Evidence of antigen evidence antigen of tumor. Medical search. Frequent questions

Nutrient-deprived conditions in the tumor microenvironment (TME) restrain cancer cell viability due to increased free radicals and reduced energy production. (nature.com)
Thus, addressing the presence of immunosuppressive myeloid cell populations in the periphery and tumor microenvironment of patients with cancer is likely to be required for effective NK cell-based immunotherapy. (elifesciences.org)
Recent evidence, however, supports a dual role for macrophages in the regulation of tumour proliferation and immune control 10 , 16 , and indicates that the local tissue microenvironment plays a critical role in determining cell phenotypes. (ersjournals.com)
While inflammatory injury drives both fibrogenesis and carcinogenesis, the tolerogenic microenvironment of the liver conveys immunosuppressive effects that encourage tumor growth. (mdpi.com)
These changes are thought to lead to tumor-microenvironment interactions via factors secreted by stromal or epithelial cells in response to lymphoma cell-produced cytokines ( 7 ). (spandidos-publications.com)
Previous studies have established CA125 as a tumor-microenvironment factor that can be detected and found elevated (above normal 35 U/ml levels) in the serum of up to 40% of FL patients and other NHL patients. (spandidos-publications.com)
Live imaging technology is becoming an increasing popular tool to visualize real-time cellular events in the tumor microenvironment during metastatic progression. (science20.com)
These changes in the tumor microenvironment may lead to tumor cell death and eventually to a long-term memory immune response against tumor antigens. (drugdiscoverynews.com)
There is an extensive body of evidence that demonstrates that modulating the tumor microenvironment is critical to a successful outcome in cancer immunotherapy," added Dr. Sudhir Agrawal, president of Research at Idera. (drugdiscoverynews.com)
We are also supplementing our basic TRuC-T cell format with innovative enhancements to combat the hostile tumor microenvironment in case certain cancer indications prove more resistant. (tcr2.com)
Costimulation occurs only in a PD-L1/2 rich tumor microenvironment upon TRuC and PD-1 ligation, resulting in a more targeted signal enhancement. (tcr2.com)

With the exception of prostate-specific antigen (PSA), tumor markers do not have sufficient sensitivity or specificity for use in screening. (aafp.org)
Secondary endpoints included toxic effects, time to prostate-specific-antigen (PSA) progression, and overall survival. (researchgate.net)
The task force continued to recommend against a blood test for prostate specific antigen (PSA) in men 70 and older, concluding the potential harms of routine screening still outweigh the benefits for this age group. (simonfoundation.org)

Natural killer (NK) cell-based immunotherapy may overcome genetic mechanisms of resistance to T cell-based immunotherapy through antigen- and MHC-independent recognition of malignant cells. (elifesciences.org)
Case Report: We reported a case of 55-year-old post menopausal woman who presented to us as ovarian mass which turned out to be malignant epithelioid gastrointestinal stromal tumor intraoperatively and by immunohistochemistry. (scirp.org)
Our case was also presented as ovarian mass which turned out to be malignant epithelioid gastrointestinal stromal tumor intraoperatively and by immunohistochemistry. (scirp.org)
She was taken for exploratory laparotomy with provisional diagnosis of malignant ovarian tumor. (scirp.org)
Histopathology report showed the retroperitoneal mass to be a malignant epithelioid gastrointestinal tumor. (scirp.org)
Histologically the tumor showed the mass to be a malignant epitheioid gastrointestinal stromal tumor with mitoses in 8 - 9 of 10 high-power fields ( Figure 1 ). (scirp.org)
CD20 is a B-cell-specific antigen expressed on malignant FL cells. (spandidos-publications.com)
The cytotoxic T cell-cognate antigen interaction forms the mechanistic basis for immune-mediated recognition and the killing of malignant cells. (aacrjournals.org)
A variety of evidence suggests that spontaneous immune responses to autologous tumor-associated antigens affect the cure of malignant tumors, and that some antibodies in sera could influence cancer cells. (okayama-u.ac.jp)
Based on the results of these studies, anti-RPL29 antibody could be a first-in-class molecular-targeted drug for the treatment of malignant tumors. (okayama-u.ac.jp)
In addition, the concentration of the anti-RPL29 antibody in sera can be a new diagnostic biomarker for the treatment of malignant tumors. (okayama-u.ac.jp)
As such we plan to eventually employ the therapeutic mAbs in combination with chemotherapy as a means of enhancing the immunogenicity of the tumor system being treated and to possibly weaken the malignant growth for easier destruction by the mAb. (jcancer.org)
Our most advanced program, gavo-cel, targets tumors that express the protein mesothelin, including ovarian cancer, non-small cell lung cancer, malignant pleural/peritoneal mesothelioma, and cholangiocarcinoma. (tcr2.com)
While its expression in normal tissues is low, mesothelin is highly expressed in a wide range of solid tumors, and it plays an active role in determining how malignant and/or aggressive tumors are. (tcr2.com)
In the current World Health Organization (WHO) classification of lymphoid malignant neoplasms, the diagnostic entity termed blastic NK-cell tumors has been proposed for tumors satisfying the diagnostic criteria for CD4/CD56 HN. (medscape.com)

In this situation, residual tumor is frequently nonviable. (medscape.com)

Tumor necrosis factor-α mRNA was seen in lung tissue. (cdc.gov)
The M1 phenotype (classically activated) macrophages are thought to be induced by interferon-γ, with or without lipopolysaccharide and tumour necrosis factor (TNF)-α, and exert a cytotoxic effect against cancer cells. (ersjournals.com)
Evidence exists that immune activation against hematopoietic elements frequently occurs in MDS patients, based on the identification of lymphocytic infiltrates in the marrow, oligoclonal expansion of T cells, and excessive production of tumor necrosis factor alpha. (acgtfoundation.org)

Although epigenetically silenced, endogenous retroviral (ERV) genes become activated in tumors and function to ignite immune responses. (frontiersin.org)
The genes for the small tumor antigen (STag), middle tumor antigen (MTag), and large tumor antigen (LTag) are encoded in the "early region" of the polyomavirus genome, so named because this region of the genome is expressed early in the infectious process. (wikipedia.org)
Transcriptomics analyses showed pathways related to TCR signaling, cytotoxicity and oxidative phosphorylation were significantly enriched in Tet lo found in both regressing and progressing tumors compared with Tet hi , whereas genes related to DNA damage, apoptosis and autophagy were downregulated. (bmj.com)
This first category also includes genes that contribute to tumor growth by inhibiting cell death. (cancerquest.org)
The genes in the second group are called tumor suppressors. (cancerquest.org)
This is in contrast with tumor suppressor genes which must BOTH be defective to lead to abnormal cell division. (cancerquest.org)

Healthy humans develop spontaneous CD8+ T cell responses to melanoma associated antigens (MA) expressed by normal melanocytes. (mdpi.com)

Alternating 2-vector therapy showed superior antigen-specific T cell responses, more robust anti-tumor activity and similar tolerability vs. single-vector therapy. (financialcontent.com)
In early phase clinical trials for both acute and chronic myeloid leukemias, we have observed the induction of anti-tumor immunity and associated clinical responses following K562/GM-CSF vaccination (see preliminary data). (acgtfoundation.org)
In our preclinical studies, we showed that TRuC-T cells targeting CD70 had an improved memory phenotype and significant anti-tumor efficacy with no evidence of fratricide. (tcr2.com)

The various tumor markers differ in their usefulness for screening, diagnosis, prognosis, assessing therapeutic response, and detecting recurrence. (medscape.com)
Each tumor marker has a variable profile of usefulness for screening, determining diagnosis and prognosis, assessing response to therapy, and monitoring for cancer recurrence. (aafp.org)
In monitoring patients for disease recurrence, tumor marker levels should be determined only when there is a potential for meaningful treatment. (aafp.org)
Gallium prostate specific membrane antigen (PSMA) ligand positron emission tomography (PET) is an increasingly used imaging modality in prostate cancer, especially in cases of tumor recurrence after curative intended therapy. (uzh.ch)
A recent study calls into question circulating tumor DNA (ctDNA) in conferring a sense of security about the risk of colorectal cancer recurrence. (aacc.org)

Comparison of tumor biopsies before and after treatment reveals an increase of activated, conventional CD4+ tumor-infiltrating lymphocytes (TIL) in most patients and higher clonality by TCRβ sequencing. (bepress.com)
MHC-I and MHC-II proteins are key components of the antigen presentation machinery responsible for neoantigen presentation to CD8 + and CD4 + T lymphocytes, respectively. (portlandpress.com)

No primary tumor was ever identified. (aafp.org)
1 Indeed, the primary tumor in most cases of Sister Joseph's nodule is intra-abdominal: stomach, large and small intestine, pancreas, kidney, uterus, ovary or gallbladder. (aafp.org)
2 In an estimated 9 to 17 percent of cases, the primary tumor is never found. (aafp.org)
Multiple studies have examined the issue of the optimal dose of radiotherapy in NSCLC but are complicated by the heterogeneity of the disease itself in terms of size and location of the primary tumor, number and size of involved lymph nodes, and the patient's comorbidities, all of which limit the treatment tolerability and risks. (frontiersin.org)
Delivery of tumoricidal doses to the primary tumor and involved lymph nodes is balanced by treatment-related toxicities, namely esophagitis, pneumonitis, and cardiac injury. (frontiersin.org)

Ovarian cancer, uterine cervical cancer, endometrial cancer, and trophoblastic neoplasms are gynecologic malignancies for which tumor markers are in clinical use. (medscape.com)
Monoclonal antibodies are used to detect serum antigens associated with specific malignancies. (aafp.org)
With the ability of the mAbs to demonstrate therapeutic antitumor activity in those patients with relatively advanced malignancies, the term tumor specific was introduced. (jcancer.org)
Mabs capable of targeting the malignancies noted above were produced following immunization of BALBc mice with the Tumor Specific Antigens. (jcancer.org)
It is required by FDA that the potential effects of tumor control and toxicity be defined using the naked antibodies produced under GMP conditions, In those situations where patients with recurrent malignancies are to be studied we have come to realize that a number of factors can influence the response to monoclonal therapy. (jcancer.org)
We have developed a genetically modified tumor cell vaccine for the treatment of myeloid malignancies. (acgtfoundation.org)
EXPERIMENTAL DESIGN: Patients ≥18 years of age with selected advanced solid tumors [namely, adenoid cystic carcinoma (ACC)] and hematologic malignancies were eligible. (bvsalud.org)

There is increasing interest in the role played by the innate and adaptive immune systems in the regulation of tumour development and progression 2 , 3 and it is anticipated that a better understanding of the molecular and cellular immunology of NSCLC will lead to the identification of novel targets for immunotherapy. (ersjournals.com)

Beta-hCG and alpha-fetoprotein have proved to be useful markers for ovarian germ cell tumors. (medscape.com)
Combined AFP and β-hCG testing is an essential adjunct in the evaluation and treatment of nonseminomatous germ cell tumors, and in monitoring the response to therapy. (aafp.org)

ICE is a bispecific engager of CD16A+ natural killer (NK) cells and macrophages and tumor antigens. (onclive.com)

The role of macrophage phenotypes in tumour progression has been extensively reviewed 6 - 10 . (ersjournals.com)
Alterations in either the innate or adaptive arm of the immune system and cross-talk between them make the immune system tolerant to tumors, leading to disease progression. (wjgnet.com)
Gone are the old school methods that produce "still" evidence of cancer progression. (science20.com)

These data provide evidence that anti-OX40 prior to surgery is safe and can increase activation and proliferation of CD4+ and CD8+ T cells in blood and tumor. (bepress.com)
In our preclinical studies, we showed that TC-510 has enhanced early TCR downstream signaling, significantly increased proliferation, prevented exhaustion upon repeated antigen stimulation, augmented the growth and effector cytokines and enhanced the efficacy of the TRuCs against PD-L1 overexpressing tumors. (tcr2.com)

A consistent increase in a tumor marker value, combined with lack of clinical improvement, may indicate treatment failure. (medscape.com)
No tumor markers with high sensitivity and high specificity for endometrial cancer are known at present, although CA-125 is often used in clinical practice. (medscape.com)
SCC antigen is useful in the clinical management of advanced cervical cancer. (medscape.com)
Despite severe and generalized clinical manifestations, the result of multiple organ dysfunction, previous limited autopsy data failed to show evidence of viral replication beyond the respiratory tract ( 10 , 11 ). (cdc.gov)
In this investigation a human RCC tissue microarray (TMA) (n=374) predominantly consisting of the most common histological tumor subtypes was hybridized with an ERV-K env antibody and correlated with patient clinical data. (frontiersin.org)
Our work suggests that increases in the tumor-reactive CD103+ CD39+ CD8+ TIL could serve as a potential biomarker of anti-OX40 clinical activity. (bepress.com)
Here, we describe the pre-clinical in vitro and in vivo study of irradiated haNK cells engineered to express a second-generation chimeric antigen receptor (CAR) targeting programmed death-ligand 1 (PD-L1). (elifesciences.org)
The possibility that immunological factors influence the development of tumors has been considered since many years ago, but only in the last decade has enough experimental and clinical evidence accumulated to support this point of view. (iptq.com)
We remain focused on driving our rich pipeline forward and generating clinical data that expands the evidence of our arenaviral platform technology to help address unmet needs in cancer. (financialcontent.com)
Recent clinical evidence suggests that high serum levels of the tumor‑produced mucin 16 (MUC16) and cancer antigen 125 (CA125) have a negative impact on the effectiveness of RTX clinical activity in up to 40% of patients with follicular lymphoma. (spandidos-publications.com)
Previous clinical evidence suggested that high levels of serum CA125 have a negative impact on the effectiveness of the experimental therapeutic antibodies farletuzumab and amatuximab ( 13 - 15 ). (spandidos-publications.com)
Key evidence showing that ADCC plays an important role in the clinical effect of RTX was provided by the analysis of Fc gamma RIIIa (CD16a) polymorphisms, where patients carrying CD16a 158V/V genotype (associated with high affinity Fc gamma receptor) showed significantly improved objective response rates compared with FL patients carrying at least one 158F allele (associated with low affinity Fc gamma receptor) ( 20 ). (spandidos-publications.com)
Tumour-specific expression of MHC-I and MHC-II has been associated with improved patient survival in most clinical studies. (portlandpress.com)
Owed to the novelty of the PSMA-targeting tracers, clinical evidence on the value of PSMA-PET is moderate but rapidly increasing. (uzh.ch)
In their review " Natural and Adaptive Immunity to Cancer ", Vesely and colleagues draw from recent mouse models of cancer and human clinical data to describe how cells, effector molecules, and pathways of the immune system act to suppress and control tumor cells. (massgenomics.org)
2. Conduct a clinical trial in MDS testing K562/GM-CSF vaccination integrated with the systemic agent(s) identified in aim 1 as being most active in combination with GM-CSF tumor vaccines (years 2 and 3). (acgtfoundation.org)
IDO is one of several immune checkpoints involved in tumor immune escape, and IDO-1 inhibitors are currently in clinical development, according to the company. (drugdiscoverynews.com)
For evaluating outcomes of both medical and social interventions, the strongest evidence is obtained from well-designed and well-conducted randomized clinical trials. (vicc.org)
For evaluating other questions, particularly those related to the prevalence of gene variants and inherited syndromes and determining the clinical validity of genetic tests, the strongest evidence is obtained from well-designed descriptive studies. (vicc.org)
Based on interim data readouts from patients in dose escalation in our Phase 1/2 clinical trial, gavo-cel has demonstrated consistent clinical benefit, with almost every patient experiencing tumor regression (15/16) and a 81% disease control rate (DCR). (tcr2.com)
As of the June 30, 2021 data cutoff date, we have observed clinical activity in all three mesothelin-expressing solid tumor types treated, a 31% Overall Response Rate (ORR) in patients infused with gavo-cel following lymphodepletion, and four RECIST partial responses (PRs) (3 confirmed and 1 unconfirmed PRs). (tcr2.com)
We are developing a TRuC-T cell targeting CD70 due to its versatility as a tumor target, where it is expressed in blood cancers and solid tumors, and clinical validation. (tcr2.com)
The major clinical, histopathologic, and phenotypic aspects of the disease and diagnostic criteria and data suggesting a plasmacytoid dendritic cell origin for the tumor cells are provided. (medscape.com)

reticulum cell sarcomas, cutaneous nodular amyloidosis) are relatively common cutaneous tumors. (merckvetmanual.com)
They now form part of the most common, if not the most frequent tumors in cats both in France and abroad since, according to investigations, they amount to 12-41% of all feline cutaneous tumors. (vin.com)

Sister Joseph (1856-1939), superintendent of St. Mary's Hospital, was credited with making the observation of lymphatic metastases to the umbilical region in metastatic tumors of intra-abdominal origin, hence the name "Sister Joseph's nodule. (aafp.org)

Carcinoembryonic antigen is used to detect relapse of colorectal cancer, and CA 19-9 may be helpful in establishing the nature of pancreatic masses. (aafp.org)
Upper endoscopy and colonoscopy were negative, and the patient's carcinoembryonic antigen level was measured as 1.1 ng per mL (normal range, 1 to 3 ng per mL). (aafp.org)

In recent studies, we have tested the feasibility and immunogenicity of a vaccine that targets up to 20 personal neoantigens predicted to be presented by autologous patient tumor. (aacrjournals.org)

This article describes the use of common tumor markers in primary care practice. (aafp.org)
A somewhat more common tumor antigen variant, an overprinted gene encoding a protein called ALTO, may be evolutionarily related to MTag. (wikipedia.org)

Furthermore, the Food & Drug Administration (FDA)-approved mIDH1 inhibitor ivosidenib (AG-120) dramatically inhibited tumor growth in preclinical models of pancreatic cancer, highlighting this approach as a potential therapeutic strategy against wild-type IDH1 cancers. (nature.com)

While the search for immunogenic tumor antigens has been the subject of decades-long studies, multiple lines of evidence have convincingly demonstrated tumor neoantigens as an important class of immunogenic tumor antigens. (aacrjournals.org)
Arlen M, Arlen P, Tsang A, Wang X, Gupta R. The Therapeutic Value of Monoclonal Antibodies Directed Against Immunogenic Tumor Glycoproteins. (jcancer.org)
Monoclonal antibodies developed against immunogenic proteins (Tumor Specific Antigens/TSA's) that are expressed in human cancers, display a unique behavioral pattern. (jcancer.org)
This includes the early recognition of these immunogenic membrane proteins that can serve as diagnostic markers, and the targeting of such markers for the destruction of the tumor, primarily thru ADCC. (jcancer.org)
The monoclonals (mAbs) that we have developed against specific immunogenic tumor membrane proteins have been studied in detail. (jcancer.org)
However, we are also very excited to further understand what other areas we can apply the technology to, such as in tumors that may not be immunogenic and perhaps unresponsive to checkpoint inhibition. (drugdiscoverynews.com)

Most humoral responses cannot prevent tumor growth. (msdmanuals.com)
In April 2022, HOOKIPA presented positive data at the 2022 American Association for Cancer Research Annual Meeting showing HOOKIPA's arenaviral immunotherapies induced potent T cell responses in novel combinations (such as co-stimulatory 4-1BB agonists or adoptive cell transfer) and against tumor self-antigens. (financialcontent.com)
Methods CT26 models were treated with anti-PD-1 on days 3, 6 and 9 following subcutaneous tumor implantation generating variable responses during early tumor development. (bmj.com)
Adoptive transfer of Tet lo showed more effective tumor control than Tet hi , and curative responses were achieved when Tet lo was combined with two doses of anti-PD-1. (bmj.com)

Failed T cell-based immunotherapies in the presence of genomic alterations in antigen presentations pathways may be overcome by NK cell-based immunotherapy. (elifesciences.org)
Their expression in tumour cells is modulated by a complex interplay of genomic, transcriptomic and post translational factors involving multiple intracellular antigen processing pathways. (portlandpress.com)
Apparently, certain immune system pathways (e.g. inflammation) instead serve to promote tumor growth. (massgenomics.org)

OX40, GITR, and 4-1BB), can enhance T cell immunity in tumor-bearing hosts. (bepress.com)
however, despite its prevalence in FL and other cancers, the role of CA125 in tumor biology and immunity has been only recently elucidated. (spandidos-publications.com)
However, this finding has triggered further interest in utilising tumour-specific MHC-II to harness sustained anti-tumour immunity through the activation of CD4 + T helper cells. (portlandpress.com)
Thus, their reactivation represents an attractive way to unleash anti-tumour immunity. (portlandpress.com)

Preclinical data demonstrate that multiple immunomodulators synergize with radiotherapy to cause the regression of irradiated tumors and, less often, nonirradiated metastases. (aacrjournals.org)
According to Doody, preclinical studies using IMO-2125 either as a single-agent or in combination with several checkpoint inhibitors-such as anti-CTLA-4, anti-PD-1 and IDO-1 inhibitor-have shown robust tumor regression. (drugdiscoverynews.com)
As Doody explained, "Tumor regression was not only observed in the injected tumor but also in the uninjected tumor, essentially creating a systemic response. (drugdiscoverynews.com)

The innate cell engager AFM24 showed greater efficacy in eliciting antibody-dependent cellular phagocytosis of EGFR wild-type and KRAS-mutant tumor cells compared with cetuximab. (onclive.com)
The innate cell engager ® (ICE) AFM24 showed greater efficacy in eliciting antibody-dependent cellular phagocytosis of EGFR wild-type and KRAS -mutant tumor cells compared with cetuximab (Erbitux), according to preclinical findings from a study presented in a poster during the 2021 SITC Annual Meeting . (onclive.com)
This mechanism of action may be instrumental to the efficacy of AFM24, especially in macrophage-rich tumors," wrote the study authors. (onclive.com)
The first evidence that radiotherapy enhances the efficacy of immune checkpoint blockers (ICB) was obtained a dozen years ago in a mouse model of metastatic carcinoma refractory to anti-CTLA-4 treatment. (aacrjournals.org)

The safety profile of gavo-cel continues to be generally well tolerated with a manageable adverse event profile with no patients experiencing on-target, off-tumor toxicities. (tcr2.com)

T cell-based immunotherapy, such as immune checkpoint blockade or adoptive T cell transfer, is limited by the ability of T cells to detect major histocompatibility complex (MHC)-presented antigen by tumor cells. (elifesciences.org)
Further insights on the roles of CD8 + specificities and TCR avidity of naturally arising tumor-specific T cells, where both high and low avidity T cells recognizing the same peptide-major histocompatibility complex (pMHC) coexist in the same tumor, are crucial for understanding T cell exhaustion and resistance to PD-1 immunotherapy. (bmj.com)

In this analysis, investigators evaluated the ability of AFM24 to elicit antibody-dependent cellular phagocytosis in solid tumor cell lines expressing EGFR wild-type or EGFR signaling pathway mutations. (onclive.com)

Ongoing research investigates mechanisms invoked by cancer cells to abrogate MHC-I expression and attenuate anti-tumour CD8 + cytotoxic T cell response. (portlandpress.com)

Because pathologic diagnosis of ovarian cancer is difficult without laparotomy, tumor markers such as CA-125, in addition to diagnostic imaging, are useful in preoperative evaluation for ovarian cancer. (medscape.com)
Departing from Condeelis' theme is the talk by Dr. Christopher Contag, who used real-time whole-body tracing to track the synergistic tumor-killing activity of cytokine-induced killer (CIK) cells and oncolytic vaccinia virus (vv) in a mouse xenograft model of ovarian cancer. (science20.com)

In 2009, we had a seminal moment when you published a manuscript in The New England Journal of Medicine describing PLA2R, phospholipase A2 receptor, as the antigen that was responsible for a majority of the cases of MN. (medscape.com)
Here, we demonstrate that NK cells (haNKs) engineered to express a PD-L1 chimeric antigen receptor (CAR) haNKs killed a panel of human and murine head and neck cancer cells at low effector-to-target ratios in a PD-L1-dependent fashion. (elifesciences.org)

Herein, we also demonstrate that compounds developed to target mutant IDH1 can be repurposed as wild-type IDH1 inhibitors, because these drugs surprisingly become potent inhibitors of wtIDH1 in cancer cells under conditions present in tumors: specifically, we found that wtIDH1 is critical for PDAC cell survival under low-glucose conditions, and allosteric IDH inhibitors effectively block wtIDH1 activity under low magnesium. (nature.com)
1. Examine the in vivo effect of: a) DNA methyltransferase inhibitors, b) HDACi, and c) IMiDs on the response to GM-CSF tumor vaccines in a mouse model (year 1). (acgtfoundation.org)

They are typically produced by tumor cells, but in some cases they may be produced by the body in response to malignancy or to certain benign conditions. (medscape.com)

Furthermore, the study characterized an RTX variant, named NAV‑006 (RTX‑N109D), which was more refractory to the immunosuppressive effects mediated by CA125 as evidenced by its reduced CA125 interaction and increased activity of ADCC and CDC when compared with parent RTX. (spandidos-publications.com)

Thus, increasing numbers of macrophages within the tumour islets conferred a marked survival advantage, while increased numbers of macrophages in the tumour stroma were associated with worse prognosis. (ersjournals.com)

We are developing gavo-cel to target mesothelin-positive solid tumors. (tcr2.com)

Tumor markers are soluble glycoproteins that are found in the blood, urine, or tissues of patients with certain types of cancer. (medscape.com)

The usefulness of a tumor marker is in its sensitivity and specificity, as well as its influence on patient management decisions. (medscape.com)
Monoclonals developed from these tumor antigens are in the initial phases of investigation with regard to their specificity and antitumor activity. (jcancer.org)
Importantly, CIKs must be pre-infected with vaccinia virus, and that vaccinia virus must be delivered by CIKs, in order to achieve this level tumor specificity, suggesting remarkable synergy between CIKs and vaccinia virus. (science20.com)

GISTs (Gastrointestinal stromal tumors) are most common mesenchymal neoplasms of gastrointestinal tract. (scirp.org)

Experimental investigation has revealed the presence of specific tumor antigens in laboratory animals. (iptq.com)

There is a marked survival advantage for patients with nonsmall cell lung cancer (NSCLC) expressing high numbers of macrophages in their tumour islets. (ersjournals.com)
The study enrolled both treatment-naive patients and heavily pretreated patients with a variety of advanced solid tumors including RET fusion-positive NSCLC, RET -mutant MTC, RET fusion-positive thyroid cancer, and certain other advanced solid tumors with RET alterations. (prnewswire.com)

Sixteen histological tumor subtypes exist and the most common are papillary, chromophobe and clear cell renal cell carcinoma (ccRCC) representing 85% of all RCC. (frontiersin.org)

Monoclonals that we were able to develop from tumor specific proteins derived from colon and pancreas cancer were found capable of targeting those tumors to induce apoptosis. (jcancer.org)
Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)

Neoantigens arise from amino acid changes encoded by somatic mutations in the tumor cell and have the potential to bind to and be presented by personal HLA molecules. (aacrjournals.org)

Macrophages infiltrating the tumour islets in nonsmall cell lung cancer were predominantly of the M1 phenotype in patients with extended survival. (ersjournals.com)
M2 (alternatively activated) macrophages are thought to be modulated by IL-4 and -13 and associated with tumour formation. (ersjournals.com)
Additionally, M2 macrophages have been traditionally thought of as being the predominant macrophage phenotype in solid tumours (tumour-associated macrophages). (ersjournals.com)
Vascular endothelial growth factor (VEGF), a key component in the process of angiogenesis, is known to be produced by tumour-associated macrophages 17 , 18 , which have been traditionally reported as M2 macrophages. (ersjournals.com)
To do so, monocyte-differentiated macrophages from healthy donor peripheral blood mononuclear cells were co-cultured for 4 hours with CMFDA-labeled, wild-type EGFR-expressing or KRAS -mutant tumor cells in the presence of 10 µg/mL of AFM24 or cetuximab. (onclive.com)
M0, M1, or M2 macrophages were co-cultured with CMFDA-labeled tumor cells in the presence of increasing concentrations of AFM24. (onclive.com)
Finally, M0 macrophages were co-cultured with pHRodo™-labeled tumor cells in the presence of 10 µg/mL of AFM24 or cetuximab. (onclive.com)
Condeelis further revealed clusters of macrophages along the blood vessels that are colocalized with the site to tumor cell intravasation, suggesting the integral role of macrophages in the cancer cell's journey into circulation. (science20.com)

Research has intensified to understand ERV protein function and their role as tumor antigens and targets for cancer (immune) therapy. (frontiersin.org)
High ERV-K env total protein expression of all tumor subtypes significantly correlated with low tumor grading and a longer disease specific survival using multivariable analyses. (frontiersin.org)
The middle tumor antigen (also called the middle T-antigen and abbreviated MTag or MT) is a protein encoded in the genomes of some polyomaviruses, which are small double-stranded DNA viruses. (wikipedia.org)
The expression level of MAGEC2 protein was significantly reduced when TRIM28 was depleted in tumor cells, and no changes were observed in MAGEC2 mRNA level. (biomedcentral.com)
Mechanistic studies indicate that the regulatory role of TRIM28 on MAGEC2 protein expression in tumor cells depends on proteasome-mediated pathway. (biomedcentral.com)
In this study, we found that expression of MAGEC2 protein in tumor cells depends on the expression of TRIM28, a reduction in the level of endogenous TRIM28 expression in melanoma cells resulting in significantly decreased expression of MAGEC2 protein. (biomedcentral.com)

MTag is expressed early in the infectious cycle along with two other related proteins, the small tumor antigen and large tumor antigen. (wikipedia.org)
These tumor proteins, when first defined, were referred to as tumor associated antigens. (jcancer.org)

Many new tumor markers have been discovered since the development of monoclonal antibodies, and most tumor markers are now detected with them. (medscape.com)
Cancer antigen (CA) 27.29 is a monoclonal antibody to a glycoprotein (MUC1) that is present on the apical surface of normal epithelial cells. (aafp.org)

Cancer/testis antigen MAGEC2 (also known as HCA587) is highly expressed in a wide variety of tumors and plays an active role in promoting growth and metastasis of tumor cells. (biomedcentral.com)

This study supports ERV-K env as a single prognostic indicator for better survival of RCC, which we propose represents a new tumor antigen. (frontiersin.org)
To date, no tumor marker has demonstrated a survival benefit in randomized controlled trials of screening in the general population. (aafp.org)
For tumors resistant to radiation and for those animals unable to receive radiation therapy, systemic treatment with administration of chemotherapeutic agents, including melphalan, chlorambucil, cyclophosphamide, and glucocorticoids, have been recommended and have yielded long-term survival. (merckvetmanual.com)
High serum level of CA125 is used as an indicator of tumor abdominal involvement, advanced staging, relapse rates and survival in NHL patients ( 8 - 12 ). (spandidos-publications.com)

Accumulating evidence has indicated that MAGEC2 expression is associated with hallmarks of aggressive cancers. (biomedcentral.com)
We are developing a wide range of cell therapies for solid tumors as well as blood cancers by targeting a number of different surface antigens on cancer cells that have beneficial expression characteristics. (tcr2.com)
We are focused on the discovery and validation of novel targets to broaden the reach of TRuC-T cells in solid tumors and hematologic cancers. (tcr2.com)

2 - 4 Additionally, there are rare reports of primary tumors outside the abdominal cavity with metastasis to the umbilicus, including breast, lung and penis. (aafp.org)

This includes the amount of shed antigen in the serum at the time of treatment that could initiate immune complex formation as well as the shedding of inhibitory material into the serum possibly effecting an immune response. (jcancer.org)

However, evidence of MTag encoding and expression has also recently been reported in at least one virus of unrelated lineage, the trichodysplasia spinulosa polyomavirus, which is a normally asymptomatic infection in humans that sometimes causes the rare disease trichodysplasia spinulosa in immunocompromised individuals. (wikipedia.org)
We demonstrate that MAGEC2 interacts with TRIM28 in melanoma cells and MAGEC2 expression in tumor cells depends on the expression of TRIM28. (biomedcentral.com)
To our knowledge, this is the first time to report the role of TRIM28 in regulating the expression of cancer/testis antigen MAGEC2. (biomedcentral.com)
Monocytes activated by tumour-derived microvesicles from pancreatic, colon and lung cancer cell lines have been found to show increased expression of human leukocyte antigen (HLA)-DR and a resulting increase in production of reactive oxygen intermediates and TNF-α 11 . (ersjournals.com)
However, several antigens with selective expression on the surface of tumor cells are not associated with the major histocompatibility complex and may be candidates for therapeutic targeting. (msdmanuals.com)
This review provides a comprehensive overview of physiologically conserved or novel mechanisms utilised by tumour cells to reduce MHC-I or MHC-II expression. (portlandpress.com)
These in vitro, and their expression in these human tumour virus. (who.int)

Host Response to Tumors The immune response to foreign antigens consists of Humoral mechanisms (eg, antibodies) Cellular mechanisms (See also Tumor Antigens. (msdmanuals.com)

In France, the mean age of cats developing a fibrosarcoma is 9.6 years within a large interval of 3.2-16 years (95% confidence interval), which is little typical of spontaneous tumors. (vin.com)

Potential of arenaviral immunotherapies in novel combinations and against tumor self-antigens highlighted at AACR. (financialcontent.com)

Treatment of syngeneic tumors resulted in CD8 and PD-L1-dependent tumor rejection or growth inhibition and a reduction in myeloid cells endogenously expressing high levels of PD-L1. (elifesciences.org)
Treatment of xenograft tumors resulted in PD-L1-dependent tumor growth inhibition. (elifesciences.org)
Obstruction affecting one side might not invariably lead to acute kidney injury, especially when the impediment develops slowly, such as with tumour growth. (randox.com)
The monoclonals, so produced, were not only more efficient in controlling tumor growth but minimized the development of a HAMA response. (jcancer.org)
On average, patients lived with little to no tumour growth for 16 months. (bvsalud.org)

Analyses of CD8+ TIL show increases in tumor-antigen reactive, proliferating CD103+ CD39+ cells in 25% of patients with evaluable tumor tissue (N = 4/16), all of whom remain disease-free. (bepress.com)
M cells in the intestinal epithelium overlying Peyer patches allow transport of antigens to the lymphoid tissue beneath it. (medscape.com)
6 , 25 , 30 ] Measured in millimeters, CRM is defined as the retroperitoneal or peritoneal adventitial soft-tissue margin closest to the deepest penetration of the tumor. (cancer.gov)
1) Dr. Contag's newest implantable confocal microscope featuring 3D YZ and XY stacked tumor videos, as well as Pulse Electron Avalanche Knife tissue sampler to allow concise and accurate tissue sampling. (science20.com)
4 Î¼m slides from FFPE tumor tissue are required. (who.int)

Treatment for these tumors targets local control using localized techniques described above. (merckvetmanual.com)

A useful analogy to consider when thinking about tumor suppressors and oncogenes is an automobile. (cancerquest.org)

AFM24 enhances macrophage-mediated antibody-dependent cellular phagocytosis of various EGFR-expressing tumor cell lines, irrespective of the EGFR signaling pathway," wrote lead study author Sheena Pinto, PhD, translational project leader at Affimed, and coauthors, in the poster. (onclive.com)
Additional results showed that AFM24 increased antibody-dependent cellular phagocytosis of EGFR -positive tumor cells regardless of macrophage subtype. (onclive.com)
Morphologically, GISTs vary from cellular spindle cell tumors (70% - 80%) to epithelioid (20% - 30%) or mixed. (scirp.org)

Anatomy18

Organisms11

Diseases34

Chemicals and Drugs123

Analytical, Diagnostic and Therapeutic Techniques and Equipment38

Phenomena and Processes35

Disciplines and Occupations1

Information Science3

Health Care5

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Prostate-specifi3

Malignant15

Residual tumor is frequently nonviable1

Necrosis3

Genes6

Melanoma associated antigens1

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Lymphocytes2

Primary tumor5

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Clinical23

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