• Involved in translational initiation. (nih.gov)
  • Biological process: cap-dependent translational initiation. (expasy.org)
  • Biological process: cytoplasmic translational initiation. (expasy.org)
  • Structure of the delta dII IRES eIF2-containing 48S initiation complex, closed conformation. (expasy.org)
  • The eIF2 protein is called an initiation factor because it is involved in starting (initiating) protein synthesis. (medlineplus.gov)
  • Eukaryotic translation initiation factor 2α (eIF2α) is a key mediator of the endoplasmic reticulum (ER) stress-induced unfolded protein response (UPR). (bvsalud.org)
  • ARTICLE HIGHLIGHTS: This study examines the impact of eukaryotic translation initiation factor 2α (eIF2α) phosphorylation, triggered by an energy deficit, on hypothalamic AgRP neurons and its subsequent influence on whole-body energy homeostasis. (bvsalud.org)
  • Candida eIF2 can be a phosphoprotein, however in this case phosphorylation by CK2 occurs on its eIF2 subunit however, not on its eIF2 subunit [29,30]. (bioinf.org)
  • Particular phosphorylation by CK2 in the eIF2 subunit in addition has been reported for eIF2 from [31] and ocean urchin [32]. (bioinf.org)
  • subunit as well as for determining that it's necessary for the discussion with eIF2 [35], which gives an answer towards the discrepancy in the outcomes obtained in prior research using endogenous phosphorylated eIF2B [35C37]. (bioinf.org)
  • EXPERIMENTAL Reagents and antibodies Apigenin, emodin and anti-His6 antibody had been extracted from Sigma, anti-eIF2 as well as the catalytic subunit from the PP2A (proteins phosphatase 2A) phosphatase had been from Cell Signaling Technology, anti-CK2 and anti-eIF5 had been from Santa Cruz Biotechnology and anti-eIF2 was from Cell Signaling Technology. (bioinf.org)
  • The protein encoded by this gene is a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex. (wikipedia.org)
  • The eIF3 complex binds the 40S ribosome and mRNAs to enable translation initiation. (wikipedia.org)
  • The RNA helicase eIF4A and the scaffold protein eukaryotic translation initiation factor 4G (eIF4G) and the capping protein eIF4E are part of the complex that loads the mRNAs onto the 40 S ribosomal subunit, together with eIF3. (biosyn.com)
  • eIF3 (eukaryotic initiation factor 3) is the largest and most complex eukaryotic mRNA translation factor in terms of the number of protein components or subunits. (manchester.ac.uk)
  • In mammals, eIF3 is composed of 13 different polypeptide subunits, of which five, i.e. a, b, c, g and i, are conserved and essential in vivo from yeasts to mammals. (manchester.ac.uk)
  • The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). (nih.gov)
  • EIF5B (Eukaryotic Translation Initiation Factor 5B) is a conserved eukaryotic translation factor that mediates association of the 40S and 60S ribosomal subunits during eukaryotic translation initiation, and modulates the cell cycle progression by regulating the translation of upstream open reading frames (uORF)-containing mRNAs such as p27 and p21 [ 3 ]. (techscience.com)
  • In the glioma cells, EIF5B promotes cell survival by enhancing the translation of several IRES-containing mRNAs including those encoding anti-apoptotic proteins such as XIAP and Bcl-xL [ 4 ]. (techscience.com)
  • Inactivation of the encoded protein has been shown to interfere with translation of herpes virus mRNAs by preventing the association of mRNAs with the ribosomes. (utsouthwestern.edu)
  • mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. (expasy.org)
  • In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs. (expasy.org)
  • mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. (expasy.org)
  • The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (expasy.org)
  • The 'closed-loop' model explains that the induction of 5'- to 3'-proximity of mRNAs requires the initiation factors eIF4E, eIF4G, and PABP. (biosyn.com)
  • Interestingly, overexpression of these last two subunits is associated with enhanced translation of specific mRNAs over and above the general enhancement of global translation. (manchester.ac.uk)
  • catalytic subunit of CK2 (CK2) inhibits its activity in proteins substrates [16]. (bioinf.org)
  • HEAT repeat domain, found in protein phosphatase 2a and initiation factor eIF4G. (eu.org)
  • MIF4G domain-like, found in eukaryotic initiation factor eIF4G, translation initiation factor eIF-2b epsilon and nuclear cap-binding protein CBP80. (eu.org)
  • In humans there exist five isoforms of the B56 type regulatory subunit and they bind to their interacting proteins through a conserved LxxIxE motif. (eu.org)
  • The motif is conserved in essential proteins throughout the eukaryotic domain of life and also in human viruses, suggesting that the motifs are required for basic cellular function. (eu.org)
  • Protein dephosphorylation by the PP2A phosphatase is mainly achieved through the interaction of its regulatory subunit with the associated proteins. (eu.org)
  • Enzyme-linked immunosorbent assay (ELISA) was employed to measure levels of five serum proteins previously demonstrated to be up-regulated in papillary thyroid cancer (PTC): angiopoietin-1 (Ang-1), cytokeratin 19 (CK-19), tissue inhibitor of metalloproteinase-1 (TIMP-1), chitinase 3 like-1 (YKL-40), and galectin-3 (GAL-3). (biomedcentral.com)
  • Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. (expasy.org)
  • Such infidelity impaired mitochondrial translation and oxidative phosphorylation, causing oxidative stress and cell cycle arrest in the G0/G1 phase. (cnrs.fr)
  • Furthermore, the function of CK2 in the basal phosphorylation of the subunit continues to be explored through the use of chemical substance inhibitors and a CK2 mutant that straight alters CK2 activity inside the cell [38]. (bioinf.org)
  • Only the PERK pathway was found to be activated in 3a-expressing cells based on (1) increased phosphorylation of eukaryotic initiation factor 2 alpha (eIF2alpha) and inhibitory effects of a dominant-negative form of eIF2alpha on GRP78 promoter activity, (2) increased translation of activating transcription factor 4 (ATF4) mRNA, and (3) ATF4-dependent activation of the C/EBP homologous protein (CHOP) gene promoter. (nih.gov)
  • The 3a protein was found to induce serine phosphorylation within the IFN alpha-receptor subunit 1 (IFNAR1) degradation motif and to increase IFNAR1 ubiquitination. (nih.gov)
  • The regulatory subunits of PP2A holoenzyme determine the substrate specificity. (eu.org)
  • Regulatory subunit H of V-type ATPases. (eu.org)
  • Additionally, the TME is influenced by m 6 A regulatory factors, impacting the progression and prognosis of CRC. (biomedcentral.com)
  • PREDICTED: splicing factor U2af small subunit B-like isoform X1 [Musa acuminata subsp. (riken.jp)
  • Part of eukaryotic translation initiation factor 3 complex, eIF3m. (nih.gov)
  • Total RNA from tumors the expression of thousands of genes (3) to address complex questions was isolated using two successive rounds of Trizol. (lu.se)
  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). (nih.gov)
  • The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). (nih.gov)
  • The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. (nih.gov)
  • Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways. (medlineplus.gov)
  • EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. (expasy.org)
  • The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. (expasy.org)
  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. (expasy.org)
  • The eIF-3 complex interacts with pix. (expasy.org)
  • The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex. (expasy.org)
  • Biological process: formation of cytoplasmic translation initiation complex. (expasy.org)
  • Figure 3 shows molecular models of the cystal structure of eIF4E, in complex with the cap m7GpppA, and a 4EBP1 peptide. (biosyn.com)
  • In the present study, we show that the eukaryotic cytosolic chaperonin CCT [chaperonin containing TCP-1 (tailless complex polypeptide 1)] binds to newly synthesized eIF3b and promotes the correct folding of eIF3h and eIF3i. (manchester.ac.uk)
  • PP2A-mediated protein dephosphorylation is involved in a broad range of cellular processes including cell-cycle progression, cytoskeletal dynamics, and growth factor signalling. (eu.org)
  • However, whether mitochondrial translation needs fidelity and the significance of editing by mitochondrial aaRSs have been unclear. (cnrs.fr)
  • The Combination of piR-823 and Eukaryotic Initiation Factor 3 B (EIF3B) Activates Hepatic Stellate Cells via Upregulating TGF-β1 in Liver Fibrogenesis. (nih.gov)
  • The CaV1 and CaV2 channels are heteromeric, consisting of an α1 pore-forming subunit, associated with auxiliary CaVβ and α2δ subunits. (stanford.edu)
  • Spilka R, Ernst C, Mehta AK, Haybaeck J (2013): Eukaryotic translation initiation factors in cancer development and progression. (fh-krems.ac.at)
  • The major risk factors associated with HCC development and progression include chronic hepatitis B or C virus infections, high alcohol consumption, and activation of oncogenes [ 2 ]. (techscience.com)
  • They are responsible for the regulation of various pro- and anti-tumor factors and play a role in the progression of the disease. (biomedcentral.com)
  • Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. (expasy.org)
  • International journal of molecular sciences, 20 (3): 690. (fh-krems.ac.at)
  • The motif binds to a well conserved and surface-exposed binding groove formed between the B56 HEAT repeats 3 and 4. (eu.org)
  • Eukaryotic translation initiation factor 3 subunit C like is a protein that in humans is encoded by the EIF3CL gene. (wikipedia.org)
  • In agreement with this, our data show that, as CCT is required for the correct folding of eIF3h and eIF3i subunits, it indirectly influences gene expression with eIF3i overexpression enhancing both cap-and IRES (internal ribosome entry segment)-dependent translation initiation, whereas eIF3h overexpression selectively increases IRES-dependent translation initiation. (manchester.ac.uk)
  • In this study, we investigated the functional role of eukaryotic initiation factor 5B (EIF5B) in hepatocellular carcinoma (HCC) and the underlying mechanisms. (techscience.com)
  • The Tumor Suppressive Role of eIF3f and Its Function in Translation Inhibition and rRNA Degradation. (msgp.pt)
  • In fungus, deletion from the lysine blocks compromises cell development, Formoterol supplier which factors to a significant role because of this structural feature [7]. (bioinf.org)
  • Contributes to translation initiation factor activity. (nih.gov)
  • The N-terminal fragment of adaptin alpha-C and beta subunits. (eu.org)
  • The diagnostic level of natriuretic peptide A (NPPA), haemoglobin subunit beta (HBB), and hyaluronan and proteoglycan link protein 1(HAPLN1) were validated by a GSE116250 dataset. (researchsquare.com)
  • The α2δ subunits are encoded in mammals by four genes, CACNA2D1-4. (stanford.edu)
  • The EIF2B5 gene provides instructions for making one of five parts of a protein called eIF2B, specifically the epsilon subunit of this protein. (medlineplus.gov)
  • In addition, there are non-cellular components such as growth factors, cytokines, and extracellular matrix that surround the tumor cells. (biomedcentral.com)
  • 2023 ). By modulating these processes, m 6 A modifications have a profound impact on the fate and cellular functions of the modified RNA molecules, influencing RNA splicing, export, translation, and stability. (biomedcentral.com)
  • This study proposes an inverse-gravity (IG) extrusion technique for creating long double-layered cellular TEVGs with diameters over 3 mm. (bvsalud.org)
  • Risk factors for thyroid cancers include prior radiation, family history and genetics. (biomedcentral.com)
  • Based on a review of these and other published studies using gene expression analysis, we concluded that YKL-40, Gal-3, cytokeratin 19 (CK19), TIMP-1 and Ang-1 were consistently found to be upregulated. (biomedcentral.com)
  • Voltage-gated calcium (CaV) channels form three sub-families (CaV1-3). (stanford.edu)
  • Cell Calcium , 55 (3), 155-165. (dpmb.ac.in)