Evidence tumor antigen to antigen antigen of tumor. Medical search. Frequent questions

Thus, addressing the presence of immunosuppressive myeloid cell populations in the periphery and tumor microenvironment of patients with cancer is likely to be required for effective NK cell-based immunotherapy. (elifesciences.org)
While inflammatory injury drives both fibrogenesis and carcinogenesis, the tolerogenic microenvironment of the liver conveys immunosuppressive effects that encourage tumor growth. (mdpi.com)
Live imaging technology is becoming an increasing popular tool to visualize real-time cellular events in the tumor microenvironment during metastatic progression. (science20.com)
These changes in the tumor microenvironment may lead to tumor cell death and eventually to a long-term memory immune response against tumor antigens. (drugdiscoverynews.com)
There is an extensive body of evidence that demonstrates that modulating the tumor microenvironment is critical to a successful outcome in cancer immunotherapy," added Dr. Sudhir Agrawal, president of Research at Idera. (drugdiscoverynews.com)
Nutrient-deprived conditions in the tumor microenvironment (TME) restrain cancer cell viability due to increased free radicals and reduced energy production. (nature.com)
We are also supplementing our basic TRuC-T cell format with innovative enhancements to combat the hostile tumor microenvironment in case certain cancer indications prove more resistant. (tcr2.com)
Costimulation occurs only in a PD-L1/2 rich tumor microenvironment upon TRuC and PD-1 ligation, resulting in a more targeted signal enhancement. (tcr2.com)
These changes are thought to lead to tumor-microenvironment interactions via factors secreted by stromal or epithelial cells in response to lymphoma cell-produced cytokines ( 7 ). (spandidos-publications.com)
Previous studies have established CA125 as a tumor-microenvironment factor that can be detected and found elevated (above normal 35 U/ml levels) in the serum of up to 40% of FL patients and other NHL patients. (spandidos-publications.com)
Recent evidence, however, supports a dual role for macrophages in the regulation of tumour proliferation and immune control 10 , 16 , and indicates that the local tissue microenvironment plays a critical role in determining cell phenotypes. (ersjournals.com)
In accordance, attempts have been made to establish a link between the immune system and the tumor microenvironment, to comprehend tumor progression and achieve effective therapeutic approaches. (fortunejournals.com)

Ovarian cancer, uterine cervical cancer, endometrial cancer, and trophoblastic neoplasms are gynecologic malignancies for which tumor markers are in clinical use. (medscape.com)
Because pathologic diagnosis of ovarian cancer is difficult without laparotomy, tumor markers such as CA-125, in addition to diagnostic imaging, are useful in preoperative evaluation for ovarian cancer. (medscape.com)
Beta-hCG and alpha-fetoprotein have proved to be useful markers for ovarian germ cell tumors. (medscape.com)
Departing from Condeelis' theme is the talk by Dr. Christopher Contag, who used real-time whole-body tracing to track the synergistic tumor-killing activity of cytokine-induced killer (CIK) cells and oncolytic vaccinia virus (vv) in a mouse xenograft model of ovarian cancer. (science20.com)
The elevation of cancer antigen 125 (CA125) levels in the serum of asymptomatic patients precedes the radiologic detection of high-grade serous ovarian cancer by at least 2 mo and the final clinical diagnosis by 5 mo. (snmjournals.org)
High-grade serous ovarian cancer (HGSOC) comprises the major malignant histotype (70%) of epithelial ovarian cancers and bears a molecular signature in the overexpression of MUC16/cancer antigen 125 (CA125), a serum biomarker for ovarian cancer ( 3 ). (snmjournals.org)
Our most advanced program, gavo-cel, targets tumors that express the protein mesothelin, including ovarian cancer, non-small cell lung cancer, malignant pleural/peritoneal mesothelioma, and cholangiocarcinoma. (tcr2.com)
Initial assessment of tumor-associated antigen CA-125 in patients with ovarian, cervical, and testicular tumors. (ox.ac.uk)
Serum CA-125, a glycoprotein antigen, has been measured in serum of patients with ovarian cancer, cervical cancer, or nonseminomatous germ-cell tumor of testis. (ox.ac.uk)
BioVaxys is pleased to announce that it has commenced the clinical development program for BVX-0918A, its haptenized tumor antigen vaccine for ovarian cancer. (financialnewsmedia.com)

Neoadjuvant anti-OX40 (MEDI6469) therapy in patients with head and neck squamous cell carcinoma activates and expands antigen-specific tumor-infiltrating T cells. (bepress.com)
Experimental investigation has revealed the presence of specific tumor antigens in laboratory animals. (iptq.com)
The biologic premise behind such a strategy is that the tumor-antigen release achieved by localized radiation will promote specific tumor targeting by the adaptive immune system, which can be augmented further by systemic immune-stimulating agents. (scienceopen.com)
CAR T-cell immunotherapy is highly efficient because of its ability to target specific tumor antigens. (valuebasedcancer.com)

In this analysis, investigators evaluated the ability of AFM24 to elicit antibody-dependent cellular phagocytosis in solid tumor cell lines expressing EGFR wild-type or EGFR signaling pathway mutations. (onclive.com)
As of the June 30, 2021 data cutoff date, we have observed clinical activity in all three mesothelin-expressing solid tumor types treated, a 31% Overall Response Rate (ORR) in patients infused with gavo-cel following lymphodepletion, and four RECIST partial responses (PRs) (3 confirmed and 1 unconfirmed PRs). (tcr2.com)
Yet, ten years ago, just before the era of immune checkpoint inhibitors (ICI), solid tumor immunotherapy was in a grim situation. (financialnewsmedia.com)

The various tumor markers differ in their usefulness for screening, diagnosis, prognosis, assessing therapeutic response, and detecting recurrence. (medscape.com)
Each tumor marker has a variable profile of usefulness for screening, determining diagnosis and prognosis, assessing response to therapy, and monitoring for cancer recurrence. (aafp.org)
In monitoring patients for disease recurrence, tumor marker levels should be determined only when there is a potential for meaningful treatment. (aafp.org)
A recent study calls into question circulating tumor DNA (ctDNA) in conferring a sense of security about the risk of colorectal cancer recurrence. (aacc.org)
Three intravenous ASEL injections typically induced initial tumor regression, but with subsequent aggressive tumor recurrence. (genengnews.com)
To address the problem of tumor recurrence, the researchers evaluated combinations of vaccination with differ-ent libraries. (genengnews.com)
sis in primary breast cancer patients, toms of metastasis or recurrence and Tumour markers assays with elevated levels reflecting adverse with no other malignant disorders. (who.int)

Failed T cell-based immunotherapies in the presence of genomic alterations in antigen presentations pathways may be overcome by NK cell-based immunotherapy. (elifesciences.org)
T cell-based immunotherapy, such as immune checkpoint blockade or adoptive T cell transfer, is limited by the ability of T cells to detect major histocompatibility complex (MHC)-presented antigen by tumor cells. (elifesciences.org)
Natural killer (NK) cell-based immunotherapy may overcome genetic mechanisms of resistance to T cell-based immunotherapy through antigen- and MHC-independent recognition of malignant cells. (elifesciences.org)
Further insights on the roles of CD8 + specificities and TCR avidity of naturally arising tumor-specific T cells, where both high and low avidity T cells recognizing the same peptide-major histocompatibility complex (pMHC) coexist in the same tumor, are crucial for understanding T cell exhaustion and resistance to PD-1 immunotherapy. (bmj.com)
Combining radiation and immunotherapy: a new systemic therapy for solid tumors? (scienceopen.com)
Moreover, any tumor cells that do manage to evade the initial antitumor immune response are mopped up after a second-line virus-based immunotherapy comprising a different set of antigens. (genengnews.com)
There is increasing interest in the role played by the innate and adaptive immune systems in the regulation of tumour development and progression 2 , 3 and it is anticipated that a better understanding of the molecular and cellular immunology of NSCLC will lead to the identification of novel targets for immunotherapy. (ersjournals.com)
This study was designed to test a novel immunotherapy strategy using a vaccine enriched for short-lived proteins (SLiPs) and defective ribosomal products (DRiPs) derived from autologous tumor cells. (biomedcentral.com)

A variety of evidence suggests that spontaneous immune responses to autologous tumor-associated antigens affect the cure of malignant tumors, and that some antibodies in sera could influence cancer cells. (okayama-u.ac.jp)
Based on the results of these studies, anti-RPL29 antibody could be a first-in-class molecular-targeted drug for the treatment of malignant tumors. (okayama-u.ac.jp)
In addition, the concentration of the anti-RPL29 antibody in sera can be a new diagnostic biomarker for the treatment of malignant tumors. (okayama-u.ac.jp)
The cytotoxic T cell-cognate antigen interaction forms the mechanistic basis for immune-mediated recognition and the killing of malignant cells. (aacrjournals.org)
As such we plan to eventually employ the therapeutic mAbs in combination with chemotherapy as a means of enhancing the immunogenicity of the tumor system being treated and to possibly weaken the malignant growth for easier destruction by the mAb. (jcancer.org)
While its expression in normal tissues is low, mesothelin is highly expressed in a wide range of solid tumors, and it plays an active role in determining how malignant and/or aggressive tumors are. (tcr2.com)
CD20 is a B-cell-specific antigen expressed on malignant FL cells. (spandidos-publications.com)
In the current World Health Organization (WHO) classification of lymphoid malignant neoplasms, the diagnostic entity termed blastic NK-cell tumors has been proposed for tumors satisfying the diagnostic criteria for CD4/CD56 HN. (medscape.com)

The monoclonals, so produced, were not only more efficient in controlling tumor growth but minimized the development of a HAMA response. (jcancer.org)
Emerging evidence indicates that Trm cells develop in human solid cancers and play a key role in controlling tumor growth. (lifeboat.com)

In this situation, residual tumor is frequently nonviable. (medscape.com)

Preclinical data demonstrate that multiple immunomodulators synergize with radiotherapy to cause the regression of irradiated tumors and, less often, nonirradiated metastases. (aacrjournals.org)
According to Doody, preclinical studies using IMO-2125 either as a single-agent or in combination with several checkpoint inhibitors-such as anti-CTLA-4, anti-PD-1 and IDO-1 inhibitor-have shown robust tumor regression. (drugdiscoverynews.com)
As Doody explained, "Tumor regression was not only observed in the injected tumor but also in the uninjected tumor, essentially creating a systemic response. (drugdiscoverynews.com)
Based on interim data readouts from patients in dose escalation in our Phase 1/2 clinical trial, gavo-cel has demonstrated consistent clinical benefit, with almost every patient experiencing tumor regression (15/16) and a 81% disease control rate (DCR). (tcr2.com)
In this manner, clinicians hope to induce a phenomenon known as the abscopal effect, whereby localized radiation results in immune-mediated tumor regression in disease sites well outside of the radiation field. (scienceopen.com)

A consistent increase in a tumor marker value, combined with lack of clinical improvement, may indicate treatment failure. (medscape.com)
No tumor markers with high sensitivity and high specificity for endometrial cancer are known at present, although CA-125 is often used in clinical practice. (medscape.com)
SCC antigen is useful in the clinical management of advanced cervical cancer. (medscape.com)
In this investigation a human RCC tissue microarray (TMA) (n=374) predominantly consisting of the most common histological tumor subtypes was hybridized with an ERV-K env antibody and correlated with patient clinical data. (frontiersin.org)
Our work suggests that increases in the tumor-reactive CD103+ CD39+ CD8+ TIL could serve as a potential biomarker of anti-OX40 clinical activity. (bepress.com)
Here, we describe the pre-clinical in vitro and in vivo study of irradiated haNK cells engineered to express a second-generation chimeric antigen receptor (CAR) targeting programmed death-ligand 1 (PD-L1). (elifesciences.org)
The possibility that immunological factors influence the development of tumors has been considered since many years ago, but only in the last decade has enough experimental and clinical evidence accumulated to support this point of view. (iptq.com)
We remain focused on driving our rich pipeline forward and generating clinical data that expands the evidence of our arenaviral platform technology to help address unmet needs in cancer. (financialcontent.com)
IDO is one of several immune checkpoints involved in tumor immune escape, and IDO-1 inhibitors are currently in clinical development, according to the company. (drugdiscoverynews.com)
This review summarizes the use of high-voltage electrical pulses (HVEPs) in clinical oncology to treat solid tumors with irreversible electroporation (IRE) and electrochemotherapy (ECT). (rsna.org)
We are developing a TRuC-T cell targeting CD70 due to its versatility as a tumor target, where it is expressed in blood cancers and solid tumors, and clinical validation. (tcr2.com)
Herein, we present a comprehensive overview of the early clinical and preclinical evidence behind this approach. (scienceopen.com)
Regarding the data collected, the clinical factors included the sex, age, smoking history, comorbidities, and the carcinoembryonic antigen (CEA) and preoperative CRP (preCRP) levels. (researchsquare.com)
Changes in CA-125 concentrations in serum during chemotherapy mirrored the progress of the disease as assessed by clinical and radiological evidence. (ox.ac.uk)
Recent clinical evidence suggests that high serum levels of the tumor‑produced mucin 16 (MUC16) and cancer antigen 125 (CA125) have a negative impact on the effectiveness of RTX clinical activity in up to 40% of patients with follicular lymphoma. (spandidos-publications.com)
Previous clinical evidence suggested that high levels of serum CA125 have a negative impact on the effectiveness of the experimental therapeutic antibodies farletuzumab and amatuximab ( 13 - 15 ). (spandidos-publications.com)
Key evidence showing that ADCC plays an important role in the clinical effect of RTX was provided by the analysis of Fc gamma RIIIa (CD16a) polymorphisms, where patients carrying CD16a 158V/V genotype (associated with high affinity Fc gamma receptor) showed significantly improved objective response rates compared with FL patients carrying at least one 158F allele (associated with low affinity Fc gamma receptor) ( 20 ). (spandidos-publications.com)
Effective cancer immuno- and virotherapies are hindered by a lack of identified tumor-associated antigens (TAAs), poor coverage of the antigenic repertoire expressed by tumors, and difficulties associated with targeting vectors to tumors in vivo , explains Dr. Vile, together with co-lead author Alan Melcher, at the U.K. Leeds Institute of Molecular Medicine and Cancer Research U.K. Clinical Center, and colleagues. (genengnews.com)
Preliminary evidence suggests identifying these patterns could be useful in profiling organ dysfunction in avapritinib clinical trials. (valuebasedcancer.com)
Bezuclastinib treatment has shown clinical activity in advanced solid tumors with little toxicity. (valuebasedcancer.com)
The major clinical, histopathologic, and phenotypic aspects of the disease and diagnostic criteria and data suggesting a plasmacytoid dendritic cell origin for the tumor cells are provided. (medscape.com)

Although epigenetically silenced, endogenous retroviral (ERV) genes become activated in tumors and function to ignite immune responses. (frontiersin.org)
The genes for the small tumor antigen (STag), middle tumor antigen (MTag), and large tumor antigen (LTag) are encoded in the "early region" of the polyomavirus genome, so named because this region of the genome is expressed early in the infectious process. (wikipedia.org)
Transcriptomics analyses showed pathways related to TCR signaling, cytotoxicity and oxidative phosphorylation were significantly enriched in Tet lo found in both regressing and progressing tumors compared with Tet hi , whereas genes related to DNA damage, apoptosis and autophagy were downregulated. (bmj.com)
In addition, recurrent tumors expressed genes associated with an epithelial-to-mesenchymal-type transition, and had lost, or at least reduced, expression of mouse homologs of the human RNAs encoding prostate-specific antigens in the ASEL. (genengnews.com)

Potential of arenaviral immunotherapies in novel combinations and against tumor self-antigens highlighted at AACR. (financialcontent.com)
In April 2022, HOOKIPA presented positive data at the 2022 American Association for Cancer Research Annual Meeting showing HOOKIPA's arenaviral immunotherapies induced potent T cell responses in novel combinations (such as co-stimulatory 4-1BB agonists or adoptive cell transfer) and against tumor self-antigens. (financialcontent.com)
Here, we demonstrated that intradermal administration of clinically relevant vaccines efficiently induces Trm cells specific for tumor-specific and self-antigens that accumulate in vaccinated and non-vaccinated skin. (lifeboat.com)
Here we demonstrated that a single intradermal administration of gene- or protein-based vaccines efficiently induces specific Trm cell responses against models of tumor-specific and self-antigens, which accumulated in vaccinated and distant non-vaccinated skin. (lifeboat.com)

Alterations in either the innate or adaptive arm of the immune system and cross-talk between them make the immune system tolerant to tumors, leading to disease progression. (wjgnet.com)
Gone are the old school methods that produce "still" evidence of cancer progression. (science20.com)
Secondary endpoints included toxic effects, time to prostate-specific-antigen (PSA) progression, and overall survival. (researchgate.net)
The role of macrophage phenotypes in tumour progression has been extensively reviewed 6 - 10 . (ersjournals.com)

Healthy humans develop spontaneous CD8+ T cell responses to melanoma associated antigens (MA) expressed by normal melanocytes. (mdpi.com)
Most humoral responses cannot prevent tumor growth. (msdmanuals.com)
Alternating 2-vector therapy showed superior antigen-specific T cell responses, more robust anti-tumor activity and similar tolerability vs. single-vector therapy. (financialcontent.com)
Methods CT26 models were treated with anti-PD-1 on days 3, 6 and 9 following subcutaneous tumor implantation generating variable responses during early tumor development. (bmj.com)
Adoptive transfer of Tet lo showed more effective tumor control than Tet hi , and curative responses were achieved when Tet lo was combined with two doses of anti-PD-1. (bmj.com)
The team's previous work had already shown that killing normal cells in situ using the adjuvant hsp70 generated T cell responses to antigens that mediated rejection of tumors of the same histological type. (genengnews.com)
In contrast, intraprostatic ASEL injection resulted in the animals developing prostatitis, which was probably induced by the observed T helper type 17 (T H 17) and IFN-γ responses against prostate antigens, the authors note. (genengnews.com)
Several reports have demonstrated that a single immunization with integration-defective lentiviral vectors (IDLVs) delivering viral or tumor model antigens in mice was able to elicit broad and long-lasting specific immune responses in the absence of vector integration. (duke.edu)
At present, no evidence has been reported showing that IDLVs are able to expand preexisting immune responses in the human context. (duke.edu)
Moreover, clinically applicable vaccination strategies that efficiently establish Trm cell responses remain largely unexplored and are expected to strongly protect against tumors. (lifeboat.com)
All 4 patients had evidence of specific antibody responses against potential tumor antigens. (biomedcentral.com)
In addition to mutated proteins, NSCLC can over-express a number of non-mutated proteins that can induce both humoral and cytotoxic T cell responses [ 10 ], and also have the potential to serve as tumor rejection antigens [ 11 ]. (biomedcentral.com)

Here, we demonstrate that NK cells (haNKs) engineered to express a PD-L1 chimeric antigen receptor (CAR) haNKs killed a panel of human and murine head and neck cancer cells at low effector-to-target ratios in a PD-L1-dependent fashion. (elifesciences.org)

Monoclonal antibodies are used to detect serum antigens associated with specific malignancies. (aafp.org)
This includes the amount of shed antigen in the serum at the time of treatment that could initiate immune complex formation as well as the shedding of inhibitory material into the serum possibly effecting an immune response. (jcancer.org)
However, elevated serum CA125 levels alone do not qualify as a criterion to initiate treatment in the absence of radiologic evidence of recurrent disease. (snmjournals.org)
High serum level of CA125 is used as an indicator of tumor abdominal involvement, advanced staging, relapse rates and survival in NHL patients ( 8 - 12 ). (spandidos-publications.com)
ABSTRACT The value of serum tumour markers in the prognosis of patients with breast cancer is controversial. (who.int)

In our preclinical studies, we showed that TRuC-T cells targeting CD70 had an improved memory phenotype and significant anti-tumor efficacy with no evidence of fratricide. (tcr2.com)
However, the specific contribution of Trm cells to anti-tumor immunity is incompletely understood. (lifeboat.com)

In recent studies, we have tested the feasibility and immunogenicity of a vaccine that targets up to 20 personal neoantigens predicted to be presented by autologous patient tumor. (aacrjournals.org)
Researchers have developed a virus-based vaccine expressing a broad spectrum of undefined antigens from normal human prostate tissue that they claim completely eradicates established mouse prostate tumors in experimental animals. (genengnews.com)
Reporting in Nature Medicine , the team in the U.S. and U.K. that developed the approach says the vaccine can be delivered systemically without the need for tumor targeting, appears to have no side effects, and doesn't induce autoimmunity. (genengnews.com)
Autologous vaccine generated from tumor cells harvested from pleural effusions was administered to patients with advanced NSCLC with the objectives of assessing safety and immune response. (biomedcentral.com)
DRibble vaccine given with GM-CSF appeared safe and capable of inducing an immune response against tumor cells in this small, pilot study. (biomedcentral.com)
At the evidence to recommend patient framework is the framework ACIP has adopted in order to systematically and transparently assess scientific evidence for vaccine recommendations. (cdc.gov)

Autologous tumor-specific immune response was seen in two of the three, manifested by IL-5 (1 patient after 3 doses), and IFN-γ, TNF-α, IL-5, IL-10 (after 4 doses in one patient). (biomedcentral.com)

Combined AFP and β-hCG testing is an essential adjunct in the evaluation and treatment of nonseminomatous germ cell tumors, and in monitoring the response to therapy. (aafp.org)

While the search for immunogenic tumor antigens has been the subject of decades-long studies, multiple lines of evidence have convincingly demonstrated tumor neoantigens as an important class of immunogenic tumor antigens. (aacrjournals.org)
Arlen M, Arlen P, Tsang A, Wang X, Gupta R. The Therapeutic Value of Monoclonal Antibodies Directed Against Immunogenic Tumor Glycoproteins. (jcancer.org)
The monoclonals (mAbs) that we have developed against specific immunogenic tumor membrane proteins have been studied in detail. (jcancer.org)

ICE is a bispecific engager of CD16A+ natural killer (NK) cells and macrophages and tumor antigens. (onclive.com)

These data provide evidence that anti-OX40 prior to surgery is safe and can increase activation and proliferation of CD4+ and CD8+ T cells in blood and tumor. (bepress.com)
In our preclinical studies, we showed that TC-510 has enhanced early TCR downstream signaling, significantly increased proliferation, prevented exhaustion upon repeated antigen stimulation, augmented the growth and effector cytokines and enhanced the efficacy of the TRuCs against PD-L1 overexpressing tumors. (tcr2.com)

Sixteen histological tumor subtypes exist and the most common are papillary, chromophobe and clear cell renal cell carcinoma (ccRCC) representing 85% of all RCC. (frontiersin.org)
The recurrent tumors demonstrated substantial histological differences from the parental tumors, and extensive interstitial lymphocyte infiltrates. (genengnews.com)

In addition, beta-hCG serves as an ideal tumor marker for monitoring gestational trophoblastic disease and has set the standard with which other assays must be compared. (medscape.com)
Tetramer staining was performed to determine the frequency and avidity of CD8 + T cells targeting the tumor-specific epitope GSW11 and confirmed with tetramer competition assays. (bmj.com)
PMID:19699081 assays, segregation, and tumor characteristics. (who.int)

There was a rat model, and the target antigen was known in the rat. (medscape.com)
Before 2009, we didn't know what the major target antigen in adult MN was. (medscape.com)
Many of these factors stem from the location of the epitope that can affect accessibility of the antibody to the epitope at a cellular or molecular level, direct inhibition of target antigen activity, conservation of function despite escape mutations, and even non-competitive inhibition sites. (preprints.org)

They now form part of the most common, if not the most frequent tumors in cats both in France and abroad since, according to investigations, they amount to 12-41% of all feline cutaneous tumors. (vin.com)
reticulum cell sarcomas, cutaneous nodular amyloidosis) are relatively common cutaneous tumors. (merckvetmanual.com)

Carcinoembryonic antigen is used to detect relapse of colorectal cancer, and CA 19-9 may be helpful in establishing the nature of pancreatic masses. (aafp.org)
This prospective study in Yazd, Islamic Republic of Iran, assessed the value of the tumour markers carcinoembryonic antigen (CEA) and cancer antigen (CA) 15-3 in 159 patients with primary breast cancer. (who.int)
Carcinoembryonic antigen (CEA) Sample and study design years of follow-up. (who.int)

Cancer antigen (CA) 27.29 most frequently is used to follow response to therapy in patients with metastatic breast cancer. (aafp.org)
First, Dr. John Condeelis used multiphoton microscopy in a mammary imaging window to monitor macrophage and tumor cell interactions in a metastatic mouse PYMT breast cancer model. (science20.com)
The first evidence that radiotherapy enhances the efficacy of immune checkpoint blockers (ICB) was obtained a dozen years ago in a mouse model of metastatic carcinoma refractory to anti-CTLA-4 treatment. (aacrjournals.org)

Herein, we also demonstrate that compounds developed to target mutant IDH1 can be repurposed as wild-type IDH1 inhibitors, because these drugs surprisingly become potent inhibitors of wtIDH1 in cancer cells under conditions present in tumors: specifically, we found that wtIDH1 is critical for PDAC cell survival under low-glucose conditions, and allosteric IDH inhibitors effectively block wtIDH1 activity under low magnesium. (nature.com)

With the ability of the mAbs to demonstrate therapeutic antitumor activity in those patients with relatively advanced malignancies, the term tumor specific was introduced. (jcancer.org)
Mabs capable of targeting the malignancies noted above were produced following immunization of BALBc mice with the Tumor Specific Antigens. (jcancer.org)
It is required by FDA that the potential effects of tumor control and toxicity be defined using the naked antibodies produced under GMP conditions, In those situations where patients with recurrent malignancies are to be studied we have come to realize that a number of factors can influence the response to monoclonal therapy. (jcancer.org)
EXPERIMENTAL DESIGN: Patients ≥18 years of age with selected advanced solid tumors [namely, adenoid cystic carcinoma (ACC)] and hematologic malignancies were eligible. (bvsalud.org)
The complexity of the human bone marrow, with context to haematological malignancies, is more difficult to elucidate with the present strategies compared to the niche of solid tumors. (fortunejournals.com)

A somewhat more common tumor antigen variant, an overprinted gene encoding a protein called ALTO, may be evolutionarily related to MTag. (wikipedia.org)
This article describes the use of common tumor markers in primary care practice. (aafp.org)

Scholars@Duke publication: Transduction of human antigen-presenting cells with integrase-defective lentiviral vector enables functional expansion of primed antigen-specific CD8(+) T cells. (duke.edu)
In the present study, we demonstrate that infection of human antigen-presenting cells (APCs), such as monocyte-derived dendritic cells (DCs) and macrophages with IDLVs expressing influenza matrix M1 protein resulted in effective induction of in vitro expansion of M1-primed CD8(+) T cells, as evaluated by both pentamer staining and cytokine production. (duke.edu)

The M1 phenotype (classically activated) macrophages are thought to be induced by interferon-γ, with or without lipopolysaccharide and tumour necrosis factor (TNF)-α, and exert a cytotoxic effect against cancer cells. (ersjournals.com)

They first tried a second vaccination comprising virally expressed immune-escape epitope libraries (IEELs) constructed using cDNA from the recurrent tumors of ASEL-treated mice. (genengnews.com)
For recurrent, invasive tumors, more aggressive attempts at excision or electroporation may be required. (merckvetmanual.com)

Thus, increasing numbers of macrophages within the tumour islets conferred a marked survival advantage, while increased numbers of macrophages in the tumour stroma were associated with worse prognosis. (ersjournals.com)
There was no evidence of efficacy in this small poor-prognosis patient population, with treatment not feasible. (biomedcentral.com)

Comparison of tumor biopsies before and after treatment reveals an increase of activated, conventional CD4+ tumor-infiltrating lymphocytes (TIL) in most patients and higher clonality by TCRβ sequencing. (bepress.com)

It is the most common primary intracranial neoplasm and the most diversified in histologic patterns among all primary tumors of the CNS. (medscape.com)

Treatment of syngeneic tumors resulted in CD8 and PD-L1-dependent tumor rejection or growth inhibition and a reduction in myeloid cells endogenously expressing high levels of PD-L1. (elifesciences.org)

The innate cell engager AFM24 showed greater efficacy in eliciting antibody-dependent cellular phagocytosis of EGFR wild-type and KRAS-mutant tumor cells compared with cetuximab. (onclive.com)
The innate cell engager ® (ICE) AFM24 showed greater efficacy in eliciting antibody-dependent cellular phagocytosis of EGFR wild-type and KRAS -mutant tumor cells compared with cetuximab (Erbitux), according to preclinical findings from a study presented in a poster during the 2021 SITC Annual Meeting . (onclive.com)
This mechanism of action may be instrumental to the efficacy of AFM24, especially in macrophage-rich tumors," wrote the study authors. (onclive.com)

In 2009, we had a seminal moment when you published a manuscript in The New England Journal of Medicine describing PLA2R, phospholipase A2 receptor, as the antigen that was responsible for a majority of the cases of MN. (medscape.com)
Preliminary evidence suggests that CAR T-cells directed against CD117, the KIT receptor, may emerge as a therapeutic option for advanced systemic mastocytosis. (valuebasedcancer.com)

We demonstrate that MAGEC2 interacts with TRIM28 in melanoma cells and MAGEC2 expression in tumor cells depends on the expression of TRIM28. (biomedcentral.com)
In this study, we found that expression of MAGEC2 protein in tumor cells depends on the expression of TRIM28, a reduction in the level of endogenous TRIM28 expression in melanoma cells resulting in significantly decreased expression of MAGEC2 protein. (biomedcentral.com)
Interestingly, vaccination-induced Trm cells strongly suppress the growth of melanoma, independently of circulating CD8 T cells, and were able to infiltrate melanoma tumors. (lifeboat.com)

Furthermore, the Food & Drug Administration (FDA)-approved mIDH1 inhibitor ivosidenib (AG-120) dramatically inhibited tumor growth in preclinical models of pancreatic cancer, highlighting this approach as a potential therapeutic strategy against wild-type IDH1 cancers. (nature.com)

Cancer/testis antigen MAGEC2 (also known as HCA587) is highly expressed in a wide variety of tumors and plays an active role in promoting growth and metastasis of tumor cells. (biomedcentral.com)
There can, however, be few similarities between the two, as the bone marrow is a common site of metastasis of solid tumors too [6]. (fortunejournals.com)

Through the incorporation of novel computational methods for predicting antigen changes to model-informed drug discovery and development, superior vaccines and antibody-based therapeutics or diagnostics can now be more easily designed to mitigate failures. (preprints.org)
Fruits, vegetables and endometrial cancer risk in women in the European forces in synthesizing evidence on new methods for the risk of cancer: a multisite case-control study in Prospective Investigation into Cancer and Nutrition cervical cancer prevention. (who.int)

Many new tumor markers have been discovered since the development of monoclonal antibodies, and most tumor markers are now detected with them. (medscape.com)
Monoclonal antibodies developed against immunogenic proteins (Tumor Specific Antigens/TSA's) that are expressed in human cancers, display a unique behavioral pattern. (jcancer.org)

Neoantigens arise from amino acid changes encoded by somatic mutations in the tumor cell and have the potential to bind to and be presented by personal HLA molecules. (aacrjournals.org)

Sometimes, tumor marker values may rise after effective treatment (due to cell lysis), but the increase may not portend treatment failure. (medscape.com)
OX40, GITR, and 4-1BB), can enhance T cell immunity in tumor-bearing hosts. (bepress.com)
AFM24 enhances macrophage-mediated antibody-dependent cellular phagocytosis of various EGFR-expressing tumor cell lines, irrespective of the EGFR signaling pathway," wrote lead study author Sheena Pinto, PhD, translational project leader at Affimed, and coauthors, in the poster. (onclive.com)
Tetravalent, bispecific innate cell engager (ICE®) AFM24 enhances macrophage mediated tumor cell phagocytosis. (onclive.com)
Many tumor cells produce antigens, which may be released in the bloodstream or remain on the cell surface. (msdmanuals.com)
References Many tumor cells produce antigens, which may be released in the bloodstream or remain on the cell surface. (msdmanuals.com)
At the heart of any cancer and host immune cell response is the tumor antigen and host antigen-specific T-cell interaction. (aacrjournals.org)
Condeelis further revealed clusters of macrophages along the blood vessels that are colocalized with the site to tumor cell intravasation, suggesting the integral role of macrophages in the cancer cell's journey into circulation. (science20.com)
This tumor cell killing appears to be CD8+ T cell mediated. (drugdiscoverynews.com)
Lichen planus associated with neoplasia: A cell-mediated immune response to tumor antigens? (psu.edu)
Results: No evidence of autoantibody production characteristic of paraneoplastic pemphigus was found, and antibodies reactive with basal cell keratinocytes were not detected. (psu.edu)
T2 - A cell-mediated immune response to tumor antigens? (psu.edu)
IRE uses HVEPs to cause cell death by inducing membrane disruption, and it is primarily used as a radical ablative therapy in the treatment of soft-tissue tumors in the liver, kidney, prostate, and pancreas. (rsna.org)
We are developing a wide range of cell therapies for solid tumors as well as blood cancers by targeting a number of different surface antigens on cancer cells that have beneficial expression characteristics. (tcr2.com)
This importance is focussed on the target binding site - epitope, where epitope selection as a part of design thinking beyond traditional antigen selection using whole cell or whole protein immunisation can positively impact success. (preprints.org)
The present study demonstrated that CA125 could bind to RTX and reduce its tumor cell killing activity. (spandidos-publications.com)
Intravenous injection generated a prostate-specific T H 17 response and led to the CD4+ T cell-mediated cure of established tumors, without generating an IFN-γ response. (genengnews.com)
There is a marked survival advantage for patients with nonsmall cell lung cancer (NSCLC) expressing high numbers of macrophages in their tumour islets. (ersjournals.com)
Macrophages infiltrating the tumour islets in nonsmall cell lung cancer were predominantly of the M1 phenotype in patients with extended survival. (ersjournals.com)
Monocytes activated by tumour-derived microvesicles from pancreatic, colon and lung cancer cell lines have been found to show increased expression of human leukocyte antigen (HLA)-DR and a resulting increase in production of reactive oxygen intermediates and TNF-α 11 . (ersjournals.com)
[ 20 ] However, there is scant evidence for an NK-cell lineage origin, and the precise derivation was not asserted in the WHO classification scheme. (medscape.com)
Meningiomas , as defined by the World Health Organization (WHO), are "meningothelial (arachnoid) cell neoplasms, typically attached to the inner surface of the dura mater," and these tumors fall into WHO grades I, II, and III. (medscape.com)

The safety profile of gavo-cel continues to be generally well tolerated with a manageable adverse event profile with no patients experiencing on-target, off-tumor toxicities. (tcr2.com)
Delivery of tumoricidal doses to the primary tumor and involved lymph nodes is balanced by treatment-related toxicities, namely esophagitis, pneumonitis, and cardiac injury. (frontiersin.org)

We are focused on the discovery and validation of novel targets to broaden the reach of TRuC-T cells in solid tumors and hematologic cancers. (tcr2.com)

Tumor-associated antigens (TAAs) are relatively restricted to tumor cells. (msdmanuals.com)

Expression of neoantigens alone is insufficient without cross-presentation by antigen presenting cells in the appropriate cytokine milieu. (biomedcentral.com)

Multiple studies have examined the issue of the optimal dose of radiotherapy in NSCLC but are complicated by the heterogeneity of the disease itself in terms of size and location of the primary tumor, number and size of involved lymph nodes, and the patient's comorbidities, all of which limit the treatment tolerability and risks. (frontiersin.org)

Ex vivo analysis of tumors and lymph nodes was performed via autoradiography, histopathology, and immunohistochemistry. (snmjournals.org)

They are typically produced by tumor cells, but in some cases they may be produced by the body in response to malignancy or to certain benign conditions. (medscape.com)

Accumulating evidence has indicated that MAGEC2 expression is associated with hallmarks of aggressive cancers. (biomedcentral.com)
however, despite its prevalence in FL and other cancers, the role of CA125 in tumor biology and immunity has been only recently elucidated. (spandidos-publications.com)

With the exception of prostate-specific antigen (PSA), tumor markers do not have sufficient sensitivity or specificity for use in screening. (aafp.org)
Others feared the new recommendation would cause more men to die from prostate cancer because their tumors would not be found until the cancer had progressed. (hawaiipublicradio.org)
The test is named after a protein called prostate-specific antigen, which prostate tumors produce. (hawaiipublicradio.org)
But the task force concluded the testing caused unnecessary suffering and that there was insufficient evidence that annual PSA screening significantly reduced the death rate from prostate cancer. (hawaiipublicradio.org)
Irreversible electroporation is a predominantly nonthermal and adjacent structure-sparring ablation method that has been proven safe and efficient in the treatment of tumors in the liver, pancreas, and prostate. (rsna.org)
The team cloned a cDNA library from normal human prostate, which they termed altered self antigen and epitope library (ASEL) into VSV, and systemically injected the antigen-expressing vector into normal experimental mice. (genengnews.com)
They then went on to test the virus-expressed human cDNA library in mice with established prostate tumors. (genengnews.com)
Nine intravenous injections of ASEL were sufficient to cure over 80% of mice with the prostate tumors, with no detectable autoim-mune prostatitis. (genengnews.com)

Cancer antigen (CA) 27.29 is a monoclonal antibody to a glycoprotein (MUC1) that is present on the apical surface of normal epithelial cells. (aafp.org)
Additional results showed that AFM24 increased antibody-dependent cellular phagocytosis of EGFR -positive tumor cells regardless of macrophage subtype. (onclive.com)

We are developing gavo-cel to target mesothelin-positive solid tumors. (tcr2.com)

Tumor markers are soluble glycoproteins that are found in the blood, urine, or tissues of patients with certain types of cancer. (medscape.com)

The usefulness of a tumor marker is in its sensitivity and specificity, as well as its influence on patient management decisions. (medscape.com)
Importantly, CIKs must be pre-infected with vaccinia virus, and that vaccinia virus must be delivered by CIKs, in order to achieve this level tumor specificity, suggesting remarkable synergy between CIKs and vaccinia virus. (science20.com)
Monoclonals developed from these tumor antigens are in the initial phases of investigation with regard to their specificity and antitumor activity. (jcancer.org)

However, several antigens with selective expression on the surface of tumor cells are not associated with the major histocompatibility complex and may be candidates for therapeutic targeting. (msdmanuals.com)
Participants who are hepatitis B surface antigen (HBsAg) positive are eligible if they have received hepatitis B virus (HBV) antiviral therapy for at least 4 weeks and have undetectable HBV viral load before randomization. (who.int)

Research has intensified to understand ERV protein function and their role as tumor antigens and targets for cancer (immune) therapy. (frontiersin.org)
High ERV-K env total protein expression of all tumor subtypes significantly correlated with low tumor grading and a longer disease specific survival using multivariable analyses. (frontiersin.org)
The middle tumor antigen (also called the middle T-antigen and abbreviated MTag or MT) is a protein encoded in the genomes of some polyomaviruses, which are small double-stranded DNA viruses. (wikipedia.org)
The expression level of MAGEC2 protein was significantly reduced when TRIM28 was depleted in tumor cells, and no changes were observed in MAGEC2 mRNA level. (biomedcentral.com)
Mechanistic studies indicate that the regulatory role of TRIM28 on MAGEC2 protein expression in tumor cells depends on proteasome-mediated pathway. (biomedcentral.com)
The level of the protein in the blood can indicate the presence of a tumor. (hawaiipublicradio.org)

Furthermore, the study characterized an RTX variant, named NAV‑006 (RTX‑N109D), which was more refractory to the immunosuppressive effects mediated by CA125 as evidenced by its reduced CA125 interaction and increased activity of ADCC and CDC when compared with parent RTX. (spandidos-publications.com)

Anatomy20

Organisms12

Diseases40

Chemicals and Drugs108

Analytical, Diagnostic and Therapeutic Techniques and Equipment38

Phenomena and Processes42

Disciplines and Occupations1

Information Science3

Health Care4

Microenvironment12

Ovarian10

Specific tumor4

Solid tumor3

Recurrence7

Immunotherapy8

Malignant8

Controlling tumor growth2

Residual tumor is frequently nonviable1

Regression5

Clinical21

Genes4

Self-antigens4

Progression4

Responses12

Chimeric antigen receptor1

Serum5

Anti-tumor2

Vaccine6

Autologous1

Germ cell t1

Immunogenic tumor3

Cells and Macrophages1

Proliferation2

Histological2

Assays3

Target antigen3

Cutaneous tumors2

Carcinoembryonic antigen3

Metastatic3

Inhibitors1

Malignancies5

Common tumor2

Human antigen2

Necrosis factor1

Recurrent2

Prognosis2

Lymphocytes1

Neoplasm1

Rejection1

Efficacy3

Receptor2

Melanoma3

Preclinical1

Metastasis2

Methods2

Monoclonal antibodies2

Mutations1

Cell22

Toxicities2

Hematologic1

TAAs1

Neoantigens1

Primary tumor1

Lymph nodes1

Benign conditions1

Cancers2

Prostate8

Antibody2

Mesothelin1

Glycoproteins1

Specificity3

Surface2

Protein6

Immunosuppressive1