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  • tissues
  • Wilms' tumor protein (WT1) is an intracellular, oncogenic transcription factor that is overexpressed in a wide range of cancers, but has limited expression in normal adult tissues. (aacrjournals.org)
  • Prevalence of endogenous type-C virus in normal hamster tissues and hamster tumors induced by chemical carcinogens, simian virus 40, and polyoma virus. (nih.gov)
  • The proper targeting of tumor-reactive cytotoxic effector cells (CD8+ T cells, NK cells) to tumor tissues appears to be an essential prerequisite for a successful immune cell-mediated tumor eradication. (dkfz.de)
  • autologous
  • First six underwent priming with intravenous bevacizumab and oral metronomic cyclophosphamide followed by vaccination with an autologous DC preparation pulsed with freeze-thaw autologous tumor lysate while the other 25 underwent vaccination with an enhanced vaccine of autologous DCs loaded with HOCl-oxidized autologous tumor lysate administered intranodally in combination with antiangiogenesis therapy. (aacrjournals.org)
  • Sarcoma
  • To demonstrate that DC vaccination loaded with tumor lysate is feasible and that therapy with the vaccine with topical imiquimod (as final step in vaccine maturation), with or without the inhibition of MDSC by gemcitabine pre-treatment, is safe in pediatric and adult subjects with metastatic and refractory sarcoma. (clinicaltrials.gov)
  • therapies
  • The lab has been focusing on designing neo-antigen-targeted therapies for tumors with low mutation burden and on the discovery of novel immune cell subsets with anti-cancer properties. (thermofisher.com)
  • Combination strategies may ultimately require converting non-T cell-inflamed tumors into T cell-inflamed tumors as a means to sensitize tumors to therapies dependent on T-cell killing. (aacrjournals.org)
  • induce
  • However, tumors acquire genetic mutations, induce immunosuppressive signaling pathways, and undergo epigenetic changes that lead to resistant phenotypes. (aacrjournals.org)
  • Vaccines
  • These findings provide insights into the mode of phosphopeptide presentation by HLA as well as providing a platform for the rational design of a generation of posttranslationally modified tumor vaccines. (pnas.org)
  • molecules
  • Our own recombinant pMHC-I and pMHC-II molecules are also used to quantitate tumor-specific T cell subpopulations by flow cytometry with high sensitivity. (dkfz.de)
  • murine
  • To gain information about immunoreactivity and self-tolerance to this antigen, we established a model using the murine tyrosinase-derived homologue of this peptide F MDGTMSQV, together with transgenic mice expressing the HLA-A*0201 recombinant molecule AAD. (pubmedcentralcanada.ca)
  • expression
  • Group-specific antigen expression during embryogenesis of the genome of the C-type RNA tumor virus: implications for ontogenesis and oncogenesis. (nih.gov)
  • Based on the findings of this preliminary retrospective study it is felt that at the time of performing a colectomy for a malignant lesion of the bowel, that it is important that those normal appearing colonocytes adjacent to tumor be evaluated for expression of tumor associated antigen. (jcancer.org)
  • The tumor origin of the cell lines was supported by the expression of the ErbB2 oncogene (seven of nine) and MAGE mRNA (eight of eight). (aacrjournals.org)
  • Paraneoplastic cerebellar degeneration (PCD) is believed to be an autoimmune disorder initiated by the ectopic expression of a neuron-specific protein in breast and ovarian tumors. (jneurosci.org)
  • The tumor subset with high expression of this signature has been described as the T cell-"inflamed" phenotype. (aacrjournals.org)
  • CTLs
  • Moreover, several of these self-TAAs have been shown to be heterogeneously expressed within the tumor mass ( 5 ) and selected against by CTLs during tumor growth allowing an immunologically unrestricted progression of the neoplasia ( 6 , 7 ). (aacrjournals.org)
  • To study the intrinsic link between the deregulated signaling cascade present in many cancers and the ability of antigen processing to alert CTLs to such molecular events, we have investigated the structural and biophysical properties and structures of 3 HLA A2 phosphopeptide complexes derived from cell division cycle (CDC) 25b, β-catenin, and insulin receptor substrate (IRS) 2 and have compared them with the structures of their nonphosphorylated counterparts. (pnas.org)
  • variants
  • Extensive efforts to isolate antigen-loss variants of CMS5 were unsuccessful, suggesting that the mutated mitogen-activated protein kinase is essential for maintenance of the malignant phenotype. (pnas.org)