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  • proteins
  • Proteins within this family are linked to one another via a disulphide bond to form heterodimers consisting of one light subunit and one heavy subunit (1). (novusbio.com)
  • inhibitor
  • The coordination of the allosteric inhibitor in the structures and the change in the transporter dynamics measured by hydrogen-deuterium exchange mass spectrometry reveal a mechanism of inhibition, in which the transporter is locked in the outward-facing states of the transport cycle. (ovid.com)
  • synaptic
  • Genetic, pharmacological, and electrophysiologic studies indicate that clearance of synaptic glutamate in the mammalian forebrain is primarily dependent upon GLT-1 (for review, see Robinson, 1998 ). (jneurosci.org)
  • Upregulation of NR2A expression suggests modified NMDA receptor signaling in mGluR2-/- and mGluR3-/- mice, and downregulation of glutamate transporter expression suggests a response to altered synaptic glutamate levels. (ox.ac.uk)
  • Interacts
  • however, it is not clear whether neuron-dependent activation of astrocytic GLT-1 expression is dependent upon NF-κB signaling in astrocytes, nor is it known whether NF-κB interacts with GLT-1 promoter regions in vivo . (jneurosci.org)
  • ASTROCYTES
  • Transduction of astrocytes from the BAC GLT-1 eGFP mice with dominant-negative inhibitors of NF-κB signaling completely blocked neuron-dependent activation of a NF-κB reporter construct and attenuated induction of eGFP. (jneurosci.org)
  • In microfluidic chambers, axons (presynaptic termini) cause a clear induction of GLT-1 that is almost exclusively restricted to astrocytes that contact these processes. (jneurosci.org)
  • Here we show that expression of achaete-scute complex homolog-like 1 ( Ascl1 ) alone is sufficient to convert dorsal midbrain astrocytes of mice into functional iN cells in vitro and in vivo . (jneurosci.org)
  • ions
  • Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:20477940). (nih.gov)
  • Small lipophilic drugs, oxygen and carbon dioxide diffuse across the blood-brain barrier (BBB), whereas ions require ATP-dependent transporters such as the (Na+ + K + ) ATPase. (nih.gov)
  • Molecular
  • Our results provide insights into the molecular mechanisms underlying the function and pharmacology of human SLC1 transporters. (ovid.com)
  • human
  • Systemic injection of kainic acid (KA) in the rat produces an animal model of human temporal lobe epilepsy. (biomedsearch.com)
  • Transepithelial Transport of 4-Chloro-2-Methylphenoxyacetic Acid (MCPA) across Human Intestinal Caco-2 Cell Monolayers. (biomedsearch.com)