Evaluation dermal exposure. Medical search. Frequent questions

Studies on repeated dermal dose toxicity in compliance to current Guidelines are not available. (europa.eu)
A literature search was conducted through February 2018 to identify information on PCP, including but not limited to data relating to its dermal absorption, acute toxicity, repeated-dose systemic toxicity, carcinogenicity, biological system/function-specific effects (including reproductive and developmental effects and immunotoxicity), irritation, and sensitization. (cdc.gov)
170) 1.Hazardous substances - toxicity 2.Environmental exposure 3.Guidelines I.Series ISBN 92 4 157170 5 (NLM Classification: WA 465) ISSN 0250-863X The World Health Organization welcomes requests for permission to reproduce or translate its publications, in part or in full. (inchem.org)
This report examines the health effects of exposure to n-butyl, isobutyl, sec-butyl, and tert-butyl acetates The best studies available indicate that the acute toxicity of n-butyl acetate by inhalation, oral and dermal routes is low. (epa.gov)
Animal studies revealed low acute toxicity in rat and rabbit models after oral and dermal contact, as well as inhalation, but a specific review on the clinical effects of exposure to the chemical is yet to be prepared, according to the Toxicology Data Network website . (naturalpedia.com)
Comprehensive reevaluation of BPA exposure and toxicity concludes that it poses no health risk to any age group, including unborn children, at current exposure levels. (newhope.com)
In addition, typical symptoms of salicylate toxicity warrant referral to the emergency department for evaluation. (medscape.com)

Dermal absorption was investigated for human volunteers indicating only 0.001 % absorption for CaNa2EDTA. (europa.eu)
Moreover, evidence for the negative impact of methylparaben on skin cells has been provided, and the main factors that may intensify dermal absorption of parabens and their impact on the skin have been described. (nih.gov)
Absorption of these carcinogens through the skin is consider an important exposure route. (chemistryviews.org)
Exposure takes place from the inhalation of the substance in the gas phase, the inhalation of substance bound to airborne particles, the dermal absorption of the substance from air (gas phase) and the oral ingestion of the substance with dust. (rivm.nl)

The summarized information and health hazard assessment are limited to an evaluation of the potential health effects of dermal exposure to PCP. (cdc.gov)
Our dermatology experts work to Product Test Guidelines for the Assessment of Human Skin Compatibility, the European Cosmetic, Toiletry and Perfumery Association (COLIPA) guidelines including the Guidelines for the Evaluation of the Efficacy of Cosmetic Products, Guidelines on the Management of Undesirable Event Reports and the Guidelines for the Safety Assessment of a Cosmetic Product. (intertek.com)
More information about the ATSDR evaluation process can be found in ATSDR's Public Health Assessment Guidance Manual at http://www.atsdr.cdc.gov/HAC/HAGM or by contacting ATSDR at 1-888-42-ATSDR. (cdc.gov)
In the occupational and laboratory setting, inhalation is a primary focus for exposure assessment and control. (acs.org)
This paper describes a new method (DREAM) for structured, semi-quantitative dermal exposure assessment for chemical or biological agents that can be used in occupational hygiene or epidemiology. (tno.nl)
It is anticipated that DREAM could serve as an initial assessment of dermal exposure, amongst others, resulting in a ranking of tasks and subsequently jobs. (tno.nl)
In addition to dermal exposure assessment, the systematic description of dermal exposure pathways helps to prioritize and determine most adequate measurement strategies and methods. (tno.nl)
DREAM could be a promising approach for structured, semi-quantitative, dermal exposure assessment. (tno.nl)
A quantitative human health risk assessment was conducted for inhalation exposure. (cdc.gov)
Nasal olfactory degeneration is the primary endpoint for risk assessment of acute exposure to iodomethane. (cdc.gov)
The DustEx model considers all pathways and will therefore enable a more complete assessment of exposure, reducing the probability of overlooking the most crucial pathways in the exposure assessment. (rivm.nl)
The resulting exposure estimates for some of the identified substances were integrated in a health risk assessment . (greenfacts.org)
During his PhD studies, Dr. Abdallah published 19 papers in high-impact peer-reviewed journals investigating environmental behaviour, fate, human exposure and risk assessment of persistent organic pollutants (POPs). (birmingham.ac.uk)
Margins of exposure were not calculated for non-cancer effects in this assessment since non-cancer effects occurred at a dose at which tumours were observed and because the information available indicates that exposures of the general Canadian population to 2-nitrotoluene from either environmental media or consumer products are expected to be negligible. (gc.ca)
The assessment of the human health risks from exposure to BTEX-covered industrial scenario for adult receptors and residential scenario for adult receptors and children. (ac.rs)
The International Fragrance Association (IFRA) has developed and implemented a model for dermal sensitization quantitative risk assessment (QRA). (criticalcatalyst.com)
In 2012, it was established the International Dialogue for the Evaluation of Allergens (IDEA) with the aim of improving the risk assessment of fragrance allergens. (criticalcatalyst.com)
For a quantitative assessment, calculated or measured numerical values are used to estimate the exposures. (canada.ca)
Although determination of serial serum salicylate concentrations offers valuable information regarding the effectiveness of the treatment implemented, assessment of these levels alone is not a substitute for clinical evaluation of the patient. (medscape.com)
A recent study evaluated the urinary levels of 9 atrazine metabolites in humans and concluded that DACT was the primary metabolite regardless of exposure scenario, and that exposure assessment based on measuring only AM or any single atrazine metabolite resulted in an underestimate of atrazine exposure (Barr et al. (who.int)
The report also contains general recommendations, in particular on the principles of exposure assessment for food additives when using food frequency questionnaires, and on guidance for the safety evaluation of enzymes produced by genetically modified microorganisms. (who.int)
Therefore it is important to provide Member States with valid information on both the general aspects of risk assessment and specific evaluations on food additives covered in this report. (who.int)

3 Primary routes of exposure for workers and laboratory personnel involved in handling engineered nanomaterials include inhalation, dermal contact, and ingestion. (acs.org)
analyzed were dermal contact with and ingestion of contaminated water, considering both cancer and non-cancer effects. (ac.rs)

Epidemiology suggests that exposure to polycyclic aromatic hydrocarbons (PAHs) is leading to an increased incidence of cancers among workers such as chimney sweeps. (chemistryviews.org)
The Health Hazard Evaluation Program carried out a study at the fire service training facility to determine if airborne polycyclic aromatic hydrocarbons (PAHs) and other aromatic hydrocarbons generated during live fire training contaminate and pass through the skin of fire fighters. (fireemsleaderpro.org)
The reports describe different cases and provide recommendations for preventing the development of rhabdomyolysis and injuries, and prevent exposures to diesel exhausts, heat stress, dermal exposure to polycyclic aromatic hydrocarbons, and traffic hazards, among others. (cdc.gov)

ATSDR identifies and evaluates exposure pathways by considering how people might come into contact with a chemical. (cdc.gov)
According to the press release, under the previous Administration, the "first 10" risk evaluations did not assess air, water, or disposal exposures to the general population because these exposure pathways were already regulated, or could be regulated, under other EPA-administered statutes, such as the Clean Air Act (CAA), Safe Drinking Water Act (SDWA), or Clean Water Act (CWA). (lawbc.com)
EPA states that the approach to exclude certain exposure pathways also resulted in a failure to address consistently and comprehensively potential exposures to potentially exposed or susceptible subpopulations (PESS), including fenceline communities ( i.e ., communities near industrial facilities). (lawbc.com)
The Biden Administration reversed this policy, and EPA developed the screening level methodology to examine further whether the policy decision to exclude air and water exposure pathways from the risk evaluations will lead to a failure to identify and protect fenceline communities. (lawbc.com)
The proposed screening level methodology states that it "uses reasonably available data, information, and models to quantify environmental releases, evaluate exposures to fenceline communities and characterize risks associated with such releases and exposures for certain air and water pathways previously not evaluated in published risk evaluations. (lawbc.com)
Estimates of exposure for Canadians or the environment are influenced by certain physical and chemical properties of the substances in the product, product use patterns, release pathways, knowledge of a substance's rate of entry and fate in the body and the environment. (canada.ca)

Intertek has a wealth of experience in safety evaluations including patch testing for primary irritation, cumulative irritation and sensitization studies. (intertek.com)
Exposure to quinoxyfen concentrate may cause irritation to the eyes and allergic skin reaction such as rashes and burns. (naturalpedia.com)
Modified PDII=8 (severe dermal irritation). (europa.eu)

inadequate warning for acute or chronic exposure. (cdc.gov)
Firefighters and departments throughout the US have embraced the Coalition's educational mission that smoke, whether through an acute or chronic exposures, will kill you. (fireemsleaderpro.org)
Optimal management of a salicylate poisoning depends on whether the exposure is acute or chronic. (medscape.com)

There is evidence that formaldehyde induces toxic effects only at the site of contact after oral, dermal or inhalation exposure. (europa.eu)
Local effects in the upper respiratory tract were induced after repeated inhalation exposure in experimental animals. (europa.eu)
The most sensitive site in rodents and monkeys following inhalation exposure is the respiratory epithelium in the anterior part of the nasal cavity. (europa.eu)
however, solid residues can result in contaminated air and inhalation exposure. (cdc.gov)
A new mask filter cartridge used to determine applicator inhalation exposure to an alachlor herbicide (Lasso®) during normal spraying operations. (exponent.com)

To date, CIPP air monitoring studies have been unable to comprehensively characterize occupational exposures because of a narrow focus on VOC vapors and the use of nonspecific detectors. (cdc.gov)
A physiologically based pharmacokinetic (PBPK) model for iodomethane was developed to characterize poten- tial human health effects from iodomethane exposure. (cdc.gov)
2007). This study found that AM accounted for only 2-12% of the detected metabolites, that most of the subjects had detectable atrazine exposure, and that future biomonitoring studies would likely need to include analysis of at least AM, DACT, DIA, and DEA in order to characterize the extent of atrazine exposure in a population. (who.int)
The overall aim of the research presented in this thesis was to characterize the physicochemical properties of indoor aerosols from cookstoves, candles, and phthalate sources, and to assess their contribution to human exposure. (lu.se)

Although occupational exposure to two other aromatic amines, 2-toluidine and 6-chloro-2-toluidine, may have occurred, it is considered by. (inchem.org)
The results of the California monitoring programme indicate that occupational exposure to chlordimeform can be significantly reduced, but not eliminated, during its use in cotton growing. (inchem.org)
Estimating Occupational Exposure to VOCs, SVOCs, Particles and Participant Survey Reported Symptoms in Central Thailand Rice Farmers Using Multiple Sampling Techniques. (umassmed.edu)
Occupational exposure to an intermediate in the manufacture of some pharmaceu- iodomethane may occur 8 hours per day, 5 days per week, ticals, in methylation processes, and in the field of micro- during the application season. (cdc.gov)
An evaluation of analytical methods, air sampling techniques, and airborne occupational exposure of metalworking fluids. (creod.on.ca)
Some PAH air levels were above occupational exposure limits during overhaul. (fireemsleaderpro.org)
All VOC air levels were below occupational exposure limits during overhaul. (fireemsleaderpro.org)
The air levels of these compounds were well below occupational exposure limits. (fireemsleaderpro.org)
Occupational exposure may occur through both inhalation and dermal adsorption during the manufacture of atrazine, its formulation, and its application. (who.int)
Since restrictions on the use of these agents in some countries came into effect, occupational exposure is likely to have decreased, although it is likely to be continuing in countries that have not introduced restrictions. (who.int)

It is concluded that systemic exposure via dermal route is negligible. (europa.eu)
Based on the available published data of the concentrations of parabens in various kinds of cosmetics, the average ranges of systemic exposure dose (SED) for methylparaben, ethylparaben, propylparaben, and butylparaben have been calculated. (nih.gov)
systemic exposure. (nih.gov)

The integration of the system of equations using suitable boundary and initial conditions (i.e. reflecting the specific exposure scenario), gives the concentrations of a substance in all different compartments (air, product, dust, airborne particles, indoor surfaces) as a function of time. (rivm.nl)
In addition to controlling airborne MWF exposure, full protection of workers would require the institution of programs for fluid management and dermal exposure prevention. (creod.on.ca)
BURDETT, G., DEWBERRY, K. and STAFF, J. Airborne asbestos exposures from warm air heating systems in schools. (hsl.gov.uk)
A human exposure study was conducted to elucidate the dermal and inhalation uptake in 16 volunteers from exposure to airborne gas- and particle phase phthalates, with participants wearing clean clothing. (lu.se)

To calculate the intake rate for dermal contact with chemicals in water, multiply the chemical-specific permeability constant by the area of skin exposed. (cdc.gov)
To calculate the intake rate for dermal contact with chemicals in soil, multiply the soil adherence factor by the area of exposed skin. (cdc.gov)
The main objective of the IPCS is to carry out and disseminate evaluations of the effects of chemicals on human health and the quality of the environment. (inchem.org)
WHO Library Cataloguing in Publication Data Assessing human health risks of chemicals: derivation of guidance values for health-based exposure limits. (inchem.org)
ATSDR scientists select chemicals for further evaluation by comparing them against health-based comparison values. (cdc.gov)
The Biden EPA announced on June 30, 2021, several policy changes surrounding TSCA risk evaluations issued by the previous Administration and the path forward for the "first 10" chemicals to undergo risk evaluation. (lawbc.com)
EPA developed the screening level methodology to evaluate potential exposures and associated potential risks to human receptors in proximity to facilities releasing chemicals undergoing risk evaluation under TSCA Section 6 to the ambient air and to waterbodies receiving facility releases (direct or indirect) of chemicals undergoing risk evaluation under TSCA Section 6. (lawbc.com)
For purposes of the proposed screening level methodology, EPA limits the proximity of receptors evaluated to those less than or equal to 10,000 meters from a facility releasing chemicals undergoing risk evaluation under TSCA Section 6 to the ambient air. (lawbc.com)
The Danish Environmental Protection Agency investigated the exposure and possible risk of chemicals in consumer products and articles. (greenfacts.org)
Other factors are also investigated, examples of this are estimations of physical demands, exposure to chemicals, presence of coronary artery disease and fitness and wellness programs implemented in the fire departments. (cdc.gov)
Exposures are expected to be highest among workers involved in producing PFOA or PFOS or using these chemicals directly in the manufacture of other products. (who.int)
The evaluation of chemicals in food by the Expert Committee is a continuing activity. (who.int)

He has particular interest in assessing the risk from human exposure to emerging contaminants using various exposure and pharmacokinetic models. (birmingham.ac.uk)

Step 2.1 Estimating Exposure Doses: Estimating a Dermal Contact Dose: When and How? (cdc.gov)
Estimating a Dermal Contact Dose: When and How? (cdc.gov)
Some comparison values used by ATSDR scientists include ATSDR's environmental media evaluation guides (EMEG), reference dose media evaluation guides (RMEG), and cancer risk evaluation guides (CREG). (cdc.gov)

Human dermal uptake and metabolism of PFAS from fabrics. (birmingham.ac.uk)
The uptake was measured, via combined inhalation and dermal air-to-skin transfer and via air-to-skin transfer only for the gas-phase diethyl phthalate (DEP) and for particle phase DEHP. (lu.se)
Dermal uptake via air-to-skin transfer only with clean clothing acting as a barrier was ten times lower than the uptake via inhalation for DEP. (lu.se)

Safety evaluations [margin of safety (MoS)] for these compounds, based on their aggregate exposure, have also been performed. (nih.gov)
This project reviewed uncertainty factors, introduced dermal aggregate exposure for fragrance ingredients, resulting in the QRA2 methodology. (criticalcatalyst.com)

Rhesus monkeys given five immunizing exposures to the Formosan strain had significant reductions in quantitative egg excretions and in worm fecundity after challenge with the Philippine strain. (ajtmh.org)
Quantitative histology was used to evaluate 8 biomarkers of photoaged skin, and associations between grades of dermal elastosis and each of the other 7 biomarkers were analysed using ordinal logistic regression models with proportional odds assumption, using histological grades of elastosis as the outcome. (karger.com)
For human health and the environment, exposure assessments of substances in products may be quantitative or qualitative. (canada.ca)
In such a case, the quantitative exposure estimates may be based on predictive computer models or on the results of environmental monitoring or human biomonitoring studies (measurements of substances in the environment or in people) conducted in Canada. (canada.ca)

ii) The cleanup action provides for appropriate institutional controls implemented in accordance with WAC 173-340-440 to limit potential exposure to residual hazardous substances. (wa.gov)
B) The degree of reduction of potential exposure to residual hazardous substances by the selected remedy. (wa.gov)
We can also provide phototoxicity and photosensitisation screening to test for irritancy and/or allergy potential following exposures to UV light. (intertek.com)
Granola 97 was evaluated for dermal sensitization potential using a modified Buehler method. (epa.gov)
EPA will use the screening level methodology to evaluate potential chemical exposures and associated potential risks to fenceline communities in its Toxic Substances Control Act (TSCA) risk evaluations. (lawbc.com)
The DustTrak, with 10-microm sampling head, was useful in pinpointing the areas of potential exposure. (creod.on.ca)
The main focus of this opinion will therefore be to evaluate the potential for exposure to DEHP from uses of DEHP-containing erasers by children. (greenfacts.org)
2-Nitrotoluene was identified as presenting an intermediate potential for exposure of individuals in Canada and had been classified by other agencies on the basis of carcinogenicity and genotoxicity. (gc.ca)
On the basis of the carcinogenic potential of 2-nitrotoluene, for which there may be a probability of harm at any exposure level, it is concluded that 2-nitrotoluene is a substance that may be entering the environment in a quantity or concentration or under conditions that constitute or may constitute a danger in Canada to human life or health. (gc.ca)
Mikolajczak CJ, Taylor PM. A method for assessing the potential for a dermal burn hazard from malfunctioning consumer electronic devices. (exponent.com)
The oil pollutant in the Sava River aquifer in the residential area of Belgrade, Serbia was investigated in order to analyze the extent, origin and spatial distribution of the pollution, with the aim to estimate potential human health risks from exposure to the compounds detected. (ac.rs)
The analysis of the lifetime incremental cancer risk indicated the potential for adverse health effects for human exposure at the investigated location, and because of that it was interpreted as an unacceptable risk level or risks of high priority which required immediate consideration for remedial measures at this location. (ac.rs)
In patients that present with problems identified at examination that have not previously been reported to a health care practitioner the dentist can be instrumental in defining potential pathology and making the appropriate referral for additional medical evaluation. (medscape.com)

This conclusion is supported by the independent evaluation of the MAK Commission for the Investigation of Health Hazards of Chemical Compounds in the work area (MAK, 46. (europa.eu)
Because the use of cosmetics shows an increasing trend and some adverse health outcomes of parabens present in these products have been reported, the present review focused on the safety of dermal application of these compounds. (nih.gov)
The levels of PAHs and benzene in fire fighters' bodies were similar to levels in occupational groups with low exposures to these compounds. (fireemsleaderpro.org)
The Expert Committee's work in its complexity and in reaching an international consensus in the evaluation of these compounds is unique in its importance and impact on global public-health decisions related to food safety. (who.int)

Chronic exposure of rats resulted in increased thyroid follicular cell tumors from sustained perturbation of thyroid hormone homeostasis. (cdc.gov)

The only exception was exposure to DEHP from erasers through sucking and chewing. (greenfacts.org)
Organic particle concentrations are often high indoors, which promotes the sorption of DEHP and other SVOCs, which in turn may contribute to increased human exposure to DEHP and other SVOCs. (lu.se)

Worksite evaluations are considered a priority for cases where the asthma trigger is a known or suspected sensitizer and/ or when co-workers appear to be at risk. (cdc.gov)
There is no indication that this product is a dermal sensitizer in guinea pigs. (epa.gov)
Criteria used to consider a positive response: The test item is considered as a skin sensitizer, if exposure to at least one concentration of the test item resulted in an incorporation of 3HTdR at least 3-fold or greater than recorded in control mice, as indicated by the stimulation index (SI ≥ 3). (europa.eu)

The direct risk that nanoparticles present to human health and to the environment will depend on the physicochemical characteristics of the surface and core of nanoparticles, on the probability of exposure occurring during each stage of their life cycle, and on the extent to which particulate materials exhibit interactions with biological systems associated with their nanostructure. (acs.org)

If no one comes into contact with a chemical, then no exposure occurs, thus no health effects could occur. (cdc.gov)
Exposure can occur by breathing, eating, drinking, or by skin contact with a substance containing the chemical. (cdc.gov)
Human exposure may occur via inhalation due to the high vapor pressure of iodomethane. (cdc.gov)

Our dermal safety studies, from our clinical study centre in Paris, France, are focused on supporting your product development through evidence-based dermatological efficacy testing and claims substantiation studies. (intertek.com)
Tests on volunteer chimney sweeps demonstrated efficacy as well as revealing that dermal exposure is a problem. (chemistryviews.org)
Niosomes, self-assembled vesicular structures composed of nonionic surfactants and cholesterol, have been extensively investigated as a means of overcoming this barrier and improving the efficacy of dermal drug delivery. (bvsalud.org)

Estimates of the concentration in the different indoor compartments are combined with equations estimating exposure from contact with these media. (rivm.nl)
BARBER, C., WIGGANS, R. and FISHWICK, D. Estimating lifetime asbestos exposure in patients with idiopathic pulmonary fibrosis. (hsl.gov.uk)

This characterization provides context for defining benchmarks for the evaluation of NAMs for skin sensitization assessments. (nih.gov)

Dermal safety studies via human clinical trials help to evaluate the safety of cosmetics, skincare and consumer products. (intertek.com)
Cosmetics are a source of lifetime exposure to various substances including parabens, being the most popular synthetic preservatives. (nih.gov)
Due to the real risk of estrogenic effects, as a result of exposure to parabens in cosmetics, simultaneous use of many cosmetic products containing these preservatives should be avoided. (nih.gov)
In 2013, Abdallah was awarded a prestigious 2-year Marie-Curie Fellowship during which he pioneered the application of 3D-Human Skin Equivalent models (3D-HSE) to study the human dermal bioavailability and metabolism of chemical pollutants in dust, fabrics, and cosmetics. (birmingham.ac.uk)
This review summarizes the current state of research on the use of niosomes in dermal drug delivery in cosmetics, with a particular focus on their formulation, characterization, and application in the delivery of various drug classes. (bvsalud.org)
Exposure from the diet or from a combination of sources (diet, dust, cosmetics and thermal paper) is considerably under the safe level (the "tolerable daily intake" or TDI). (newhope.com)

The histology is similar in both wrist and heel papules, revealing fragmentation of dermal elastic tissue and herniation of subcutaneous fat into the dermis. (medscape.com)
This thinning is also primarily a dermal change, with loss of elastic fibers, epithelial appendages, and ground substance. (medscape.com)

Dermal contact doses should be estimated when the chemical being evaluated is one that can pass through a person's skin or when most of the skin on a person's body is exposed to a chemical, for example, while swimming. (cdc.gov)
The union submitted the HHE request due to concerns regarding employee exposure to metalworking fluids (MWFs) and skin rash. (cdc.gov)
The criteria for the search strategy, evaluation, and selection of data are described in Appendix E in Current Intelligence Bulletin 61: A Strategy for Assigning New NIOSH Skin Notations [NIOSH 2009]. (cdc.gov)
DREAM supplies estimates for exposure levels on the outside clothing layer as well as on skin, and provides insight into the distribution of dermal exposure over the body. (tno.nl)
The dermal regeneration template, a bioengineered skin substitute, is a remarkable alternative to the traditional reconstructive choices. (rbcp.org.br)
Dermal elastosis is considered the histological 'gold standard' for evaluation of skin photoaging, but the relation of the level of dermal elastosis to other histological indicators of photoaging is not clear. (karger.com)
Amonga range of suggested biomarkers of photoaged skin, only p53-positive cells appear to be strongly associated with the level of dermal elastosis. (karger.com)

At higher exposure levels also the olfactory epithelium, larynx or trachea were affected. (europa.eu)

It is essential to evaluate land uses and zoning for compliance with this definition in the context of this exposure scenario. (wa.gov)
How does ATSDR determine which exposure situations to evaluate? (cdc.gov)

Identity and physical/chemical properties -- Analytical methods -- Sources of human and environmental exposure -- Environmental transport, distribution, and transformation -- Environmental levels and human exposure -- Comparative kinetics and metabolism in laboratory animals and humans -- Effects on laboratory mammals and in virto test systems -- Effects on humans -- Effects on other organisms in the laboratory and the field -- Effects evaluation -- Previous evaluations by IOMC bodies. (epa.gov)
7 Extensive research and field and laboratory evaluations have generated a significant body of knowledge on the safe handling of nanomaterials. (acs.org)
No laboratory evaluation is required. (medscape.com)

Exposures of the general population to 2-nitrotoluene through environmental media (air, drinking water and soil) are expected to be negligible. (gc.ca)
Based upon the information obtained on current uses of 2-nitrotoluene in Canada , exposure of the general population is expected to be negligible. (gc.ca)

The Hazard Evaluation and Technical Assistance Branch (HETAB) of the National Institute for Occupational Safety and Health (NIOSH) conducts field investigations of possible health hazards in the workplace. (cdc.gov)
care, and the hazards of MWF exposures. (cdc.gov)
As for what's to come in 2014, a study focused on the tertiary hazards from fire smoke and debris exposure to firefighters related to their PPE. (fireemsleaderpro.org)

2008) concluded that the amount of atrazine applied to the fields by an agricultural worker is likely to provide a valid surrogate of atrazine exposure in epidemiologic studies. (who.int)

The specific purpose of the NIOSH evaluation was to determine if currently employed workers were at risk for developing asthma from exposures at this workplace. (cdc.gov)
EVALUATION FOR ACCEPTABLE DAILY INTAKE BIOLOGICAL DATA Observations in humans Results of a programme of monitoring the urine of more than 200 workers who had received training in the use of chlordimeform in cotton in California have been reported. (inchem.org)
Hazard Exposure with Health and Safety Outcomes Hinder the Work Ability of Salt Farm Workers in Thailand. (umassmed.edu)
Two examples of dermal exposure of workers of a car-construction company show that DREAM characterizes tasks and gives insight into exposure mechanisms, forming a basis for systematic exposure reduction. (tno.nl)
Iodomethane HECs for workers and bystanders were derived using the PBPK model and NOAELs for acute exposure endpoints of concern. (cdc.gov)
The study also found that the proportion of these urinary metabolites varied considerably depending on whether the subjects had high or low acute exposures or whether the subjects had general environmental exposures (i.e., not agricultural workers). (who.int)
At the time of the previous IARC evaluation of atrazine (Vol. 73, 1999), the most relevant epidemiologic studies consisted of two cohort studies of manufacturing workers, three population-based case-control studies of lymphatic and hematopoietic malignancies in agricultural areas of the U.S., and a population-based case-control study of ovarian cancer in a rice-growing area of Italy. (who.int)
Inhalation is thought to be the main route of exposure for workers, although dermal exposure is possible. (who.int)

The critical effects of acute duration iodomethane exposure are: (1) fetal losses in rabbits, (2) lesions in rat nasal epithelium, and (3) transient neurotoxicity in rats. (cdc.gov)

The DustEx model is used to assess exposure to semi-volatile substances (SVOCs) in products that are introduced into the indoor environment. (rivm.nl)
Information from various sources is evaluated to assess the risk to Canadians and the environment from exposure to substances in products. (canada.ca)

Little is known about CIPP worker exposures and health risks. (cdc.gov)
The conclusion in the report is that, in general, the investigated exposures do not present a health risks for the children. (greenfacts.org)

For SVOCs released indoors it may not be clear beforehand which exposure pathway(s) will be relevant. (rivm.nl)

Dermal drug delivery has emerged as a promising alternative to traditional methods of drug administration due to its non-invasive nature and ease of use. (bvsalud.org)
METHODS: We used a two-stage cluster sampling method to recruit HIV treatment initiators with and without prior exposure to antiretroviral therapies (ART) in selected clinics. (cdc.gov)

EMEGs, RMEGs, and CREGs are non-enforceable, health-based comparison values developed by ATSDR for screening environmental contamination for further evaluation. (cdc.gov)
On January 21, 2022, the U.S. Environmental Protection Agency (EPA) announced the availability of and solicited public comments on the " Draft TSCA Screening Level Approach for Assessing Ambient Air and Water Exposures to Fenceline Communities Version 1.0 " (screening level methodology). (lawbc.com)

This fact sheet does not cover direct or indirect exposures to substances present in foods or food packaging materials. (canada.ca)
Therefore, risk assessments of existing substances and new substances are carried out under CEPA 1999 and often include looking at the exposure of Canadians and the environment to substances from products. (canada.ca)
In other cases, exposures to substances in products are qualitatively determined, meaning estimates are not calculated numerically. (canada.ca)
The cancer risk associated with substances or agents that are assigned the same classification may be very different, depending on factors such as the type and extent of exposure and the size of the effect of the agent at a given exposure level. (who.int)

Human exposure to microplastics in the indoor environment. (birmingham.ac.uk)

Exposure does not always result in harmful health effects. (cdc.gov)
Comparison values are developed by ATSDR from available scientific literature concerning exposure and health effects. (cdc.gov)
If chemical concentrations are above comparison values, ATSDR further analyzes exposure variables (e.g., duration and frequency) for health effects, including the toxicology of the chemical, other epidemiology studies, and the weight of evidence. (cdc.gov)
Currently, he is completing research on exposure and health effects of chemical warfare agents and is working to identify countermeasures to sulfur mustard exposure. (rutgers.edu)
Exposure to air pollution is associated with adverse health effects in humans, with special concern for exposure to fine particulate matter (PM2.5). (lu.se)

Members of the general population that are in proximity to air emitting facilities or a receiving waterbody, and who therefore may be disproportionately exposed to a chemical undergoing risk evaluation under TSCA section (6). (lawbc.com)
Quinoxyfen applicators and handlers should exercise caution and adhere to the appropriate clothing gear before any contact or exposure to the chemical. (naturalpedia.com)
Because humans are the primary subject of interest for regulatory safety testing, it is advantageous to have human reference data available for evaluation of NAMs for assessing chemical safety. (nih.gov)

The Evaluation Report(s) of the pesticide, reflecting the evaluation of the data package carried out by WHO and the JMPS. (who.int)

Thus, an evaluation to determine compliance with this definition should include a review of the actual text in the comprehensive plan and zoning ordinance pertaining to the site and a visit to the site to observe land uses in the zone. (wa.gov)

These investigations, called Health Hazard Evaluations (HHEs) are conducted to determine whether or not any substance normally found in the place of employment has potentially toxic effects. (cdc.gov)
Information was considered from studies of humans, animals, or appropriate modeling systems that are relevant to assessing the effects of dermal exposure to PCP. (cdc.gov)
Exposure by any route can cause systemic effects. (cdc.gov)
Exposure to 2-nitrotoluene has also been associated with non-cancer effects in experimental animals, including developmental and reproductive effects as well as effects in the lungs, liver, spleen, bone marrow and the hematopoietic system. (gc.ca)

In view of the human data indicating increased incidence of bladder cancer following exposure to 4-chloro-2-toluidine, a metabolite of chlordimeform, and the occurrence of this compound as a residue in treated crops, the meeting recommends that chlordimeform should not be used where its residues, or those of its metabolite 4-chloro-2-toluidine, can arise in food. (inchem.org)
For evaluated aquatic exposure routes, EPA limits proximity to the extent of the identified waterbody receiving a facility discharge and therefore does not have a specific distance associated with the human receptor. (lawbc.com)
Iodomethane is a new agricultural of approximately 24 hours due to the emission patterns of active ingredient, and there are no human exposure incident the compound and air dispersion patterns ( EPA OPP Health reports related to agricultural uses. (cdc.gov)
Comparative evaluation of human exposure to PFAS from drinking water in UK and China. (birmingham.ac.uk)
Human dietary exposure to organophosphate esters. (birmingham.ac.uk)
The results presented in this thesis highlight the importance of detailed physicochemical characterization of indoor aerosols, and the need for a more complete evaluation of their impact on human health. (lu.se)

the adequacy of ventilation and work practices used to limit exposures. (cdc.gov)

Chlordimeform was detectable in urine as early as four hours after dermal exposure. (inchem.org)
Immunization alone induced dermal immediate hypersensitivity reactions in all monkeys and circulating specific reaginic antibody detectable by P-K testing in 6 of 8 monkeys. (ajtmh.org)

3) Recognition of this entity should prevent unnecessary evaluations, surgery, and parental angst. (aad.org)

However, the classification does not indicate the level of cancer risk associated with exposure at different levels or in different scenarios. (who.int)

Although new data and refined methodologies have led EFSA's experts to considerably reduce the safe level of BPA from 50 micrograms per kilogram of body weight per day (µg/kg of bw/day) to 4 µg/kg of bw/day, the highest estimates for dietary exposure and for exposure from a combination of sources (called "aggregated exposure" in EFSA's opinion) are three to five times lower than the new TDI. (newhope.com)

This section shall be used to establish soil cleanup levels where the department has determined that industrial land use represents the reasonable maximum exposure. (wa.gov)
Soil cleanup levels for this presumed exposure scenario shall be established in accordance with this section. (wa.gov)
Industrial soil cleanup levels are based on an adult worker exposure scenario. (wa.gov)
If exposure is possible, ATSDR scientists then consider whether contamination is present at levels that might affect public health. (cdc.gov)
Occupational quartz and particle exposure affect systemic levels of inflammatory markers related to inflammasome activation and cardiovascular disease. (oru.se)
Older age, male sex and high outdoor exposure levels were confirmed as predictors ofhigh levels of dermal elastosis. (karger.com)

EPA Exposure Factor Handbook external icon , EPA Soil Screening Guides external icon , and EPA RAGs external icon . (cdc.gov)

These put limits on the applicability of the model in exposure assessments. (rivm.nl)

The major exposure route to phthalates from the items investigated in the Danish study is by licking and chewing on the items as well as swallowing small pieces of the item. (greenfacts.org)
In one study, authors reviewed US poison center data for 2004 and determined that over 40,000 exposures to salicylate-containing products occurred. (medscape.com)
However, variability in animal study data represents a barrier to an objective evaluation of NAM accuracy. (nih.gov)

At contaminated sites, drinking-water is the main exposure source for the general population. (who.int)

This evaluation included sample recovery, determination of detection limits, and stability of samples during storage. (creod.on.ca)
The report explains the need of establishing PPE guidelines and offers advice for its use and compatibility, and provides guidance on how to set safe exposure limits. (cdc.gov)

Anatomy3

Diseases2

Chemicals and Drugs25

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Phenomena and Processes3

Disciplines and Occupations1

Technology, Industry, Agriculture17

Named Groups1

Health Care19

Geographicals3

Toxicity7

Absorption4

Assessment22

Ingestion2

Polycyclic aromatic hyd3

Pathways6

Irritation3

Acute or chronic3

Inhalation exposure5

Characterize4

Occupational exposure10

Systemic exposure3

Airborne4

Chemicals12

Contaminants1

Dose3

Uptake3

Aggregate exposure2

Quantitative4

Potential13

Compounds4

Chronic1

DEHP2

Sensitizer3

Nanoparticles1

Occur3

Efficacy3

Estimating2

Sensitization1

Cosmetics6

Elastic2

Skin7

Olfactory1

Evaluate2

Laboratory3

Negligible2

Hazards3

Surrogate1

Workers8

Rabbits1

Assess2

Risks2

SVOCs1

Methods2

Environmental2

Substances4

Indoor environment1

Health effects5

Chemical3

Pesticide1

Compliance1

Effects4

Human6

Ventilation1

Detectable2

Prevent1

Risk1

Estimates1

Levels6

Soil1

Assessments1

Study3

General1

LIMITS2