Molecular mimicry and ganglioside antibodies play an important role in the pathogenesis of some variants of Guillain-Barré syndrome (eg, acute motor axonal neuropathy). (medlink.com)
Cerebrospinal fluid anti-GM1 ganglioside antibodies and oligoclonal band were negative and the IgG index was normal. (who.int)
The presence of cerebrospinal fluid albuminocytological dissociation (raised protein, normal cell count), antiganglioside antibodies and neurophysiological evidence of axonal or demyelinating neuropathy also support a diagnosis in many cases, but should not be relied upon. (bmj.com)
Anti-ganglioside antibodies were negative. (bvsalud.org)
Cranial2
GBS is a group of autoimmune diseases with acute/subacute evolution characterized by progressive and ascending motor deficit in the limbs, often with sensory, cranial nerve involvement ( 4 , 6 ). (spandidos-publications.com)
CONCLUSION: GBS following varicella is a rare but severe disease occurring most often in adults and marked by greater involvement of the cranial nerves. (bvsalud.org)
Axonal2
Mutations in the ganglioside-induced differentiation associated protein-1 gene (GDAP1) cause autosomal recessive (AR) demyelinating or axonal Charcot-Marie-Tooth neuropathy (CMT). (nih.gov)
As the disease course evolves, there is less evidence of ongoing remyelination, further axonal loss, and more extensive gliosis. (docksci.com)
Endogenous2
Studies have demonstrated the peripheral and central analgesic mechanisms of PNS by modulating the inflammatory pathways, the autonomic nervous system, the endogenous pain inhibition pathways, and the involvement of the cortical and subcortical areas. (bvsalud.org)
All 53 patients with MFS with the clinical triad of MFS (ophthalmoplegia, ataxia, and areflexia) and acute onset without major limb weakness or other signs suggestive of CNS involvement were selected. (neurology.org)
Molecular2
In this review we provide current evidence for BAFF-dependent signaling through the NgR multimeric complex, elucidating their association within the CNS compartment and underlying the importance of these potential pathogenic molecular regulators as possible therapeutic targets to limit relapse rates and potentially MS progression. (medsci.org)
The effects of MP are the subject of new and interesting research with evidence indicating that galactan-rich tiny molecular weight pectin fragments can bind to the carbohydrate recognition domain (CRD) on the pro-metastatic protein, GAL-3. (encyclopedia.pub)
Peripheral3
A variant with CNS involvement named combined central and peripheral demyelination (CCPD). (wikipedia.org)
Most of the evidence supports the conclusion that the immune damage is triggered by shared reactivity to peripheral nerve components and epitopes on the surface of infectious particles. (nursingcenter.com)
Current evidence suggests GBS occurs due to immune system activation against these pathogens, where the immune response mistakes key components of peripheral nerves for the virus it is attacking. (geekymedics.com)
Possibility2
These findings support the possibility that under pathological conditions, gangliosides serve as cytotoxic factors in the central nervous system (CNS). (biomedcentral.com)
The ganglioside antibody test may increase the possibility of diagnosing isolated FD. (e-acn.org)
Syndrome3
The display by DH1, of a surface glycan that mimics the terminal trisaccharide portion of disialosyl-containing gangliosides, provides strong evidence for its involvement in the development of Fisher syndrome. (diva-portal.org)
Finally, the inflammatory and demyelinating findings in clinically isolated syndrome (CIS) and the evidence in radiologically isolated syndrome (RIS) are supportive of MS in undiagnosed individuals [ 2 , 3 ]. (medsci.org)
Experimental Guillain-Barre syndrome induced by immunization with gangliosides: Keyhole limpet hemocyanin is required for disease triggering. (conicet.gov.ar)
Disorders1
Some evidence indicates that at least in certain disorders, combination ERT and hematopoietic stem cell transplantation together might be superior to hematopoietic stem cell transplantation alone in patients who are appropriate candidates. (medscape.com)
Findings1
Of the 27 patients whose ophthalmoplegia was examined monthly, few had findings suggestive of supranuclear involvement: preservation of Bell's phenomenon despite paralysis of voluntary upward gaze in two, gaze-evoked horizontal dissociated nystagmus in two, preservation of convergence despite adduction palsy with conjugate gaze in one, and internuclear ophthalmoplegia in one. (neurology.org)
Limbs1
All Czech GDAP1 patients developed involvement of all four limbs evident by the end of second decade, except for one isolated patient showing very slow disease progression. (nih.gov)
Autoimmune1
This article gives an overview of some autoimmune neurologic diseases and explores the clinical evidence supporting the use of IVIG. (nursingcenter.com)
Protein2
Immunologic and confocal microscopic evidence also suggested a transient but significant stimulation of tyrosine phosphorylation of Cav-1 in β-cells briefly (for 15 min) exposed to IL-1β that was markedly attenuated by three structurally distinct inhibitors of protein tyrosine phosphorylation. (diabetesjournals.org)
Gupta DD, Saha S, Chakrabarti MK (2005) Involvement of protein kinase C in the mechanism of action of Escherichia coli heat-stable enterotoxin (STa) in a human colonic carcinoma cell line, COLO-205. (springer.com)
Diseases1
MUO includes all the specific subtypes of non-infectious inflammatory disease that can be identified through histopathology, including granulomatous meningoencephalomyelitis (GME) and necrotizing encephalitis (NE), but does not include the diseases without evidence of explicit CNS involvement, such as steroid-responsive meningitis-arteritis (SRMA) [ 1 ]. (biomedcentral.com)
Occurs1
It occurs in about 15% of cases and results from basal ganglia involvement. (msdmanuals.com)
Data2
With a few exceptions, most methods integrate more than two different data sources by combining evidences obtained from pairwise analyses (Van Steen & Malats, 2014). (researchgate.net)
These data are the first evidence that chronic exposure to ceramide and its metabolites enhances expression of the MDR phenotype in cancer cells. (sphingolipidclub.com)
Cases1
Aside from facial diplegia, which is found in at least half of the cases, involvement of extraocular muscles has been described. (medlink.com)
Provide1
Here we provide the first evidence to suggest that tyrosine phosphorylation of Cav-1 and subsequent interaction among members of the Ras signaling pathway within the membrane lipid microdomains represent early signaling mechanisms of IL-1β in β-cells. (diabetesjournals.org)
Cells2
Morphological evidence revealed GT1b-induced chromatin condensation and nuclear fragmentation as well as an increased number of TUNEL-positive cells, compared to control cultures. (biomedcentral.com)
Recent compelling evidence has demonstrated that T cells are actually crucial in the pathogenesis of SLE in that they enhance the production of autoantibodies by offering substantial help to B cells through stimulating the latter to differentiate, proliferate, and mature, in addition to their support on class-switching of autoantibodies which B cells are expressing [ 3 ]. (hindawi.com)
Upper1
It is due to upper motor neuron involvement and may mildly or severely affect motor function. (msdmanuals.com)
Common1
L239F previously described in a German-Italian family is a prevalent mutation in Czech population and we give evidence for its common ancestral origin. (nih.gov)
Level1
The level of evidence is low and more research is needed to assess its safety and effectiveness. (bvsalud.org)
Significant1
IV immunoglobulin has been tried but again, a significant evidence is lacking. (boneandspine.com)
Complex1
Recently, attention has been paid to the potential involvement of pectin as a bioactive complex polysaccharide, which when broken down into smaller fragments is referred to as modified pectin (MP). (encyclopedia.pub)