutive heparin + (HP) mast cells (MCs) in mice express mouseMCprotease (mMCP)-5 and carboxypeptidaseA (mMC-CPA). (johnshopkins.edu)
  • Extracellular vesicles (EVs), including exosomes, are membranous particles released by cells into the extracellular space. (mdpi.com)
  • and foreign particles by phagocytic cells (PHAGOCYTES). (lookformedical.com)
  • Certainly, VWF is necessary for development of WPBs19,20, and heterologous manifestation of VWF in non-endothelial cells can induce the forming of WPB-like constructions21,22. (buyresearchchemicalss.net)
  • When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (lookformedical.com)
  • Prior to starting her Ph.D, she studied BSc Biomedical Sciences at University College London (UCL), where she first became interested in cell biology. (portlandpress.com)
  • Improved understanding of the pathology of histiocytic disorders requires knowledge of the origins, biology, and physiology of the cells involved. (medscape.com)
  • from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed. (lookformedical.com)
  • Mammalian cell lines are most commonly used for recombinant antibody production, although cell lines of bacterial, yeast, or insect origin are also suitable. (cellsignal.com)
  • Amp^r (E. coli), Neo^R (mammalian cells). (riken.jp)
  • The first signal may involve interaction between an MHC I-bound and/or MHC II-bound peptide on an APC with the T-cell receptor (TCRs) on the effector lymphocytes. (medscape.com)
  • A 438079 hydrochloride is a competitive P2X 7 receptor antagonist (pIC 50 = 6.9 for the inhibition of Ca 2+ influx in the human recombinant P2X 7 cell line). (tocris.com)
  • One such function is tissue-specific bacterial engulfment in human cells which do not normally undergo phagocytosis. (umich.edu)
  • they function in ECM turnover, phagocytosis of dead cells and debris, and antigen presentation to lymphocytes. (mhmedical.com)
  • Furthermore, a distinct cell type devoid of surface folds, designated as a raspberry-type cell, is found to occur as an integral part of a normal population of mast cells. (rupress.org)
  • The salivary glands of the terrestrial slug, Ariolimax , are composed of several morphologically distinct cell types which are observable in thin pieces of living glands and in sectioned tissue viewed with the light or electron microscope. (silverchair.com)
  • Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix. (uni-freiburg.de)
  • In different immune cell types, each MiT family member is shown to play distinct or redundant roles and we expect that there is far more to learn about their functions and regulatory mechanisms in host defense and inflammatory responses. (molcells.org)
  • As an antioxidant, Quercetin has demonstrated beneficial effects on cell health and supporting normal inflammation. (gaiaherbs.com)
  • LAMP1 + TRAIL + astrocytes limit inflammation in the CNS by inducing T cell apoptosis through TRAIL-DR5 signalling. (nature.com)
  • Altogether, we show that LAMP1 + TRAIL + astrocytes limit CNS inflammation by inducing T cell apoptosis, and that this astrocyte subset is maintained by meningeal IFNγ + NK cells that are licensed by the microbiome. (nature.com)
  • Mast cell counts was completed on toluidine blue stained slides. (iranpath.org)
  • In addition to their efficient lipid-lowering effects, statins exhibit independent so called pleiotropic effects potentially affecting several immune response properties including immune cell activation, migration, cytokine generation, immune metabolism, and survival. (archivesofmedicalscience.com)