• Symptoms include delayed relaxation of the muscles after voluntary contraction (myotonia), and may also include stiffness, hypertrophy (enlargement), transient weakness in some forms of the disorder (from certain genetic mutations), severe masseter spasm, and cramping. (wikipedia.org)
  • Becker disease usually appears later in childhood than Thomsen disease, and causes more severe myotonia, muscle stiffness and transient weakness. (wikipedia.org)
  • In the initial stage of the disease, the patient has an exaggerated upright posture and may report back discomfort or stiffness or pain in the entire back, which is worse with tension or stress. (medscape.com)
  • The muscle stiffness usually begins in the jaw (lockjaw) and neck and then becomes generalized. (cdc.gov)
  • it is also referred to as an unusual "tightness", stiffness, or "pull" of muscles. (autoimmunearthriticsystemiclife.com)
  • hepatosplenomegaly) and skeletal abnormalities. (medlineplus.gov)
  • The characteristic features of this type include involuntary tensing of various muscles (dystonia) and abnormalities of the spinal bones ( vertebrae ). (medlineplus.gov)
  • Three major clinical subtypes have been suggested: A mild form recognized after age ten years with absence of skeletal abnormalities, myopathy, and slow progression (type 1). (beds.ac.uk)
  • A moderate form recognized before age ten years with presence of skeletal abnormalities, myopathy, and slow progression (type 2). (beds.ac.uk)
  • Individuals with a milder phenotype have mild-to-moderate intellectual disability, impaired hearing, characteristic coarse features, clinical or radiographic skeletal abnormalities, immunodeficiency, and primary central nervous system disease - mainly cerebellar involvement causing ataxia. (beds.ac.uk)
  • Alpha-mannosidosis is an autosomal recessive lysosomal storage disease characterized by mental retardation, coarse facial features, skeletal abnormalities, hearing impairment, neurologic motor problems, and immune deficiency. (beds.ac.uk)
  • Additional features may include psychomotor delay, hypergonadotropic hypogonadism, short stature, and various skeletal abnormalities. (beds.ac.uk)
  • The PMC coordinates the urethral sphincter relaxation and detrusor contraction to facilitate urination. (medscape.com)
  • The hallmark of the disease is the failure of initiated contraction to terminate, often referred to as delayed relaxation of the muscles (myotonia) and rigidity. (wikipedia.org)
  • That's right, it depends solely on the regular contraction and relaxation of your body's muscle structures for its efficient circulation. (acudoc.com)
  • used as an anticholinergic for relaxation of smooth muscles in various organs, to increase heart rate by blocking the vagus nerve, and as a local application to the eye to dilate the pupil and to paralyze ciliary muscle for accommodation. (wildliferesearch.com)
  • Alternate muscular contraction and relaxation in rapid succession. (wildliferesearch.com)
  • This is the only skeletal connection between the axial skeleton and the upper extremity. (medscape.com)
  • 3, 4] Usually, it begins in the axial muscles and extends to the proximal limb muscles, but the severity of the limb muscle involvement may overwhelm the axial muscle involvement (stiff limb syndrome). (medscape.com)
  • Stiff person syndrome usually begins insidiously in the axial muscles. (medscape.com)
  • To test the hypothesis that the responses in renal sympathetic nerve activity (RSNA) and mean arterial pressure (MAP) during SpMA are exaggerated with hypertension, this study aimed to compare the responses in decerebrate, paralyzed SHR, WKY, and normotensive Sprague-Dawley (SD) rats. (bvsalud.org)
  • Insufficient hepatic O 2 in animal and human studies has been shown to elicit a hepatorenal reflex in response to increased hepatic adenosine, resulting in the stimulation of renal as well as muscle sympathetic nerve activity and activating the renin angiotensin system. (surgicalneurologyint.com)
  • Over time, excessive storage of fats can cause permanent cellular and tissue damage, particularly in the brain, peripheral nervous system (the nerves from the spinal cord to the rest of the body), liver, spleen, and bone marrow. (nih.gov)
  • Type B (juvenile onset) does not generally affect the brain but most children develop ataxia, damage to nerves exiting from the spinal cord (peripheral neuropathy), and pulmonary difficulties that progress with age. (nih.gov)
  • GM1 gangliosidosis is an inherited disorder that destroys nerve cells (neurons) in the brain and spinal cord. (medlineplus.gov)
  • ALL of our hospitals have their own specialty's but Baylor is just a "golden" egg for Rehab and accidents with lots of brain injury, or spinal cord and nerves. (autoimmunearthriticsystemiclife.com)
  • Additionally the resistance of the exit of the flow can be owed by a rapid contraction of the striated musculature of the urethral sphincter. (vin.com)
  • Stimulation of the mesencephalic locomotor region elicits exaggerated sympathetic nerve and pressor responses in spontaneously hypertensive rats (SHR) as compared with normotensive Wistar-Kyoto rats (WKY). (bvsalud.org)
  • Clinically, spasticity is defined as velocity-dependent resistance to stretch, where a lack of inhibition results in excessive contraction of the muscles, ultimately leading to hyperflexia, an exaggerated deep tendon reflex on stimulation with a reflex hammer (or spontaneous firing of deep tendon reflexes as in clonus . (autoimmunearthriticsystemiclife.com)
  • The actions of epinephrine resemble the effects of stimulation of adrenergic nerves. (drugs-library.com)
  • When given by rapid intravenous injection, it produces a rapid rise in blood pressure, mainly systolic, by (1) direct stimulation of cardiac muscle which increases the strength of ventricular contraction, (2) increasing the heart rate and (3) constriction of the arterioles in the skin, mucosa and splanchnic areas of the circulation. (drugs-library.com)
  • The bladder and urethra are innervated by 3 sets of peripheral nerves arising from the autonomic nervous system (ANS) and somatic nervous system. (medscape.com)
  • ataxia - a problem of muscle coordination not due to apraxia, weakness, rigidity, spasticity or sensory loss. (brainline.org)
  • Stiff person syndrome is a rare disease characterized by muscle rigidity that waxes and wanes with concurrent spasms. (medscape.com)
  • Clinically, stiff person syndrome is characterized by muscle rigidity that waxes and wanes with concurrent spasms. (medscape.com)
  • It is characterized by generalized rigidity and convulsive spasms of skeletal muscles. (cdc.gov)
  • Total peripheral resistance decreases by action of epinephrine on beta receptors of the skeletal muscle vasculature and blood flow is thereby enhanced. (drugs-library.com)
  • The aim of this investigation was to determine the effects of insulin on CAP-activated currents in small DRG neurons and CAP-induced action potentials in thin-fibre muscle afferents of normal healthy rodents. (bvsalud.org)
  • KEY POINTS: Evidence suggests insulin centrally activates the sympathetic nervous system, and a chemical stimulus to tissues activates the sympathetic nervous system via thin fibre muscle afferents. (bvsalud.org)
  • In the present study, it is demonstrated that insulin potentiates the responsiveness of thin fibre afferents to capsaicin at muscle tissue levels as well as at the level of dorsal root ganglion neurons. (bvsalud.org)
  • Some studies have also found evidence that Botox can help relieve migraine headaches, excessive sweating and muscle contractions in the neck and eye areas. (blueridgeplasticsurgery.net)
  • The findings suggest that insulin potentiates TRPV1 responsiveness to CAP at the DRG and muscle tissue levels, possibly contributing to the augmentation in sympathoexcitation during activities such as physical exercise. (bvsalud.org)
  • Herein, we tested the hypothesis that a single high-fat Western meal would impair the ability of contracting skeletal muscle to offset vascular responsiveness to sympathetic activation during exercise, termed functional sympatholysis. (researchgate.net)
  • In addition, it is demonstrated that insulin augments the sympathetic nerve activity response to capsaicin in vivo. (bvsalud.org)
  • The X-linked otopalatodigital (X-OPD) spectrum disorders, characterized primarily by skeletal dysplasia, include the following: Otopalatodigital syndrome type 1 (OPD1). (beds.ac.uk)
  • Eyelid surgery, or blepharoplasty, is a procedure to remove fat, excess skin, and/or muscle from the upper and lower eyelids. (blueridgeplasticsurgery.net)
  • examined radial, median, and ulnar nerve specimens from a CRPS-affected amputated limb and showed widespread (47-58%) selective degeneration in the larger myelinated Aα fibers (motor/proprioception) and in groups of small unmyelinated C fibers (Remak bundles), while the smaller Aδ (pain/temperature) fibers were spared. (frontiersin.org)
  • The authors postulated that large Aα fiber degeneration could consequently affect the associated innervated muscles. (frontiersin.org)
  • Faulty postural habits are a leading cause of poor lymphatic circulation (not to mention accelerated skeletal degeneration). (acudoc.com)
  • The premotor area aids in controlling movements of the core muscles to maintain posture during movement, whereas the supplemental motor area is hypothesized to be responsible for planning and coordinating movement. (foobrdigital.com)
  • Exercises and activities can include range of motion exercises (ROM), strengthening exercises focused on building endurance and muscle, balance exercises which will target areas of deficit, and gait training to improve posture and walking. (braininjurycanada.ca)
  • When the bladder becomes full, the stretch receptors of the detrusor muscle send a signal to the pons, which in turn notifies the brain. (medscape.com)
  • The primary activity of this area is to send tonically inhibitory signals to the detrusor muscle to prevent the bladder from emptying (contracting) until a socially acceptable time and place to urinate is available. (medscape.com)
  • Myotonia congenita is a congenital neuromuscular channelopathy that affects skeletal muscles (muscles used for movement). (wikipedia.org)
  • Electromyography (EMG) can be used to show characteristic continuous motor unit activity with normal morphology, which is especially prominent in the paraspinal muscles. (medscape.com)
  • The associated muscle imbalances and structural deviations often impede the circulation of lymph fluids along the major lymphatic ducts. (acudoc.com)
  • As muscles contract and squeeze the lymph vessels, fluids are forced through the one way valves which then shut behind, serving to prevent the ebbing of fluids back to where they were prior to contraction. (acudoc.com)
  • Pertaining to a small pyramidal space between the upper lateral part of the chest and the medial side of the arm, and including, in addition to the armpit, axillary vessels, the bronchial plexus of nerves, a large number of lymph nodes, and fat and loose alveolar tissue. (wildliferesearch.com)
  • Somatic senses inform the nervous system about the external environment, but the response to that is through voluntary muscle movement. (foobrdigital.com)
  • However, some aspects of the somatic system use voluntary muscles without conscious control. (foobrdigital.com)
  • However, the muscles that are responsible for the basic process of breathing are also utilized for speech, which is entirely voluntary. (foobrdigital.com)
  • Active Release Technique practitioners use palpation to look for unevenness or unusual patterns in the texture, tightness, and movement of muscles and fascia. (nhpcanada.org)
  • An unusual or exaggerated allergic reaction of an organism to foreign protein or other substances which may produce shock. (wildliferesearch.com)
  • Its most prominent actions are on the beta receptors of the heart, vascular and other smooth muscle. (drugs-library.com)
  • Sometimes larger breasts can cause certain complications like neck and back pain, skeletal deformities, skin irritations, and indentations in the skin caused by bra straps. (blueridgeplasticsurgery.net)
  • Rarely, people with osteoporosis-pseudoglioma syndrome have additional signs or symptoms such as mild intellectual disability, weak muscle tone (hypotonia), abnormally flexible joints, or seizures. (nih.gov)
  • Additionally, we investigated whether insulin potentiates sympathetic nerve activity (SNA) responses to CAP. (bvsalud.org)
  • Epinephrine relaxes the smooth muscles of the bronchi and iris and is a physiologic antagonist of histamine. (drugs-library.com)
  • It remains unknown whether the changes in sympathetic nerve activity and hemodynamics during SpMA are altered by hypertension. (bvsalud.org)
  • Contracting skeletal muscle can overcome sympathetic vasoconstrictor activity (functional sympatholysis), which allows for a blood supply that matches the metabolic demand. (researchgate.net)
  • Simultaneous continuous motor activity is noted in opposing muscles. (medscape.com)
  • It will likely come as little surprise here, that most people fall well short of the necessary muscle activity to maintain proper lymphatic circulation. (acudoc.com)
  • Active Release Technique (ART) focuses on reducing myofascia associated with pain syndromes, loss of strength, and reduced mobility through releasing scar tissue and thickened states of tissues surrounding muscles and organs. (nhpcanada.org)
  • The scapula is a triangular-shaped bone that functions mainly as a site for muscle attachment. (medscape.com)
  • Our approach has instead addressed muscle dysfunction through dry needling, a treatment where needles of 32-G are placed at 1 cm intervals along both the length and breadth of muscles. (frontiersin.org)
  • The exact mechanisms behind coccydynia are not fully understood, but it is believed to involve inflammation, nerve sensitivity, or muscle dysfunction. (physiotherapistahmedabad.com)
  • Although the influence of different range of motions and muscle-tendon unit lengths has been investigated in pure stretch-hold experiments in vivo, the contribution to a SSC movement in human muscles remains unclear. (nature.com)
  • A stretch-shortening cycle (SSC) is a common muscle action during exercise and everyday movement. (nature.com)
  • In stretch-hold experiments, the force or torque during active stretch but also in the isometric hold phase after active stretch is enhanced compared to a fixed-end reference contraction. (nature.com)
  • Purpose ATP could play an important role in skeletal muscle blood flow regulation by inducing vasodilation via purinergic P2 receptors. (researchgate.net)
  • Risk factors for developing acute stress disorder include a previously existing mental health diagnosis, avoidant coping mechanisms, and exaggerated appraisals of events. (cloudfront.net)
  • Functional sympatholysis has been identified as an underappreciated cause of poor contracting muscle perfusion (53) and may result in functional changes in exercise capacity (12). (researchgate.net)
  • Muscle damage caused, in part, by lactic acidosis resulting from extreme exercise or exertion such as occurs when animals are chased or physically restrained during capture. (wildliferesearch.com)