Oxidative stress markers including superoxide dismutase (SOD), glutathione peroxidase (GPx) and malondialdehyde (MDA) were detected by enzyme linked immunosorbent assay (ELISA). (bvsalud.org)
Ferroptosis acts as an independent pathway for suppressing tumor growth and is tightly connected with metabolism and oxidative stress responses. (nature.com)
HO-1 and their products exert beneficial effects through the protection against oxidative injury, regulation of apoptosis, modulation of inflammation as well as contribution to angiogenesis. (springer.com)
Living organisms are frequently exposed to oxidative stress and toxic insults, like radiation, UV light, air pollution, toxins and others. (springer.com)
Oxidative stress generated during such stressful conditions may damage DNA and proteins, and as a consequence the cellular processes are disturbed. (springer.com)
Single cells and organisms may adapt to harmful oxidative stress conditions, through stress-activated factors. (springer.com)
other agents commonly ingested by the humans, such as drugs and food additives), the production of reactive species/free radicals may increase, leading to oxidative or nitrosative stress, depending on the specific reactive species are generated. (databasefootball.com)
Finally, pro-ceramide genes, examined because ceramides cause insulin resistance, oxidative stress, and neurodegeneration, were significantly up-regulated by HFD and/or NDEA exposure, but the highest levels were generally present in brains of HFD+NDEA treated rats. (biomedcentral.com)
Pterostilbene alleviated neuroinflammation by suppressing oxidative stress and carbonyl stress damage, astrocyte and microglia activation, and dopaminergic neuronal loss. (qualitycounts.com)
Astragaloside IV might suppress autophagy initiation directly or indirectly through suppressing the oxidative stress and inflammatory response, which further enhances the cell viability and tight junction and reduces apoptosis in LPS-stimulated pulmonary endothelial ARDS cell model, thus exerting its therapeutic function in ARDS. (karger.com)
Melatonin has been shown to reduce mitochondrial oxidative stress (37) and increase nitric oxide availability while reducing endothelin expression (38). (ectrx.org)
The production of this aldehyde is used as a biomarker to measure the level of oxidative stress in an organism. (ac.ir)
Contrary to oxidative stress, antioxidants can control autoxidation by interrupting the propagation of free radicals or by inhibiting the formation of free radicals and subsequently reducing oxidative stress, improving immune function, and increasing healthy longevity. (ac.ir)
Support healthy, glowing skin and hair - As an inducer of natural antioxidants in your body, sulforaphane can protect your skin from oxidative stress and help reduce the appearance of aging. (healthrangerstore.com)
TCDD for every step of the mechanism described for 2,3,7,8-TCDD carcinogenesis in humans including receptor binding, gene expression, protein activity changes, cellular replication, oxidative stress, promotion in initiation-promotion studies and complete carcinogenesis in laboratory animals. (who.int)
Inflammation4
The key inducer of such inflammation, and also the best understood, is gut microflora-derived lipopolysaccharide (LPS). (wjgnet.com)
For example, if your joints hurt due to arthritis you could find creams with capsaicin which works by depleting the nerves of certain neurotransmitters like substance P (a pain inducer) which decreases the amount of inflammation and discomfort. (happyhealthylady.com)
There are natural remedies such as creams with capsaicin which works by depleting nerves of certain neurotransmitters like substance P (a pain inducer) that decreases inflammation and discomfort. (happyhealthylady.com)
We go into the emotional/mental component of Diabetes, some techniques you can try to help with calming stress levels (which contribute to inflammation and blood sugar imbalance). (drarjan.com)
Nrf22
This review summarizes our knowledge about Nrf2 and HO-1 across different phyla suggesting their conservative role as stress-protective and anti-aging factors. (springer.com)
It turns out that sulforaphane is also an Nrf2 inducer, which together with its Wnt-activating properties makes it distinct from other phytochemicals in terms of its brain-healing potential. (box1.ws)
Neuroprotection1
Nicotinamide mononucleotide (NMN), a key nicotinamide adenine dinucleotide (NAD + ) intermediate, has been shown to exert neuroprotection for retinal diseases. (mdpi.com)
Glutathione1
Sulforaphane also acts as an inducer of antioxidants like glutathione, which help protect your cells from free radical damage. (healthrangerstore.com)
Inhibitors1
instead, through its metabolic targets, p53 is able to modulate the ferroptosis response in the presence of ferroptosis inducers such as GPX4 inhibitors or high levels of ROS. (nature.com)
Sulforaphane1
Promote healthy liver function - The sulforaphane and glucoraphanin in broccoli sprouts can help ease the stress on your liver by supporting your body's natural detoxification process. (healthrangerstore.com)
Beneficial effects1
The SIRT1 activator resveratrol has been also known to exert CR-like beneficial effects on obese humans' life quality ( Blagosklonny, 2010 ). (peerj.com)
Physiological2
What is the physiological ferroptosis inducer(s) for p53 during tumor suppression? (nature.com)
C. elegans survival assays have been key tools for studying physiological processes, including aging, stress resistance, and immunity. (molcells.org)
Antioxidant2
The ability of carnosic acid in exerting antioxidant effects is not associated only with its chemical structure, i.e. carnosic acid is not just a scavenger of reactive species. (databasefootball.com)
In this discussion of antioxidant molecules, it is also important to include melatonin, which exerts multiple protective effects in hepatic ischemia and reperfusion (33-36). (ectrx.org)
Effects3
p53's ability to inhibit tumors can be considered as a specific outcome of its stress-responsive effects. (nature.com)
Nitrosamines exert their toxic and mutagenic effects by alkylating N-7 of guanine, leading to increased DNA damage [ 5 ] and generation of reactive oxygen species such as superoxide (O 2 -) and hydrogen peroxide (H 2 O 2 ). (biomedcentral.com)
How do drugs know where to exert their effects? (msdmanuals.com)
Gene expression1
HRE are used in transgenic animal cells as inducers of gene expression. (wikipedia.org)
Cellular2
In contrast to the influx of amino acids, the degradation of proteins is also the important intracellular mechanism for releasing free amino acids both under steady-state conditions and during cellular stresses. (spandidos-publications.com)
They are an integral part of the later phase of the cellular stress response, i.e. the stress-induced senescence-like phenotype, as well as the senescence-associated secretory phenotype. (spandidos-publications.com)
Resistance2
for example, C. elegans stress resistance and lifespan assays usually take several days and weeks, respectively. (molcells.org)
Here, we briefly discuss the methods, requirements, advantages, and disadvantages of different survival assays using C. elegans , such as lifespan assays crucial for aging research, various abiotic stress resistance assays, and pathogen resistance assays important for studying immunity. (molcells.org)
Acute1
Once activated, p53 coordinates multiple downstream pathways, thereby maintaining the homeostasis of the host cell or organism (if the stress is mild, transient, and repairable) or eliminating damaged cells (if the stress is acute, prolonged, and difficult to resist). (nature.com)
Cells1
Our results demonstrate that tumor growth, peritoneal dissemination and peritoneum or organ metastasis implanted MKN45 cells were significantly decreased in shAhR and Biseugenol-treated mice and that endoplasmic reticulum (ER) stress was caused. (oncotarget.com)
Cortisol1
You should also limit stress as this releases cortisol which breaks down collagen and cartilage. (happyhealthylady.com)
Mechanisms2
Although the conventional activities of p53 such as cell cycle arrest, senescence, and apoptosis are well accepted as the major checkpoints in stress responses, accumulating evidence implicates the importance of other tumor suppression mechanisms. (nature.com)
CBD could also be useful in treating psychiatric disorders involved in altered stress coping mechanisms, such as depression. (contentcalendar.io)
Regulation1
Because of their expanding roles in the endocrine regulation of homeostasis and stress, and their involvement in human pathophysiology, exosomes are now the epicenter of a new field, termed 'exosomics' ( 3 ). (spandidos-publications.com)
Homeostasis2
The profound roles of exosomes in homeostasis, stress and several pathological conditions, in conjunction with their selective and cell‑specific composition/function, allude to their use as promising circulating clinical biomarkers of systemic stress and specific pathologic states, and as biocompatible vehicles of therapeutic cargo. (spandidos-publications.com)
Exosomes, via their cargo or surface composition, are signals/mediators of systemic homeostasis and stress for specific cell-to-cell or tissue-to-tissue communication ( 5 ). (spandidos-publications.com)
Conditions2
Under conditions of stress, a transcription activator protein binds to the response element and stimulates transcription. (wikipedia.org)
It is crucial in the treatment of plant diseases caused by deficiencies and stress caused by adverse climatic conditions or production imbalances. (spaa.it)
Emotional1
An imbalance in the spleen/pancreas or adrenal/kidney energy flow resulting from accident, injury and/or emotional/mental stress. (drarjan.com)
Response2
A gene may have many different response elements, allowing complex control to be exerted over the level and rate of transcription. (wikipedia.org)
C. elegans survival assays have played key roles in identifying novel genetic factors that regulate many aspects of animal physiology, such as aging and lifespan, stress response, and immunity against pathogens. (molcells.org)
Cell1
The initiation and development of tumor cell is accompanied by elevated stresses, such as oncogene activation, DNA damage, genome instability, and reprogrammed tumor metabolism. (nature.com)
External1
Myxedema coma is a severe form of hypothyroidism that most commonly occurs in individuals with undiagnosed or untreated hypothyroidism who are subjected to an external stress. (medscape.com)
Drugs1
A number of ferroptosis inducers have been proposed as potential drugs for cancer therapy. (nature.com)
System1
It exerts a balanced stimulating action on entire plant metabolic system by strengthening both the synthesis system of endogenous regulators and the energy production system in favour of the subsequent productive biological functions. (spaa.it)