Title: Identification of the Drosophila eIF4A gene as a target of the DREF transcription factor. (genscript.com)
Although eIF4A is an ATP-dependent RNA helicase that binds the MA3 domain of eIF4G to promote translation initiation, binding of eIF4A to the MA3 domains of PDCD4 inhibits protein synthesis. (biomedcentral.com)
While eIF4E binds to the 5′-cap structure, eIF4A is an ATP-dependent RNA helicase that hydrolyzes ATP in order to unwind secondary structure present in the 5′-leader of an mRNA that would otherwise inhibit 40S subunit scanning during its search for the initiation codon [ 2 ]. (biomedcentral.com)
EIF4A22
Eukaryotic initiation factor 4A-II is a protein that in humans is encoded by the EIF4A2 gene. (wikipedia.org)
Overview of all the structural information available in the PDB for UniProt: Q14240 (Human Eukaryotic initiation factor 4A-II (EIF4A2)) at the PDBe-KB. (wikipedia.org)
Pathways1
The results suggest that the roles for the two factors in DNA methylation maintenance pathways can be traced back to the last eukaryotic common ancestor and that the CDC7A-HELLS-DNMT axis shaped the evolutionary retention of DNA methylation in eukaryotes. (elifesciences.org)
EIF4G1
The interaction of eIF4G with eIF4E bound to the 5′-cap and PABP bound to the poly(A) tail circularizes an mRNA and stimulates translation by promoting 40 S subunit recruitment [ 10 , 11 ]. (biomedcentral.com)
Protein5
Our analysis of this data reveals an absolute protein-to-RNA ratio of 10 2 -10 4 for bacterial populations and 10 3 -10 5 for an archaeon, which is more comparable to Eukaryotic representatives' humans and yeast. (nature.com)
Hepatocyte growth factor receptor (c-Met), a member of tyrosine protein kinase receptors (TPKR), is phosphorylated during LPLI-induced proliferation, but tumor necrosis factor alpha (TNF-alpha) receptor has not been affected. (biomedcentral.com)
Although initially discovered as a retinoblastoma binding protein it has an affinity for core HISTONES and is a subunit of chromatin assembly factor-1 and polycomb repressive complex 2. (lookformedical.com)
The programmed cell death 4 (PDCD4) protein is induced in animals during apoptosis and functions to inhibit translation and tumor promoter-induced neoplastic transformation. (biomedcentral.com)
PDCD4 is composed of two MA3 domains that share similarity with the single MA3 domain present in the eukaryotic translation initiation factor (eIF) 4G, which serves as a scaffold protein to assemble several initiation factors needed for the recruitment of the 40S ribosomal subunit to an mRNA. (biomedcentral.com)
MRNA4
A trimeric peptide initiation factor complex that associates with the 5' MRNA cap structure of RNA ( RNA CAPS ) and plays an essential role in MRNA TRANSLATION . (nih.gov)
Trans -acting splicing factors, pre-mRNA secondary structure and chromatin organization are now known to directly affect alternative splicing decisions [ 6 ]. (biomedcentral.com)
However, both the accumulation of splicing factors at sites of pre-mRNA synthesis as well as pre-mRNA splicing are dramatically reduced, demonstrating that IGC disassembly perturbs coordination between transcription and pre-mRNA splicing in mammalian cell nuclei. (rupress.org)
Although the bacterial 30 S ribosomal subunit can identify the initiation codon through base-pairing between the 3′-end of its16 S ribosomal RNA subunit and the Shine-Dalgarno sequence upstream of the initiation codon, the 40 S ribosomal subunit of the eukaryotic 80 S ribosome requires several translation initiation factors (eIFs) for its binding to an mRNA and to identify the initiation codon [ 1 - 3 ]. (biomedcentral.com)
Elongation2
The human ortholog of MEF2 is the Elongation Factor Gene (EF-G) 2, which has previously been shown to play a specific role in mitochondrial ribosome recycling. (prolekarniky.cz)
Mitochondrial translation, essential for synthesis of the electron transport chain complexes in the mitochondria, is governed by nuclear encoded genes. (prolekarniky.cz)
Furthermore, LPLI induces the synthesis or release of many molecules, like growth factors, interleukins, inflammatory cytokines and others, which are related to promotive effects of LPLI. (biomedcentral.com)
IGCs are composed of particles measuring 20-25 nm in diameter, and they contain numerous factors that are involved in RNA synthesis and processing. (rupress.org)
The extracellular transport of molecules 1, 4A and 103( synthesis) for regulation cell membranes and upstream DCs triggers reduced through modfiying to the functional midwifery CCR6 and not another extracellular different melanin( Yang et al. (erik-mill.de)
Gene2
Recently a mutation in a novel gene, believed to be a member of the class of mitochondrial peptide release factors, was identified in patients exhibiting symptoms of Leigh syndrome [4] . (prolekarniky.cz)
Gene expression, Kaplan-Meier survival, microRNA and transcription factor target analyses were performed with the University of Alabama Cancer (UALCAN) Database, Kaplan-Meier Plotter, LinkedOmics, WebGestalt and gene set enrichment analysis, respectively. (xiahepublishing.com)
Humans1
OBJECTIVE: The innate immune response in humans involves a wide variety of factors, including the tripartite motif-containing 5α (TRIM5α) and 22 (TRIM22) as a cluster of genes on chromosome 11 that have exhibited antiviral activity in several viral infections. (bvsalud.org)
Proteins2
This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS. (lookformedical.com)
proteins are 6 caused download rarefied receptors that in starts 1, 4A and 103( factor) have carefully cross-presented to obtain certain 1-5, 2-4, 3-6. (erik-mill.de)
Regulation2
MicroRNA (miRNA) are a subset of short (~22 bp) endogenous non-coding RNA that play a significant role in post-transcriptional regulation, via repression of translation. (biomedcentral.com)
This important manuscript reveals signatures of co-evolution of two nucleosome remodeling factors, Lsh/HELLS and CDCA7, which are involved in the regulation of eukaryotic DNA methylation. (elifesciences.org)
Fatty1
2 Risk factors, including viral infection, alcoholic cirrhosis and fatty liver, along with chronic inflammatory disorders of the biliary tract, genetic diseases and carcinogens, contribute to the risk of HCC. (xiahepublishing.com)
In addition, we showed that MTA2, a chromatin remodeling factor, possesses potent flavivirus-specific antiviral functions induced by IFN. (bvsalud.org)
Yeast1
Based on yeast genetic studies, we identify the mitochondrial translation factor MEF2 as a mediator of atorvastatin toxicity. (prolekarniky.cz)
ELISA Kit1
Description: A sandwich ELISA kit for detection of Myogenic Factor 5 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (1elisakits.com)
Respiratory1
Low power laser irradiation (LPLI) promotes proliferation of multiple cells, which (especially red and near infrared light) is mainly through the activation of mitochondrial respiratory chain and the initiation of cellular signaling. (biomedcentral.com)
Mitotic1
However, impaired splicing affects only a subset of human transcripts, enriched for mitotic cell cycle factors, leading to mitotic arrest. (biomedcentral.com)
Mitochondrial1
Several components of the electron transport chain are encoded in the mitochondrial genome, the translation of which is governed largely by nuclear encoded genes. (prolekarniky.cz)
Tumor3
Description: A sandwich quantitative ELISA assay kit for detection of Human Tumor Necrosis Factor Ligand Superfamily, Member 9 (TNFSF9) in samples from serum, plasma, tissue homogenates or other biological fluids. (1elisakits.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Tumor Necrosis Factor Ligand Superfamily, Member 9 (TNFSF9) in serum, plasma, tissue homogenates and other biological fluids. (1elisakits.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Tumor Necrosis Factor Ligand Superfamily, Member 9 (TNFSF9) in samples from serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (1elisakits.com)
Human3
The main factor associated with the onset and progression of this neoplasia is the human papillomavirus (HPV) infection. (bvsalud.org)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Myogenic Factor 5 (MYF5) in Tissue homogenates and other biological fluids. (1elisakits.com)
Description: Quantitative sandwich ELISA for measuring Human Myogenic factor 5 (MYF5) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (1elisakits.com)
Transcription factor1
SNHG4 is closely associated with miR-154 and miR-206, transcription factor target E2F family and the signaling pathway for MAPK/ERK and mTOR. (xiahepublishing.com)
Our study suggests that a unique specialized role of CDCA7 in HELLS-dependent DNA methylation maintenance is broadly inherited from the last eukaryotic common ancestor. (elifesciences.org)
Important1
This makes the selection of the internal reference an important factor in the design of a qPCR experiment. (biomedcentral.com)
Role2
In addition, EPCs can also play a crucial role in neovascularization, blood vessel and tissue repair, and so on, by secreting a variety of cytokines and angiogenic growth factors [ 8 ]. (biomedcentral.com)
ROS may play a role in fungal pathogenicity in ST, the fruit-body initiation in PR, sexual reproduction and highland adaptation in MF. (peerj.com)
Cell1
Description: Quantitative sandwich ELISA for measuring Mouse Myogenic factor 5 (MYF5) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (1elisakits.com)
Expression1
U2 auxiliary factor 2 (U2AF2) showed strong correlation with SNHG4 , while low-expression of U2AF2 showed good prognosis. (xiahepublishing.com)
Small1
LINC00659 knock-down promoted the proliferation, migration, and angiogenesis ability of EPCs, while an pcDNA-eukaryotic translation initiation factor 4A3 (EIF4A3), a EIF4A3 overexpression vector, or fibroblast growth factor 1 (FGF1) small interfering RNA (siRNA) combined with LINC00659 siRNA could not enhance this effect. (biomedcentral.com)