• The negative results for cytotoxic and antimicrobial assays indicated possible low cytotoxicity to the extract. (researchgate.net)
  • In addition, hydroxyapatite whiskers (wHA) have been considered the best option as reinforcing filler in comparison with other whiskers based on carbon, ceramic, glass, metal, and polymer due to the absence of cytotoxicity effects [ 12 , 13 ]. (hindawi.com)
  • Effects of taspine on proliferation and apoptosis by regulating caspase-3 expression and the ratio of Bax/Bcl-2 in A431 cells. (rain-tree.com)
  • To investigate the putative anti-proliferative effect, apoptosis assay, microRNA expression profile and study of cell cycle were performed. (biomedcentral.com)
  • Since epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors, including gefitinib (GEF) have been reported to induce the apoptosis of several cancer cell lines, in the present study, we examined whether the cytotoxic effects of GEF are further enhanced under amino acid starvation (AAS) culture conditions. (spandidos-publications.com)
  • After antigen recognition and activation, CD8 + cytotoxic T cells may trigger keratinocyte apoptosis. (medscape.com)
  • Gemcitabine plus cisplatin exert comparable activity and a lower toxicity profile when compared to the methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) regimen [ 6 ]. (hindawi.com)
  • This investigation aims to analyse the in vitro effects of cisplatin and sunitinib malate in isolation and in combination, on one human nonmuscle invasive urinary bladder-cancer cell line (5637) and on two human muscle-invasive urinary bladder-cancer cell lines (T24 and HT1376). (hindawi.com)
  • Cisplatin is a platinum-containing compound that exerts an antineoplastic effect by covalently binding to DNA, with preferential binding to N-7 position of guanine and adenosine. (medscape.com)
  • Cisplatin, a platinum compound, exerts its cytotoxic effects by coordinating to DNA where it inhibits both replication and transcription, and induces programmed cell death. (ijpsonline.com)
  • These results are in line with previous studies showing that ultrafine carbon particles and carbon nanotube s may impair alveolar macrophage ingestion of microorganisms, and suggest that tissue homeostasis may be compromised by SWCNT due to suppressive effects on macrophages. (cdc.gov)
  • TIGIT is known to exert immune suppressive functions, such as inhibiting T cell activation, proliferation, and functions that inhibit inflammation and anti-tumor responses. (cdc.gov)
  • Trifluridine is the cytotoxic chemotherapeutic component of TAS-102, causing damage to DNA, which can ultimately trigger cell death, while tipiracil prevents rapid breakdown of trifluridine, thereby maintaining adequate levels of the trifluridine in the body. (aacr.org)
  • In this study, we show that Tfh exert an antitumor immune effect in a CD8 + -dependent manner. (nih.gov)
  • Second, injections of multiple low doses of STZ (LD-STZ), administered intraperitoneally on 5 consecutive days, induce both β-cytotoxic effects and STZ-specific T-cell-dependent immune reactions. (diabetesjournals.org)
  • They occasionally exhibit toxic, mutagenic or carcinogenic effects, or they modulate immune responses. (cdc.gov)
  • Black seed might have effects in the body that help boost the immune system, fight cancer, prevent pregnancy, reduce swelling, and lessen allergic reactions by acting as an antihistamine. (medlineplus.gov)
  • Potential y neoplastic cel s that of the effect increases with increasing tem to respond effectively to foreign arise natural y, or that have been dose or continuing exposure - and is antigens, including surface antigens transformed by carcinogens acting usually transient: immune function on tumour cells. (who.int)
  • An uncommon but potential y lized to act as an alkylating agent, Infection with HIV-1 is the cause of dangerous side effect of immuno- causes acute myeloid leukaemia and the acquired immune deficiency syn- suppression to support organ trans- carcinoma of the urinary bladder in drome (AIDS). (who.int)
  • Based on antineoplastic effect of brivaracetam and lacosamide on glioma cells, we assume that patients with glioma could benefit by the treatment with these two molecules, in addition to standard therapeutic options. (biomedcentral.com)
  • For this purpose, we performed in vitro assays, proving that Lf exerts an antiviral activity against SARS-COV-2 through direct attachment to both SARS-CoV-2 and cell surface components. (frontiersin.org)
  • Aim of this study was to evaluate possible in vitro cytotoxic effects of two new-generation antiepileptic drugs on a human glioma cell line U87MG. (biomedcentral.com)
  • The postulated mechanisms of action of corticosteroids in brain tumors include reduction in vascular permeability, cytotoxic effects on tumors, inhibition of tumor formation, and decreased CSF production. (medscape.com)
  • Because most tumors are deficient in one or more aspects of the function of the p53 tumor suppressor, either as a consequence of mutations within p53, or impairment of upstream and downstream modulators of p53 activity 19 , targeting MK2 has the potential to selectively enhance tumor cell killing without increasing the genotoxic effects of chemotherapy on normal p53-wild type tissues. (nature.com)
  • Etoposide is a glycosidic derivative of podophyllotoxin that exerts a cytotoxic effect by stabilizing the normally transient covalent intermediates formed between the DNA substrate and topoisomerase II. (medscape.com)
  • Podophyllotoxin derivative antineoplastic agents have cytotoxic effects on cell growth. (medscape.com)
  • The metal complexes of the compounds had stronger cytotoxic effects and cleaved caspase-3 expression than their ligands. (ijpsonline.com)
  • However, the various lactoferrin forms did effectively inhibit the pro-inflammatory response in macrophages that were activated with lipopolysaccharide with the most potent effect observed for apolactoferrin. (springer.com)
  • CD68 + macrophages expressing markers of a cytotoxic M1 phenotype or a noncytotoxic M2 phenotype were identified in the islets and stroma of surgically resected tumours from 20 patients with extended survival (median 92.7 months) and 20 with poor survival (median 7.7 months), using immunohistochemistry. (ersjournals.com)
  • The M1 phenotype (classically activated) macrophages are thought to be induced by interferon-γ, with or without lipopolysaccharide and tumour necrosis factor (TNF)-α, and exert a cytotoxic effect against cancer cells. (ersjournals.com)
  • Supporting proteome analyses confirmed that organic PM extracts induce a hierarchical oxidative stress response in macrophages and epithelial cells, in which the induction of electrophile-response element (EpRE) regulated genes (for example, heme oxygenase 1, catalase, and superoxide dismutase) at lower levels of oxidative stress prevented the more damaging pro-inflammatory and pro-apoptotic effects seen at higher levels of oxidative stress [ 10 ]. (biomedcentral.com)
  • They exert their effect by secreting type one interferons and cytotoxic molecules. (news-medical.net)
  • The CAR-containing exosomes express a high level of cytotoxic molecules and inhibit tumour growth. (nature.com)
  • Antiproliferative effects of compounds were determined using carboxyfluorescein succinimidyl ester assay. (ijpsonline.com)
  • Both compounds proved to have an antitumor effect which was significantly enhanced in combination with insulin. (oncotarget.com)
  • Compared with CAR-T cells, CAR exosomes do not express Programmed cell Death protein 1 (PD1), and their antitumour effect cannot be weakened by recombinant PD-L1 treatment. (nature.com)
  • Tfh produce interleukin-21, which sustains proliferation, viability, cytokine production and cytotoxic functions of exhausted T cells. (nih.gov)
  • In this study, the anti-cancer effects of pentadecanoic acid were evaluated in human breast carcinoma MCF-7/stem-like cells (SC), a cell line with greater mobility, invasiveness, and cancer stem cell properties compared to the parental MCF-7 cells. (mdpi.com)
  • Crucial cells in CLE pathogenesis comprise plasmacytoid dendritic cells (pDCs) as major producers of type I IFN, T cells exerting cytotoxic effects, and B cells, previously believed to contribute via secretion of autoantibodies. (frontiersin.org)
  • Moreover, macrophage engulfment of apoptotic target cells was significantly impaired following pre-incubation of HMDM with SWCNT at non-cytotoxic concentrations. (cdc.gov)
  • We assessed their cytotoxic effect after sensitizing cancer cells with insulin. (oncotarget.com)
  • No cytotoxic effects were observed on bone cells in drug-treated animals. (nih.gov)
  • particularly, the effect of miR-195-5p modulation seemed to affect cell cycle, while miR-107 seemed to be implicated in the inhibition of cells migration. (biomedcentral.com)
  • The major polyphenolic compound in ethanolic olive leaf extract (OLE) is oleuropein (about 20%), thus we compared the effects of OLE with the effects of standard oleuropein on INS-1 cells. (unige.ch)
  • Under AAS culture conditions, the cell killing effect of GEF was synergistically pronounced in the EGFR-expressing cell lines, namely, CAL 27, Detroit 562, A549 and PANC-1 cells compared with those treated with either GEF or AAS alone. (spandidos-publications.com)
  • TNF alpha-1a is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells and certain other target cells. (genscript.com)
  • The results indicate that the sea anemone venom is cytotoxic to human cancer cells. (scielo.br)
  • H. malu, C. adhaesivum and E. quadricolor had a significant inhibitory effect on A431 cells. (scielo.br)
  • Lymphotoxin-α (LT-α), also known as tumor necrosis factor-beta (TNF-β), is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells and certain other target cells. (biolegend.com)
  • First, the intraperitoneal injection of a single high dose (HD-STZ) exerts direct toxicity on β-cells, which results in necrosis within 48-72 h and overt permanent hyperglycemia. (diabetesjournals.org)
  • We have used human microvascular endothelial cells (HMEC) to study the combined effects of a model air pollutant, diesel exhaust particles (DEP), and oxidized 1-palmitoyl-2-arachidonyl- sn -glycero-3-phosphorylcholine (ox-PAPC) on genome-wide gene expression. (biomedcentral.com)
  • Although the intended target is the malignant cells of Hodgkin lymphoma, the effects of chemotherapy on normal cells of the body are considerable and account for the adverse effects observed with these agents. (medscape.com)
  • It exerts cytotoxic effect by inhibiting rapid proliferation of cancer cells. (medscape.com)
  • Cytotoxic T lymphocytes (CTLs) recognize antigens on target cells and lyse these cells. (msdmanuals.com)
  • Anti-melanocyte-specific cytotoxic T cells exert a central role in the final effector stage. (medscape.com)
  • BT-ON013 trade name] treatment should only be initiated by a health care provider experienced in the administration of cytotoxic chemotherapy (see section 4.4), and should be administered by a health care provider only. (who.int)
  • Antitumor effect of Tfh was evaluated by adoptive transfer in different tumor-bearing mice models. (nih.gov)
  • Rutin exerts antitumor effects on nude mice bearing SW480 tumor. (rain-tree.com)
  • Antitumor effect of Croton lechleri Mull. (rain-tree.com)
  • Inhibitory effect of taspine on mouse S180 sarcoma and its mechanism]. (rain-tree.com)
  • Mechanism of Action Ganite exerts a hypocalcemic effect by inhibiting calcium resorption from bone, possibly by reducing increased bone turnover. (nih.gov)
  • The mechanism by which cladribine exerts its therapeutic effects in patients with multiple sclerosis has not been fully elucidated but is thought to involve cytotoxic effects on B and T lymphocytes through impairment of DNA synthesis, resulting in depletion of lymphocytes. (businesswire.com)
  • This is a heavy metal coordination complex that exerts its cytotoxic effect by platination of DNA, a mechanism analogous to alkylation, leading to interstrand and intrastrand DNA crosslinks and inhibition of DNA replication. (medscape.com)
  • The survival advantage conferred by islet macrophage infiltration may be related to their cytotoxic antitumour activity. (ersjournals.com)
  • 5-FdUMP inhibits thymidylate synthase (key enzyme in DNA synthesis), which leads to accumulation of dUMP, which then gets misincorporated into the DNA in the form of 5-FdUTP resulting in inhibition of DNA synthesis and function with cytotoxic DNA strandbreaks. (medscape.com)
  • Its therapeutic effects on urinary bladder cancer have already been assessed in two clinical studies of phase II cancers and showed clinical benefits [ 10 , 11 ]. (hindawi.com)
  • Honey is a natural product known for its varied biological or pharmacological activities-ranging from anti-inflammatory, antioxidant, antibacterial, antihypertensive to hypoglycemic effects. (mdpi.com)
  • Lactoferrin was also able to neutralize microbial-derived antigens, thereby potentially reducing their pro-inflammatory effect. (springer.com)
  • Anti-inflammatory, antioxidant, and cytotoxic properties have yet to be fully explored. (drugs.com)
  • Lupus erythematosus (LE) skin lesions typically feature a histopathologic pattern termed interface dermatitis, defined by the presence of necroptotic keratinocytes and an epitheliotropic cytotoxic lymphocytic infiltrate at the dermo-epidermal junction ( 7 , 8 ). (frontiersin.org)
  • The effects of oleuropein on insulin secretion were more pronounced than those of OLE, while OLE exerted a stronger anti-cytotoxic effect than oleuropein. (unige.ch)
  • Fenugreek has been documented to have uterine stimulant effects and has been used in traditional medicine to induce childbirth. (drugs.com)
  • Doxorubicin, a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. (medscape.com)
  • At the equal mass, asbestiform EMP were more cytotoxic, however EMP of both habits induced similar LDH leakage and decrease in viability at s.a. and p.n. equivalent doses. (cdc.gov)
  • It reviews available evidence (some of which is very recent) with regards to the antimetastatic, antiproliferative and anticancer effects of honey in various forms of cancer. (mdpi.com)
  • MRLs are based on noncancerous health effects only and do not consider carcinogenic effects. (cdc.gov)
  • Furthermore, H. malu and C. adhaesivum had a significant inhibitory effect on T47D cell line at 40 µg/mL. (scielo.br)
  • These effects of honey have been thoroughly investigated in certain cancers such as breast, liver and colorectal cancer cell lines. (mdpi.com)
  • To evaluate the effects of radioiodine therapy on salivary flow in patients with differentiated thyroid cancer. (bvsalud.org)
  • They are less effective than T-cell-mediated cytotoxic mechanisms. (msdmanuals.com)
  • It is crucial that we continue to develop new therapies for use in uveitis that aim to suppress disease activity, prevent accumulation of damage, and preserve visual function for patients with the minimum possible side effects. (dovepress.com)
  • Data indicated that ApoA-I variants exerted a cytotoxic effect in a time and cell-type-specific manner that seems to be due to protein accumulation in lysosomes. (lu.se)
  • Contact allergen-induced innate immunity contrast to irritant contact dermatitis (ICD), which evolves emollients may help reduce irritancy and stabilize the barrier as a consequence of direct toxic effects of physical or chemi- function of the skin avoiding the penetration of contact aller- cal agents resulting in keratinocyte damage and local inflam- gens. (cdc.gov)
  • Brivaracetam and lacosamide showed a dose-dependent cytotoxic and anti-migratory effects. (biomedcentral.com)
  • 3. HEALTH EFFECTS the effects vary with dose and/or duration, and place into perspective the possible significance of these effects to human health. (cdc.gov)
  • However, the potential adverse effects on the brain caused by tongue-instilled ZnO NPs are not fully known. (biomedcentral.com)
  • Because most patients with Hodgkin lymphoma are long-term survivors, one of the goals of current therapy is to decrease the long-term adverse effects while maintaining excellent cure rates. (medscape.com)
  • Although adverse effects vary with each drug, some are common to many drugs. (medscape.com)
  • The points in the figures showing no-observed-adverse-effect levels (NOAELs) or lowest-observed-adverse-effect levels (LOAELs) reflect the actual doses (levels of exposure) used in the studies. (cdc.gov)
  • Public health officials and others concerned with appropriate actions to take at hazardous waste sites may want information on levels of exposure associated with more subtle effects in humans or animals (LOAELs) or exposure levels below which no adverse effects (NOAELs) have been observed. (cdc.gov)
  • An MRL is defined as an estimate of daily human exposure to a substance that is likely to be without an appreciable risk of adverse effects (noncarcinogenic) over a specified duration of exposure. (cdc.gov)
  • Reported associations between oral lichen planus and systemic diseases may be coincidental, because (1) oral lichen planus is relatively common, (2) oral lichen planus occurs predominantly in older adults, and (3) many drugs used in the treatment of systemic diseases trigger the development of oral lichenoid lesions as an adverse effect. (medscape.com)
  • In LD-STZ models, only a combination of toxic and immunological effects result in gradually increasing hyperglycemia, provided male mice of susceptible strains are being used. (diabetesjournals.org)
  • Deshielding is an effect of a nearby electronegative atom withdrawing electron density from a given atom nucleus, eliciting an increased chemical shift as measured by NMR. (wikipedia.org)
  • Our findings show that SWCNT with a low content of metal impurities do not exert direct cytotoxic effects on HMDM. (cdc.gov)
  • Despite great progress in nanotechnology, the effects of ZnO NPs exposure on the human body, in general and specifically on the brain, are not well understood. (biomedcentral.com)
  • As these kinds of health effects data become available and methods to assess levels of significant human exposure improve, these MRLs will be revised. (cdc.gov)
  • The objective of the present study was to evaluate the effects of iodine 131 on the salivary glands by subjective symptom of dryness in the mouth (xerostomia) and reduced salivary flow (hyposalivation) of patients with differentiated thyroid carcinoma submitted to radioiodine therapy. (bvsalud.org)
  • Taken together, the present study revealed that MWCNTs exert epigenetic effects in the lungs of exposed animals, potentially driving the subsequent gene expression changes. (cdc.gov)
  • Effects of olive leaf polyphenols. (unige.ch)
  • As an example, acute inhalation MRLs may not be protective for health effects that are delayed in development or are acquired following repeated acute insults, such as hypersensitivity reactions, asthma, or chronic bronchitis. (cdc.gov)
  • Kerkhof studied the effect of VPA on survival of patients with newly diagnosed GBM. (biomedcentral.com)
  • Visual impairment is common, affecting between 2.8% and 10% of patients, 1 - 3 and may result directly from damage to uveal tract structures, or may occur due to secondary effects on neighboring tissues: for example, accelerated cataract formation, glaucoma, and macular edema. (dovepress.com)
  • To elucidate whether epigenetic effects play a role for these gene expression changes, we performed whole genome bisulphite sequencing to assess DNA methylation patterns in the lungs 56 days after exposure to MWCNTs. (cdc.gov)
  • The two drugs in the new pill-trifluridine and tipiracil-work together to exert an anticancer effect. (aacr.org)
  • In addition to their anticonvulsant action, some drugs have been documented for cytotoxic effects. (biomedcentral.com)
  • This can interfere with drugs used during and after surgical procedures and cause severe side effects. (medlineplus.gov)