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  • impairs
  • These results suggest that, consistent with a GTP-dependent regulation of Rab function, GDP-bound Rab11b indirectly inhibits Ca 2+ -triggered exocytosis by causing the loss of hGH from the PC12 cells, whereas GTP-bound Rab11b directly impairs Ca 2+ -triggered exocytosis. (jneurosci.org)
  • cells
  • In contrast, SNAP-23 is a ubiquitously expressed SNAP-25 homolog that is critical for regulated exocytosis in non-neuronal cells. (wordnik.com)
  • Furthermore, viruses have learned to use this Atg supported exocytosis to exit cells, acquire envelopes in the cytosol and select lipids into their surrounding membranes that might allow for increased robustness of their virions and altered infection behavior. (frontiersin.org)
  • This simple method also allows distinguishing between different modes of regulated exocytosis in cells that are difficult to manipulate genetically. (jove.com)
  • In this study, we examine the mechanism by which the voltage-dependent K + (Kv) channel Kv2.1 ( KCNB1 ) facilitates depolarization-induced exocytosis in INS 832/13 cells and β-cells from human donors with and without type 2 diabetes (T2D). (diabetesjournals.org)
  • endosomes
  • This complexation induced larger particle assemblies that remained sequestered in the endosomes, inhibiting exocytosis of the particles without any observed cytotoxicity. (rsc.org)
  • Two compartments contribute to focal exocytosis during phagocytosis: the VAMP3- and Rab11-positive recycling endosomes ( 5 , 6 , 7 ) and the TI-VAMP/VAMP7-positive late endosomes/lysosomes ( 8 ). (jimmunol.org)
  • regulates
  • Furthermore, our results are consistent with the concept that focal exocytosis of endocytic organelles is a key event in phagocytosis and suggest that Syt V regulates this process. (jimmunol.org)
  • cell
  • It is a process of which the contents of a vacuole are released, since the plant cell has large amounts of content in its vacuole, when Exocytosis is in process a large amount of molecules are released thus making it a form of bulk transport. (wikipedia.org)
  • Here we detail a method for live cell imaging of regulated exocytosis. (jove.com)
  • process
  • This process is called exocytosis , and it is triggered by an arriving nerve impulse with some small probability. (wordnik.com)
  • A model developed by Beck and Eccles applies concrete quantum mechanical features to describe details of the process of exocytosis . (wordnik.com)
  • The approach by Beck and Eccles is most detailed and concrete with respect to the application of standard quantum mechanics to the process of exocytosis . (wordnik.com)
  • Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis. (broadinstitute.org)
  • Machinery
  • Regulated exocytosis is essential for many biological processes and many components of the protein trafficking machinery are ubiquitous. (wordnik.com)
  • occurs
  • On the basis of the evidence, we propose that export of the mycotoxin aflatoxin in Aspergillus parasiticus occurs by exocytosis, and we present a model to illustrate this export mechanism. (mendeley.com)
  • protein
  • This has been particularly well studied for yeast exocytosis, in which the Rab protein Sec4p is essential ( Salminen and Novick, 1987 ). (jneurosci.org)
  • burst
  • Upon wounding by a laser beam, both eggs and embryos showed a rapid burst of localized Ca(2+)-regulated exocytosis. (rupress.org)
  • fusion events
  • Activation of purinergic P2Y 1 receptors with a specific agonist 2MeSADP (20 μM) stimulates glutamate exocytosis as measured by number of fusion events (Suppl. (hindawi.com)