CarcinomaRadiotherapyTherapeuticDisease-Free SurvivalBone Marrow TransplaIntensive chemotherapyCisplatinMeSHAdjuvant chemotherapyTherapyGenesAdultCyclophosphamideCarboplatinSurvivalNeoadjuvantColorectalLungCytotoxicMetastaticAcuteMechanismsAllogeneicTumourOxaliplatinRegimenClinicalNSCLCSignificantlyTreatmentPatients treatedChildhoodMATERIAL AND METHODSOutcomeResponseSuccessfully
Carcinoma2
- Metastatic non-small cell bronchogenic carcinoma: a randomized trial of sequential vs combination chemotherapy. (uchicago.edu)
- A 57-year-old woman diagnosed with intestinal spinocellular carcinoma, showed OM score 3 (WHO) after 5-fluorouracil and cisplatin chemotherapy. (bvsalud.org)
Radiotherapy5
- We hypothesized that, following a response to induction chemotherapy, surgical resection would be superior to thoracic radiotherapy as locoregional therapy. (nih.gov)
- In selected patients with pathologically proven stage IIIA-N2 NSCLC and a response to induction chemotherapy, surgical resection did not improve overall or progression-free survival compared with radiotherapy. (nih.gov)
- The authors conclude that combined radiotherapy and chemotherapy, although significantly more effective in reducing recurrence than no therapy, is significantly more toxic than single-modality therapy in many parameters, although most of the toxicity is transient and therefore not limiting. (emmes.com)
- Oral mucositis (OM) is a debilitating acute inflammation of patients undergoing cancer therapy including high doses of chemotherapy or head and neck radiotherapy. (bvsalud.org)
- Surgical technique, use of radiotherapy, and method of administering chemotherapy are important factors. (medscape.com)
Therapeutic1
- The impact of therapeutic drug management (TDM) on reducing toxicity and improving efficacy in colorectal cancer (CRC) patients receiving fluorouracil-based chemotherapy is still unclear. (medscimonit.com)
Disease-Free Survival1
- The results of this study are published elsewhere and show a significantly reduced recurrence rate and prolonged disease-free survival time for the combined modality arm compared with the no therapy arm. (emmes.com)
Bone Marrow Transpla2
- Forty infants have subsequently been treated on a protocol incorporating further intensification with an option for high-dose chemotherapy and autologous or allogeneic bone marrow transplantation. (nih.gov)
- High-dose chemotherapy and autologous bone marrow transplantation compared with MACOP-B in aggressive B-cell lymphoma. (semanticscholar.org)
Intensive chemotherapy5
- These results show the susceptibility of infants to the toxicity of intensive chemotherapy and do not support the use of short term high-dose chemotherapy alone in the management of infant leukaemia. (nih.gov)
- Extended intrathecal methotrexate may replace cranial irradiation for prevention of CNS relapse in children with intermediate-risk acute lymphoblastic leukemia treated with Berlin-Frankfurt-Münster-based intensive chemotherapy. (unimib.it)
- Purpose: To assess the effect of treatment intensification and that of extended intrathecal methotrexate substitution for cranial irradiation in intermediate-risk acute lymphoblastic leukemia (ALL) children treated with a Berlin-Frankfurt-Munster (BFM)-based intensive chemotherapy. (unimib.it)
- Conclusion: Cranial irradiation may be omitted safely in IR ALL patients treated with BFM-based intensive chemotherapy when extended intrathecal chemotherapy is given. (unimib.it)
- Comparison of a standard regimen (CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin's lymphoma. (semanticscholar.org)
Cisplatin1
- The majority of the patients had combined cisplatin-based chemoradiation. (bepress.com)
MeSH1
- Antineoplastic Protocols" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
Adjuvant chemotherapy6
- Effects of adjuvant chemotherapy on specific and non-specific immune mechanisms. (curehunter.com)
- Adjuvant chemotherapy is a well accepted concept in the treatment of breast cancer and has resulted in most clinical studies in a significant prolongation of the disease-free interval in certain subgroups of patients. (curehunter.com)
- However, very little is known about the late effects of adjuvant chemotherapy and its influence upon the function of a series of physiologic mechanisms. (curehunter.com)
- The Glasgow Microenvironment Score associates with prognosis and adjuvant chemotherapy response in colorectal cancer. (ox.ac.uk)
- 862 TNM I-III CRC validation cohort, and 2912 TNM II-III CRC adjuvant chemotherapy cohort (TransSCOT). (ox.ac.uk)
- Exploratory endpoint was adjuvant chemotherapy interaction.ResultsGMS independently associated with DFS (p = 0.001) and RFS (p interaction = 0.013), but not duration (p = 0.64) was dependent on GMS. (ox.ac.uk)
Therapy3
- Severe toxicity in the combined therapy arm was significantly worse (P less than 0.001) than in either single modality arm. (emmes.com)
- This schedule of combined modality therapy is not only effective but appears to have tolerable toxicity, because of the relative lack of late effects. (emmes.com)
- Possible reasons for the plateau in event-free survival (including type and dose of induction steroid, dropping of induction anthracycline, type and dose of asparaginase, gaps early in therapy following intensification, and overall lack of compliance in maintenance) are being explored in the latest protocol ALL '97. (ox.ac.uk)
Genes1
Adult1
- DESIGN, SETTING, AND PARTICIPANTS: The I-SPY2 is a multicenter, platform adaptive, randomized clinical trial in the US that compares, by subtype, investigational agents in combination with chemotherapy vs chemotherapy alone in adult women with stage 2/3 breast cancer at high risk of early recurrence. (providence.org)
Cyclophosphamide2
- INTERVENTIONS: Neoadjuvant paclitaxel plus/minus 1 of several investigational agents for 12 weeks, then 12 weeks of cyclophosphamide/doxorubicin chemotherapy followed by surgery. (providence.org)
- In response to restrictions brought on by the COVID-19 pandemic, our institution adopted triple intrathecal (IT) chemotherapy for CNS prophylaxis during HyperCVAD (hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone alternating with high-dose methotrexate and cytarabine). (bvsalud.org)
Carboplatin1
- Compared with AUC5, carboplatin at AUC6 would associate with a 2.7-fold increased risk of grade 3 or 4 chemotherapy-induced anaemia. (yonsei.ac.kr)
Survival2
- Induction chemotherapy before surgical resection increases survival compared with surgical resection alone in patients with stage IIIA-N2 non-small-cell lung cancer (NSCLC). (nih.gov)
- It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. (lookformedical.com)
Neoadjuvant1
- The effects of adding zoledronic acid to neoadjuvant chemotherapy on tumour response: exploratory evidence for direct anti-tumour activity in breast cancer. (ox.ac.uk)
Colorectal3
- PURPOSE: This nationwide study evaluated results of cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal metastasis of colorectal origin in the Netherlands following a national protocol. (lu.se)
- METHODS: In a multi-institutional study prospective databases of patients with peritoneal carcinomatosis (PC) from colorectal cancer and pseudomyxoma peritonei (PMP) treated according to the Dutch HIPEC protocol, a uniform approach for the CRS and HIPEC treatment, were reviewed. (lu.se)
- TDM in colorectal cancer can reduce toxicity, improve efficacy and clinical outcome, and can be routinely used in 5-FU-based chemotherapy. (medscimonit.com)
Lung1
- BACKGROUND: In the single-arm CHRYSALIS study, amivantamab showed durable responses and manageable safety in patients with advanced non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) exon 20 insertion mutations (ex20ins) who progressed on prior platinum-based chemotherapy. (henryford.com)
Cytotoxic1
- Triple-negative breast cancer (TNBC) is an aggressive malignancy for which cytotoxic chemotherapy remains the backbone of treatment. (duke.edu)
Metastatic2
- Of these, a total of 98 patients received chemotherapy for metastatic disease. (ox.ac.uk)
- These data confirm that the majority of patients now presenting with metastatic NSGCT are curable with chemotherapy, but that a small proportion with very large volume metastases or extragonadal tumours require alternative chemotherapy schedules. (ox.ac.uk)
Acute3
- One other patient on the chemotherapy arm died of acute nonlymphocytic leukemia. (emmes.com)
- Long-term follow-up of the United Kingdom Medical Research Council protocols for childhood acute lymphoblastic leukaemia, 1980-1997. (ox.ac.uk)
- Comparison of allogeneic transplant versus chemotherapy for relapsed childhood acute lymphoblastic leukaemia in the MRC UKALL R1 trial. (ox.ac.uk)
Mechanisms1
- This study thus investigated the potential effect of paclitaxel combined with wilfortrine on cultured liver cancer cells and related mechanisms, in order to provide evidence for pathogenesis and treatment of liver cancer. (medscimonit.com)
Allogeneic1
- PATIENTS AND METHODS: Analyses comparing the outcome of related donor allogeneic BMT (related allograft) with chemotherapy are unreliable because of selection biases. (ox.ac.uk)
Tumour2
- BACKGROUND: Pre-clinical studies have demonstrated synergistic anti-tumour effects of chemotherapy (CT) and zoledronic acid (ZOL). (ox.ac.uk)
- BackgroundThe Glasgow Microenvironment Score (GMS) combines peritumoural inflammation and tumour stroma percentage to assess interactions between tumour and microenvironment. (ox.ac.uk)
Oxaliplatin1
- Patients were allocated to oxaliplatin plus fluoropyrimidine chemotherapy with or without the addition of weekly cetuximab. (ox.ac.uk)
Regimen1
- 5'fluorouracil (FU) and folinic acid (FA) in either the weekly 'Roswell Park' or the 4-weekly 'Mayo' regimen should be standard chemotherapy for colon cancer. (ox.ac.uk)
Clinical2
- Clinical protocols used to inhibit the growth or spread of NEOPLASMS. (ouhsc.edu)
- A phase II clinical trial of 6-mercaptopurine (6MP) and methotrexate in patients with BRCA defective tumours: a study protocol. (ox.ac.uk)
NSCLC2
- Selected patients with histologic or cytologic proven stage IIIA-N2 NSCLC were given three cycles of platinum-based induction chemotherapy. (nih.gov)
- Key inclusion criteria were diagnosis of EGFR ex20ins advanced NSCLC, prior platinum-based chemotherapy, and performance status score ≤ 1. (henryford.com)
Significantly2
- CONCLUSIONS: Related allograft was not found to be significantly better than chemotherapy, but there was the possibility of a moderate EFS benefit with related allograft. (ox.ac.uk)
- Adjusted on the other haematological toxicities as a multivariate analysis, neutropenia was significantly associated to non-adherence to chemotherapy (OR: 0.43). (bvsalud.org)
Treatment12
- The two enteritis fatalities occurred late at 605 and 1000 days after start of combined modality treatment, respectively. (emmes.com)
- Liver cancer cell line HpeG2 was divided into control, paclitaxel, wilfortrine, and combined treatment groups. (medscimonit.com)
- The combined treatment using wilfortrine and paclitaxel can inhibit proliferation and invasion of liver cancer cells via down-regulating Bcl-2 and up-regulating Bax, with better efficacy than single use of either drug. (medscimonit.com)
- This phase II study combined elotuzumab (Elo) with carfilzomib, lenalidomide, and dexamethasone (KRd) for treatment of MM in first relapse with the aim of improving efficacy. (bvsalud.org)
- Studies were included when they included 10 or more children with OPG, main treatment was chemotherapy and visual outcome was described. (prinsesmaximacentrum.nl)
- Based on our systematic review it appears that treatment with chemotherapy does not improve resulting vision in the majority of children with OPG. (prinsesmaximacentrum.nl)
- Anthracycline-based chemotherapy as primary treatment for intravascular lymphoma. (semanticscholar.org)
- MACOP-B chemotherapy for the treatment of diffuse large-cell lymphoma. (semanticscholar.org)
- Analysis by treatment received gave similar results, with BMT patients having a 5% (P = 0.8) eight-year EFS advantage over patients who received chemotherapy. (ox.ac.uk)
- All adults having received six treatment sessions as fi rst-line chemotherapy were taken into account. (bvsalud.org)
- See also Cervical Cancer Treatment Protocols . (medscape.com)
- Multiagent chemotherapy in combination with rituximab is the most common first-line treatment strategy for follicular lymphoma. (medscape.com)
Patients treated1
- This study aims to identify the infl uence of chemotherapy induced haematological toxicities on adherence to anti-cancer chemotherapy in patients treated for cancer at Yalgado Ouédraogo University Hospital (Ouagadougou, Burkina Faso). (bvsalud.org)
Childhood1
- DISCUSSION: Published studies on childhood low grade gliomas have not shown satisfactorily whether chemotherapy improves outcome of vision in children with OPG. (prinsesmaximacentrum.nl)
MATERIAL AND METHODS1
- MATERIAL AND METHODS: A systematic review of the literature was carried out to identify all studies published in PubMed, EMBASE and Cochrane Library between 1990 and 2008 reporting visual outcome in children with OPG after chemotherapy. (prinsesmaximacentrum.nl)
Outcome2
- Does chemotherapy affect the visual outcome in children with optic pathway glioma? (prinsesmaximacentrum.nl)
- Little is known, however, about the effect of chemotherapy on visual outcome of these patients. (prinsesmaximacentrum.nl)
Response1
- Induction chemotherapy resulted in a response rate of 61% (95% confidence interval [CI] = 57% to 65%) among the 579 eligible patients. (nih.gov)
Successfully1
- all have been successfully treated with chemotherapy. (ox.ac.uk)