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  • forebrain
  • demonstrated that mild hypothermia (35 degrees Celsius) afforded a greater degree of histopathologic protection against forebrain ischemia than did isoflurane. (asahq.org)
  • focal
  • In this study, we used a rat model of focal cerebral ischemia and performed a direct, longitudinal, morphological comparison between estimated 1 H T2 maps, estimated 1 H ADC maps, 23 Na images, and triphenyltetrazolium chloride (TTC)-stained sections. (ahajournals.org)
  • Evidence vs experience in the surgical management of necrotizing enterocolitis and focal intestinal perforation. (springer.com)
  • resuscitation
  • This was clear evidence that the effects of birth asphyxia might become manifest only some days after resuscitation, and indeed more recent data suggest that abnormal cerebral energy metabolism and cell death can persist for weeks and months. (bmj.com)
  • 11 Thus rescue treatment of hypoxia-ischaemia after resuscitation was confirmed as a real possibility, and in some cases treatment could still be effective even if delayed for a considerable time after the hypoxic-ischaemic insult. (bmj.com)
  • The following guidelines are an interpretation of the evidence presented in the 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations 1 ). (aappublications.org)
  • epilepsy
  • 1-6 Such increased lipolytic activity has mainly been studied by measuring free fatty acids and membrane phospholipids extracted from brain homogenate samples in animal models of ischaemia, hypoxia, hypoglycaemia, and epilepsy. (bmj.com)
  • Glial
  • The adhesion molecules E- and P-selectin, cell adhesion molecules (CAMs), both intercellular (ICAM-1) and vascular (VCAM-1), as well as glial fibrillary acidic protein (GFAP), and cleaved caspase-3 were measured at 48 h after ischemia in the cerebral cortex and hippocampus using Western blot, qPCR and immunofluorescence techniques. (springer.com)
  • Additionally, 4-PBA inhibited the expression of inducible nitric-oxide synthase and tumor necrosis factor-α in primary cultured glial cells under hypoxia/reoxygenation. (aspetjournals.org)
  • stroke
  • Selective regional sensitivity and delayed damage in cerebral ischemia provide opportunities for directed and late therapy for stroke. (ovid.com)
  • Therefore, the multiple actions of 4-PBA may provide a strong effect in treatment of cerebral ischemia, and its use as a chemical chaperone would provide a novel approach for the treatment of stroke. (aspetjournals.org)
  • occurs
  • Some considerations are made about the lack of evidences on increase in glucose consumption or lactate production when hyperglycemia occurs in association with brain damage and ischemia caused by head trauma. (worldwidescience.org)
  • Renal ischemia that occurs intraoperatively during procedures requiring clamping of the renal artery (such as renal procurement for transplantation and partial nephrectomy for renal cancer) is known to have a significant impact on the viability of that kidney. (spiedigitallibrary.org)
  • hypothermic
  • Global cerebral ischemia related to cardiopulmonary bypass (CPB) and deep hypothermic circulatory arrest (DHCA), used in the repair of the cardiovascular defects, appears to play an important role in the neurologic morbidity. (asahq.org)
  • Mean relative oxy-hemoglobin concentrations decrease more significantly during ischemia for normothermic kidneys compared to hypothermic kidneys. (spiedigitallibrary.org)
  • ionic
  • Occurring during the first seconds after the onset of ischemia is a complex series of ionic events that may not be dependent on adenosine triphosphate (ATP). (asahq.org)
  • tissue
  • We performed a direct, longitudinal, morphological comparison of 1 H T2 relaxation, 1 H apparent diffusion coefficient (ADC), 23 Na content, and histopathology after cerebral ischemia to address the hypotheses that (a) 23 Na MRI is unique in comparison to 1 H MRI, and (b) accumulation of 23 Na is an unambiguous marker for dead tissue. (ahajournals.org)
  • increases
  • Clinical events involving secondary hypoxia/ischaemia were generally associated with pronounced increases (up to 15-fold) of the dialysate glycerol concentration. (bmj.com)
  • process
  • 2 Now the belief is gaining ground again among basic researchers that moderate brain cooling to around 32 o C is one of several interventions which can be applied after hypoxia-ischaemia to modify the process of brain cell death and so lessen cerebral damage. (bmj.com)
  • consensus
  • A cornerstone of this growing consensus was the realisation that not only do some cells die during hypoxia-ischaemia, but many more may die hours or days later. (bmj.com)
  • cells
  • Ischemia induced by femoral artery ligature improved the number of CXCR3-expressing cells and the level of its ligand, CXCL10. (ahajournals.org)
  • Hypoxia-driven proliferation of embryonic neural stem/progenitor cells--role of hypoxia-inducible transcription factor-1alpha. (semanticscholar.org)
  • Neural stem/progenitor cells promote endothelial cell morphogenesis and protect endothelial cells against ischemia via HIF-1alpha-regulated VEGF signaling. (semanticscholar.org)